CY1114063T1 - Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων - Google Patents

Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων

Info

Publication number
CY1114063T1
CY1114063T1 CY20131100491T CY131100491T CY1114063T1 CY 1114063 T1 CY1114063 T1 CY 1114063T1 CY 20131100491 T CY20131100491 T CY 20131100491T CY 131100491 T CY131100491 T CY 131100491T CY 1114063 T1 CY1114063 T1 CY 1114063T1
Authority
CY
Cyprus
Prior art keywords
fighters
opiates
tamper
oral formulations
resistant oral
Prior art date
Application number
CY20131100491T
Other languages
English (en)
Inventor
Benjamin Oshlack
Curtis Wright
J David Haddox
Original Assignee
Euro-Celtique S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US18136900P priority Critical
Priority to EP09006024A priority patent/EP2092936B1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22663996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114063(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro-Celtique S.A. filed Critical Euro-Celtique S.A.
Publication of CY1114063T1 publication Critical patent/CY1114063T1/el

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/1617Organic compounds, e.g. phospholipids, fats
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
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    • A61K9/1629Organic macromolecular compounds
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    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
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    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
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    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/501Inorganic compounds
    • AHUMAN NECESSITIES
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    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
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    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5026Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
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    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates

Abstract

Κοινοποιείται σύνθεση οπιούχων ανταγωνιστών και στοματική μορφή δοσολογίας, η οποία περιλαμβάνει ένα σωματίδιο οπιούχου ανταγωνιστή σε ένα επίχρισμα που είναι αδιάλυτο στο γαστρεντερικό σύστημα ή έναν οπιούχο ανταγωνιστή που είναι διασκορπισμένος σε μια μήτρα που καθιστά τον ανταγωνιστή ουσιαστικά μη-αποδεσμευόμενο ή έναν οπιούχο ανταγωνιστή που είναι διασκορπισμένος σε μια μήτρα εξελασμένου τήγματος.
CY20131100491T 2000-02-08 2013-06-18 Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων CY1114063T1 (el)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US18136900P true 2000-02-08 2000-02-08
EP09006024A EP2092936B1 (en) 2000-02-08 2001-02-08 Tamper-resistant oral opioid agonist formulations

Publications (1)

Publication Number Publication Date
CY1114063T1 true CY1114063T1 (el) 2016-07-27

Family

ID=22663996

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20091100824T CY1109270T1 (xx) 2000-02-08 2009-08-04 Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων
CY20131100491T CY1114063T1 (el) 2000-02-08 2013-06-18 Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20091100824T CY1109270T1 (xx) 2000-02-08 2009-08-04 Ανθεκτικα στην παραβιαση στοματικα σκευασματα οπιουχων αγωνιστων

Country Status (34)

Country Link
US (14) US6696088B2 (el)
EP (6) EP3130338A1 (el)
JP (10) JP2003522144A (el)
CN (3) CN100563656C (el)
AP (1) AP1665A (el)
AT (1) AT431145T (el)
AU (2) AU776666B2 (el)
BG (1) BG65828B1 (el)
BR (3) BRPI0108380B1 (el)
CA (1) CA2400567C (el)
CY (2) CY1109270T1 (el)
CZ (1) CZ299991B6 (el)
DE (1) DE60138706D1 (el)
DK (5) DK2517710T3 (el)
EA (1) EA004876B1 (el)
EE (1) EE05171B1 (el)
ES (5) ES2415407T3 (el)
GE (1) GEP20053614B (el)
HK (2) HK1056822A1 (el)
HU (2) HU229705B1 (el)
IL (5) IL151057D0 (el)
ME (1) ME00398B (el)
MX (2) MXPA02007686A (el)
NO (2) NO324717B1 (el)
NZ (1) NZ520554A (el)
OA (1) OA12215A (el)
PL (2) PL210845B1 (el)
PT (6) PT2517710E (el)
RS (1) RS50407B (el)
SI (5) SI2283842T1 (el)
SK (1) SK287107B6 (el)
TW (1) TWI292317B (el)
UA (1) UA79069C2 (el)
WO (2) WO2001058447A1 (el)

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