SG189556A1 - Methods and compositions for treating hepatitis c virus - Google Patents
Methods and compositions for treating hepatitis c virus Download PDFInfo
- Publication number
- SG189556A1 SG189556A1 SG2008069635A SG2008069635A SG189556A1 SG 189556 A1 SG189556 A1 SG 189556A1 SG 2008069635 A SG2008069635 A SG 2008069635A SG 2008069635 A SG2008069635 A SG 2008069635A SG 189556 A1 SG189556 A1 SG 189556A1
- Authority
- SG
- Singapore
- Prior art keywords
- alkyl
- monophosphate
- acyl
- independently
- base
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract description 63
- 239000000203 mixture Substances 0.000 title abstract description 26
- 241000711549 Hepacivirus C Species 0.000 title description 77
- 229940002612 prodrug Drugs 0.000 claims abstract description 149
- 239000000651 prodrug Substances 0.000 claims abstract description 149
- 150000003839 salts Chemical class 0.000 claims abstract description 104
- 238000011282 treatment Methods 0.000 claims abstract description 39
- 150000001875 compounds Chemical class 0.000 claims description 202
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 183
- 239000010452 phosphate Substances 0.000 claims description 183
- 239000003814 drug Substances 0.000 claims description 15
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 3
- 208000010710 hepatitis C virus infection Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 208000005176 Hepatitis C Diseases 0.000 abstract description 23
- 208000006454 hepatitis Diseases 0.000 abstract description 8
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ES2255295T3 (es) * | 1998-08-10 | 2006-06-16 | Idenix (Cayman) Limited | 2'-deoxi-beta-l-nucleosidos para el tratamiento de la hepatitis b. |
US6444652B1 (en) * | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
AU2001245575A1 (en) * | 2000-03-09 | 2001-09-17 | Videoshare, Inc. | Sharing a streaming video |
ES2319732T3 (es) | 2000-04-13 | 2009-05-12 | Pharmasset, Inc. | Derivados de nucleosido 3'- o 2'-hidroximetilo sustituido para el tratamiento de infecciones virales. |
MY164523A (en) * | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
EP1736478B1 (en) * | 2000-05-26 | 2015-07-22 | IDENIX Pharmaceuticals, Inc. | Methods and compositions for treating flaviviruses and pestiviruses |
US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
EP1539188B1 (en) * | 2001-01-22 | 2015-01-07 | Merck Sharp & Dohme Corp. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
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GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
WO2003000713A1 (en) * | 2001-06-21 | 2003-01-03 | Glaxo Group Limited | Nucleoside compounds in hcv |
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AU2002353164A1 (en) * | 2001-12-17 | 2003-06-30 | Ribapharm Inc. | Unusual nucleoside libraries, compounds, and preferred uses as antiviral and anticancer agents |
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NZ536123A (en) * | 2002-05-06 | 2006-09-29 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
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CN101172993A (zh) * | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′-c-甲基-3′-o-l-缬氨酸酯核糖呋喃基胞苷 |
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MXPA04012802A (es) * | 2002-06-28 | 2005-04-19 | Idenix Cayman Ltd | Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae. |
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JP2005533108A (ja) * | 2002-07-16 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | Rna依存性rnaウイルスポリメラーゼの阻害剤としてのヌクレオシド誘導体 |
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