MX2010009372A - Derivado heterociclico fusionado y su uso. - Google Patents
Derivado heterociclico fusionado y su uso.Info
- Publication number
- MX2010009372A MX2010009372A MX2010009372A MX2010009372A MX2010009372A MX 2010009372 A MX2010009372 A MX 2010009372A MX 2010009372 A MX2010009372 A MX 2010009372A MX 2010009372 A MX2010009372 A MX 2010009372A MX 2010009372 A MX2010009372 A MX 2010009372A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally
- substituent
- ring
- fused heterocyclic
- heterocyclic derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención proporciona un compuesto que tiene una actividad inhibidora de Smo superior y baja toxicidad, que es suficientemente satisfactoria como producto farmacéutico. La presente invención proporciona un compuesto representado por la fórmula (ver fórmula (I)) en donde anillo A es anillo de 5 a 7 miembros que esta opcionalmente sustituido, donde los sustituyentes están unidos opcionalmente entre sí para formar un anillo; X es O, S o NR1 (R1 es un átomo de hidrógeno o un grupo hidrocarburo que esta opcionalmente sustituido); R2 es carbamoilo que esta opcionalmente sustituido; y R3 es hidroxi que esta opcionalmente sustituido, o una sal del mismo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008045134 | 2008-02-26 | ||
| JP2008256755 | 2008-10-01 | ||
| PCT/JP2009/054007 WO2009107850A2 (en) | 2008-02-26 | 2009-02-25 | Fused heterocyclic derivative and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010009372A true MX2010009372A (es) | 2010-09-22 |
Family
ID=40905094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010009372A MX2010009372A (es) | 2008-02-26 | 2009-02-25 | Derivado heterociclico fusionado y su uso. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8217176B2 (es) |
| EP (1) | EP2247588B1 (es) |
| JP (2) | JP4719317B2 (es) |
| KR (1) | KR101569949B1 (es) |
| CN (1) | CN102015705B (es) |
| AR (1) | AR070479A1 (es) |
| AU (1) | AU2009217982B2 (es) |
| BR (1) | BRPI0908417B1 (es) |
| CA (1) | CA2716773C (es) |
| CL (1) | CL2009000429A1 (es) |
| CO (1) | CO6321277A2 (es) |
| CR (1) | CR11661A (es) |
| DO (1) | DOP2010000260A (es) |
| EA (1) | EA020144B1 (es) |
| EC (1) | ECSP10010496A (es) |
| ES (1) | ES2586252T3 (es) |
| GE (1) | GEP20125664B (es) |
| HK (1) | HK1150274A1 (es) |
| IL (1) | IL207735A (es) |
| JO (1) | JO3259B1 (es) |
| MA (1) | MA32164B1 (es) |
| MX (1) | MX2010009372A (es) |
| MY (1) | MY150379A (es) |
| NZ (1) | NZ587719A (es) |
| PE (1) | PE20091556A1 (es) |
| TW (1) | TWI480282B (es) |
| WO (1) | WO2009107850A2 (es) |
| ZA (1) | ZA201006063B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102015705B (zh) * | 2008-02-26 | 2013-11-13 | 武田药品工业株式会社 | 稠合的杂环衍生物及其用途 |
| SI2459176T1 (en) | 2009-07-31 | 2018-01-31 | Gruenenthal Gmbh | Crystallization process and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2011013752A1 (ja) * | 2009-07-31 | 2011-02-03 | 塩野義製薬株式会社 | 縮合へテロ環誘導体を含有する医薬組成物 |
| JP5722781B2 (ja) | 2009-08-26 | 2015-05-27 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| WO2011024871A1 (ja) * | 2009-08-26 | 2011-03-03 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| SG178504A1 (en) * | 2009-08-26 | 2012-04-27 | Takeda Pharmaceutical | Fused heterocyclic ring derivative and use thereof |
