US6872699B2
(en)
|
1992-11-13 |
2005-03-29 |
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. |
Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein
|
US6177401B1
(en)
|
1992-11-13 |
2001-01-23 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften |
Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
|
US5837815A
(en)
*
|
1994-12-15 |
1998-11-17 |
Sugen, Inc. |
PYK2 related polypeptide products
|
US6147106A
(en)
*
|
1997-08-20 |
2000-11-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
US6906093B2
(en)
|
1995-06-07 |
2005-06-14 |
Sugen, Inc. |
Indolinone combinatorial libraries and related products and methods for the treatment of disease
|
US6316635B1
(en)
*
|
1995-06-07 |
2001-11-13 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
US5880141A
(en)
*
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
US6846839B1
(en)
*
|
1995-06-07 |
2005-01-25 |
Sugen, Inc. |
Methods for treating diseases and disorders related to unregulated angiogenesis and/or vasculogenesis
|
ATE253908T1
(de)
*
|
1995-08-16 |
2003-11-15 |
Huntington Medical Res Inst |
Rhodamin 123 zusammensetzungen für behandlung von prostatakrebs
|
ES2201266T3
(es)
*
|
1996-01-17 |
2004-03-16 |
Taiho Pharmaceutical Company Limited |
Inhibidores del espesamiento de la capa intima.
|
JP3118467B2
(ja)
*
|
1996-03-29 |
2000-12-18 |
ファイザー インク. |
5―ht1aおよび/または5―ht1d受容体の選択的(アンタ)アゴニストとしてのベンジル(イデン)―ラクタム誘導体、その調製法及びその使用法
|
US6696448B2
(en)
|
1996-06-05 |
2004-02-24 |
Sugen, Inc. |
3-(piperazinylbenzylidenyl)-2-indolinone compounds and derivatives as protein tyrosine kinase inhibitors
|
US6682921B1
(en)
|
1996-08-21 |
2004-01-27 |
New York University |
Crystals of the tyrosine kinase domain of non-insulin receptor tyrosine kinases
|
EP1247803A3
(en)
*
|
1996-08-23 |
2002-10-16 |
Sugen, Inc. |
Indolinone compounds suitable for modulation of protein kinases
|
AU7622698A
(en)
*
|
1996-12-05 |
1998-06-29 |
Sugen, Inc. |
Use of indolinone compounds as modulators of protein kinases
|
JP2001505779A
(ja)
*
|
1996-12-11 |
2001-05-08 |
スージェン・インコーポレーテッド |
Pyk2関連産物および方法
|
ATE554750T1
(de)
*
|
1997-03-05 |
2012-05-15 |
Sugen Inc |
Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
|
AR012634A1
(es)
|
1997-05-02 |
2000-11-08 |
Sugen Inc |
Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
|
CA2289102A1
(en)
*
|
1997-05-07 |
1998-11-12 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
US6486185B1
(en)
|
1997-05-07 |
2002-11-26 |
Sugen, Inc. |
3-heteroarylidene-2-indolinone protein kinase inhibitors
|
US6316429B1
(en)
|
1997-05-07 |
2001-11-13 |
Sugen, Inc. |
Bicyclic protein kinase inhibitors
|
US6987113B2
(en)
|
1997-06-11 |
2006-01-17 |
Sugen, Inc. |
Tyrosine kinase inhibitors
|
US6114371A
(en)
*
|
1997-06-20 |
2000-09-05 |
Sugen, Inc. |
3-(cyclohexanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors
|
US6313158B1
(en)
|
1997-06-20 |
2001-11-06 |
Sugen, Inc. |
Bioavailability of 3-heteroarylidenyl-2-indolinones active as protein tyrosine kinase inhibitors
|
TW527355B
(en)
|
1997-07-02 |
2003-04-11 |
Bristol Myers Squibb Co |
Inhibitors of farnesyl protein transferase
|
US6235769B1
(en)
*
|
1997-07-03 |
2001-05-22 |
Sugen, Inc. |
Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase
|
GB9716557D0
(en)
*
|
1997-08-06 |
1997-10-08 |
Glaxo Group Ltd |
Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
|
US20040067531A1
(en)
*
|
1997-08-20 |
2004-04-08 |
Sugen, Inc. |
Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
|
ATE368665T1
(de)
|
1997-08-22 |
2007-08-15 |
Astrazeneca Ab |
Oxindolylchinazolinderivate als angiogenesehemmer
|
GB9718913D0
(en)
|
1997-09-05 |
1997-11-12 |
Glaxo Group Ltd |
Substituted oxindole derivatives
|
US6133305A
(en)
|
1997-09-26 |
2000-10-17 |
Sugen, Inc. |
3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
|
WO1999016438A1
(en)
*
|
1997-09-26 |
1999-04-08 |
Asta Medica Aktiengesellschaft |
Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
|
UA71555C2
(en)
|
1997-10-06 |
2004-12-15 |
Zentaris Gmbh |
Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
|
US20030219380A1
(en)
*
|
1997-11-07 |
2003-11-27 |
Annie Fong |
Method of determining an efficacious dose of a drug
|
US7494816B2
(en)
|
1997-12-22 |
2009-02-24 |
Roche Diagnostic Operations, Inc. |
System and method for determining a temperature during analyte measurement
|
US8071384B2
(en)
*
|
1997-12-22 |
2011-12-06 |
Roche Diagnostics Operations, Inc. |
Control and calibration solutions and methods for their use
|
US6531502B1
(en)
|
1998-01-21 |
2003-03-11 |
Sugen, Inc. |
3-Methylidenyl-2-indolinone modulators of protein kinase
|
JP2002507598A
(ja)
*
|
1998-03-26 |
2002-03-12 |
スージェン・インコーポレーテッド |
チロシン蛋白質キナーゼを調節するためのヘテロ環式化合物のファミリー
|
US6514981B1
(en)
|
1998-04-02 |
2003-02-04 |
Sugen, Inc. |
Methods of modulating tyrosine protein kinase function with indolinone compounds
|
DE19816624A1
(de)
*
|
1998-04-15 |
1999-10-21 |
Boehringer Ingelheim Pharma |
Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
US6569868B2
(en)
|
1998-04-16 |
2003-05-27 |
Sugen, Inc. |
2-indolinone derivatives as modulators of protein kinase activity
|
HUP0103617A2
(hu)
*
|
1998-05-29 |
2002-02-28 |
Sugen, Inc. |
Protein kinázt gátló, pirrolilcsoporttal helyettesített 2-indolszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása
|
US6319918B1
(en)
|
1998-06-04 |
2001-11-20 |
Boehringer Ingelheim Pharma Kg |
Substituted indolinones with kinase inhibitory activity
|
DE19824922A1
(de)
*
|
1998-06-04 |
1999-12-09 |
Boehringer Ingelheim Pharma |
Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
WO2000012084A1
(en)
|
1998-08-31 |
2000-03-09 |
Sugen, Inc. |
Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
|
YU21301A
(sh)
*
|
1998-09-25 |
2003-04-30 |
Boehringer Ingelheim Pharama Gmbh. & Co. Kg. |
Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdk
|
US6153634A
(en)
*
|
1998-12-17 |
2000-11-28 |
Hoffmann-La Roche Inc. |
4,5-azolo-oxindoles
|
EP1149093A1
(en)
|
1998-12-17 |
2001-10-31 |
F. Hoffmann-La Roche Ag |
4-aryloxindoles as inhibitors of jnk protein kinases
|
CN1147486C
(zh)
*
|
1998-12-17 |
2004-04-28 |
霍夫曼-拉罗奇有限公司 |
4-和5-炔基羟吲哚和4-和5-烯基羟吲哚
|
BR9916327A
(pt)
|
1998-12-17 |
2001-09-18 |
