WO2012010413A1 - Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents
Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Download PDFInfo
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- WO2012010413A1 WO2012010413A1 PCT/EP2011/061334 EP2011061334W WO2012010413A1 WO 2012010413 A1 WO2012010413 A1 WO 2012010413A1 EP 2011061334 W EP2011061334 W EP 2011061334W WO 2012010413 A1 WO2012010413 A1 WO 2012010413A1
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- WIPO (PCT)
- Prior art keywords
- alkyl
- alkylene
- cycloalkyl
- radical
- phenyl
- Prior art date
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- 238000004519 manufacturing process Methods 0.000 title claims description 8
- LJVJBUXEKOPNPQ-UHFFFAOYSA-N 4-hydroxy-4-phenylhex-2-ynoic acid Chemical class OC(=O)C#CC(O)(CC)C1=CC=CC=C1 LJVJBUXEKOPNPQ-UHFFFAOYSA-N 0.000 title abstract description 4
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 22
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- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
- 108010010132 valyl-histidyl-threonyl-aspartamide Proteins 0.000 description 1
- TWYFGYXQSYOKLK-CYUSMAIQSA-N varenicline tartrate Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O.C12=CC3=NC=CN=C3C=C2[C@H]2C[C@@H]1CNC2 TWYFGYXQSYOKLK-CYUSMAIQSA-N 0.000 description 1
- 229960003977 varenicline tartrate Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229950006508 velneperit Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000664 voltage gated sodium channel blocking agent Substances 0.000 description 1
- PNAMDJVUJCJOIX-XVZWKFLSSA-N vytorin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1.N1([C@@H]([C@H](C1=O)CC[C@@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 PNAMDJVUJCJOIX-XVZWKFLSSA-N 0.000 description 1
- 229940009349 vytorin Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- UBQNRHZMVUUOMG-UHFFFAOYSA-N zonisamide Chemical compound C1=CC=C2C(CS(=O)(=O)N)=NOC2=C1 UBQNRHZMVUUOMG-UHFFFAOYSA-N 0.000 description 1
- 229960002911 zonisamide Drugs 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Definitions
- the invention relates to aryloxy-alkylene-substituted hydroxy-phenyl-hexynoic acid derivatives, and their physiologically acceptable salts. Structure-like compounds are already described in the prior art (see Eisai WO2002 / 100812) and their use as PPAR agonists or antagonists.
- the invention had the object to provide compounds that develop a therapeutically useful effect. Another object was to find new compounds which are useful in the treatment of hyperglycemia and diabetes. Further, the task was to find new compounds that activate the GPR40 receptor and are thus suitable for the treatment of hyperglycemia and diabetes.
- the invention therefore relates to compounds of the formula I,
- R 4, R 5, R 6, R 7, R 8, R 9, R 10, R 1 independently of one another are H, (C 1 -C 6 ) -alkyl,
- R 13, R 14 independently of one another are H, F, Cl, Br, I, NO 2 , CN, O- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene (C 3 -C 6) cycloalkyl, SO 2 -CH 3, SO 2 -NH 2, SO 2 - NH (Ci-C 6) -alkyl, SO 2 -N ((Ci-C 6) alkyl) 2 , CONH 2, CONH (Ci-C 6) -alkyl, CON ((Ci-C 6) -alkyl) 2, SF 5, (C 6 -C 0) aryl, (C 3 -C 0) -cycloalkyl or a 4 to 12-membered heterocycle, where the O- (C 1 -C 6 ) -alkyl radical, the (C 1 -C 6 ) -alkyl radical,
- R1 CH 3; R 2, R 3 independently of one another are H, F, Cl, Br, CN, CO- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkyl or O- (C 1 -C 6 ) -alkyl, where the CO- (C 1 -C 6 ) -alkyl radical, the (C 1 -C 6 ) -alkyl radical and the O- (C 1 -C 6 ) -alkyl radical may each be substituted one or more times by F; R 4, R 5, R 6, R 7, R 8, R 9, R 10, R 1 independently of one another are H, (C 1 -C 6 ) -alkyl,
- R 12, R 13, R 14 independently of one another are H, F, Cl, Br, I, NO 2 , CN, O- (C 1 -C 6 ) -alkyl,
- a further embodiment relates to compounds of the formula I in which one or more radicals have the following meanings: R1
- R2, R3 H; R4, R5 independently of one another are H, (C 1 -C 6) -alkyl;
- R6, R7 independently of one another H, (Ci-C 6) -alkyl, (Ci-C 3) -alkylene- (C 3 -C 6) cycloalkyl
- R8, R9 independently of one another are H, (C 1 -C 6) -alkyl
- R 10, R 1 independently of one another are H, (C 1 -C 6) -alkyl; q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (C 1 -C 6 ) -alkyl, where the O- (C 1 -C 6 ) -alkyl radical and the (C 1 -C 6 ) -alkyl radical may each be substituted one or more times by F;
- A is phenyl, pyridyl; and their physiologically acceptable salts.
- R4, R5 independently of one another are H, (C 1 -C 6) -alkyl
- R 6, R 7 independently of one another are H, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene- (C 3 -C 6 ) -cycloalkyl,
- R8, R9 independently of one another are H, (C 1 -C 6) -alkyl
- R 10, R 1 independently of one another are H, (C 1 -C 6) -alkyl; q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (d-
- A is phenyl; and their physiologically acceptable salts.
- R4, R5 independently of one another are H, (C 1 -C 6) -alkyl; independently of one another are H, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene- (C 3 -C 6 ) -cycloalkyl (C 3 -C 6 ) -cycloalkyl, phenyl, OH, O- (C 1 -C 6 ) - Alkyl, O- (Ci-C 3 ) alkylene-phenyl, O- (Ci -C 3 ) alkylene- (C 3 -C 6 ) -cycloal kyl, O- (C 3 -C 6 ) -cycloal kyl , (C 1 -C 3 ) -alkylene-OH; (C 1 -C 3 ) -alkylene-O- (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alky
- R8, R9 independently of one another are H, (C 1 -C 6) -alkyl; R 10, R 1 independently of one another are H, (C 1 -C 6) -alkyl; n, p, q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (d-
- a pyridyl and their physiologically acceptable salts.
- a further embodiment relates to compounds of the formula I in which one or more radicals have the following meanings: R 1 is CH 3 ;
- R2, R3 H; R4, R5 independently of one another are H, (C 1 -C 6) -alkyl;
- R 6, R 7 independently of one another are H, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene- (C 3 -C 6 ) -cycloalkyl,
- R 10, R 1 independently of one another are H, (C 1 -C 6) -alkyl; n, p, q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (d-
- a pyrazinyl and their physiologically acceptable salts.
- a further embodiment relates to compounds of the formula I in which one or more radicals have the following meanings: R 1 is CH 3 ;
- R2, R3 H; R4, R5 independently of one another are H, (C 1 -C 6) -alkyl;
- R 6, R 7 independently of one another are H, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene- (C 3 -C 6 ) -cycloalkyl,
- R8, R9 independently of one another are H, (C 1 -C 6) -alkyl
- R 10, R 1 independently of one another are H, (C 1 -C 6) -alkyl; q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (d-
- A is phenyl, pyridyl, pyrazinyl; and their physiologically acceptable salts.
- R2, R3 H; R4, R5 independently of one another are H, (C 1 -C 6) -alkyl;
- R 6, R 7 independently of one another are H, (C 1 -C 6 ) -alkyl, (C 1 -C 3 ) -alkylene- (C 3 -C 6 ) -cycloalkyl,
- R 8, R 9 independently of one another are H, (C 1 -C 6) -alkyl; R 10, R 1 independently of one another are H, (C 1 -C 6 ) -alkyl; q, r are independently 0, 1;
- R 12, R 13 independently of one another are H, F, Cl, Br, I, CN, O- (C 1 -C 6 ) -alkyl, (d-
- A is phenyl, 2-pyridyl, 3-pyridyl, 2-pyrazinyl; and their physiologically acceptable salts.
- q, r are independently 0, 1; where the sum of q and r is 0 and all other groups and numbers are as in the general definition of
- q, r are independently 0, 1; where the sum of q and r is 1 and all other groups and numbers are defined as in the general definition of the compounds of formula I or in one of the specified embodiments of the invention or definitions of structural elements.
- a further embodiment relates to compounds of the formula I in which one or more radicals have the following meanings:
- q, r are independently 0, 1; wherein the sum of q and r is 2 and all other groups and numbers are as defined in the general definition of the compounds of formula I or in one of the specified embodiments of the invention or definitions of structural elements.
- A is phenyl or a 5- to 6-membered heterocycle
- A is phenyl or a 6-membered heterocycle
- A is phenyl or a 6-membered nitrogen-containing heterocycle
- A is phenyl
- A is a 6-membered nitrogen-containing heterocycle
- alkyl and alkynyl radicals in the radicals R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R1, R12 and R13 can be both straight-chain and branched.
- the invention relates to compounds of the formula I in the form of their salts, racemates, racemic mixtures and pure enantiomers, and their diastereomers and mixtures thereof.
- the invention furthermore relates to stereoisomer mixtures of the formula I as well as to the pure stereoisomers of the formula I and to diastereomer mixtures of the formula I and also to the pure diastereomers.
- the separation of the mixtures is e.g. by chromatographic means.
