MX2010006107A - Derivados de espiroindolinona. - Google Patents

Derivados de espiroindolinona.

Info

Publication number
MX2010006107A
MX2010006107A MX2010006107A MX2010006107A MX2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A MX 2010006107 A MX2010006107 A MX 2010006107A
Authority
MX
Mexico
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
compounds
esters
Prior art date
Application number
MX2010006107A
Other languages
English (en)
Inventor
Zhuming Zhang
Jing Zhang
Qingjie Ding
Nan Jiang
Song Yang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010006107A publication Critical patent/MX2010006107A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan compuestos de la fórmula (I), (ver fórmula (1)) y sales farmacéuticamente aceptables y ésteres de los mismos, en donde W, V, X, Y, A, R y R´ son como se describe en la presente, procedimientos para elaborar los compuestos y métodos para usarlos, en particular como agentes anticáncer.
MX2010006107A 2007-12-14 2008-12-05 Derivados de espiroindolinona. MX2010006107A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1369107P 2007-12-14 2007-12-14
US10743108P 2008-10-22 2008-10-22
PCT/EP2008/066874 WO2009077357A1 (en) 2007-12-14 2008-12-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
MX2010006107A true MX2010006107A (es) 2010-06-25

Family

ID=40289301

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006107A MX2010006107A (es) 2007-12-14 2008-12-05 Derivados de espiroindolinona.

Country Status (12)

Country Link
US (1) US8134001B2 (es)
EP (1) EP2229396B1 (es)
JP (1) JP2011506380A (es)
KR (1) KR20100076037A (es)
CN (1) CN101896486A (es)
AT (1) ATE519764T1 (es)
AU (1) AU2008337651A1 (es)
BR (1) BRPI0821255A2 (es)
CA (1) CA2707456A1 (es)
IL (1) IL205354A0 (es)
MX (1) MX2010006107A (es)
WO (1) WO2009077357A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
KR20120099462A (ko) * 2009-11-12 2012-09-10 더 리젠츠 오브 더 유니버시티 오브 미시건 스피로-옥신돌 ｍｄｍ2 길항제
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
UY33725A (es) 2010-11-12 2012-06-29 Sanofi Sa Antagonistas de mdm2 de espiro-oxindol
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
PL2684880T3 (pl) 2011-03-10 2018-07-31 Daiichi Sankyo Company, Limited Pochodna dispiropirolidyny
SG194873A1 (en) 2011-05-11 2013-12-30 Sanofi Sa Spiro-oxindole mdm2 antagonists
CN102321095B (zh) * 2011-05-26 2014-09-10 兰州大学 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用
MX352672B (es) * 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
CN102627650B (zh) * 2012-03-08 2015-07-08 徐州师范大学 手性四氢吡咯-3,2′-氧化吲哚螺环化合物及其合成方法
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
EP3816155A1 (en) * 2013-08-23 2021-05-05 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
JP6503386B2 (ja) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
CA2982435C (en) 2015-04-13 2020-05-26 Daiichi Sankyo Company, Limited Treatment method by combined use of mdm2 inhibitor and btk inhibitor
CA3000063A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
CN109843329A (zh) 2016-10-17 2019-06-04 第一三共株式会社 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法
JP7413346B2 (ja) 2019-03-06 2024-01-15 第一三共株式会社 ピロロピラゾール誘導体
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN116253736B (zh) * 2023-01-06 2024-06-18 中山大学 一种吡唑β-内酰胺类衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7495007B2 (en) 2006-03-13 2009-02-24 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US20070213341A1 (en) * 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
BRPI0708883A2 (pt) 2006-03-13 2011-06-14 Hoffmann La Roche derivados de espiroindolinona
US7638548B2 (en) 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives

Also Published As

Publication number Publication date
WO2009077357A1 (en) 2009-06-25
CN101896486A (zh) 2010-11-24
BRPI0821255A2 (pt) 2015-06-16
US8134001B2 (en) 2012-03-13
CA2707456A1 (en) 2009-06-25
US20090156610A1 (en) 2009-06-18
KR20100076037A (ko) 2010-07-05
EP2229396A1 (en) 2010-09-22
AU2008337651A1 (en) 2009-06-25
JP2011506380A (ja) 2011-03-03
IL205354A0 (en) 2010-12-30
EP2229396B1 (en) 2011-08-10
ATE519764T1 (de) 2011-08-15

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