Hoffmann La Roche |
Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2
|
ATE387448T1
(de)
|
1998-12-17 |
2008-03-15 |
Hoffmann La Roche |
4,5-pyrazinoxindole als proteinkinasehemmer
|
US20030119895A1
(en)
*
|
1998-12-23 |
2003-06-26 |
Pharmacia Corporation |
Methods using a combination of a 3-heteroaryl-2-indolinone and a cyclooxygenase-2 inhibitor for the treatment of neoplasia
|
US6861442B1
(en)
*
|
1998-12-30 |
2005-03-01 |
Sugen, Inc. |
PYK2 and inflammation
|
EP1630559A3
(en)
*
|
1998-12-30 |
2006-06-07 |
Sugen, Inc. |
PYK2 (RAFTK) and inflammation
|
AU760964B2
(en)
*
|
1998-12-31 |
2003-05-22 |
Sugen, Inc. |
3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activityand for use in cancer chemotherapy
|
US6972182B1
(en)
*
|
1999-02-26 |
2005-12-06 |
Cyclacel, Ltd. |
Methods and compositions using coiled binding partners
|
US6656696B2
(en)
*
|
1999-02-26 |
2003-12-02 |
Cyclacel |
Compositions and methods for monitoring the phosphorylation of natural binding partners
|
US6828106B2
(en)
*
|
1999-02-26 |
2004-12-07 |
Cyclacel Limited |
Methods and compositions using coiled binding partners
|
US6670144B1
(en)
*
|
1999-02-26 |
2003-12-30 |
Cyclacel, Ltd. |
Compositions and methods for monitoring the phosphorylation of natural binding partners
|
GB9904933D0
(en)
|
1999-03-04 |
1999-04-28 |
Glaxo Group Ltd |
Compounds
|
US6492398B1
(en)
|
1999-03-04 |
2002-12-10 |
Smithkline Beechman Corporation |
Thiazoloindolinone compounds
|
US6624171B1
(en)
|
1999-03-04 |
2003-09-23 |
Smithkline Beecham Corporation |
Substituted aza-oxindole derivatives
|
US7064114B2
(en)
|
1999-03-19 |
2006-06-20 |
Parker Hughes Institute |
Gel-microemulsion formulations
|
US7226991B1
(en)
*
|
1999-03-23 |
2007-06-05 |
United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Phenylalanine derivatives
|
WO2000056760A1
(en)
*
|
1999-03-23 |
2000-09-28 |
The United States Of America, Represented By Secretary, Department Of Health And Human Services |
Phenylalanine derivatives
|
JP2002540096A
(ja)
*
|
1999-03-24 |
2002-11-26 |
スージェン・インコーポレーテッド |
キナーゼ阻害剤としてのインドリノン化合物
|
US6689806B1
(en)
|
1999-03-24 |
2004-02-10 |
Sugen, Inc. |
Indolinone compounds as kinase inhibitors
|
AU5003200A
(en)
|
1999-05-14 |
2000-12-05 |
United States Of America As Represented By The Department Of Veterans Affairs, The |
Isolation and characterization of epidermal growth factor related protein
|
US7049410B2
(en)
*
|
1999-05-14 |
2006-05-23 |
Majumdar Adhip P N |
Antibodies to a novel EGF-receptor related protein (ERRP)
|
UA75054C2
(uk)
*
|
1999-10-13 |
2006-03-15 |
Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг |
Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
|
US6762180B1
(en)
|
1999-10-13 |
2004-07-13 |
Boehringer Ingelheim Pharma Kg |
Substituted indolines which inhibit receptor tyrosine kinases
|
DE19949209A1
(de)
*
|
1999-10-13 |
2001-04-19 |
Boehringer Ingelheim Pharma |
In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
|
JP2003512838A
(ja)
*
|
1999-10-22 |
2003-04-08 |
ファルマシア・アンド・アップジョン・カンパニー |
ショウジョウバエgタンパク質結合レセプター、核酸、およびそれに関連する方法。
|
US7364866B2
(en)
*
|
1999-10-22 |
2008-04-29 |
Pharmacia & Upjohn Company |
Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
|
US7871981B2
(en)
*
|
1999-10-22 |
2011-01-18 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibition of cell motility, angiogenesis, and metastasis
|
US20030162223A1
(en)
*
|
1999-10-22 |
2003-08-28 |
Lowery David E. |
Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
|
DE60034959T2
(de)
|
1999-10-22 |
2008-01-17 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Hemmung der zellmotilität und angiogenese mit grb2 sh2-domäne inhibitoren
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
US20030082534A1
(en)
*
|
1999-11-16 |
2003-05-01 |
Peter Lind |
Novel G protein-coupled receptors
|
CA2388865A1
(en)
*
|
1999-11-16 |
2001-05-25 |
Pharmacia & Upjohn Company |
Novel g protein-coupled receptors
|
US8682005B2
(en)
|
1999-11-19 |
2014-03-25 |
Gentex Corporation |
Vehicle accessory microphone
|
ATE330818T1
(de)
|
1999-11-24 |
2006-07-15 |
Donnelly Corp |
Rückblickspiegel mit nutzfunktion
|
WO2001037820A2
(en)
*
|
1999-11-24 |
2001-05-31 |
Sugen, Inc. |
Ionizable indolinone derivatives and their use as ptk ligands
|
US6878733B1
(en)
|
1999-11-24 |
2005-04-12 |
Sugen, Inc. |
Formulations for pharmaceutical agents ionizable as free acids or free bases
|
US6313310B1
(en)
|
1999-12-15 |
2001-11-06 |
Hoffmann-La Roche Inc. |
4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
|
CA2395461C
(en)
|
1999-12-22 |
2010-05-25 |
Sugen, Inc. |
Methods of modulating c-kit tyrosine kinase function with indolinone compounds
|
US6339100B1
(en)
*
|
1999-12-29 |
2002-01-15 |
The Trustees Of Columbia University In The City Of New York |
Methods for inhibiting mastocytosis
|
EP1259234B9
(en)
*
|
1999-12-30 |
2007-02-14 |
Sugen, Inc. |
3-heteroarylidenyl-2-indolinone compounds for modulating protein kinase activity and for use in cancer chemotherapy
|
CA2399358C
(en)
*
|
2000-02-15 |
2006-03-21 |
Sugen, Inc. |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
US6620818B1
(en)
|
2000-03-01 |
2003-09-16 |
Smithkline Beecham Corporation |
Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
|
MY128450A
(en)
|
2000-05-24 |
2007-02-28 |
Upjohn Co |
1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
EP1294688A2
(en)
*
|
2000-06-02 |
2003-03-26 |
Sugen, Inc. |
Indolinone derivatives as protein kinase/phosphatase inhibitors
|
GB0016454D0
(en)
|
2000-07-04 |
2000-08-23 |
Hoffmann La Roche |
Thienopyrrolidinones
|
US7425537B2
(en)
*
|
2000-08-22 |
2008-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
SH2 domain binding inhibitors
|
EP1383792A2
(en)
*
|
2000-08-22 |
2004-01-28 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Sh2 domain binding inhibitors
|
US20030133972A1
(en)
*
|
2000-10-11 |
2003-07-17 |
Targesome, Inc. |
Targeted multivalent macromolecules
|
US20030129223A1
(en)
*
|
2000-10-11 |
2003-07-10 |
Targesome, Inc. |
Targeted multivalent macromolecules
|
ES2318649T3
(es)
*
|
2000-10-20 |
2009-05-01 |
EISAI R&D MANAGEMENT CO., LTD. |
Procedimiento de preparacion de derivados de 4-fenoxi quinolinas.