- the present invention includes all possible tautomeric forms of
- Salts with a non-pharmaceutically acceptable anion are also within the scope of the invention as useful intermediates for the preparation or purification of pharmaceutically acceptable salts and / or for use in non-therapeutic, for example, in vitro applications.
- the compounds of the invention may also be in various polymorphic forms, e.g. as amorphous and crystalline polymorphic forms. All polymorphic forms of the compounds of the invention are within the scope of the invention and are a further aspect of the invention.
- alkyl radical is understood as meaning a straight-chain or branched hydrocarbon chain, such as, for example, methyl, ethyl, isopropyl, tert-butyl, hexyl.
- the alkyl radicals may be monosubstituted or polysubstituted as described above.
- Heterocycle or heterocyclic radical is understood as meaning rings and ring systems which, in addition to carbon, also contain heteroatoms, such as, for example, nitrogen, oxygen or sulfur. Furthermore, ring systems also belong to this definition, in which the heterocyclic or the heterocyclic radical is fused with a further ring system.
- the heterocyclic or the heterocyclic radical may be saturated, partially saturated or aromatic.
- the invention also includes solvates, hydrates and alcohol adducts of the compounds of the formula I.
- the compound (s) of the formula I can also be administered in combination with other active substances.
- the daily dose is in the range of 0.3 mg to 100 mg (typically 3 mg and 50 mg) per day per kilogram of body weight, e.g. 3-10 mg / kg / day.
- An intravenous dose may e.g. in the range of 0.3 mg to 1.0 mg / kg, which can be suitably administered as an infusion of 10 ng to 100 ng per kilogram per minute.
- Suitable infusion solutions for these purposes may e.g. from 0.1 ng to 100 mg, typically from 1 ng to 100 mg per milliliter.
- Single doses may e.g. from 1 mg to 10 g of the active ingredient.
- vials for injections, and orally administrable unit dose formulations such as tablets or capsules, may contain, for example, from 1.0 to 1000 mg, typically from 10 to 600 mg.
- the compounds according to formula I can themselves be used as compound, but they are preferably present with a compatible carrier in the form of a pharmaceutical composition. The wearer must of course be tolerated, in the sense that he is with the others
- Components of the composition is compatible and not harmful to health for the patient.
- the carrier may be a solid or a liquid, or both, and is preferably formulated with the compound as a single dose.
- compositions according to the invention may be prepared according to one of the known
- compositions consist essentially in that the ingredients are mixed with pharmacologically acceptable carriers and / or excipients.
- compositions according to the invention are those which are suitable for oral, rectal, topical, peroral (eg sublingual) and parenteral (eg subcutaneous, intramuscular, intradermal or intravenous) administration, although the most suitable mode of administration in each individual case is the nature and severity of the treatment State and on the nature of the particular compound used in accordance with formula I is dependent.
- coated formulations and coated slow release formulations are within the scope of the invention. Preference is given to acid and enteric formulations. Suitable enteric coatings include cellulose acetate phthalate, polyvinyl acetate phthalate,
- Hydroxypropylmethylcellulosephthalat and anionic polymers of methacrylic acid and methyl methacrylate are examples of hydroxypropylmethylcellulosephthalat and anionic polymers of methacrylic acid and methyl methacrylate.
- Suitable pharmaceutical compounds for oral administration may be in separate units, such as capsules, cachets,
- Lozenges or tablets each containing a certain amount of the compound of formula I; as a powder or granules; as a solution or suspension in an aqueous or non-aqueous liquid; or as an oil-in-water or water-in-oil emulsion.
- these compositions may be prepared by any suitable pharmaceutical method comprising a step of contacting the active ingredient and the carrier (which may consist of one or more additional ingredients). In general, the compositions become uniform and homogeneous Mixing the active ingredient with a liquid and / or finely divided solid carrier, after which the product is shaped if necessary. So can
- a tablet may be prepared by compressing or molding a powder or granules of the compound, optionally with one or more additional ingredients.
- Compressed tablets can be prepared by tableting the compound in free-flowing form, such as a powder or granules, optionally mixed with a binder, lubricant, inert diluent and / or surfactant / dispersant in a suitable machine.
- Molded tablets may be prepared by shaping the powdered compound moistened with an inert liquid diluent in a suitable machine.
- compositions suitable for peroral (sublingual) are provided.
- Administration include lozenges containing a compound of Formula I with a flavor, usually sucrose and gum arabic or tragacanth, and lozenges comprising the compound in an inert base such as gelatin and glycerine or sucrose and gum arabic.
- Suitable pharmaceutical compositions for parenteral administration preferably comprise sterile aqueous preparations of a compound according to formula I which are preferably isotonic with the blood of the intended recipient. These preparations are preferably administered intravenously, although the administration may also be subcutaneous, intramuscular or intradermal as an injection. These preparations may preferably be prepared by mixing the compound with water and rendering the resulting solution sterile and isotonic with the blood. Injectable compositions of the invention generally contain from 0.1% to 5% by weight of the active compound.
- Suitable pharmaceutical compositions for rectal administration are preferably as single dose suppositories. These can be prepared by reacting a compound of formula I with one or more conventional solid Carriers, such as cocoa butter, mixes and brings the resulting mixture in the form.
- solid Carriers such as cocoa butter
- Suitable pharmaceutical compositions for topical application to the skin are preferably as an ointment, cream, lotion, paste, spray, aerosol or oil.
- Vaseline, lanolin, polyethylene glycols, alcohols and combinations of two or more of these substances can be used as the carrier.
- the active ingredient is generally present at a level of from 0.1% to 15% by weight of the composition, for example from 0.5% to 2%.
- Suitable pharmaceutical compositions for transdermal applications may exist as single patches suitable for long-term close contact with the epidermis of the patient. Such patches suitably contain the active ingredient in an optionally buffered aqueous solution, dissolved and / or dispersed in an adhesive or dispersed in a polymer.
- a suitable active ingredient concentration is about 1% to 35%, preferably about 3% to 15%.
- the active ingredient can be released by electrotransport or iontophoresis as described, for example, in Pharmaceutical Research, 2 (6): 318 (1986).
- Active ingredient combination can be carried out either by separate administration of the active ingredients to the patient or in the form of combination preparations in which several active ingredients are present in a pharmaceutical preparation. If the administration of the active ingredients by separate administration of the active ingredients, so this can be done simultaneously or sequentially. Most of the active ingredients listed below are in USP Dictionary of US and International Drug Names, US Pharmacopeia, Rockville, 2006.
- Antidiabetics include insulin and insulin derivatives, such as Lantus ® (see
- Exubera®, Nasulin TM, or oral insulins such as For example, IN-105 (Nobex) or Oral-lyn TM (Generex Biotechnology) or Technosphere (R) insulin (MannKind) or Cobalamin TM oral insulin or ORMD-0801 or insulins or insulin precursors (insulin
- WO2009133099 or insulins which can be administered transdermally;
- insulin derivatives are included by a
- bifunctional linkers are bound to albumin as described e.g. in WO2009121884 are described;
- GLP-1 derivatives and GLP-1 agonists such as exenatides or special preparations thereof, as described, for example, in WO2008061355, WO2009080024, WO2009080032, liraglutide, Taspoglutide (R-1583), albiglutide, lixisenatide or those described in WO 98/08871 WO2005027978, WO200603781 1, WO2006037810 of Novo Nordisk A / S, in WO 01/04156 of Zealand or in WO 00/34331 of Beaufour-Ipsen, Pramlintide acetate (Symlin; Amylin Pharmaceuticals), inhalable GLP-1 (MKC) 253 from MannKind), AVE-0010, BIM-51077 (R-1583, ITM-077), PC-DAC: Exendin-4 (an exendin-4 analogue covalently linked to recombinant human albumin), biotinylated exendin ( WO2009
- peptide CNTO-736 (a GLP-1 analog bound to a domain that includes the Fc portion of an antibody), PGC-GLP-1 (GLP-1 linked to a nanocarrier), agonists or modulators as they are for example, in D. Chen et al., Proc. Natl. Acad. Be. USA 104 (2007) 943 are described, such as those in
- Antidiabetic agents also include gastrin analogs, such as e.g. TT-223rd
- antidiabetic agents include poly- or monoclonal antibodies which are e.g. against interleukin-1-beta (IL-1 ⁇ ), e.g. XOMA-052, are addressed.
- IL-1 ⁇ interleukin-1-beta
- XOMA-052 XOMA-052
- Antidiabetics also include peptides which bind to the human pro-islet
- Peptide receptor human pro-islet petide (HIP) receptor
- HIP human pro-islet petide
- Antidiabetics also include agonists of the glucose-dependent insulinotropic polypeptide (GIP) receptor as described, for example, in WO2006121860.
- GIP glucose-dependent insulinotropic polypeptide
- Antidiabetics also include the glucose-dependent insulinotropic polypeptide (GIP) as well as analogous compounds as described e.g. in WO2008021560, WO2010016935, WO2010016936, WO2010016938, WO2010016940, WO2010016944 are described.
- GIP glucose-dependent insulinotropic polypeptide
- Antidiabetic agents further comprise encapsulated insulin-producing porcine cells, e.g. DiabeCell (R).
- R DiabeCell
- Antidiabetic agents also include analogs and derivatives of fibroblast growth factor 21 (FGF-21, fibroblast growth factor 21) as described e.g. in WO2009149171,
- WO2010006214 are described.
