WO2009072581A1 - ラクタム化合物又はその塩及びｐｐａｒ活性化剤 - Google Patents

ラクタム化合物又はその塩及びｐｐａｒ活性化剤 Download PDF

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Publication number
WO2009072581A1
WO2009072581A1 PCT/JP2008/072094 JP2008072094W WO2009072581A1 WO 2009072581 A1 WO2009072581 A1 WO 2009072581A1 JP 2008072094 W JP2008072094 W JP 2008072094W WO 2009072581 A1 WO2009072581 A1 WO 2009072581A1
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group
atom
salt
integer
single bond
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PCT/JP2008/072094
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English (en)
French (fr)
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Tomoji Aotsuka
Hashime Kanazawa
Kentarou Kumazawa
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Aska Pharmaceutical Co., Ltd.
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Priority to JP2009544722A priority Critical patent/JP5632612B2/ja
Publication of WO2009072581A1 publication Critical patent/WO2009072581A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

　ＰＰＡＲ活性化剤として有用なラクタム骨格を有する化合物又はその塩を提供する。 　式（１）で表されるラクタム化合物又はその塩。 ［式中、Ｒ１はハロゲン、炭化水素基、カルボキシル基などを示し、Ｚ１はアレーン環又はヘテロ環、Ｚ３は脂環族又は芳香族炭化水素環を示し、Ｚ２は、５～６員窒素原子含有環であり、Ｘ１は、Ｃ、Ｏ、Ｓ又はＮ原子、基－Ｎ－Ｃ（＝Ｏ）－又は基－Ｃ（＝Ｏ）－Ｎ－を示し、Ｒ２は、水素原子又は置換基を有していてもよいアルキル基を示し、Ｒ３及びＲ４はそれぞれ単結合又は二価の脂肪族炭化水素基を示し、少なくとも一方が脂肪族炭化水素基であり、Ｘ２及びＸ３は、単結合、Ｏ又はＳ原子、イミノ基などを示し、Ａ１は、単結合又は置換基を有していてもよいフェニレン基を示し、Ｙ１は水素原子、ハロゲン原子、カルボキシル基などを示し、ａは０～５、ｂは０～２及びｃは１～３の整数を示す］  
PCT/JP2008/072094 2007-12-05 2008-12-04 ラクタム化合物又はその塩及びｐｐａｒ活性化剤 WO2009072581A1 (ja)

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JP2009544722A JP5632612B2 (ja) 2007-12-05 2008-12-04 ラクタム化合物又はその塩及びｐｐａｒ活性化剤

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JP2007-315021 2007-12-05
JP2007315021 2007-12-05

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Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010280592A (ja) * 2009-06-03 2010-12-16 Aska Pharmaceutical Co Ltd ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JP2012512893A (ja) * 2008-12-18 2012-06-07 メタボレックス， インコーポレイテッド Ｇｐｒ１２０受容体作動薬およびその使用
WO2012081570A1 (ja) * 2010-12-14 2012-06-21 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2013217695A (ja) * 2012-04-05 2013-10-24 Shimadzu Corp 質量分析用マトリックスの添加剤
WO2016114668A1 (en) 2015-01-16 2016-07-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method to prepare phenolics from biomass
EP3184505A1 (en) 2015-12-22 2017-06-28 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Method for preparing phenolics using a catalyst
WO2018172852A1 (en) * 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
KR101902045B1 (ko) 2011-07-05 2018-09-27 바스프 에스이 락탐, 활성화제 및 촉매를 함유하는 고체 입자, 상기 고체 입자의 제조 방법, 및 상기 고체 입자의 용도
CN110526856A (zh) * 2019-09-12 2019-12-03 天津瑞岭化工有限公司 Dwp205190的合成方法
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
US10752626B2 (en) * 2016-07-14 2020-08-25 Shanghai Meton Pharmaceutical Co., Ltd Iso-citrate dehydrogenase (IDH) inhibitor
US11071793B2 (en) * 2014-08-29 2021-07-27 Chdi Foundation, Inc. Probes for imaging huntingtin protein
US11236103B2 (en) 2018-07-27 2022-02-01 Biotheryx, Inc. Bifunctional compounds
CN114773162A (zh) * 2022-03-27 2022-07-22 江苏壹药新材料有限公司 一种4-(3-羟基丙烯基)-2-三氟甲基苯酚的合成方法
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012512893A (ja) * 2008-12-18 2012-06-07 メタボレックス， インコーポレイテッド Ｇｐｒ１２０受容体作動薬およびその使用
JP2010280592A (ja) * 2009-06-03 2010-12-16 Aska Pharmaceutical Co Ltd ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPWO2012081570A1 (ja) * 2010-12-14 2014-05-22 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
WO2012081570A1 (ja) * 2010-12-14 2012-06-21 あすか製薬株式会社 ラクタム化合物又はその塩及びｐｐａｒ活性化剤
KR101902045B1 (ko) 2011-07-05 2018-09-27 바스프 에스이 락탐, 활성화제 및 촉매를 함유하는 고체 입자, 상기 고체 입자의 제조 방법, 및 상기 고체 입자의 용도
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP2013217695A (ja) * 2012-04-05 2013-10-24 Shimadzu Corp 質量分析用マトリックスの添加剤
US11071793B2 (en) * 2014-08-29 2021-07-27 Chdi Foundation, Inc. Probes for imaging huntingtin protein
WO2016114668A1 (en) 2015-01-16 2016-07-21 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method to prepare phenolics from biomass
EP3184505A1 (en) 2015-12-22 2017-06-28 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Method for preparing phenolics using a catalyst
WO2017111595A1 (en) 2015-12-22 2017-06-29 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method for preparing phenolics using a catalyst
US10752626B2 (en) * 2016-07-14 2020-08-25 Shanghai Meton Pharmaceutical Co., Ltd Iso-citrate dehydrogenase (IDH) inhibitor
WO2018172852A1 (en) * 2017-03-21 2018-09-27 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
US11098010B2 (en) 2017-03-21 2021-08-24 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
US10927104B2 (en) 2017-08-25 2021-02-23 Biotheryx, Inc. Ether compounds and uses thereof
US11236103B2 (en) 2018-07-27 2022-02-01 Biotheryx, Inc. Bifunctional compounds
CN110526856A (zh) * 2019-09-12 2019-12-03 天津瑞岭化工有限公司 Dwp205190的合成方法
CN110526856B (zh) * 2019-09-12 2023-04-07 天津瑞岭化工有限公司 Dwp205190的合成方法
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
CN114773162A (zh) * 2022-03-27 2022-07-22 江苏壹药新材料有限公司 一种4-(3-羟基丙烯基)-2-三氟甲基苯酚的合成方法

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JP5632612B2 (ja) 2014-11-26

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