WO2008096820A1 - ビフェニル誘導体 - Google Patents
ビフェニル誘導体 Download PDFInfo
- Publication number
- WO2008096820A1 WO2008096820A1 PCT/JP2008/052044 JP2008052044W WO2008096820A1 WO 2008096820 A1 WO2008096820 A1 WO 2008096820A1 JP 2008052044 W JP2008052044 W JP 2008052044W WO 2008096820 A1 WO2008096820 A1 WO 2008096820A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen atom
- biphenyl derivative
- represent
- alkyl group
- different
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
一般式(I) [式中、R1は、-COOR3(式中、R3は水素原子等を表す)等を表し、R2aおよびR2bは、同一または異なって、水素原子等を表し、 Wは、 [式中、R6は、置換基を有していてもよい低級アルキル等を表し、R7aおよびR7bは、同一または異なって、水素原子等を表し、R8は、置換基を有していてもよい低級アルキル等を表す]等を表す]で表されるビフェニル誘導体またはその薬学的に許容される塩を提供する。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-027535 | 2007-02-07 | ||
JP2007027535 | 2007-02-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008096820A1 true WO2008096820A1 (ja) | 2008-08-14 |
Family
ID=39681724
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/052044 WO2008096820A1 (ja) | 2007-02-07 | 2008-02-07 | ビフェニル誘導体 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008096820A1 (ja) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010119700A1 (ja) | 2009-04-17 | 2010-10-21 | 興和株式会社 | 新規な3-ヘテロアリールピリミジン-4-(3h)-オン構造を有する化合物及びこれを含有する医薬 |
WO2010137336A1 (ja) | 2009-05-29 | 2010-12-02 | 興和株式会社 | 新規なα-フェノキシベンゼン酢酸誘導体及びこれを含有する医薬 |
WO2011024468A1 (ja) | 2009-08-27 | 2011-03-03 | 興和株式会社 | 新規なスルホンアミド誘導体及びこれを含有する医薬 |
WO2011040004A1 (ja) | 2009-09-29 | 2011-04-07 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
WO2011105099A1 (ja) * | 2010-02-25 | 2011-09-01 | 興和株式会社 | 新規な4-アルコキシピリミジン構造を有する化合物及びこれを含有する医薬 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2011161030A1 (de) | 2010-06-21 | 2011-12-29 | Sanofi | Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren |
WO2012004270A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012004269A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012010413A1 (de) | 2010-07-05 | 2012-01-26 | Sanofi | Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012124311A1 (ja) | 2011-03-14 | 2012-09-20 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013068486A1 (en) | 2011-11-08 | 2013-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of male infertility |
CN110669012A (zh) * | 2019-11-28 | 2020-01-10 | 陈志龙 | 一类氟取代的苯并咪唑衍生物及其制备方法与医药领域的应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0597813A (ja) * | 1991-03-19 | 1993-04-20 | Merck & Co Inc | アンギオテンシンii拮抗剤としての酸性官能基を有するイミダゾール誘導体 |
JPH05112533A (ja) * | 1991-05-08 | 1993-05-07 | Upjohn Co:The | イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
JP2006515566A (ja) * | 2002-08-10 | 2006-06-01 | ベセスダ ファーマシューティカルズ, インコーポレイテッド | 体液貯溜、浮腫またはうっ血性心不全を誘発しない新規pparリガンド |
-
2008
- 2008-02-07 WO PCT/JP2008/052044 patent/WO2008096820A1/ja active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0597813A (ja) * | 1991-03-19 | 1993-04-20 | Merck & Co Inc | アンギオテンシンii拮抗剤としての酸性官能基を有するイミダゾール誘導体 |
JPH05112533A (ja) * | 1991-05-08 | 1993-05-07 | Upjohn Co:The | イミダゾベンゾキノン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤 |
JP2006515566A (ja) * | 2002-08-10 | 2006-06-01 | ベセスダ ファーマシューティカルズ, インコーポレイテッド | 体液貯溜、浮腫またはうっ血性心不全を誘発しない新規pparリガンド |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2420501A1 (en) * | 2009-04-17 | 2012-02-22 | Kowa Company, Ltd. | Novel compound having 3-heteroarylpyrimidin-4-(3h)-one structure and pharmaceutical preparation containing same |
WO2010119700A1 (ja) | 2009-04-17 | 2010-10-21 | 興和株式会社 | 新規な3-ヘテロアリールピリミジン-4-(3h)-オン構造を有する化合物及びこれを含有する医薬 |
US8664226B2 (en) | 2009-04-17 | 2014-03-04 | Kowa Company, Ltd. | Compound having 3-heteroarylpyrimidin-4-(3H)-one structure and pharmaceutical preparation containing same |
JPWO2010119700A1 (ja) * | 2009-04-17 | 2012-10-22 | 興和株式会社 | 新規な3−ヘテロアリールピリミジン−4−(3h)−オン構造を有する化合物及びこれを含有する医薬 |
EP2420501A4 (en) * | 2009-04-17 | 2012-08-29 | Kowa Co | NEW COMPOUNDS WITH 3-HETEROARYLPYRIMIDIN-4- (3H) -ONE STRUCTURE AND PHARMACEUTICAL PREPARATION THEREWITH |
WO2010137336A1 (ja) | 2009-05-29 | 2010-12-02 | 興和株式会社 | 新規なα-フェノキシベンゼン酢酸誘導体及びこれを含有する医薬 |
WO2011024468A1 (ja) | 2009-08-27 | 2011-03-03 | 興和株式会社 | 新規なスルホンアミド誘導体及びこれを含有する医薬 |
WO2011040004A1 (ja) | 2009-09-29 | 2011-04-07 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
US8778954B2 (en) | 2009-09-29 | 2014-07-15 | Kowa Company, Ltd. | Phenylpyridine derivative and medicinal agent comprising same |
WO2011105099A1 (ja) * | 2010-02-25 | 2011-09-01 | 興和株式会社 | 新規な4-アルコキシピリミジン構造を有する化合物及びこれを含有する医薬 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
WO2011161030A1 (de) | 2010-06-21 | 2011-12-29 | Sanofi | Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren |
WO2012010413A1 (de) | 2010-07-05 | 2012-01-26 | Sanofi | Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012004269A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012004270A1 (de) | 2010-07-05 | 2012-01-12 | Sanofi | Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
WO2012124311A1 (ja) | 2011-03-14 | 2012-09-20 | 興和株式会社 | 新規なフェニルピリジン誘導体及びこれを含有する医薬 |
US9315493B2 (en) | 2011-03-14 | 2016-04-19 | Kowa Company, Ltd. | Phenylpyridine derivative and drug containing same |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013068486A1 (en) | 2011-11-08 | 2013-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of male infertility |
CN110669012A (zh) * | 2019-11-28 | 2020-01-10 | 陈志龙 | 一类氟取代的苯并咪唑衍生物及其制备方法与医药领域的应用 |
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