|
PE20020572A1
(es)
|
2000-12-06 |
2002-07-31 |
Centro Inmunologia Molecular |
Preparaciones para potenciar la inmunogenicidad de antigenos poco inmunogenicos
|
JP2004518669A
(ja)
|
2000-12-20 |
2004-06-24 |
スージェン・インコーポレーテッド |
4−アリール置換インドリノン
|
EP1349614A2
(en)
*
|
2001-01-03 |
2003-10-08 |
President And Fellows Of Harvard College |
Compounds regulating cell proliferation and differentiation
|
AR032028A1
(es)
|
2001-01-05 |
2003-10-22 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
US6504034B2
(en)
|
2001-01-23 |
2003-01-07 |
Hoffmann-La Roche Inc. |
Naphthostyrils
|
US20050069976A1
(en)
*
|
2001-02-14 |
2005-03-31 |
Peter Lind |
Protein-coupled receptor
|
AR042586A1
(es)
*
|
2001-02-15 |
2005-06-29 |
Sugen Inc |
3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
|
PT3351246T
(pt)
|
2001-02-19 |
2019-06-07 |
Novartis Pharma Ag |
Derivado de rapamicina para o tratamento de um tumor sólido associado a angiogenese desregulada
|
FR2821358B1
(fr)
*
|
2001-02-27 |
2006-04-07 |
Aventis Pharma Sa |
Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique
|
JP2004529110A
(ja)
*
|
2001-03-06 |
2004-09-24 |
アストラゼネカ アクチボラグ |
脈管損傷活性を有するインドール誘導体
|
FR2822155B1
(fr)
*
|
2001-03-13 |
2003-12-12 |
Aventis Pharma Sa |
Composes derives des oxindoles et leur application therapeutique en cancerologie
|
SE0101230L
(sv)
*
|
2001-04-06 |
2002-10-07 |
Innoventus Project Ab |
Ny användning av en tyrosinkinasinhibitor
|
WO2002081466A1
(en)
*
|
2001-04-09 |
2002-10-17 |
Sugen, Inc. |
Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
|
PL392652A1
(pl)
|
2001-05-16 |
2010-12-06 |
Novartis Ag |
Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację
|
US6599902B2
(en)
|
2001-05-30 |
2003-07-29 |
Sugen, Inc. |
5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
|
WO2003000194A2
(en)
|
2001-06-21 |
2003-01-03 |
Pfizer Inc. |
Thienopyridine and thienopyrimidine anticancer agents
|
DE60212627T2
(de)
*
|
2001-06-29 |
2007-06-14 |
Ab Science |
Verwendung von Tyrosinkinase-Inhibitoren zur Behandlung von entzündlichen Krankheiten
|
EP1401413B1
(en)
|
2001-06-29 |
2006-11-22 |
AB Science |
Use of tyrosine kinase inhibitions for treating allergic diseases
|
JP2005500041A
(ja)
*
|
2001-06-29 |
2005-01-06 |
アブ サイエンス |
強力で選択的かつ非毒性のc−kit阻害剤
|
DE60227709D1
(de)
*
|
2001-06-29 |
2008-08-28 |
Ab Science |
Die verwendung von c-kithemmern zur behandlung von autoimmunerkrankungen
|
JP2004537542A
(ja)
*
|
2001-06-29 |
2004-12-16 |
アブ サイエンス |
炎症性腸疾患(ibd)を治療するための、チロシンキナーゼ阻害剤の使用
|
CA2452366A1
(en)
*
|
2001-06-29 |
2003-01-16 |
Ab Science |
Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
|
DE10134196B4
(de)
*
|
2001-07-13 |
2005-08-18 |
Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt |
Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
AR038957A1
(es)
*
|
2001-08-15 |
2005-02-02 |
Pharmacia Corp |
Terapia de combinacion para el tratamiento del cancer
|
RS53251B
(sr)
*
|
2001-08-15 |
2014-08-29 |
Pharmacia & Upjohn Company Llc |
Kristali koji sadrže n-[2-dietilamino)etil]-5-[(5-fluoro-2-okso-3h-indol-3-iliden)metil]-2,4-dimetil-1h-pirol-3- karboksamid so jabučne kiseline, procesi za njihovu pripremu i njihovi preparati
|
WO2003039550A1
(en)
*
|
2001-09-20 |
2003-05-15 |
Ab Science |
Use of tyrosine kinase inhibitors for whitening human skin and treating melanocyte dysfunction associated diseases
|
WO2003024386A2
(en)
*
|
2001-09-20 |
2003-03-27 |
Ab Science |
Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
|
CA2461182A1
(en)
*
|
2001-09-20 |
2003-05-01 |
Ab Science |
Use of tyrosine kinase inhibitors for promoting hair growth
|
WO2003027102A1
(en)
*
|
2001-09-27 |
2003-04-03 |
Allergan, Inc. |
3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
|
US6559173B1
(en)
|
2001-09-27 |
2003-05-06 |
Allergan, Inc. |
3-(heteroarylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
|
JP2005508953A
(ja)
|
2001-10-10 |
2005-04-07 |
スージェン・インコーポレーテッド |
キナーゼ阻害剤としての3−[4−(置換ヘテロサイクリル)−ピロール−2−イルメチリデン]−2−インドリノン誘導体
|
AR039067A1
(es)
*
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
BR0214357A
(pt)
*
|
2001-11-21 |
2004-09-14 |
Sugen Inc |
Formulações farmacêuticas compreendendo derivados de indolinona
|
US6797825B2
(en)
|
2001-12-13 |
2004-09-28 |
Abbott Laboratories |
Protein kinase inhibitors
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
PE20030701A1
(es)
|
2001-12-20 |
2003-08-21 |
Schering Corp |
Compuestos para el tratamiento de trastornos inflamatorios
|
AU2002360753B2
(en)
|
2001-12-27 |
2008-08-21 |
Theravance, Inc. |
Indolinone derivatives useful as protein kinase inhibitors
|
MXPA04006614A
(es)
*
|
2002-01-07 |
2004-10-04 |
Eisai Co Ltd |
Deazapurinas y usos de las mismas.
|
PT1478380E
(pt)
*
|
2002-02-27 |
2006-12-29 |
Ab Science |
Utilização de inibidores de tirosina-cinases para tratar doenças do snc
|
MXPA04008403A
(es)
*
|
2002-03-01 |
2004-11-26 |
Pfizer |
Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos, y procedimientos para su uso.