- the orally active hypoglycemic agents preferably comprise
- Potassium channel opener e.g. Pinacidil, cromakalim, diazoxide, diazoxide choline salt or those as described in RD Carr et al., Diabetes 52, 2003, 25132515, JB Hansen et al, Current Medicinal Chemistry 11, 2004, 1595-1615, TM Tagmose et al. J. Med. Chem. 47, 2004, 3202-321 1 or MJ Coghlan et al., J. Med. Chem. 44, 2001, 1627-1653, or those described in WO 97/26265 and WO 99 / 03861 of Novo Nordisk A / S,
- DPP-IV dipeptidyl peptidase-IV
- Modulators of sodium-dependent glucose transporters 1 or 2 (SGLT1, SGLT2), inhibitors of 1 1 -beta-hydroxysteroid dehydrogenase-1 (1 1 ⁇ -HSD1),
- PTP-1 B protein tyrosine phosphatase 1 B
- Nicotinic receptor agonists
- Inhibitors of acetyl-CoA carboxylase ACC1 and / or ACC2
- lipid metabolism-altering compounds such as antihyperlipidemic agents and antilipidemic agents.
- FXR Farnesoid X Receptor
- MTP inhibitors Agonists of the estrogen receptor gamma (ERR agonists),
- SST5 receptor Antagonists of the somatostatin 5 receptor
- the compound of the formula I is administered in combination with an insulin sensitizer, e.g. PN-2034 or ISIS-1 13715 administered.
- an insulin sensitizer e.g. PN-2034 or ISIS-1 13715 administered.
- the compound of formula I is administered in combination with an agent that acts on the ATP-dependent potassium channel of beta cells, e.g.
- Sulfonylureas e.g. Tolbutamide, glibenclamide, glipizide, gliclazides or
- the compound of formula I is administered in combination with a tablet containing both glimepiride which is rapidly released and contains metformin which is released over an extended period of time (as described, for example, in US2007264331, WO2008050987, WO2008062273).
- the compound of formula I is used in combination with a biguanide, e.g. Metformin or one of its salts.
- a biguanide e.g. Metformin or one of its salts.
- the compound of the formula I is administered in combination with a guanidine, such as, for example, benzylguanidine or one of its salts, or such guanidines as are described in WO2009087395.
- a guanidine such as, for example, benzylguanidine or one of its salts, or such guanidines as are described in WO2009087395.
- the compound of formula I is administered in combination with a meglitinide such as repaglinide, nateglinide or mitiglinide.
- the compound of formula I is treated with a combination of mitiglinides with a glitazone, e.g. Pioglitazone hydrochloride, administered.
- a glitazone e.g. Pioglitazone hydrochloride
- the compound of formula I is administered with a combination of mitiglinides with an alpha-glucosidase inhibitor.
- the compound of the formula I is administered in combination with antidiabetic compounds, as described in WO2007095462, WO2007101060, WO2007105650.
- the compound of the formula I is administered in combination with antihypoglycemic compounds, as described in WO2007137008, WO2008020607.
- the compound of formula I is used in combination with a thiazolidinedione, e.g. Troglitazone, ciglitazone, pioglitazone, rosiglitazone or those described in WO 97/41097 by Dr. med. Reddy's Research Foundation disclosed compounds, particularly 5 - [[4 - [(3,4-dihydro-3-methyl-4-oxo-2-quinazolinylmethoxy) phenyl] methyl] -2,4-thiazolidinedione.
- PPAR gamma agonist e.g. Rosiglitazone, pioglitazone, JTT-501, GI 262570, R-483, CS-01 1 (rivoglitazone), DRL-17564, DRF-2593
- Glimepiride administered.
- the compound of formula I in combination with a solid combination of pioglitazone hydrochloride with an angiotensin II agonist, e.g. TAK-536 administered.
- PPAR alpha agonist or mixed PPAR alpha / PPAR delta agonists e.g. GW9578, GW-590735, K-1 1, LY-674, KRP-101, DRF-10945, LY-518674, CP-900691, BMS-687453, BMS-71 1939 or those as described in WO2001040207, WO2002096894, WO2005097076 , WO2007056771,
- WO2007103252 JP2007246474, WO20071 18963, WO20071 18964, WO2007126043, WO2008006043, WO2008006044, WO2008012470, WO2008035359,
- PPAR delta agonist e.g. GW-501516 or as described in WO2006059744, WO2006084176, WO2006029699, WO2007039172-WO2007039178, WO2007071766, WO2007101864, US2007244094,
- pan-SPPARM selective PPAR modulator alpha, gamma, delta
- GFT-505 indeglitazar
- indeglitazar those as described in WO2008035359, WO2009072581 administered.
- the compound of formula I is combined with metaglidases or with MBX-2044 or other partial PPAR gamma
- the compound of the formula I is used in combination with an .alpha.-glucosidase inhibitor, such as, for example, miglitol or acarbose or those as described, for example, in US Pat WO20071 14532, WO2007140230, US2007287674, US2008103201, WO2008065796, WO2008082017, US2009076129.
- an .alpha.-glucosidase inhibitor such as, for example, miglitol or acarbose or those as described, for example, in US Pat WO20071 14532, WO2007140230, US2007287674, US2008103201, WO2008065796, WO2008082017, US2009076129.
- the compound of formula I is used in combination with a glycogen phosphorylase inhibitor, e.g. PSN-357 or FR-258900 or those as in WO2003084922, WO2004007455, WO2005073229-31,
- a glycogen phosphorylase inhibitor e.g. PSN-357 or FR-258900 or those as in WO2003084922, WO2004007455, WO2005073229-31,
- the compound of the formula I in combination with an inhibitor of the interaction of the liver glycogen phosphorylase with the protein PPP1 R3 (GL subunit of the glycogen-associated protein phosphatase 1 (PP1)), such as. described in WO2009030715.
- PPP1 R3 GL subunit of the glycogen-associated protein phosphatase 1 (PP1)
- the compound of the formula I is used in combination with
- Glucagon receptor antagonists e.g. A-770077 or NNC-25-2504 or as in WO2004100875, WO2005065680, WO2006086488, WO2007047177,
- the compound of formula I is used in combination with an antisense compound, e.g. ISIS-325568, which inhibits the production of the glucagon receptor.
- an antisense compound e.g. ISIS-325568
- the compound of the formula I in combination with activators of glucokinase such as. LY-2121260 (WO2004063179), PSN-105, PSN 1 10, GKA-50 or such as z.
- activators of glucokinase such as. LY-2121260 (WO2004063179), PSN-105, PSN 1 10, GKA-50 or such as z.
- LY-2121260 WO2004063179
- PSN-105 PSN-105
- PSN 1 10 GKA-50 or such as z.
- WO2004072031 WO2004072066
- the compound of the formula I in combination with an inhibitor of gluconeogenesis as z.
- an inhibitor of gluconeogenesis as z.
- the compound of formula I is used in combination with inhibitors of fructose-1, 6-bisphosphatase (FBPase) such as MB-07729, CS-917 (MB-06322) or MB-07803 or those as described in WO2006023515,
- FBPase 6-bisphosphatase
- the compound of the formula I in combination with modulators of the glucose transporter-4 (GLUT4), such as. KST-48 (D.O. Lee et al .: Arzneim.-Forsch. Drug Res. 54 (12), 835 (2004)).
- the compound of formula I is used in combination with inhibitors of glutamine-fructose 6-phosphate amidotransferase (GFAT), as described e.g. As described in WO2004101528 administered.
- GFAT glutamine-fructose 6-phosphate amidotransferase
- the compound of formula I in combination with inhibitors of dipeptidyl peptidase-IV in combination with inhibitors of dipeptidyl peptidase-IV (DPP-IV), such as. Vildagliptin (LAF-237), sitagliptin (MK-0431), sitagliptin phosphate, saxagliptin (BMS-4771 18), GSK-823093, PSN-9301, SYR-322, SYR-619, TA-6666, TS-021 , GRC-8200 (melogliptin), GW-825964X, KRP-104, DP-893, ABT-341, ABT-279 or other salt thereof, S-40010, S-40755, PF-00734200, BI-1356, PHX -1 149, DSP-7238, alogliptin benzoate, linagliptin, melogliptin, carmegliptin or such compounds as described in U.S. Pat
- WO2003074500 WO2003106456, WO2004037169, WO200450658, WO2005037828, WO2005058901, WO2005012312, WO2005 / 012308, WO2006039325,
- WO2006127530 WO20061 1 1261, US2006890898, US2006803357, US2006303661, WO2007015767 (LY-2463665), WO2007024993, WO2007029086, WO2007063928, WO2007070434, WO2007071738, WO2007071576, WO2007077508,
- WO2007087231 WO2007097931, WO2007099385, WO2007100374, WO20071 12347, WO20071 12669, WO20071 13226, WO20071 13634, WO20071 15821, WO20071 16092, US2007259900, EP1852108, US2007270492, WO2007126745, WO2007136603, WO2007142253, WO2007148185,
- the compound of Formula I is in combination with Janumet TM, a solid combination of sitagliptin phosphate with metformin
- the compound of formula I is administered in combination with Eucreas (R) , a solid combination of vildagliptin with metformin hydrochloride. In another embodiment, the compound of formula I is administered in combination with a solid combination of alogliptin benzoate with pioglitazone.