| JP5739334B2 (ja) | 2009-08-26 | 2015-06-24 | 武田薬品工業株式会社 | 縮合複素環誘導体およびその用途 |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| WO2012154731A1 (en) * | 2011-05-08 | 2012-11-15 | Vanderbilt University | Substituted 1h-pyrrolo[3,2-c]quinolin-4(5h)-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| US8975398B2 (en) | 2012-05-11 | 2015-03-10 | Abbvie Inc. | NAMPT inhibitors |
| WO2015084958A1 (en) * | 2013-12-03 | 2015-06-11 | Lee Allen J | Rationale-based design of a targeted therapy for cancer |
| WO2015140964A1 (ja) | 2014-03-19 | 2015-09-24 | 株式会社 東芝 | 電池用電極材料、非水電解質電池及び電池パック |
| EP3127907A4 (en) * | 2014-03-31 | 2018-04-04 | Boston Biomedical, Inc. | New tricyclic quinone derivative |
| US10464896B2 (en) | 2015-06-11 | 2019-11-05 | Basilea Pharmaceutica International AG | Efflux-pump inhibitors and therapeutic uses thereof |
| AU2015101598A4 (en) * | 2015-09-17 | 2015-12-03 | Macau University Of Science And Technology | Novel ros1 inhibitor and its use |
| EP3954372A1 (en) | 2016-02-01 | 2022-02-16 | Takeda Pharmaceutical Company Limited | Cocrystal |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| US11299469B2 (en) | 2016-11-29 | 2022-04-12 | Sumitomo Dainippon Pharma Oncology, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| JP7091201B2 (ja) | 2018-09-14 | 2022-06-27 | 株式会社東芝 | 活物質、電極、二次電池、電池パック、及び車両 |
| RU2711968C1 (ru) * | 2018-11-22 | 2020-01-24 | федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский национальный исследовательский политехнический университет" | Анальгезирующее средство |
| CN110172068A (zh) * | 2019-06-05 | 2019-08-27 | 河南龙湖生物技术有限公司 | 具有抗肿瘤活性的苯并噻唑类化合物及其制备方法和应用 |
| US20230301950A1 (en) | 2020-06-26 | 2023-09-28 | Raqualia Pharma Inc. | Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent |
| CN113292477B (zh) * | 2021-06-01 | 2023-06-02 | 四川大学 | 一种铱催化的碳氢活化反应合成异吲哚-1-酮类化合物的方法 |
| CN113429422B (zh) * | 2021-07-26 | 2022-05-10 | 中国人民解放军军事科学院军事医学研究院 | 一种噻吩并喹诺酮类化合物及其制备方法和应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3012684B2 (ja) | 1989-12-08 | 2000-02-28 | 大日本製薬株式会社 | チエノキノリン誘導体、チエノナフチリジン誘導体およびそれらの塩 |
| WO1993013664A2 (en) | 1992-01-11 | 1993-07-22 | Schering Agrochemicals Limited | Biheterocyclic fungicidal compounds |
| FR2695126B1 (fr) * | 1992-08-27 | 1994-11-10 | Sanofi Elf | Dérivés d'acide thiényl ou pyrrolyl carboxyliques, leur préparation et médicaments les contenant. |
| JP3223289B2 (ja) | 1992-10-22 | 2001-10-29 | 東洋アルミニウム株式会社 | 肉類調理器具および肉類調理方法 |
| PL345906A1 (en) | 1998-06-04 | 2002-01-14 | Abbott Lab | Cell adhesion-inhibiting antinflammatory compounds |
| WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| EP1217000A1 (en) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibitors of factor Xa and factor VIIa |
| EP1465869B1 (en) | 2001-12-21 | 2013-05-15 | Exelixis Patent Company LLC | Modulators of lxr |
| WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
| JP2006151810A (ja) | 2002-12-26 | 2006-06-15 | Daiichi Asubio Pharma Co Ltd | ジヒドロチエノキノリン誘導体及びそれを含む細胞接着阻害剤 |
| US20050043346A1 (en) | 2003-08-08 | 2005-02-24 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