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
NZ534842A
(en)
*
|
2002-04-03 |
2007-02-23 |
Allergan Inc |
(3Z)-3-(3-hydro-isobenzofuran-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
|
US6541504B1
(en)
|
2002-04-03 |
2003-04-01 |
Allergan Sales, Llc |
(3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors
|
EP1944026B1
(en)
|
2002-05-16 |
2013-06-26 |
Novartis AG |
Use of EDG receptor binding agents in cancer
|
UA77303C2
(en)
*
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
US20060166982A1
(en)
*
|
2002-08-01 |
2006-07-27 |
Danilo Giribone |
Isotopically labelly indlinone derivatives and process for their preparation
|
BRPI0313165B8
(pt)
|
2002-08-02 |
2021-05-25 |
Ab Science |
2-(3-aminoaril)amino-4-aril-tiazóis e sua utilização como inibidores de c-kit
|
US8450302B2
(en)
*
|
2002-08-02 |
2013-05-28 |
Ab Science |
2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
|
US20050032871A1
(en)
*
|
2002-09-03 |
2005-02-10 |
Sugen, Inc. |
Sulfonylated pyrrole-2-indolinone derivatives as kinase inhibitors
|
US7626031B2
(en)
*
|
2002-11-15 |
2009-12-01 |
Symphony Evolution, Inc. |
Substituted 3-(diarylmethylene)indolin-2-ones and methods of their use
|
WO2004048525A2
(en)
*
|
2002-11-21 |
2004-06-10 |
Genentech, Inc. |
Therapy of non-malignant diseases or disorders with anti-erbb2 antibodies
|
US6699863B1
(en)
|
2002-11-27 |
2004-03-02 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
US6747025B1
(en)
*
|
2002-11-27 |
2004-06-08 |
Allergan, Inc. |
Kinase inhibitors for the treatment of disease
|
US20040186160A1
(en)
*
|
2002-12-13 |
2004-09-23 |
Sugen, Inc. |
Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
|
JP3814285B2
(ja)
*
|
2002-12-19 |
2006-08-23 |
ファイザー・インク |
眼疾患の治療に有用なプロテインキナーゼ阻害剤としての2−(1h−インダゾール−6−イルアミノ)−ベンズアミド化合物
|
US20040138104A1
(en)
*
|
2003-01-14 |
2004-07-15 |
The Government Of The United States Of America Represented By The Secretary, |
Peptides
|
ITRM20030074A1
(it)
*
|
2003-02-21 |
2004-08-22 |
Pharmacia Italia Spa |
Formulazioni semisolide a rilascio immediato intese
|
GEP20084341B
(en)
|
2003-02-26 |
2008-03-25 |
Sugen Inc |
Aminoheteroaryl compounds as protein kinase inhibitors
|
US20040266843A1
(en)
*
|
2003-03-07 |
2004-12-30 |
Sugen, Inc. |
Sulfonamide substituted indolinones as inhibitors of DNA dependent protein kinase (DNA-PK)
|
US7157577B2
(en)
*
|
2003-03-07 |
2007-01-02 |
Sugen Inc. |
5-sulfonamido-substituted indolinone compounds as protein kinase inhibitors
|
US7994159B2
(en)
*
|
2003-03-10 |
2011-08-09 |
Eisai R&D Management Co., Ltd. |
c-Kit kinase inhibitor
|
BRPI0409230A
(pt)
*
|
2003-04-03 |
2006-03-28 |
Pfizer |
formas de dosagem compreendendo ag013736
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
CA2524048C
(en)
|
2003-05-19 |
2013-06-25 |
Irm Llc |
Immunosuppressant compounds and compositions
|
JP5105874B2
(ja)
|
2003-07-18 |
2012-12-26 |
アムジエン・インコーポレーテツド |
肝細胞増殖因子に対する特異的結合因子
|
DE10334582A1
(de)
*
|
2003-07-28 |
2005-02-24 |
Basf Ag |
Verfahren zur Herstellung von Maleinsäureanhydrid
|
HN2004000285A
(es)
*
|
2003-08-04 |
2006-04-27 |
Pfizer Prod Inc |
ANTICUERPOS DIRIGIDOS A c-MET
|
BRPI0413281A
(pt)
*
|
2003-08-06 |
2006-10-10 |
Sugen Inc |
3-ciclopentilideno-1,3,dihidroindol-2-onas geometricamente restringidas como potentes inibidores de proteìna cinase
|
EP1653934B1
(en)
*
|
2003-08-15 |
2008-05-14 |
AB Science |
Use of c-kit inhibitors for treating type ii diabetes
|
CA2536788A1
(en)
*
|
2003-08-29 |
2005-03-10 |
Pfizer Inc. |
Naphthalene carboxamides and their derivatives useful as new anti-angiogenic agents
|
DE602004017479D1
(de)
*
|
2003-08-29 |
2008-12-11 |
Pfizer |
Als neue antiangiogene mittel geeignete thienopyridinphenylacetamide und derivate davon
|
AR045563A1
(es)
*
|
2003-09-10 |
2005-11-02 |
Warner Lambert Co |
Anticuerpos dirigidos a m-csf
|
US20050119163A1
(en)
|
2003-09-18 |
2005-06-02 |
The Government Of The United States Of America, As Represented By The Secretary, |
SH2 domain binding inhibitors
|
JP4971797B2
(ja)
*
|
2003-10-23 |
2012-07-11 |
アブ サイエンス |
チロシンキナーゼ阻害薬としての2−アミノアリールオキサゾール化合物
|
MXPA06004438A
(es)
*
|
2003-10-24 |
2006-06-20 |
Schering Ag |
Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer.
|
CN101337930B
(zh)
*
|
2003-11-11 |
2010-09-08 |
卫材R&D管理有限公司 |
脲衍生物的制备方法
|
WO2005051919A1
(en)
*
|
2003-11-26 |
2005-06-09 |
Pfizer Products Inc. |
Aminopyrazole derivatives as gsk-3 inhibitors
|
EP1696906A1
(en)
*
|
2003-12-16 |
2006-09-06 |
Leo Pharma A/S |
Novel therapeutic use of indolinone derivatives
|
BRPI0418102A
(pt)
*
|
2003-12-23 |
2007-04-27 |
Pfizer |
derivados de quinolina
|
WO2005073366A1
(en)
*
|
2004-01-30 |
2005-08-11 |
Lifecord Inc. |
Method for isolating and culturing multipotent progenitor/stem cells from umbilical cord blood and method for inducing differentiation thereof
|
US20060035907A1
(en)
*
|
2004-02-23 |
2006-02-16 |
Christensen James G |
Methods of treating abnormal cell growth using c-MET and m-TOR inhibitors
|
DE102004012070A1
(de)
*
|
2004-03-12 |
2005-09-29 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
|
BRPI0509580A
(pt)
*
|
2004-03-30 |
2007-11-27 |
Pfizer Prod Inc |
combinações de inibidores de transdução de sinal
|
US7771742B2
(en)
*
|
2004-04-30 |
2010-08-10 |
Allergan, Inc. |
Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
|
US8455656B2
(en)
*
|
2004-04-30 |
2013-06-04 |
Allergan, Inc. |
Kinase inhibitors
|
BRPI0510485A
(pt)
|
2004-04-30 |
2007-11-13 |
Allergan Inc |
implantes inibidores de tirosina cinase intravìtreos biodegradáveis
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
CA2571421A1
(en)
|
2004-06-24 |
2006-01-05 |
Nicholas Valiante |
Compounds for immunopotentiation
|
CA2573821A1
(en)
*
|
2004-07-16 |
2006-01-26 |
Pfizer Products Inc. |
Combination treatment for non-hematologic malignancies using an anti-igf-1r antibody
|
JP2008510792A
(ja)
*
|
2004-08-26 |
2008-04-10 |
ファイザー・インク |
タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物
|
ATE463486T1
(de)
|
2004-08-26 |
2010-04-15 |
Pfizer |
Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer
|
CN101018780B
(zh)
*
|
2004-08-26 |
2012-01-11 |
辉瑞大药厂 |
作为蛋白激酶抑制剂的吡唑取代的氨基杂芳基化合物
|
EP2364699A1
(en)
|
2004-09-13 |
2011-09-14 |
Eisai R&D Management Co., Ltd. |
Joint use of sulfonamide based compound with angiogenesis inhibitor
|
US8772269B2
(en)
*
|
2004-09-13 |
2014-07-08 |
Eisai R&D Management Co., Ltd. |
Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
|
US8969379B2
(en)
*
|
2004-09-17 |
2015-03-03 |
Eisai R&D Management Co., Ltd. |
Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
|
GB0423043D0
(en)
*
|
2004-10-16 |
2004-11-17 |
Astrazeneca Ab |
Compounds
|
US20060107555A1
(en)
*
|
2004-11-09 |
2006-05-25 |
Curtis Marc D |
Universal snow plow adapter
|
CA2589501A1
(en)
*
|
2004-12-17 |
2006-06-22 |
Boehringer Ingelheim International Gmbh |
Indolinones and their use as antiproliferative agents
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
NZ561215A
(en)
|
2005-02-22 |
2010-12-24 |
Univ Michigan |
Small molecule inhibitors of MDM2 and uses thereof
|
NZ562453A
(en)
|
2005-03-31 |
2010-04-30 |
Agensys Inc |
Antibodies and related molecules that bind to 161P2F10B proteins
|
MX2007012392A
(es)
*
|
2005-04-04 |
2007-12-05 |
Ab Science |
Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
|
BRPI0608096A2
(pt)
|
2005-04-26 |
2009-11-10 |
Pfizer |
anticorpos p-caderina
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
US7309787B2
(en)
*
|
2005-07-13 |
2007-12-18 |
Allergan, Inc. |
Kinase inhibitors
|
US7749530B2
(en)
|
2005-07-13 |
2010-07-06 |
Allergan, Inc. |
Kinase inhibitors
|
EP1902024B1
(en)
|
2005-07-13 |
2013-04-17 |
Allergan, Inc. |
Kinase inhibitors
|
WO2007008895A1
(en)
*
|
2005-07-13 |
2007-01-18 |
Allergan, Inc. |
Kinase inhibitors
|
US20100105031A1
(en)
*
|
2005-08-01 |
2010-04-29 |
Esai R & D Management Co., Ltd. |
Method for prediction of the efficacy of vascularization inhibitor
|
WO2007015578A1
(ja)
|
2005-08-02 |
2007-02-08 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質の効果を検定する方法
|
EP1938842A4
(en)
*
|
2005-09-01 |
2013-01-09 |
Eisai R&D Man Co Ltd |
METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION COMPRISING IMPROVED CRASHING CHARACTERISTICS
|
UA94060C2
(ru)
|
2005-09-07 |
2011-04-11 |
Эмджен Фримонт Инк. |
Моноклональное антитело, которое специфически связывает alk-1
|
WO2007035744A1
(en)
|
2005-09-20 |
2007-03-29 |
Osi Pharmaceuticals, Inc. |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
AR058065A1
(es)
|
2005-09-27 |
2008-01-23 |
Novartis Ag |
Compuestos de carboxiamina y uso de los mismos.composiciones farmaceuticas.
|
WO2007052849A1
(ja)
*
|
2005-11-07 |
2007-05-10 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質とc-kitキナーゼ阻害物質との併用
|
CA2629245C
(en)
|
2005-11-21 |
2016-07-12 |
Novartis Ag |
Neuroendocrine tumor treatment
|
US20090247576A1
(en)
*
|
2005-11-22 |
2009-10-01 |
Eisai R & D Management Co., Ltd. |
Anti-tumor agent for multiple myeloma
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
US8338415B2
(en)
*
|
2006-01-24 |
2012-12-25 |
Allergan, Inc. |
Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase inhibitors
|
PE20070978A1
(es)
*
|
2006-02-14 |
2007-11-15 |
Novartis Ag |
COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
|
AU2007224020A1
(en)
|
2006-03-07 |
2007-09-13 |
Array Biopharma Inc. |
Heterobicyclic pyrazole compounds and methods of use
|
US7977351B2
(en)
|
2006-03-22 |
2011-07-12 |
Allergan, Inc. |
Heteroaryl dihydroindolones as kinase inhibitors
|
CN101415409B
(zh)
|
2006-04-05 |
2012-12-05 |
诺瓦提斯公司 |
用于治疗癌症的治疗剂的组合
|
TW200808739A
(en)
*
|
2006-04-06 |
2008-02-16 |
Novartis Vaccines & Diagnostic |
Quinazolines for PDK1 inhibition
|
CN101472915A
(zh)
|
2006-04-19 |
2009-07-01 |
诺瓦提斯公司 |
吲唑化合物和抑制cdc7的方法
|
EA200802058A1
(ru)
|
2006-05-09 |
2009-06-30 |
Пфайзер Продактс Инк. |
Производные циклоалкиламинокислот и их фармацевтические композиции
|
CN101443002B
(zh)
|
2006-05-09 |
2012-03-21 |
诺瓦提斯公司 |
包含铁螯合剂和抗肿瘤药的组合及其用途
|
CA2652442C
(en)
*
|
2006-05-18 |
2014-12-09 |
Eisai R & D Management Co., Ltd. |
Antitumor agent for thyroid cancer
|
CA2655128A1
(en)
*
|
2006-06-08 |
2007-12-21 |
Array Biopharma Inc. |
Quinoline compounds and methods of use
|
GB0612721D0
(en)
|
2006-06-27 |
2006-08-09 |
Novartis Ag |
Organic compounds
|
JPWO2008001956A1
(ja)
*
|
2006-06-29 |
2009-12-03 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
肝線維症治療剤
|
US8217177B2
(en)
|
2006-07-14 |
2012-07-10 |
Amgen Inc. |
Fused heterocyclic derivatives and methods of use
|
PE20121506A1
(es)
|
2006-07-14 |
2012-11-26 |
Amgen Inc |
Compuestos triazolopiridinas como inhibidores de c-met
|
US8246966B2
(en)
*
|
2006-08-07 |
2012-08-21 |
University Of Georgia Research Foundation, Inc. |
Trypanosome microsome system and uses thereof
|
US8034957B2
(en)
*
|
2006-08-11 |
2011-10-11 |
Allergan, Inc. |
Kinase inhibitors
|
KR101472600B1
(ko)
*
|
2006-08-28 |
2014-12-15 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
미분화형 위암에 대한 항종양제
|
WO2008037477A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as p13k lipid kinase inhibitors
|
WO2008066626A2
(en)
*
|
2006-10-25 |
2008-06-05 |
The Rockefeller University |
METHODS FOR THE TREATMENT OF Aβ RELATED DISORDERS AND COMPOSITIONS THEREFOR
|
US8143410B2
(en)
|
2006-11-16 |
2012-03-27 |
Allergan, Inc. |
Kinase inhibitors
|
US8558002B2
(en)
|
2006-11-16 |
2013-10-15 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
CA2669704A1
(en)
|
2006-11-16 |
2008-05-22 |
Allergan, Inc. |
Sulfoximines as kinase inhibitors
|
CA2669531A1
(en)
|
2006-11-22 |
2008-06-05 |
University Of Georgia Research Foundation, Inc. |
Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
|
SG177225A1
(en)
*
|
2006-12-01 |
2012-01-30 |
Agency Science Tech & Res |
Cancer-related protein kinases
|
CA2676796C
(en)
*
|
2007-01-29 |
2016-02-23 |
Eisai R & D Management Co., Ltd. |
Composition for treatment of undifferentiated gastric cancer
|
US9187485B2
(en)
*
|
2007-02-02 |
2015-11-17 |
Baylor College Of Medicine |
Methods and compositions for the treatment of cancer and related hyperproliferative disorders
|
CN101626758A
(zh)
|
2007-02-15 |
2010-01-13 |
诺瓦提斯公司 |
用于治疗癌症的lbh589和其他治疗剂的组合
|
WO2008103277A2
(en)
|
2007-02-16 |
2008-08-28 |
Amgen Inc. |
Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors
|
WO2008127707A1
(en)
*
|
2007-04-13 |
2008-10-23 |
Dana Farber Cancer Institute, Inc. |
Receptor tyrosine kinase profiling
|
JP5926487B2
(ja)
|
2007-04-13 |
2016-05-25 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
ErbB療法に耐性である癌を治療するための方法
|
US7825143B2
(en)
*
|
2007-07-10 |
2010-11-02 |
Montana State University - Billings |
Method for controlling the yeast-to-filamentous growth transition in fungi
|
CL2008002444A1
(es)
|
2007-08-21 |
2009-09-04 |
Amgen Inc |
Anticuerpo o fragmento del mismo que se une a la proteina c-fms humana; molecula de acido nucleico que la codifica; vector y celula huesped; metodo de elaboracion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir una condicion asociada con c-fms en un paciente.
