AU2005245875C1 - Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta - Google Patents

Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta Download PDF

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Publication number
AU2005245875C1
AU2005245875C1 AU2005245875A AU2005245875A AU2005245875C1 AU 2005245875 C1 AU2005245875 C1 AU 2005245875C1 AU 2005245875 A AU2005245875 A AU 2005245875A AU 2005245875 A AU2005245875 A AU 2005245875A AU 2005245875 C1 AU2005245875 C1 AU 2005245875C1
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Australia
Prior art keywords
compound
phenyl
quinazolin
methyl
purin
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AU2005245875A
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AU2005245875A1 (en
AU2005245875B2 (en
Inventor
Kerry W. Fowler
Danwen Huang
Edward A. Kesicki
Amy R. Oliver
Hua Chee Ooi
Kamal Deep Pri
Fuqiang Ruan
Jennifer Treiberg
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Icos Corp
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Icos Corp
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Publication of AU2005245875A1 publication Critical patent/AU2005245875A1/en
Publication of AU2005245875B2 publication Critical patent/AU2005245875B2/en
Priority to AU2009230739A priority Critical patent/AU2009230739A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
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  • Biochemistry (AREA)
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AU2005245875A 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta Active 2030-02-09 AU2005245875C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009230739A AU2009230739A1 (en) 2004-05-13 2009-10-23 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13
US60/570,784 2004-05-13
PCT/US2005/016778 WO2005113556A1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009230739A Division AU2009230739A1 (en) 2004-05-13 2009-10-23 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta

Publications (3)

Publication Number Publication Date
AU2005245875A1 AU2005245875A1 (en) 2005-12-01
AU2005245875B2 AU2005245875B2 (en) 2009-07-30
AU2005245875C1 true AU2005245875C1 (en) 2017-08-31

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ID=34969603

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Application Number Title Priority Date Filing Date
AU2005245875A Active 2030-02-09 AU2005245875C1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
AU2009230739A Abandoned AU2009230739A1 (en) 2004-05-13 2009-10-23 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta

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AU2009230739A Abandoned AU2009230739A1 (en) 2004-05-13 2009-10-23 Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta

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US (14) USRE44638E1 (enExample)
EP (4) EP1761540B1 (enExample)
JP (1) JP2007537291A (enExample)
CN (2) CN101031569B (enExample)
AU (2) AU2005245875C1 (enExample)
BE (1) BE2017C002I2 (enExample)
CA (1) CA2566609C (enExample)
CY (3) CY2016046I1 (enExample)
DK (2) DK2612862T3 (enExample)
ES (3) ES2607804T3 (enExample)
FR (1) FR17C1007I2 (enExample)
HR (2) HRP20161751T1 (enExample)
HU (3) HUE030839T2 (enExample)
IL (4) IL179176A (enExample)
LT (3) LT2612862T (enExample)
LU (1) LUC00005I2 (enExample)
ME (2) ME02688B (enExample)
NL (1) NL300867I2 (enExample)
PL (3) PL2612862T3 (enExample)
PT (3) PT1761540T (enExample)
RS (2) RS55546B1 (enExample)
SI (2) SI3153514T1 (enExample)
WO (2) WO2005113554A2 (enExample)

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US20050043239A1 (en) * 2003-08-14 2005-02-24 Jason Douangpanya Methods of inhibiting immune responses stimulated by an endogenous factor
CA2566436C (en) * 2004-05-13 2011-05-10 Vanderbilt University Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis
RS55546B1 (sr) 2004-05-13 2017-05-31 Icos Corp Hinazolinoni kao inhibitori humane fosfatidilonozitol 3-delta kinaze
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
AU2006214190A1 (en) * 2005-02-17 2006-08-24 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
GB2431156A (en) * 2005-10-11 2007-04-18 Piramed Ltd 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase
AU2007347115A1 (en) 2006-04-04 2008-10-23 The Regents Of The University Of California PI3 kinase antagonists
CA2669399A1 (en) 2006-11-13 2008-05-29 Eli Lilly & Co. Thienopyrimidinones for treatment of inflammatory disorders and cancers
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US20110123486A1 (en) * 2007-06-25 2011-05-26 Prolexys Pharmaceuticals, Inc. Methods of treating multiple myeloma and resistant cancers
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AU2014203687B2 (en) * 2008-01-04 2016-04-14 Intellikine Llc Certain chemical entities, compositions and methods
US8637542B2 (en) * 2008-03-14 2014-01-28 Intellikine, Inc. Kinase inhibitors and methods of use
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