- the compound of formula I is administered in combination with a solid combination of a salt of sitagliptin with metformin hydrochloride. In one embodiment, the compound of the formula I is administered in combination with a combination of a DPP-IV inhibitor with omega-3 fatty acids or omega-3 fatty acid esters, as described, for example, in WO2007128801. In one embodiment, the compound of formula I is used in combination with a combination of a DPP-IV inhibitor with metformin hydrochloride, such as in
- the compound of formula I is administered in combination with a combination of a DPP-IV inhibitor with a GPR-1 19 agonist, such as e.g. described in WO2009123992 administered.
- the compound of formula I is administered in combination with a combination of a DPP-IV inhibitor with miglitol, e.g. in WO2009139362, administered.
- the compound of formula I is administered in combination with a solid combination of a salt of sitagliptin with metformin hydrochloride.
- the compound of formula I is administered in combination with a fixed combination of alopliptin benzoate with pioglitazone hydrochloride.
- the compound of formula I in combination with an insulin secretion enhancing substance such as. KCP-265 (WO2003097064), or those as described in WO2007026761, WO2008045484, US2008194617,
- the compound of the formula I in combination with agonists of the glucose-dependent insulinotropic receptor (GDIR) such.
- GDIR glucose-dependent insulinotropic receptor
- the compound of the formula I is described in
- the compound of the formula I is used in combination with modulators of the sodium-dependent glucose transporter 1 and / or 2 (SGLT1, SGLT2), e.g. KGA-2727, T-1095, SGL-0010, AVE 2268, SAR 7226, SGL-5083, SGL-5085, SGL-5094, ISIS-388626, Sergliflozin, Dapagliflozin or Remogliflozin Etanobat, Canagliflozin or as described e.g. In WO2004007517, WO200452903,
- the compound of the formula I is administered in combination with a solid combination of a SGLT inhibitor with a DPP-IV inhibitor as described in WO2009091082.
- the compound of the formula I is administered in combination with a stimulator of glucose transport, as described, for example, in WO2008136392, WO2008136393.
- the compound of the formula I in combination with inhibitors of 1 1 -beta-hydroxysteroid dehydrogenase-1 (1 1 ß-HSD1), such as.
- 1 1 -beta-hydroxysteroid dehydrogenase-1 (1 1 ß-HSD1) such as.
- WO200190090-94, WO200343999, WO20041 12782 In WO200190090-94, WO200343999, WO20041 12782,
- WO200344000 WO200344009, WO20041 12779, WO20041 13310, WO2004103980, WO20041 12784, WO2003065983, WO2003104207, WO2003104208,
- WO2007127765 WO2007127901, US2007270424, JP2007291075, WO2007130898, WO2007135427, WO2007139992, WO2007144394, WO2007145834.
- WO200800361 1, WO2008005910, WO2008006702, WO2008006703, WO200801 1453, WO2008012532, WO2008024497, WO2008024892, WO2008032164, WO2008034032, WO2008043544, WO2008044656,
- WO2010010174, WO201001 1917 are administered.
- the compound of formula I in combination with inhibitors of protein tyrosine phosphatase-1 B (PTP-1 B), as described, for.
- PTP-1 B protein tyrosine phosphatase-1 B
- WO2009032321, WO2009109999, WO2009109998 In another embodiment, the compound of formula I in combination with stimulators of tyrosine kinase B (Trk-B), as described, for. As described in WO2010014613 administered.
- Trk-B tyrosine kinase B
- GPR109A HM74A receptor agonists; NAR agonists (nicotinic acid receptor agonists)
- Nicotinic acid or extended release niacin in conjunction with MK-0524A (laropiprant) or MK-0524 or such compounds as described in WO2004041274, WO2006045565, WO2006045564,
- the compound of formula I is administered in combination with a solid combination of niacin with simvastatin.
- the compound of formula I is administered in combination with nicotinic acid or extended release niacin in conjunction with MK-0524A (laropiprant).
- the compound of the formula I is administered in combination with nicotinic acid or extended release niacin in conjunction with MK-0524A (laropiprant) and with simvastatin
- the compound of the formula I is disclosed in US Pat
- nicotinic acid or another nicotinic acid receptor agonist and a prostaglandin DP receptor antagonist such as those described in WO2008039882.
- the compound of formula I in combination with a solid combination of niacin with meloxicam e.g. described in WO2009149056.
- the compound of formula I in combination with an agonist of GPR1 16, e.g. in WO2006067531, WO2006067532.
- the compound of formula I is used in combination with modulators of GPR40, as described, e.g. in WO2007013689, WO2007033002,
- the compound of formula I is used in combination with modulators of GPR1 19 (G protein-coupled glucose-dependent insulinotropic receptor), such as e.g. PSN-1 19-1, PSN-821, PSN-1 19-2, MBX-2982 or such as those described e.g. In WO2004065380, WO2005061489 (PSN-632408), WO2006083491,
- GPR1 19 G protein-coupled glucose-dependent insulinotropic receptor
- PSN-1 19-1, PSN-821, PSN-1 19-2, MBX-2982 or such as those described e.g. In WO2004065380, WO2005061489 (PSN-632408), WO2006083491,
- the compound of formula I is used in combination with modulators of the GPR120, e.g. in EP1688138, WO2008066131,
- the compound of formula I is used in combination with antagonists of GPR105, as described e.g. in WO2009000087, WO2009070873.
- the compound of formula I is administered in combination with agonists of GPR43, e.g. ESN-282 administered. In one embodiment, the compound of the formula I is used in combination with
- HSL hormone-sensitive lipase
- WO2005073199 WO2006074957
- WO2006087309 WO20061 1 1321
- WO2009009287 described, administered.
- the compound of the formula I in combination with inhibitors of endothelial lipase, such as. As described in WO20071 10216 administered.
- the compound of formula I is administered in combination with a phospholipase A2 inhibitor such as darapladib or A-002 or those as described in WO2008048866, WO20080488867, US2009062369.
- the compound of the formula I is administered in combination with myricitrin, a lipase inhibitor (WO20071 19827).
- the compound of the formula I in combination with an inhibitor of glycogen synthase kinase-3 beta (GSK-3 beta), such as.
- GSK-3 beta glycogen synthase kinase-3 beta
- WO20081 13469 WO2008121063, WO2008121064, EP-1992620, EP-1992621, EP1992624, EP-1992625, WO2008130312, WO2009007029, EP2020232,
- the compound of formula I is administered in combination with an inhibitor of phosphoenolpyruvate carboxykinase (PEPCK) such as those described in WO2004074288.
- PPCK phosphoenolpyruvate carboxykinase
- the compound of the formula I is used in combination with an inhibitor of phosphoinositide kinase-3 (PI3K), for example those as described in WO2008027584, WO2008070150, WO2008125833, WO2008125835, WO2008125839,
- the compound of the formula I is used in combination with a serum / glucocorticoid regulated kinase (SGK) inhibitor, such as, e.g. In
- SGK serum / glucocorticoid regulated kinase
- the compound of formula I in combination with a modulator of the glucocorticoid receptor, such.
- a modulator of the glucocorticoid receptor such.
- the compound of formula I in combination with a modulator of the mineralocorticoid receptor (MR), such as.
- MR mineralocorticoid receptor
- drospirenones or those as described in WO2008104306, WO20081 19918 administered.
- the compound of formula I in combination with an inhibitor of protein kinase C beta (PKC beta), such as. Ruboxistaurin, or those as described in WO2008096260, WO2008125945 administered.
- PLC beta protein kinase C beta
- Ruboxistaurin or those as described in WO2008096260, WO2008125945 administered.
- the compound of formula I in combination with an inhibitor of protein kinase D such as. B. Doxazosin (WO2008088006) administered.
- the compound of the formula I in combination with an activator / modulator of the AMP-activated protein kinase (AMPK), as described, for.
- AMPK AMP-activated protein kinase
- the compound of the formula I in combination with an inhibitor of ceramide kinase, as z.
- an inhibitor of ceramide kinase as described in WO20071 12914, WO2007149865.
- the compound of formula I is used in combination with an inhibitor of MAPK-interacting kinase 1 or 2 (MNK1 or 2), as described, e.g. in WO2007104053, WO20071 15822, WO2008008547, WO2008075741.
- MNK1 or 2 an inhibitor of MAPK-interacting kinase 1 or 2
- the compound of the formula I is used in combination with inhibitors of " ⁇ -kappaB kinase" (IKK inhibitors), as described, for example, in WO2001000610, WO2001030774, WO2004022057, WO2004022553, WO2005097129, US Pat.
- IKK inhibitors inhibitors of " ⁇ -kappaB kinase”
- the compound of formula I in combination with inhibitors of NF-kappaB (NFKB) activation as described, for. As salsalates administered.
- the compound of the formula I in combination with inhibitors of ASK-1 (apoptosis signal-regulating kinase 1) as described for.
- HMGCoA reductase inhibitor such as simvastatin, fluvastatin, pravastatin, lovastatin, atorvastatin, cerivastatin, rosuvastatin, pitavastatin, L-659699, BMS-644950, NCX-6560 or those as described in US2007249583,
- the compound of formula I in combination with a farnesoid X receptor (FXR) modulator e.g. WAY-362450 or those as described in WO2003099821, WO2005056554, WO2007052843, WO2007070796, WO2007092751, JP2007230909, WO2007095174, WO2007140174, WO2007140183, WO2008000643, WO2008002573, WO2008025539,
- FXR farnesoid X receptor
- the compound of the formula I is used in combination with a liver X receptor (LXR) ligand, e.g. in WO2007092965, WO2008041003, WO2008049047, WO2008065754,
- LXR liver X receptor
- a fibrate such as fenofibrate, clofibrate, bezafibrate, or those as described in WO2008093655 administered.
- a fibrate such as fenofibrate, clofibrate, bezafibrate, or those as described in WO2008093655 administered.
- the compound of the formula I is described in
- fibrates e.g. the choline salt of fenofibrate (SLV-348; Trilipix TM).
- the compound of the formula I is administered in combination with bezafibrate and diflunisal.
- the compound of the formula I is administered in combination with a fixed combination of fenofibrate or a salt thereof with simvastatin, rosuvastatin, fluvastatin, lovastatin, cerivastatin, pravastatin,
- the compound of formula I is administered in combination with Synordia (R), a fixed combination of fenofibrate with metformin.
- the compound of formula I is administered in combination with a solid combination of metformin with an MTP inhibitor as described in WO2009090210.
- a cholesterol resorption inhibitor e.g. Ezetimibe, Tiqueside, Pamaqueside, FM-VP4 (sitostanol / campesterol ascorbyl phosphate; Forbes Medi-Tech, WO2005042692, WO2005005453), MD-0727 (Microbia Inc., WO2005021497,
- the further active ingredient is a
- Diphenylazetidinone derivative e.g. in US 6,992,067 or US 7,205,290.
- the further active ingredient is a
- Diphenylazetidinonderivat as described for example in US 6,992,067 or US 7,205,290 combined with a statin such as simvastatin, fluvastatin, pravastatin, lovastatin, cerivastatin, atorvastatin, pitavastatin or rosuvastatin.
- a statin such as simvastatin, fluvastatin, pravastatin, lovastatin, cerivastatin, atorvastatin, pitavastatin or rosuvastatin.
- a statin such as simvastatin, fluvastatin, pravastatin, lovastatin, cerivastatin, atorvastatin, pitavastatin or rosuvastatin.
- a statin such as simvastatin, fluvastatin, pravastatin, lovastatin, cerivastatin, atorvastatin, pitavastatin or rosuvastatin.
- the compound of the formula I is administered in combination with a conjugate consisting of the HMGCoA reductase inhibitor atorvastatin with the renin inhibitor aliskiren (WO2009090158).
- a conjugate consisting of the HMGCoA reductase inhibitor atorvastatin with the renin inhibitor aliskiren WO2009090158.
- the compound of the formula I is described in
- CETP inhibitor e.g. Torcetrapib, anacetrapib or JTT-705 (dalcetrapib) or those as described in WO2006002342, WO2006010422,
- WO2007120621 US2007265252, US2007265304, WO2007128568, WO2007132906, WO2008006257, WO2008009435, WO2008018529, WO2008058961,
- Bile acid transporter (IBAT)) (see, e.g., U.S. 6,245,744, U.S. 6,221,897 or U.S. Pat
- WOOO / 61568) e.g. HMR 1741 or those described in DE 10 2005 033099.1 and DE 10 2005 033100.9, DE 10 2006 053635, DE 10 2006 053637, WO2007009655-56, WO2008058628, WO2008058629, WO2008058630, WO2008058631.
- the compound of the formula I is used in combination with
- GPBAR1 G-protein-coupled-bile-acid-receptor-1; TGR5
- TGR5 G-protein-coupled-bile-acid-receptor-1
- the compound of formula I is used in combination with histone deacetylase modulators, e.g. Ursodeoxycholic acid as in
- the compound of formula I is used in combination with inhibitors / modulators of the TRPM5 channel (TRP cation channel M5), e.g. in WO2008097504, WO2009038722.
- the compound of formula I is used in combination with inhibitors / modulators of the TRPA1 channel (TRP cation channel A1), e.g. in US2009176883, WO2009089083, WO2009144548.
- the compound of formula I is used in combination with inhibitors / modulators of the TRPV3 channel (TRP cation channel V3), as described e.g. in WO2009084034, WO2009130560.
- MTTP inhibitor e.g. Implitapide, BMS-201038, R-103757, AS-1552133, SLx-4090, AEGR-733, JTT-130 or such as in WO2005085226, WO2005121091, WO2006010423, WO20061 13910, WO2007143164, WO2008049806,
- the compound of formula I is used in combination with a combination of a cholesterol absorption inhibitor, e.g. Ezetimibe, and an inhibitor of the triglyceride transfer protein (MTP inhibitor), such as. Implitapide as described in WO2008030382 or WO2008079398 described.
- a cholesterol absorption inhibitor e.g. Ezetimibe
- MTP inhibitor an inhibitor of the triglyceride transfer protein
- the compound of the formula I is administered in combination with an antagonist of the somatostatin 5 receptor (SST5
- Receptor e.g. such as those described in WO2006094682 administered.
- ACAT inhibitor e.g. Avasimibe, SMP-797 or KY-382 or those as described in WO2008087029, WO2008087030, WO2008095189,
- WO2009070130, WO2009081957, WO2009081957 are administered.
- the compound of the formula I is combined with an inhibitor of hepatic carnitine palmitoyltransferase-1 (L-CPT1), as described, for example, in WO2007063012, WO2007096251 (ST-3473), WO2008015081, US2008103182, WO2008074692, WO2008145596 , WO2009019199,
- the compound of formula I is used in combination with an inhibitor of carnitine O-palmitoyltransferase II (CPT2), as described e.g. in US2009270500, US2009270505, WO2009132978, WO2009132979
- CPT2 carnitine O-palmitoyltransferase II
- the compound of formula I is used in combination with a modulator of serine palmitoyltransferase (SPT), as described e.g. in WO2008031032, WO2008046071, WO2008083280, WO2008084300.
- SPT serine palmitoyltransferase
- squalene synthetase inhibitor e.g. BMS-188494, TAK-475 (Lapaquistat acetate) or as described in WO2005077907, JP2007022943, WO2008003424, WO2008132846, WO2008133288, WO2009136396.
- the compound of formula I is administered in combination with an HDL cholesterol increasing agent, e.g. those as described in WO2008040651, WO2008099278, WO2009071099, WO2009086096,
- a lipoprotein (a) antagonist e.g. Gemcabene (CI-1027).
- adenosine A1 receptor agonist e.g. CVT-3619 or such as e.g. in EP1258247, EP1375508, WO2008028590, WO2008077050, WO2009050199, WO2009080197, WO2009100827,
- WO20091 12155 are administered.
- adenosine A2B receptor agonist e.g. ATL-801 administered.
- the compound of the formula I is used in combination with a modulator of the adenosine A2A and / or adenosine A3
- Receptors such as e.g. in WO20071 1 1954, WO2007121918, WO2007121921,
- the compound of formula I is used in combination with a ligand of adenosine A1 / A2B receptors, such as e.g. in
- adenosine A2B receptor antagonist as described in US2007270433, WO2008027585, WO2008080461, WO2009037463,
- the compound of the formula I in combination with inhibitors of acetyl-CoA carboxylase (ACC1 and / or ACC2) such.
- inhibitors of acetyl-CoA carboxylase ACC1 and / or ACC2
- the compound of the formula I is used in combination with modulators of the microsomal acyl-CoA: glycerol-3-phosphate acyltransferase 3 (GPAT3, described in WO2007100789) or with modulators of the microsomal acyl-CoA: glycerol-3-phosphate Acyltransferase 4 (GPAT4, described in
- the compound of the formula I is administered in combination with modulators of xanthine oxidoreductase (XOR).
- XOR xanthine oxidoreductase
- the compound of formula I is used in combination with soluble epoxide hydrolase (sEH) inhibitors, e.g. in WO2008051873, WO2008051875, WO2008073623, WO2008094869, WO20081 12022,
- the compound of the formula I is used in combination with CART modulators (see “Cocaine-amphetamine-regulated transcript-influenced energy metabolism, anxiety and gastric emptying in mice” Asakawa, A. et al.: Hormones and Metabolism Research (2001 ), 33 (9), 554-558);
- NPY antagonists such as naphthalene-1-sulfonic acid ⁇ 4 - [(4-amino-quinazolin-2-ylamino) -methyl] -cyclohexylmethyl ⁇ -amide hydrochloride (CGP 71683A) or Velneperit or those as described in WO2009110510 ;
- NPY-5 receptor antagonists / receptor modulators such as L-152804 or the compound "NPY-5-BY” from Banyu or as described, for example, in WO2006001318, WO2007103295, WO2007125952, WO2008026563, WO2008026564, WO2008052769,
- NPY-4 receptor antagonists as they are e.g. As described in WO2007038942; NPY-2 receptor antagonists / modulators as described, for. In WO2007038943,
- Peptide YY 3-36 PYY3-36 or analogous compounds such.
- CJC-1682 PYY3-36 conjugated to human serum albumin via Cys34
- CJC-1643 derivative of PYY3-36 conjugated to serum albumin in vivo
- NPY-2 receptor agonists as described e.g. in WO2009080608
- CB1R Cannabinoid Receptor 1
- inverse agonist e.g.