| EP1671962A1 (en) | 2003-10-10 | 2006-06-21 | Ono Pharmaceutical Co., Ltd. | Novel fused heterocyclic compound and use thereof |
| JPWO2005063241A1 (ja) | 2003-12-26 | 2007-07-19 | 小野薬品工業株式会社 | ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤 |
| US20070299102A1 (en) | 2004-04-08 | 2007-12-27 | Topo Target A/S | Diphenyl Ox-Indol-2-One Compounds and Their Use in the Treatment of Cancer |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| JP5016601B2 (ja) * | 2005-08-16 | 2012-09-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
| AR056560A1 (es) * | 2005-10-06 | 2007-10-10 | Astrazeneca Ab | Pirrolopiridinonas como moduladores cb1 |
| JP5256047B2 (ja) * | 2006-01-27 | 2013-08-07 | シャンハイ ヘンルイ ファーマシューティカル カンパニー リミテッド | ピロロ［３，２−ｃ］ピリジン−４−オン２−インドリノン（ｉｎｄｏｌｉｎｏｎｅ）プロテインキナーゼ阻害剤 |
| MX2008013204A (es) * | 2006-04-14 | 2008-10-22 | Novartis Ag | Uso de biarilcarboxamidas en el tratamiento de trastornos relacionados con la ruta hedgehog. |
| EP2527330A1 (en) * | 2007-03-14 | 2012-11-28 | Exelixis, Inc. | Inhibitors of the hedgehog pathway |
| PE20090188A1 (es) * | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
| CN102015705B (zh) | 2008-02-26 | 2013-11-13 | 武田药品工业株式会社 | 稠合的杂环衍生物及其用途 |
-
2009
- 2009-02-25 CN CN2009801148111A patent/CN102015705B/zh active Active
- 2009-02-25 CA CA2716773A patent/CA2716773C/en active Active
- 2009-02-25 ES ES09714922.3T patent/ES2586252T3/es active Active
- 2009-02-25 WO PCT/JP2009/054007 patent/WO2009107850A2/en active Application Filing
- 2009-02-25 BR BRPI0908417-7A patent/BRPI0908417B1/pt active IP Right Grant
- 2009-02-25 US US12/392,640 patent/US8217176B2/en active Active
- 2009-02-25 GE GEAP200911952A patent/GEP20125664B/en unknown
- 2009-02-25 US US12/919,413 patent/US8399449B2/en active Active
- 2009-02-25 MX MX2010009372A patent/MX2010009372A/es active IP Right Grant
- 2009-02-25 TW TW098105923A patent/TWI480282B/zh active
- 2009-02-25 PE PE2009000279A patent/PE20091556A1/es active IP Right Grant
- 2009-02-25 AU AU2009217982A patent/AU2009217982B2/en active Active
- 2009-02-25 NZ NZ587719A patent/NZ587719A/en unknown
- 2009-02-25 MY MYPI2010004006A patent/MY150379A/en unknown
- 2009-02-25 JO JOP/2009/0079A patent/JO3259B1/ar active
- 2009-02-25 CL CL2009000429A patent/CL2009000429A1/es unknown
- 2009-02-25 JP JP2010533355A patent/JP4719317B2/ja active Active
- 2009-02-25 KR KR1020107021331A patent/KR101569949B1/ko active IP Right Grant
- 2009-02-25 EA EA201070994A patent/EA020144B1/ru unknown
- 2009-02-25 EP EP09714922.3A patent/EP2247588B1/en active Active
- 2009-02-25 AR ARP090100644A patent/AR070479A1/es active IP Right Grant
-
2010
- 2010-08-22 IL IL207735A patent/IL207735A/en active IP Right Grant
- 2010-08-25 ZA ZA2010/06063A patent/ZA201006063B/en unknown
- 2010-08-26 DO DO2010000260A patent/DOP2010000260A/es unknown
- 2010-08-31 CR CR11661A patent/CR11661A/es unknown
- 2010-09-21 MA MA33195A patent/MA32164B1/fr unknown
- 2010-09-23 CO CO10117653A patent/CO6321277A2/es active IP Right Grant
- 2010-09-23 EC EC2010010496A patent/ECSP10010496A/es unknown
-
2011
- 2011-02-03 JP JP2011022188A patent/JP5490030B2/ja active Active
- 2011-04-29 HK HK11104328.2A patent/HK1150274A1/zh unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |