JP2007537291A - ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン - Google Patents

ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン Download PDF

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Publication number
JP2007537291A
JP2007537291A JP2007513402A JP2007513402A JP2007537291A JP 2007537291 A JP2007537291 A JP 2007537291A JP 2007513402 A JP2007513402 A JP 2007513402A JP 2007513402 A JP2007513402 A JP 2007513402A JP 2007537291 A JP2007537291 A JP 2007537291A
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JP
Japan
Prior art keywords
phenyl
ylamino
quinazolin
purin
methyl
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Pending
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JP2007513402A
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English (en)
Japanese (ja)
Inventor
ケリー ダブリュー． フォウラー，
ダンウェン ファン，
エドワード エー． ケシッキー，
ファー チー ウイ，
エイミー アール． オリバー，
フーカン ルワン，
ジェニファー トレイベルグ，
カマル ディープ プリ，
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Icos Corp
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Icos Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34969603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2007537291(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Icos Corp filed Critical Icos Corp
Publication of JP2007537291A publication Critical patent/JP2007537291A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
JP2007513402A 2004-05-13 2005-05-12 ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン Pending JP2007537291A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57078404P 2004-05-13 2004-05-13
PCT/US2005/016778 WO2005113556A1 (en) 2004-05-13 2005-05-12 Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

Publications (1)

Publication Number Publication Date
JP2007537291A true JP2007537291A (ja) 2007-12-20

Family

ID=34969603

Family Applications (1)

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JP2007513402A Pending JP2007537291A (ja) 2004-05-13 2005-05-12 ヒトホスファチジルイノシトール３−キナーゼデルタの阻害剤としてのキナゾリノン

Country Status (23)

Country Link
US (14) USRE44638E1 (enExample)
EP (4) EP1761540B1 (enExample)
JP (1) JP2007537291A (enExample)
CN (2) CN102229609A (enExample)
AU (2) AU2005245875C1 (enExample)
BE (1) BE2017C002I2 (enExample)
CA (1) CA2566609C (enExample)
CY (3) CY2016046I2 (enExample)
DK (2) DK2612862T3 (enExample)
ES (3) ES2873875T3 (enExample)
FR (1) FR17C1007I2 (enExample)
HR (2) HRP20161751T1 (enExample)
HU (3) HUE030950T2 (enExample)
IL (4) IL179176A (enExample)
LT (3) LT1761540T (enExample)
LU (1) LUC00005I2 (enExample)
ME (2) ME02688B (enExample)
NL (1) NL300867I2 (enExample)
PL (3) PL2612862T3 (enExample)
PT (3) PT3153514T (enExample)
RS (2) RS55546B1 (enExample)
SI (2) SI2612862T1 (enExample)
WO (2) WO2005113556A1 (enExample)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011508782A (ja) * 2008-01-04 2011-03-17 インテリカイン， インコーポレイテッド 特定の化学的実体、組成物および方法
JP2012508775A (ja) * 2008-11-13 2012-04-12 ギリアード カリストガ エルエルシー 血液学的な悪性疾患のための療法
JP2012524126A (ja) * 2009-04-20 2012-10-11 ギリアド カリストガ リミテッド ライアビリティ カンパニー 固形腫瘍の治療方法
JP2013545749A (ja) * 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
JP2014513137A (ja) * 2011-05-04 2014-05-29 ライゼン・ファーマシューティカルズ・エスアー タンパク質キナーゼのモジュレーターとしての新規化合物
WO2014112646A1 (ja) * 2013-01-21 2014-07-24 国立大学法人大阪大学 フェノキシアルキルアミン化合物
JP2015509537A (ja) * 2012-03-05 2015-03-30 ギリアード カリストガ エルエルシー （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの多形性形態
JP2015526421A (ja) * 2012-07-27 2015-09-10 ハチソン メディファーマ リミテッド 新規なヘテロアリールおよび複素環式化合物、その組成物および方法
JP2015533181A (ja) * 2012-10-16 2015-11-19 アルミラル・ソシエダッド・アノニマＡｌｍｉｒａｌｌ， Ｓ．Ａ． Ｐｉ３ｋ阻害剤としてのピロロトリアジノン誘導体
JP2017502021A (ja) * 2013-12-20 2017-01-19 ギリアード カリストガ エルエルシー ホスファチジルイノシトール３−キナーゼ阻害剤のためのプロセス方法
JP2017504638A (ja) * 2014-01-30 2017-02-09 ▲蘇▼州▲澤▼▲ジン▼生物制▲薬▼有限公司 重水素化キナゾリノン化合物及び該化合物を含む薬物組成物
US9708327B2 (en) 2013-12-20 2017-07-18 Gilead Calistoga Llc Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
JP2017522274A (ja) * 2014-06-13 2017-08-10 ギリアード サイエンシーズ， インコーポレイテッド ホスファチジルイノシトール３−キナーゼ阻害剤
US10092563B2 (en) 2014-06-13 2018-10-09 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors
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