|
WO2009060945A1
(ja)
|
2007-11-09 |
2009-05-14 |
Eisai R & D Management Co., Ltd. |
血管新生阻害物質と抗腫瘍性白金錯体との併用
|
CN101952282A
(zh)
|
2007-12-20 |
2011-01-19 |
诺瓦提斯公司 |
用作pi 3激酶抑制剂的噻唑衍生物
|
CN101970426A
(zh)
|
2007-12-21 |
2011-02-09 |
大学健康网络 |
吲唑基、苯并咪唑基、苯并三唑基取代的二氢吲哚酮衍生物作为癌症治疗中有用的激酶抑制剂
|
WO2009092052A2
(en)
|
2008-01-18 |
2009-07-23 |
Massachusetts Eye And Ear Infirmary |
Methods and compositions for treating polyps
|
AU2009210098B2
(en)
*
|
2008-01-29 |
2013-06-13 |
Eisai R & D Management Co., Ltd. |
Combined use of angiogenesis inhibitor and taxane
|
US8232402B2
(en)
|
2008-03-12 |
2012-07-31 |
Link Medicine Corporation |
Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
|
EP2260020B1
(en)
|
2008-03-26 |
2014-07-23 |
Novartis AG |
Hydroxamate-based inhibitors of deacetylases b
|
ES2537529T3
(es)
*
|
2008-06-05 |
2015-06-09 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Novedosos moduladores de la señalización de proteínas cinasas
|
CN102137866A
(zh)
*
|
2008-06-30 |
2011-07-27 |
赛林药物股份有限公司 |
羟吲哚化合物
|
US20100029491A1
(en)
*
|
2008-07-11 |
2010-02-04 |
Maike Schmidt |
Methods and compositions for diagnostic use for tumor treatment
|
WO2010011349A2
(en)
*
|
2008-07-25 |
2010-01-28 |
Supergen, Inc. |
Pyrimidine-2,4-diamine jak2 kinase inhibiting anti-inflammation use
|
US8993615B2
(en)
*
|
2008-08-08 |
2015-03-31 |
The Johns Hopkins University |
Compositions and methods for treatment of neurodegenerative disease
|
TW201012935A
(en)
*
|
2008-08-29 |
2010-04-01 |
Genentech Inc |
Diagnostics and treatments for VEGF-independent tumors
|
WO2010044753A1
(en)
*
|
2008-10-14 |
2010-04-22 |
National University Of Singapore |
Novel benzylidene-indolinone and their medical and diagnostic uses
|
CA2737597C
(en)
|
2008-10-16 |
2017-03-14 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof
|
EP2344161B1
(en)
|
2008-10-16 |
2018-12-19 |
Celator Pharmaceuticals, Inc. |
Combinations of a liposomal water-soluble camptothecin with cetuximab or bevacizumab
|
CA2743717A1
(en)
|
2008-11-13 |
2010-05-20 |
Link Medicine Corporation |
Azaquinolinone derivatives and uses thereof
|
US20100222371A1
(en)
*
|
2008-11-20 |
2010-09-02 |
Children's Medical Center Corporation |
Prevention of surgical adhesions
|
JP2012512884A
(ja)
|
2008-12-18 |
2012-06-07 |
ノバルティス アーゲー |
1−(4−{1−[(e)−4−シクロヘキシル−3−トリフルオロメチル−ベンジルオキシイミノ]−エチル}−2−エチル−ベンジル)−アゼチジン−3−カルボン酸の新規の多形相
|
DK2676953T3
(en)
|
2008-12-18 |
2017-07-03 |
Novartis Ag |
Hemifumarate salt of 1- [4- [1- (4-cyclohexyl-3-trifluoromethyl-benzyloxyimino) -ethyl] -2-ethyl-benzyl] -acetidine-3-carboxylic acid for use in the treatment of lymphocyte-mediated diseases
|
MX2011006622A
(es)
|
2008-12-18 |
2011-07-12 |
Novartis Ag |
Sales novedosas.
|
DK2391366T3
(da)
|
2009-01-29 |
2013-01-07 |
Novartis Ag |
Substituerede benzimidazoler til behandling af astrocytomer
|
SG172857A1
(en)
|
2009-02-09 |
2011-08-29 |
Supergen Inc |
Pyrrolopyrimidinyl axl kinase inhibitors
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
US20100222381A1
(en)
|
2009-02-27 |
2010-09-02 |
Hariprasad Vankayalapati |
Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012519282A
(ja)
|
2009-02-27 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
|
EP2417127B1
(en)
|
2009-04-06 |
2014-02-26 |
University Health Network |
Kinase inhibitors and method of treating cancer with same
|
JPWO2010131460A1
(ja)
|
2009-05-12 |
2012-11-01 |
大鵬薬品工業株式会社 |
テガフール・ギメラシル・オテラシルカリウム配合剤及びオキサリプラチンを含有する抗腫瘍剤
|
DK2445903T3
(da)
|
2009-06-26 |
2014-06-23 |
Novartis Ag |
1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
SG10201510152RA
(en)
|
2009-07-13 |
2016-01-28 |
Genentech Inc |
Diagnostic methods and compositions for treatment of cancer
|
WO2011014726A1
(en)
|
2009-07-31 |
2011-02-03 |
Osi Pharmaceuticals, Inc. |
Mtor inhibitor and angiogenesis inhibitor combination therapy
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
AU2010283806A1
(en)
|
2009-08-12 |
2012-03-01 |
Novartis Ag |
Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
|
JP5819831B2
(ja)
|
2009-08-17 |
2015-11-24 |
インテリカイン, エルエルシー |
複素環式化合物およびそれらの使用
|
KR20120089463A
(ko)
|
2009-08-20 |
2012-08-10 |
노파르티스 아게 |
헤테로시클릭 옥심 화합물
|
IN2012DN01693A
(no)
|
2009-08-26 |
2015-06-05 |
Novartis Ag |
|
WO2011027249A2
(en)
|
2009-09-01 |
2011-03-10 |
Pfizer Inc. |
Benzimidazole derivatives
|
US9340555B2
(en)
|
2009-09-03 |
2016-05-17 |
Allergan, Inc. |
Compounds as tyrosine kinase modulators
|
MX2012002596A
(es)
|
2009-09-03 |
2012-07-03 |
Allergan Inc |
Compuestos como moduladores de tirosina cinasas.
