EA200971044A1 - Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина - Google Patents

Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина

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Publication number
EA200971044A1
EA200971044A1 EA200971044A EA200971044A EA200971044A1 EA 200971044 A1 EA200971044 A1 EA 200971044A1 EA 200971044 A EA200971044 A EA 200971044A EA 200971044 A EA200971044 A EA 200971044A EA 200971044 A1 EA200971044 A1 EA 200971044A1
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EA
Eurasian Patent Office
Prior art keywords
aryl
heteroaryl
diazepines
serotonin
dopamine
Prior art date
Application number
EA200971044A
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English (en)
Other versions
EA017249B1 (ru
EA017249B8 (ru
Inventor
Питер Р. Газзо
Брюс Ф. Молино
Вэнэ Цуй
Шуан Лю
Ричард Е. Олсон
Original Assignee
Олбани Молекьюлар Рисерч, Инк.
Бристоль-Мейерз Сквибб Компани
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Application filed by Олбани Молекьюлар Рисерч, Инк., Бристоль-Мейерз Сквибб Компани filed Critical Олбани Молекьюлар Рисерч, Инк.
Publication of EA200971044A1 publication Critical patent/EA200971044A1/ru
Publication of EA017249B1 publication Critical patent/EA017249B1/ru
Publication of EA017249B8 publication Critical patent/EA017249B8/ru

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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
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Abstract

Арил- и гетероарилзамещенные производные тетрагидробензо-1,4-диазепиновые соединения настоящего изобретения представлены формулой I(A-D), имеющей следующую структуру:где заместители Х и R-Rимеют указанные в описании значения.
EA200971044A 2007-05-10 2008-05-08 Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина EA017249B8 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91718907P 2007-05-10 2007-05-10
PCT/US2008/063039 WO2008141081A1 (en) 2007-05-10 2008-05-08 Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Publications (3)

Publication Number Publication Date
EA200971044A1 true EA200971044A1 (ru) 2010-06-30
EA017249B1 EA017249B1 (ru) 2012-11-30
EA017249B8 EA017249B8 (ru) 2013-01-30

Family

ID=40002593

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Application Number Title Priority Date Filing Date
EA200971044A EA017249B8 (ru) 2007-05-10 2008-05-08 Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина

Country Status (14)

Country Link
US (1) US9096546B2 (ru)
EP (1) EP2146722A4 (ru)
JP (1) JP2010526825A (ru)
KR (1) KR20100017766A (ru)
CN (1) CN101686983A (ru)
AU (1) AU2008251557B2 (ru)
BR (1) BRPI0811204A8 (ru)
CA (1) CA2685860A1 (ru)
CO (1) CO6251238A2 (ru)
EA (1) EA017249B8 (ru)
IL (1) IL201922A0 (ru)
MX (1) MX2009011923A (ru)
NZ (1) NZ580801A (ru)
WO (1) WO2008141081A1 (ru)

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KR20160080799A (ko) 2014-12-30 2016-07-08 한국해양과학기술원 금 촉매를 이용한 α-피론 유도체 전합성 방법 및 이에 의해 합성되어 인간 암세포주에 세포독성을 가지는 α-피론 유도체
CR20170513A (es) * 2015-05-04 2018-02-13 Astrazeneca Ab Derivados de pirazol útiles como inhibidores de proteína activadora de 5-li-poxigenasa (flap).
CN105461635B (zh) * 2015-11-18 2018-06-08 乳源瑶族自治县大众药品贸易有限公司 苯基哌嗪衍生物及其使用方法和用途
EA202092490A1 (ru) 2018-04-18 2020-12-23 Констеллейшен Фармасьютикалс, Инк. Модуляторы метилмодифицирующих ферментов, композиции и их применения
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EA017249B8 (ru) 2013-01-30
KR20100017766A (ko) 2010-02-16
EP2146722A1 (en) 2010-01-27
CA2685860A1 (en) 2008-11-20
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US9096546B2 (en) 2015-08-04
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IL201922A0 (en) 2010-06-16
JP2010526825A (ja) 2010-08-05
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EP2146722A4 (en) 2011-08-03
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