- Rimonabant Surinabant (SR147778), SLV-319 (Ibipinabant), AVE-1625, Taranabant (MK-0364) or salts thereof, Otenabant (CP-945,598), Rosonabant, V-24343, or such compounds as described in e.g. EP 0656354, WO 00/15609, WO2001 / 64632-64634, WO 02/076949, WO2005080345, WO2005080328, WO2005080343,
- WO2007031720 WO2007031721, WO2007036945, WO2007038045,
- WO2007084319 WO2007084450, WO2007086080, ⁇ 1816125, US2007213302, WO2007095513, WO2007096764, US2007254863, WO20071 19001,
- WO20080441 1 1, WO2008048648, ⁇ 1921072- ⁇ 1, WO2008053341, WO2008056377, WO2008059207, WO2008059335, WO2008062424, WO2008068423,
- WO2010012437 WO2010019762 are described; Cannabinoid receptor 1 / cannabinoid receptor 2 (CB1, / CB2) modulating
- Cannabinoid Receptor 2 (CB2) modulating compounds e.g. such as e.g. in WO2008063625, WO2008157500, WO2009004171, WO2009032754,
- FAAH fatty acid amide hydrolase
- WO2009105220, WO2009109504, WO2009109743, WO20091 17444, WO2009127944, WO2009138416, WO2009151991, WO2009152025, WO2009154785, WO2010005572, WO2010017079 are described;
- FAS fatty acid synthase
- LCE Long chain fatty acid elongase
- WO2009038021 Long chain fatty acid CoA ligase inhibitors
- Vanilloid-1 receptor modulators modulators of TRPV1
- Modulators, ligands, antagonists or inverse agonists of opioid receptors such as e.g. GSK-982 or such as e.g. in WO2007047397, WO2008021849, WO2008021851, WO2008032156, WO2008059335, WO2008125348,
- WO20091 15257 are described; Modulators of the "orphan opioid (ORL-1) receptor" as described, for example, in US2008249122, WO2008089201;
- Agonists of the prostaglandin receptor e.g. Bimatoprost or such
- MC4 receptor agonists (melanocortin-4 receptor agonists, MC4R agonists such as 1-amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid [2- (3a-benzyl-2-methyl-3-oxo) 2,3,3a, 4,6,7-hexahydro-pyrazolo [4,3-c] pyridin-5-yl) -1- (4-chloro-phenyl) -2-oxo-ethyl] -amide; (WO 01/91752)) or LB53280, LB53279, LB53278 or THIQ, MB243, RY764, CHIR-785, PT-141, MK-0493 or those as described in WO2005060985,
- WO2007041061 WO2007041052, JP2007131570, EP-1842846, WO2007096186, WO2007096763, WO2007141343, WO2008007930, WO2008017852,
- WO2009015867, WO200906141 1, US2009076029, US2009131465, WO2009071 101, US2009305960, WO2009144432, WO2009151383, WO2010015972 are described;
- MC4 receptor modulators (melanocortin-4 receptor modulators) as described e.g. in WO2009010299, WO2009074157 are described;
- Orexin receptor 1 antagonist (OX1 R antagonist), Orexin receptor 2
- OX2R antagonists or mixed OX1 R / OX2R antagonists (eg 1 - (2-Methyl-benzoxazol-6-yl) -3- [1,5] naphthyridin-4-yl-urea hydrochloride (SB-334867-A) or those as described e.g. In WO200196302, WO200185693, WO2004085403, WO2005075458, WO2006067224, WO2007085718, WO2007088276,
- Histamine H3 receptor antagonists / inverse agonists eg, 3-cyclohexyl-1 - (4,4-dimethyl-1,4,6,7-tetrahydro-imidazo [4,5-c] pyridin-5-yl) - propan-1-one oxalic acid salt (WO 00/63208) or those as described in WO200064884, WO2005082893, WO2005123716, US2005171 181 (eg PF-00389027), WO2006107661, WO2007003804,
- WO20071351 1 1, WO2007137955, US2007281923, WO2007137968,
- Histamine H1 / histamine H3 modulators such as. B. Betahistin or his
- Transporters such as e.g. in WO2008002816, WO2008002817, WO2008002818, WO2008002820 are described;
- Vesicular monoamine transporter 2 modulators (vesicular monoamine transporter 2 (VMAT2)) as described e.g. in WO2009126305 are described;
- Histamine H4 modulators as described e.g. in WO20071 17399, US2009156613 are described;
- CRF antagonists eg [2-methyl-9- (2,4,6-trimethyl-phenyl) -9H-1,3,9-triaza-fluoren-4-yl] -dipropyl-amine (WO 00/66585) or those CRF1 antagonists, as in
- CRF BP antagonists e.g., urocortin
- Modulators of the beta-3 adrenoceptor such as e.g. 1 - (4-chloro-3-methanesulfonylmethyl-phenyl) -2- [2- (2,3-dimethyl-1H-indol-6-yloxy) -ethyl-amino] -ethanol hydrochloride (WO 01/83451) or solabegron ( GW-427353) or N-5984 (KRP-204) or those as described in JP20061 1 1553, WO2002038543, WO2002038544, WO2007048840-843,
- MSH melanocyte-stimulating hormone
- MCH melanin-concentrating hormone receptor antagonists
- NBI-845 melanocyte-stimulating hormone
- A-761 melanin-concentrating hormone
- A-798 a-798 receptor antagonist
- T-226296 T-71 (AMG-071, AMG-076 )
- GW-856464 NGD-4715, ATC-0453, ATC-0759, GW-803430 or such compounds as described in WO2005085200, WO2005019240, WO2004011438, WO2004012648, WO2003015769, WO2004072025, WO2005070898, WO2005070925,
- WO2007042660 WO2007042668, WO2007042669, US2007093508, US2007093509, WO2007048802, JP2007091649, WO2007092416; WO2007093363-366,
- CCK-A CCK-1 agonists / modulators (such as ⁇ 2- [4- (4-chloro-2,5-dimethoxyphenyl) -5- (2-cyclohexyl-ethyl) -thiazol-2-ylcarbamoyl] -5,7-dinethyl-indol-1-yl ⁇ -acetic acid trifluoroacetic acid salt (WO 99/15525) or SR-146131 (WO 0244150) or SSR-125180) or those as described in WO20051 16034, WO2007120655,
- Serotonin reuptake inhibitors eg dexfenfluramines
- WO2009043834, WO2009077858 are described; mixed serotonin / dopamine reuptake inhibitors (e.g., bupropion) or those as described in WO2008063673 or fixed combinations of bupropion with naltrexone or bupropion with zonisamide; mixed reuptake inhibitors such as e.g. DOV-21947 or those as described in WO2009016214, WO2009016215, WO2009077584, WO2009098208,
- WO2009109519, WO2009109608, WO2009145357, WO2009149258 are described; mixed serotonin and noradrenergic compounds (e.g., WO 00/71549);
- 5-HT receptor agonists e.g. 1 - (3-ethylbenzofuran-7-yl) -piperazine oxalic acid salt (WO 01/091 11); mixed dopamine / norepinephrine / acetylcholine reuptake inhibitors (e.g., tesofensins) or those as described e.g. in WO20060851 18, WO2008150480;
- Norepinephrine reuptake inhibitors as described e.g. in US2008076724, WO2009062318;
- 5-HT1A receptor modulators as described e.g. in WO2009006227, WO2009137679, WO2009137732 are described;
- 5-HT2A receptor antagonists as described, for example, in WO2007138343; 5-HT2C receptor agonists (such as Lorcaserin hydrochloride (APD-356) or BVT-933 or those as described in WO200077010, WO200077001 -02, WO2005019180, WO2003064423, WO200242304, WO2005035533, WO2005082859, WO2006004937, US2006025601, WO2006028961, WO2006077025, WO200610351 1 ,
- 5-HT2C receptor agonists such as Lorcaserin hydrochloride (APD-356) or BVT-933 or those as described in WO200077010, WO200077001 -02, WO2005019180, WO2003064423, WO200242304, WO2005035533, WO2005082859, WO2006004937, US2006025601, WO2006028961, WO2006077025, WO2006103
- 5-HT6 receptor modulators e.g. E-6837, BVT-74316, PF-3246799 or PRX-07034 or those as described e.g. in WO2005058858, WO2007054257, WO2007107373, WO2007108569, WO2007108742-744, WO2008003703, WO2008027073,
- estrogen receptor gamma e.g. in
- estrogen receptor alpha (ERR / ERR1 agonists), as described e.g. in WO2008109727 are described;
- estrogen receptor beta agonists e.g. in
- WO2009055734 WO2009100335, WO2009127686 are described; Sigma-1 receptor antagonists, as described, for example, in WO2007098953, WO2007098961, WO2008015266, WO2008055932, WO2008055933, WO2009071657; Muscarinic 3 receptor (M3R) antagonists, as described, for example, in WO20071 10782,
- WO2008041 184 are described; Bombesin receptor agonists (BRS-3 agonists), as described e.g. in WO2008051404, WO2008051405, WO2008051406, WO200807331 1 are described;
- BRS-3 agonists Bombesin receptor agonists
- Galanin receptor antagonists e.g., human growth hormone or AOD-9604;
- Growth Hormone Secretagogue Receptor Antagonists such as B. A-778193 or those as described in WO2005030734, WO2007127457,
- WO2008008286, WO2009056707 are described; Growth Hormone Secretagogue Receptor Modulators (ghrelin modulators), e.g. JMV-2959, JMV-3002, JMV-2810, JMV-2951 or those as described in WO2006012577 (e.g., YIL-781 or YIL-870), WO2007079239, WO2008092681, WO2008145749, WO2008148853, WO2008148854, WO2008148856, WO2009047558,
- ghrelin modulators e.g. JMV-2959, JMV-3002, JMV-2810, JMV-2951 or those as described in WO2006012577 (e.g., YIL-781 or YIL-870), WO2007079239, WO2008092681, WO2008145749, WO2008148853, WO2008148854, WO2008148856, WO2009047558,
- TRH agonists see, e.g., EP 0 462 884; decoupling protein 2- or 3-modulators (as in WO2009128583
- WO2009147216, WO2009147219, WO2009147221 are described; DA agonists (bromocriptine, bromocriptine mesylate, doprexine) or those as described in US2009143390;
- Lipase / amylase inhibitors e.g., WO 00/40569, WO2008107184, WO2009049428, WO2009125819;
- Inhibitors of diacylglycerol O-acyltransferases such.