|
CN102596963A
(zh)
|
2009-09-10 |
2012-07-18 |
诺瓦提斯公司 |
二环杂芳基的醚衍生物
|
AU2010292060A1
(en)
|
2009-09-11 |
2012-04-12 |
Genentech, Inc. |
Method to identify a patient with an increased likelihood of responding to an anti-cancer agent
|
CN102612566B
(zh)
|
2009-09-17 |
2016-02-17 |
霍夫曼-拉罗奇有限公司 |
用于癌症患者中诊断学用途的方法和组合物
|
BR112012010519A2
(pt)
|
2009-11-04 |
2017-12-05 |
Novartis Ag |
derivados de sulfonamida heterocíclicos
|
JP2013512215A
(ja)
|
2009-11-25 |
2013-04-11 |
ノバルティス アーゲー |
二環式ヘテロアリールのベンゼン縮合6員酸素含有ヘテロ環誘導体
|
EA201200823A1
(ru)
|
2009-12-08 |
2013-02-28 |
Новартис Аг |
Гетероциклические производные сульфонамидов
|
WO2011073521A1
(en)
|
2009-12-15 |
2011-06-23 |
Petri Salven |
Methods for enriching adult-derived endothelial progenitor cells and uses thereof
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
WO2011098971A1
(en)
|
2010-02-12 |
2011-08-18 |
Pfizer Inc. |
Salts and polymorphs of 8-fluoro-2-{4-[(methylamino}methyl]phenyl}-1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one
|
US20110217309A1
(en)
|
2010-03-03 |
2011-09-08 |
Buck Elizabeth A |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
JP2013527748A
(ja)
|
2010-03-03 |
2013-07-04 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
インスリン様増殖因子1受容体キナーゼ阻害剤に対する抗癌反応の予測に役立つ生物学的マーカー
|
ES2603613T3
(es)
|
2010-04-06 |
2017-02-28 |
University Health Network |
Inhibidores de quinasa y su uso en el tratamiento del cáncer
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
ES2611479T3
(es)
|
2010-06-16 |
2017-05-09 |
University Of Pittsburgh- Of The Commonwealth System Of Higher Education |
Anticuerpos contra endoplasmina y su uso
|
WO2011157787A1
(en)
|
2010-06-17 |
2011-12-22 |
Novartis Ag |
Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
US20130085161A1
(en)
|
2010-06-17 |
2013-04-04 |
Novartis Ag |
Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
EP2586443B1
(en)
|
2010-06-25 |
2016-03-16 |
Eisai R&D Management Co., Ltd. |
Antitumor agent using compounds having kinase inhibitory effect in combination
|
JP2013538338A
(ja)
|
2010-07-19 |
2013-10-10 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
抗癌治療への応答可能性の増大した患者を同定する方法
|
SG187018A1
(en)
|
2010-07-19 |
2013-02-28 |
Hoffmann La Roche |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
WO2012012750A1
(en)
|
2010-07-23 |
2012-01-26 |
Trustees Of Boston University |
ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
|
CN101912363A
(zh)
*
|
2010-07-29 |
2010-12-15 |
蔡海德 |
溶解超滤-喷雾干燥-分子分散包衣-水化制粒-冷冻干燥生产脂质体组合药物
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
WO2012027716A1
(en)
|
2010-08-27 |
2012-03-01 |
Collabrx, Inc. |
Method to treat melanoma in braf inhibitor-resistant subjects
|
WO2012035078A1
(en)
|
2010-09-16 |
2012-03-22 |
Novartis Ag |
17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
|
WO2012042421A1
(en)
|
2010-09-29 |
2012-04-05 |
Pfizer Inc. |
Method of treating abnormal cell growth
|
EP2630134B9
(en)
|
2010-10-20 |
2018-04-18 |
Pfizer Inc |
Pyridine-2- derivatives as smoothened receptor modulators
|
AP2013007043A0
(en)
|
2011-01-31 |
2013-08-31 |
Novartis Ag |
Novel heterocyclic derivatives
|
WO2012107500A1
(en)
|
2011-02-10 |
2012-08-16 |
Novartis Ag |
[1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
US20120214830A1
(en)
|
2011-02-22 |
2012-08-23 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
EP2683722A1
(en)
|
2011-03-08 |
2014-01-15 |
Novartis AG |
Fluorophenyl bicyclic heteroaryl compounds
|
DK2688887T3
(en)
|
2011-03-23 |
2015-06-29 |
Amgen Inc |
DEHYDRATED tricyclic DUALINHIBITORER OF CDK 4/6 AND FLT3
|
US9150644B2
(en)
|
2011-04-12 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Human monoclonal antibodies that bind insulin-like growth factor (IGF) I and II
|
CA2828946C
(en)
|
2011-04-18 |
2016-06-21 |
Eisai R&D Management Co., Ltd. |
Therapeutic agent for tumor
|
EP2699598B1
(en)
|
2011-04-19 |
2019-03-06 |
Pfizer Inc |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
ES2656218T3
(es)
|
2011-04-28 |
2018-02-26 |
Novartis Ag |
Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa
|
ES2705950T3
(es)
|
2011-06-03 |
2019-03-27 |
Eisai R&D Man Co Ltd |
Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
|
CA2838029A1
(en)
|
2011-06-09 |
2012-12-13 |
Novartis Ag |
Heterocyclic sulfonamide derivatives
|
WO2012175520A1
(en)
|
2011-06-20 |
2012-12-27 |
Novartis Ag |
Hydroxy substituted isoquinolinone derivatives
|
US8859586B2
(en)
|
2011-06-20 |
2014-10-14 |
Novartis Ag |
Cyclohexyl isoquinolinone compounds
|
ES2671748T3
(es)
|
2011-07-21 |
2018-06-08 |
Tolero Pharmaceuticals, Inc. |
Inhibidores heterocíclicos de proteína quinasas
|
SG187375A1
(en)
|
2011-08-04 |
2013-02-28 |
Univ Singapore |
Benzylidene-indolinone compounds and their medical uses
|
US9745288B2
(en)
|
2011-08-16 |
2017-08-29 |
Indiana University Research And Technology Corporation |
Compounds and methods for treating cancer by inhibiting the urokinase receptor
|
EP2755976B1
(en)
|
2011-09-15 |
2018-07-18 |
Novartis AG |
6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
|
WO2013042006A1
(en)
|
2011-09-22 |
2013-03-28 |
Pfizer Inc. |
Pyrrolopyrimidine and purine derivatives
|
EP3275902A1
(en)
|
2011-10-04 |
2018-01-31 |
IGEM Therapeutics Limited |
Ige anti-hmw-maa antibody
|
WO2013061305A1
(en)
|
2011-10-28 |
2013-05-02 |
Novartis Ag |
Novel purine derivatives and their use in the treatment of disease
|
BR112014011115A2
(pt)
|
2011-11-08 |
2017-06-13 |
Pfizer |
métodos para tratamento de distúrbios inflamatórios usando anticorpos anti-m-csf
|
JP5992054B2
(ja)
|
2011-11-29 |
2016-09-14 |
ノバルティス アーゲー |
ピラゾロピロリジン化合物
|
BR112014015308A2
(pt)
|
2011-12-23 |
2017-06-13 |
Novartis Ag |
compostos para inibição da interação de bcl2 com contrapartes de ligação
