EA201070994A1 - Конденсированное гетероциклическое производное и его применение - Google Patents

Конденсированное гетероциклическое производное и его применение

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Publication number
EA201070994A1
EA201070994A1 EA201070994A EA201070994A EA201070994A1 EA 201070994 A1 EA201070994 A1 EA 201070994A1 EA 201070994 A EA201070994 A EA 201070994A EA 201070994 A EA201070994 A EA 201070994A EA 201070994 A1 EA201070994 A1 EA 201070994A1
Authority
EA
Eurasian Patent Office
Prior art keywords
optionally containing
containing substituent
application
ring
condensed heterocyclic
Prior art date
Application number
EA201070994A
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English (en)
Other versions
EA020144B1 (ru
Inventor
Нобухиро Фудзии
Юя Огуро
Сатоси Сасаки
Сигеру Кондо
Original Assignee
Такеда Фармасьютикал Компани Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201070994A1 publication Critical patent/EA201070994A1/ru
Publication of EA020144B1 publication Critical patent/EA020144B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Настоящее изобретение относится к соединению, обладающему превосходной ингибирующей активностью по отношению к Smo и более низкой токсичностью, которое является в достаточной мере подходящим в качестве фармацевтического продукта. Настоящее изобретение относится к соединению, представленному формулой (I)где кольцо А представляет собой 5-7-членное кольцо, необязательно содержащее заместитель(и), где заместители необязательно связаны друг с другом с образованием кольца; Х представляет собой О, S или NR(Rпредставляет собой атом водорода или углеводородную группу, необязательно содержащую заместитель(и)), Rпредставляет собой карбамоил, необязательно содержащий заместитель(и), и Rпредставляет собой гидрокси, необязательно содержащий заместитель(и), или его соль.
EA201070994A 2008-02-26 2009-02-25 Конденсированные производные пиридина и их применение EA020144B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008045134 2008-02-26
JP2008256755 2008-10-01
PCT/JP2009/054007 WO2009107850A2 (en) 2008-02-26 2009-02-25 Fused heterocyclic derivative and use thereof

Publications (2)

Publication Number Publication Date
EA201070994A1 true EA201070994A1 (ru) 2011-04-29
EA020144B1 EA020144B1 (ru) 2014-09-30

Family

ID=40905094

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EA201070994A EA020144B1 (ru) 2008-02-26 2009-02-25 Конденсированные производные пиридина и их применение

Country Status (28)

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US (2) US8399449B2 (ru)
EP (1) EP2247588B1 (ru)
JP (2) JP4719317B2 (ru)
KR (1) KR101569949B1 (ru)
CN (1) CN102015705B (ru)
AR (1) AR070479A1 (ru)
AU (1) AU2009217982B2 (ru)
BR (1) BRPI0908417B1 (ru)
CA (1) CA2716773C (ru)
CL (1) CL2009000429A1 (ru)
CO (1) CO6321277A2 (ru)
CR (1) CR11661A (ru)
DO (1) DOP2010000260A (ru)
EA (1) EA020144B1 (ru)
EC (1) ECSP10010496A (ru)
ES (1) ES2586252T3 (ru)
GE (1) GEP20125664B (ru)
HK (1) HK1150274A1 (ru)
IL (1) IL207735A (ru)
JO (1) JO3259B1 (ru)
MA (1) MA32164B1 (ru)
MX (1) MX2010009372A (ru)
MY (1) MY150379A (ru)
NZ (1) NZ587719A (ru)
PE (1) PE20091556A1 (ru)
TW (1) TWI480282B (ru)
WO (1) WO2009107850A2 (ru)
ZA (1) ZA201006063B (ru)

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Also Published As

Publication number Publication date
HK1150274A1 (zh) 2011-11-18
CO6321277A2 (es) 2011-09-20
DOP2010000260A (es) 2010-10-15
AU2009217982B2 (en) 2013-04-11
ECSP10010496A (es) 2010-10-30
KR101569949B1 (ko) 2015-11-18
US8217176B2 (en) 2012-07-10
WO2009107850A3 (en) 2010-01-28
MY150379A (en) 2013-12-31
CL2009000429A1 (es) 2009-09-25
US8399449B2 (en) 2013-03-19
JP2011098978A (ja) 2011-05-19
EA020144B1 (ru) 2014-09-30
EP2247588A2 (en) 2010-11-10
AU2009217982A2 (en) 2010-10-07
BRPI0908417B1 (pt) 2022-01-11
GEP20125664B (en) 2012-10-10
CN102015705A (zh) 2011-04-13
CA2716773A1 (en) 2009-09-03
CN102015705B (zh) 2013-11-13
AR070479A1 (es) 2010-04-07
US20090227561A1 (en) 2009-09-10
KR20100137482A (ko) 2010-12-30
IL207735A (en) 2014-12-31
MA32164B1 (fr) 2011-03-01
ZA201006063B (en) 2011-10-26
CA2716773C (en) 2016-04-26
WO2009107850A2 (en) 2009-09-03
TWI480282B (zh) 2015-04-11
JO3259B1 (ar) 2018-09-16
IL207735A0 (en) 2010-12-30
JP5490030B2 (ja) 2014-05-14
EP2247588B1 (en) 2016-04-13
ES2586252T3 (es) 2016-10-13
TW200940548A (en) 2009-10-01
AU2009217982A1 (en) 2009-09-03
JP4719317B2 (ja) 2011-07-06
BRPI0908417A2 (pt) 2020-08-18
PE20091556A1 (es) 2009-11-03
JP2011513199A (ja) 2011-04-28
US20110003788A1 (en) 2011-01-06
NZ587719A (en) 2012-04-27
CR11661A (es) 2010-10-11
MX2010009372A (es) 2010-09-22

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