ATE519764T1 - Spiroindolinon-derivate - Google Patents

Spiroindolinon-derivate

Info

Publication number
ATE519764T1
ATE519764T1 AT08861848T AT08861848T ATE519764T1 AT E519764 T1 ATE519764 T1 AT E519764T1 AT 08861848 T AT08861848 T AT 08861848T AT 08861848 T AT08861848 T AT 08861848T AT E519764 T1 ATE519764 T1 AT E519764T1
Authority
AT
Austria
Prior art keywords
spiroindolinone derivatives
spiroindolinone
derivatives
compounds
esters
Prior art date
Application number
AT08861848T
Other languages
English (en)
Inventor
Qingjie Ding
Nan Jiang
Song Yang
Jing Zhang
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE519764T1 publication Critical patent/ATE519764T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT08861848T 2007-12-14 2008-12-05 Spiroindolinon-derivate ATE519764T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1369107P 2007-12-14 2007-12-14
US10743108P 2008-10-22 2008-10-22
PCT/EP2008/066874 WO2009077357A1 (en) 2007-12-14 2008-12-05 Spiroindolinone derivatives

Publications (1)

Publication Number Publication Date
ATE519764T1 true ATE519764T1 (de) 2011-08-15

Family

ID=40289301

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08861848T ATE519764T1 (de) 2007-12-14 2008-12-05 Spiroindolinon-derivate

Country Status (12)

Country Link
US (1) US8134001B2 (de)
EP (1) EP2229396B1 (de)
JP (1) JP2011506380A (de)
KR (1) KR20100076037A (de)
CN (1) CN101896486A (de)
AT (1) ATE519764T1 (de)
AU (1) AU2008337651A1 (de)
BR (1) BRPI0821255A2 (de)
CA (1) CA2707456A1 (de)
IL (1) IL205354A0 (de)
MX (1) MX2010006107A (de)
WO (1) WO2009077357A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7776875B2 (en) * 2007-12-19 2010-08-17 Hoffman-La Roche Inc. Spiroindolinone derivatives
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
KR20120099462A (ko) 2009-11-12 2012-09-10 더 리젠츠 오브 더 유니버시티 오브 미시건 스피로-옥신돌 ｍｄｍ2 길항제
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
CA2817585A1 (en) 2010-11-12 2012-05-18 The Regents Of The University Of Michigan Spiro-oxindole mdm2 antagonists
CN102584835B (zh) * 2011-01-17 2014-08-27 苏州大学 一种含吲哚结构的螺杂环化合物及其制备方法
HUE038714T2 (hu) 2011-03-10 2018-11-28 Daiichi Sankyo Co Ltd Dispiropirrolidin származék
AU2012253339B2 (en) 2011-05-11 2016-03-31 Sanofi Spiro-oxindole MDM2 antagonists
CN102321095B (zh) * 2011-05-26 2014-09-10 兰州大学 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用
WO2013049250A1 (en) * 2011-09-27 2013-04-04 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
CN102627650B (zh) * 2012-03-08 2015-07-08 徐州师范大学 手性四氢吡咯-3,2′-氧化吲哚螺环化合物及其合成方法
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
EP3816155A1 (de) * 2013-08-23 2021-05-05 Virginia Commonwealth University Esternitratderivate von aromatischen aldehyden mit mehreren pharmalogischen eigenschaften zur behandlung von sichelzellanämie
US10576064B2 (en) 2014-07-03 2020-03-03 Boehringer Ingelheim International Gmbh Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors
WO2016133194A1 (ja) 2015-02-20 2016-08-25 第一三共株式会社 がんの併用治療法
WO2016167236A1 (ja) 2015-04-13 2016-10-20 第一三共株式会社 Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法
CA3000063A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
PL3458101T3 (pl) 2016-05-20 2021-05-31 F. Hoffmann-La Roche Ag Koniugaty PROTAC-przeciwciało i sposoby ich stosowania
EP3527226A4 (de) 2016-10-17 2020-06-17 Daiichi Sankyo Company, Limited Kombinationstherapieverfahren mit mdm2-inhibitor und dna-methyltransferase-inhibitor
TW202100526A (zh) 2019-03-06 2021-01-01 日商第一三共股份有限公司 吡咯并吡唑衍生物
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN116253736A (zh) * 2023-01-06 2023-06-13 中山大学 一种吡唑β-内酰胺类衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2644758A1 (en) 2006-03-13 2007-09-20 F. Hoffmann-La Roche Ag Spiroindolinone derivatives
US7495007B2 (en) * 2006-03-13 2009-02-24 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US20070213341A1 (en) 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives

Also Published As

Publication number Publication date
JP2011506380A (ja) 2011-03-03
AU2008337651A1 (en) 2009-06-25
CA2707456A1 (en) 2009-06-25
EP2229396A1 (de) 2010-09-22
US8134001B2 (en) 2012-03-13
WO2009077357A1 (en) 2009-06-25
EP2229396B1 (de) 2011-08-10
US20090156610A1 (en) 2009-06-18
MX2010006107A (es) 2010-06-25
BRPI0821255A2 (pt) 2015-06-16
CN101896486A (zh) 2010-11-24
KR20100076037A (ko) 2010-07-05
IL205354A0 (en) 2010-12-30

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