- DGATs diacylglycerol O-acyltransferases
- WO200713831 1, WO2007141502, WO2007141517, WO2007141538,
- WO2009150196, WO2009156484, WO2010006962, WO2010007482 are described; Inhibitors of fatty acid desaturase-1 (delta- ⁇ desaturase) as described e.g. in
- MML monoglyceride lipase
- WO2008039087, WO2009051 1 19 are described; Inhibitors of "adipocyte fatty acid-binding protein aP2" such as BMS-309403 or those as described in WO2009028248; activators of adiponectin secretion as described, for example, in WO2006082978, WO2008105533, WO2008136173;
- Promoters of adiponectin production e.g. in WO2007125946, WO2008038712 described;
- modified adiponectins such as e.g. described in WO2008121009;
- Oxyntomodulin or analogs thereof such as TKS-1225; Oleoyl estrone or agonists or partial agonists of the thyroid hormone receptor agonists such.
- B KB-21 15 (Eprotirome), QRX-431 (Sobetirome) or DITPA or those as described in WO20058279, WO200172692, WO200194293, WO2003084915, WO2004018421, WO2005092316, WO2007003419,
- WO2008106213, JP2009155261 described or agonists of the thyroid hormone receptor beta (TR-beta) such.
- TR-beta thyroid hormone receptor beta
- the compound of the formula I is administered in combination with a modulator of the "Trace Amine Associated Receptor-1" (TAAR1), as described, for example, in US2008146523, WO2008092785.
- TAAR1 Race Amine Associated Receptor-1
- the compound of the formula I is used in combination with an RNAi (siRNA) therapeutic which is resistant to PCSK9
- the compound of formula I is administered in combination with Omacor® or Lovaza TM (omega-3 fatty acid esters, high-concentration ethyl esters of eicosapentaenoic acid and docosahexaenoic acid).
- Omacor® or Lovaza TM omega-3 fatty acid esters, high-concentration ethyl esters of eicosapentaenoic acid and docosahexaenoic acid.
- the compound of the formula I is administered in combination with lycopene. In one embodiment of the invention, the compound of the formula I is described in
- Combination with a vitamin such as As vitamin B6 or vitamin B12 administered.
- the compound of formula I in combination with more than one of the aforementioned compounds, eg in combination with a sulfonylurea and metformin, a sulfonylurea and acarbose, repaglinide and metformin (PrandiMet (TM)), insulin and a sulfonylurea, insulin and metformin, insulin and troglitazone, insulin and lovastatin, etc.
- the compound of the formula I is administered in combination with an activator of the soluble guanylate cyclase (soluble guanylate cyclase (sGC)) as described, for example, in WO2009032249.
- the compound of formula I is used in combination with an inhibitor of carbonic anhydrase type 2, such as carbonic anhydrase type 2, e.g. such as described in WO2007065948, WO2009050252 administered.
- an inhibitor of carbonic anhydrase type 2 such as carbonic anhydrase type 2, e.g. such as described in WO2007065948, WO2009050252 administered.
- the compound of formula I is administered in combination with topiramate or a derivative thereof as described in WO2008027557, US2009304789.
- the compound of formula I is administered in combination with a solid combination of topiramate with phentermine (Qnexa TM).
- the compound of formula I is used in combination with an antisense compound, e.g. ISIS-377131, which inhibits the production of the glucocorticoid receptor.
- the compound of the formula I is used in combination with an aldosterone synthase inhibitor and an antagonist of the
- Glucocorticoid receptor a cortisol synthesis inhibitor and / or an antagonist of corticotropin releasing factor, e.g. described in EP1886695, WO20081 19744.
- the compound of formula I in combination with an agonist of the RUP3 receptor, such. As described in WO2007035355, WO2008005576.
- the compound of the formula I in combination with an activator of the gene coding for the Ataxia Telangiectasia Mutated (ATM) protein kinase such as. As chloroquine administered.
- the compound of the formula I is administered in combination with a "c-Jun N-terminal kinase" inhibitor (JNK inhibitor), such as, for example, BI-78D3 or those as described in WO2007125405, WO2008028860, WO20081 18626
- JNK inhibitor c-Jun N-terminal kinase inhibitor
- the compound of Formula I is administered in combination with an endothelin A receptor antagonist, such as avosentan (SPP-301).
- the compound of formula I is used in combination with neutral endopeptidase inhibitors (NEP inhibitors), e.g. in
- the compound of formula I is used in combination with modulators of the glucocorticoid receptor (GR), e.g. KB-3305 or such compounds as e.g. In WO2005090336, WO2006071609, WO2006135826, WO2007105766, WO2008120661, WO2009040288, WO2009058944,
- GR glucocorticoid receptor
- the other active ingredient is varenicl ine tartrate, a partial agonist of the alpha 4-beta 2 nicotinic acetylcholine receptor.
- the further active ingredient is an agonist of the alpha-7 nicotinic acetylcholine receptor, as described, for example, in WO2009018551, WO2009071519, WO2009071576, WO2009071577.
- the other active ingredient is trodusquemine.
- the further active ingredient is a modulator of the enzyme SIRT1 and / or SIRT3 (an NAD + -dependent protein deacetylase); this active ingredient may be, for example, resveratrol in suitable formulations, or such compounds as described in WO2007019416 (eg SRT-1720), WO2008073451, WO2008156866,
- WO2009061453, WO2009134973, WO2009146358, WO2010003048 are mentioned.
- the further active ingredient is DM-71 (N-acetyl-L-cysteine with bethanechol).
- the compound of formula I is used in combination with anti-hypercholesterolemic compounds, such as those described e.g. in WO2004000803, WO2006000804, WO2004000805, WO2004087655, WO20051 13496,
- the compound of formula I is used in combination with inhibitors of the SREBP (sterol regulatory element-binding protein), e.g.
- Fatostatin or such as e.g. in WO2008097835.
- the compound of formula I is used in combination with a cyclic peptide agonist of the VPAC2 receptor, as described e.g. in
- the compound of the formula I is administered in combination with an agonist of the endothelin receptor, as described, for example, in WO20071 12069.
- the compound of the formula I is administered in combination with AKP-020 (bis (ethylmaltolato) oxovanadium-IV).
- the compound of Fornnel I is administered in combination with tissue-selective androgen receptor modulators (SARM), as described, for example, in WO2007099200, WO2007137874.
- the compound of formula I is used in combination with an AGE (advanced glycation endproduct) inhibitor, e.g. in
- the further active ingredient is leptin
- the further active ingredient is metreleptin (recombinant methionyl-leptin) combined with pramlintide.
- the further active ingredient is the tetrapeptide ISF-402.
- the further active ingredient is dexamphetamine or
- the other active ingredient is fenfluramine or dexfenfluramine.
- the other active ingredient is sibutramine or such derivatives as described in WO2008034142.
- the other active ingredient is mazindol or phentermine.
- the further active ingredient is geniposidic acid
- the further active ingredient is an agonist of
- Neuropeptides FF2 as described e.g. in WO2009038012 is described.
- the further active ingredient is a nasally administered one
- Calcium channel blockers such as e.g. Diltiazem or those as described in US 7,138,107.
- the further active ingredient is an inhibitor of sodium-calcium ion exchange such as e.g. those as described in WO2008028958, WO200808571 1.
- the further active ingredient is a blocker of
- Calcium channels such as e.g. of the CaV3.2 or CaV2.2 as described in WO2008033431, WO2008033447, WO2008033356, WO2008033460, WO2008033464,
- the further active ingredient is a modulator of a calcium channel, e.g. those as described in WO2008073934, WO2008073936, WO2009107660.
- the further active ingredient is an inhibitor of
- the further active ingredient is a blocker of the "T-type calcium channel" as described for example in WO2008033431, WO20081 10008, US2008280900,
- the further active ingredient is an inhibitor of KCNQ potassium channel 2 or -3 such as those described in US2008027049, US2008027090.
- the further active ingredient is a KCNN potassium channel-1, -2, or -3 modulator (SK1, SK2, and / or SK3 channel modulators), such as those described in US2009036475.
- the further active ingredient is an inhibitor / blocker of the potassium Kv1 .3 ion channel such as those described in WO2008040057, WO2008040058, WO2008046065, WO20090431 17.
- the further active ingredient is a potassium channel modulator such as e.g. those as described in WO2008135447, WO2008135448, WO2008135591,
- the further active ingredient is a
- hyperpolarization-activated and cyclic nucleotide-controlled potassium sodium channel inhibitor (“hyperpolarization-activated cyclic nucleotide-gated (HCN) potassium-sodium channel inhibitor”) such as those described in US2009069296.
- the further active ingredient is an inhibitor of the sodium-potassium-2-chloride (NKCCI) co-transporter such as e.g. those as described in WO2009130735.
- NKCCI sodium-potassium-2-chloride
- the further active ingredient is a voltage-gated sodium channel inhibitor (e.g. those as described in WO2009049180, WO2009049181.
- the further active ingredient is a modulator of the MCP-1 receptor (monocyte chemoattractant protein-1 (MCP-1)) such as those described in WO2008014360, WO2008014381. In one embodiment, the further active ingredient is a modulator of
- Somatostatin receptor 3 SSTR3
- the further active ingredient is a modulator of
- Somatostatin receptor 5 (SSTR5), e.g. those as described in WO2008019967,
- the further active ingredient is a modulator of
- Somatostatin receptor 2 (SSTR2), e.g. those as described in WO2008051272.
- the further active ingredient is a compound capable of reducing the amount of retinol-binding protein 4 (RBP4), such as e.g. those as in WO2009051244, WO2009145286.
- RBP4 retinol-binding protein 4
- the further active ingredient is an erythropoietin-mimetic peptide which acts as an erythropoietin (EPO) receptor agonist.
- EPO erythropoietin
- the further active ingredient is an anorectic / hypoglycemic compound, e.g. those as described in WO2008035305,
- the further active ingredient is an inducer of
- Lipoic acid synthetase e.g. those as described in WO2008036966, WO2008036967.
- the further active ingredient is a stimulator of endothelial nitric oxide synthase (eNOS), such as e.g. those as described in WO2008058641,
- the further active ingredient is a modulator of the carbohydrate and / or lipid metabolism, such as, for example, those described in WO2008059023, US Pat.
- the further active ingredient is an angiotensin II receptor antagonist, such as e.g. those as described in WO2008062905, WO2008067378, WO2008062905.
- the further active ingredient is an agonist of the sphingosine-1-phosphate receptor (S1 P), such as e.g. those as described in WO2008064315,
- the further active ingredient is an agent containing the
- the additional active ingredient is a tryptophan 5-hydroxylase inhibitor-1 (TPH1 inhibitor) which modulates gastrointestinal motility, e.g. in WO2009014972.
- TPH1 inhibitor tryptophan 5-hydroxylase inhibitor-1
- the further active ingredient is a muscle relaxant substance as described e.g. in WO2008090200 is described.
- the further active ingredient is an inhibitor of
- MAO-B Monoamine oxidase B (MAO-B), e.g. those as described in WO2008092091,
- WO2009066152 are described.
- the further active ingredient is an inhibitor of
- Monoamine oxidase A such as those described in WO2009030968.
- the further active ingredient is an inhibitor of the binding of cholesterol and / or triglycerides to the SCP-2 protein (sterol carrier protein-2) such as those described in US2008194658.
- the further active ingredient is a compound which binds to the ⁇ subunit of the trimeric GTP-binding protein, e.g. those as described in WO2008126920. In one embodiment, the further active ingredient is an inhibitor of
- Uric acid anion exchanger-1 (urate-anion-exchanger-inhibitor-1), e.g. in WO2009070740 are described.
- the further active ingredient is a modulator of the ATP transporter, such as e.g. in WO2009108657.
- the other active ingredient is lisofylline, which prevents autoimmune damage to insulin-producing cells.
- the further active ingredient is an extract of Bidens pilosa with the ingredient Cytopiloin as described in EP1955701.
- the further active ingredient is an inhibitor of glucosylceramide synthase, e.g. in WO2008150486.
- the further active ingredient is a
- Glycosidase inhibitor e.g. in WO20091 17829, WO2009155753.
- the further active ingredient is an ingredient of the plant Hoodia Gordonii as described in US2009042813, EP2044852. In one embodiment, the further active ingredient is an antidiabetic such as D-tagatose.
- the further active ingredient is a zinc complex of curcumin as described in WO2009079902.
- the further active ingredient is an inhibitor of the cAMP response element binding protein (CREB) as described in WO2009143391
- the further active ingredient is an antagonist of the bradykinin B1 receptor as described in WO2009124746.
- the additional active ingredient is a compound capable of modulating diabetic peripheral neuropathy (DPN).
- DPN diabetic peripheral neuropathy
- modulators are e.g. FK-1706 or SB-509 or those as described in WO1989005304, WO2009092129, WO2010002956.
- the additional active ingredient is a compound capable of modulating diabetic nephropathy.
- Such compounds are e.g. in WO2009089545, WO2009153261.
- the additional active ingredient is an inhibitor (e.g., an anti-CD38 antibody) of CD38 as described in US2009196825.
- the further active ingredient is an inhibitor of the human
- Fibroblast growth factor receptor 4 (FGFR4) receptor 4 (e.g. in WO2009046141.
- the further active ingredient is a beta cell protective compound such as 14-alpha-lipolyl-andrographolide (AL-1).
- the further active ingredient is the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide containing the INGAP peptide (isletneogenesis associated protein), a peptide
- the further active ingredient is a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR) as described e.g. in
- the further active ingredient is a compound that stimulates / modulates insulin release, such as e.g. such as in
- the further active ingredient is an extract of Hippophae rhamnoides, as described e.g. in WO2009125071 is described.
- the further active ingredient is one of Huanglian and Ku Ding Cha, as described e.g. in WO2009133458 is described.
- the further active ingredient is a root extract of Cipadessa baccifera, as described in US2009238900.
- the further active ingredients Borapetoside A and / or Borapetoside C which from the plant SDH-V, a species of
- Tinospora crispa can be isolated as e.g. in US2010016213.
- the compound of formula I in combination with bulking agents preferably insoluble bulking agents
- bulking agents preferably insoluble bulking agents
- Caromax is a carob containing product of the company Nutrinova, Nutrition Specialties & Food Ingredients GmbH, Industriepark availability, 65926 Frankfurt / Main)) administered.
- Combination with Caromax ® is possible in one preparation or by separate administration of compounds of the formula I and Caromax ®.
- Caromax ® can also be administered in the form of food, such as in baked goods or muesli bars.
- - H is lu- Gly T r- P herthr
- beta-receptors all beta-receptors, calcium channel blockers and inhibitors of renin-angiotensin
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
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BR112013000255A BR112013000255A2 (pt) | 2010-07-05 | 2011-07-05 | ácidos hidróxifenil-hexinoicos substituídos por ariloxialquileno, método para preparação dos mesmos e seu uso dos mesmos como um medicamento |
JP2013517362A JP2013535410A (ja) | 2010-07-05 | 2011-07-05 | アリールオキシアルキレン置換ヒドロキシフェニルへキシン酸、その製造方法、及び医薬としてのその使用 |
SG2012093712A SG186771A1 (en) | 2010-07-05 | 2011-07-05 | Aryloxy-alkylene substituted hydroxyphenyl hexynoic acids, methods for the production thereof and use of the same as medicament |
KR1020137002936A KR20130095255A (ko) | 2010-07-05 | 2011-07-05 | 아릴옥시―알킬렌 치환된 하이드록시페닐 헥신산, 이의 제조방법 및 약제로서의 이의 용도 |
EP11733622.2A EP2590929A1 (de) | 2010-07-05 | 2011-07-05 | Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
MX2013000073A MX2013000073A (es) | 2010-07-05 | 2011-07-05 | Acidos hidroxifenilhexinoicos ariloxialquileno - sustituidos, procedimiento para su preparacion y su uso como medicamento. |
AU2011281835A AU2011281835A1 (en) | 2010-07-05 | 2011-07-05 | Aryloxy-alkylene substituted hydroxyphenyl hexynoic acids, methods for the production thereof and use of the same as medicament |
CA2804110A CA2804110A1 (en) | 2010-07-05 | 2011-07-05 | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
CN2011800427622A CN103080063A (zh) | 2010-07-05 | 2011-07-05 | 芳基氧基-亚烷基取代的羟基苯基己炔酸、其制备方法及其作为药物的用途 |
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EP10305732 | 2010-07-05 | ||
EP10305732.9 | 2010-07-05 |
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US (1) | US20120004166A1 (de) |
EP (1) | EP2590929A1 (de) |
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JP2016513135A (ja) * | 2013-02-28 | 2016-05-12 | エスケー ケミカルズ カンパニー リミテッド | 三環式化合物およびその使用 |
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WO2015097713A1 (en) | 2013-11-14 | 2015-07-02 | Cadila Healthcare Limited | Novel heterocyclic compounds |
WO2016151018A1 (en) | 2015-03-24 | 2016-09-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
US11555029B2 (en) | 2018-02-13 | 2023-01-17 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US10710986B2 (en) | 2018-02-13 | 2020-07-14 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
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US10774071B2 (en) | 2018-07-13 | 2020-09-15 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
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Publication number | Publication date |
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SG186771A1 (en) | 2013-02-28 |
EP2590929A1 (de) | 2013-05-15 |
CA2804110A1 (en) | 2012-01-26 |
BR112013000255A2 (pt) | 2016-05-24 |
US20120004166A1 (en) | 2012-01-05 |
CN103080063A (zh) | 2013-05-01 |
KR20130095255A (ko) | 2013-08-27 |
MX2013000073A (es) | 2013-02-15 |
JP2013535410A (ja) | 2013-09-12 |
AR082101A1 (es) | 2012-11-14 |
UY33483A (es) | 2012-01-31 |
AU2011281835A1 (en) | 2013-01-24 |
TW201221505A (en) | 2012-06-01 |
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