|
CA2859876A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
CA2859873A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
US9126980B2
(en)
|
2011-12-23 |
2015-09-08 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
CA2859869A1
(en)
|
2011-12-23 |
2013-06-27 |
Novartis Ag |
Compounds for inhibiting the interaction of bcl2 with binding partners
|
CN102491932A
(zh)
*
|
2011-12-26 |
2012-06-13 |
天津科技大学 |
一种3-吲哚啉酮类衍生物及其制备方法及其应用
|
JO3357B1
(ar)
|
2012-01-26 |
2019-03-13 |
Novartis Ag |
مركبات إيميدازوبيروليدينون
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
CA2868202C
(en)
|
2012-04-03 |
2021-08-10 |
Novartis Ag |
Combination products with tyrosine kinase inhibitors and their use
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
JP6381523B2
(ja)
|
2012-05-16 |
2018-08-29 |
ノバルティス アーゲー |
Pi−3キナーゼ阻害剤の投与レジメン
|
US9365576B2
(en)
|
2012-05-24 |
2016-06-14 |
Novartis Ag |
Pyrrolopyrrolidinone compounds
|
US9394257B2
(en)
|
2012-10-16 |
2016-07-19 |
Tolero Pharmaceuticals, Inc. |
PKM2 modulators and methods for their use
|
US9260426B2
(en)
|
2012-12-14 |
2016-02-16 |
Arrien Pharmaceuticals Llc |
Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
|
CN104755463A
(zh)
|
2012-12-21 |
2015-07-01 |
卫材R&D管理有限公司 |
非晶态形式的喹啉衍生物及其生产方法
|
EP2948453B1
(en)
|
2013-01-22 |
2017-08-02 |
Novartis AG |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction
|
WO2014115077A1
(en)
|
2013-01-22 |
2014-07-31 |
Novartis Ag |
Substituted purinone compounds
|
US10202356B2
(en)
|
2013-03-14 |
2019-02-12 |
Tolero Pharmaceuticals, Inc. |
JAK2 and ALK2 inhibitors and methods for their use
|
CA2906542A1
(en)
|
2013-03-15 |
2014-09-25 |
Intellikine, Llc |
Combination of kinase inhibitors and uses thereof
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
US9206188B2
(en)
|
2013-04-18 |
2015-12-08 |
Arrien Pharmaceuticals Llc |
Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors
|
MX368099B
(es)
|
2013-05-14 |
2019-09-19 |
Eisai R&D Man Co Ltd |
Biomarcadores para predecir y evaluar el grado de respuesta de sujetos con cancer de endometrio a compuestos de tipo lenvatinib.
|
WO2015008206A1
(en)
|
2013-07-14 |
2015-01-22 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Igf-1r signaling pathway inhibitors useful in the treatment of neurodegenerative diseases
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
DK3052102T3
(da)
|
2013-10-04 |
2020-03-09 |
Aptose Biosciences Inc |
Sammensætninger til behandling af cancere
|
WO2015054781A1
(en)
|
2013-10-18 |
2015-04-23 |
University Health Network |
Treatment for pancreatic cancer
|
WO2015073833A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Pharmacyclics, Inc. |
Methods for delaying or preventing the onset of type 1 diabetes
|
UA115388C2
(uk)
|
2013-11-21 |
2017-10-25 |
Пфайзер Інк. |
2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Mdm2抑制劑與BRAF抑制劑之組合及其用途
|
JP2016539149A
(ja)
|
2013-12-06 |
2016-12-15 |
ノバルティス アーゲー |
アルファ−アイソフォーム選択的ホスファチジルイノシトール3−キナーゼ阻害剤の投薬レジメン
|
WO2015106158A1
(en)
|
2014-01-09 |
2015-07-16 |
Intra-Cellular Therapies, Inc. |
Organic compounds
|
BR112016021383A2
(pt)
|
2014-03-24 |
2017-10-03 |
Genentech Inc |
Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
|
CN111808957A
(zh)
|
2014-04-04 |
2020-10-23 |
中美冠科生物技术(太仓)有限公司 |
用于确定对mek/erk抑制剂的应答性的方法
|
WO2015155624A1
(en)
|
2014-04-10 |
2015-10-15 |
Pfizer Inc. |
Dihydropyrrolopyrimidine derivatives
|
PT3137460T
(pt)
|
2014-04-30 |
2019-12-30 |
Pfizer |
Derivados de di-heterociclo ligado a cicloalquilo
|
WO2016001789A1
(en)
|
2014-06-30 |
2016-01-07 |
Pfizer Inc. |
Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
|
CA2954862A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
ES2848857T3
(es)
|
2014-07-31 |
2021-08-12 |
Us Gov Health & Human Services |
Anticuerpos monoclonales humanos contra EphA4 y su uso
|
JO3783B1
(ar)
|
2014-08-28 |
2021-01-31 |
Eisai R&D Man Co Ltd |
مشتق كوينولين عالي النقاء وطريقة لإنتاجه
|
CN104326964A
(zh)
*
|
2014-09-16 |
2015-02-04 |
中国科学院海洋研究所 |
一类氟代2-吲哚酮衍生物及其制备和应用
|
CN105481751A
(zh)
*
|
2014-09-16 |
2016-04-13 |
中国科学院海洋研究所 |
一类2-吲哚酮衍生物及其制备和应用
|
ES2746839T3
(es)
|
2014-12-18 |
2020-03-09 |
Pfizer |
Derivados de pirimidina y triazina y su uso como inhibidores de AXL
|
CN112494653A
(zh)
|
2015-02-05 |
2021-03-16 |
特尔诺沃有限公司 |
用于治疗癌症的irs/stat3双重调节剂与抗癌剂的组合
|
DK3263106T3
(da)
|
2015-02-25 |
2024-01-08 |
Eisai R&D Man Co Ltd |
Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
|
CA2978226A1
(en)
|
2015-03-04 |
2016-09-09 |
Merck Sharpe & Dohme Corp. |
Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
|
MX2017013383A
(es)
|
2015-04-20 |
2017-12-07 |
Tolero Pharmaceuticals Inc |
Prediccion de respuesta a alvocidib mediante perfilado mitocondrial.
|
US10011629B2
(en)
|
2015-05-01 |
2018-07-03 |
Cocrystal Pharma, Inc. |
Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
|
KR102608921B1
(ko)
|
2015-05-18 |
2023-12-01 |
스미토모 파마 온콜로지, 인크. |
생체 이용률이 증가된 알보시딥 프로드러그
|
CN107801379B
(zh)
|
2015-06-16 |
2021-05-25 |
卫材R&D管理有限公司 |
抗癌剂
|
WO2017009751A1
(en)
|
2015-07-15 |
2017-01-19 |
Pfizer Inc. |
Pyrimidine derivatives
|
MX2018001289A
(es)
|
2015-08-03 |
2018-04-30 |
Tolero Pharmaceuticals Inc |
Terapias de combinacion para el tratamiento del cancer.
|
AU2016347881A1
(en)
|
2015-11-02 |
2018-05-10 |
Novartis Ag |
Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
|
JP6877429B2
(ja)
|
2015-12-03 |
2021-05-26 |
アジオス ファーマシューティカルズ, インコーポレイテッド |
Mtapヌル癌を処置するためのmat2a阻害剤
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
US11279694B2
(en)
|
2016-11-18 |
2022-03-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Alvocidib prodrugs and their use as protein kinase inhibitors
|
US10132797B2
(en)
|
2016-12-19 |
2018-11-20 |
Tolero Pharmaceuticals, Inc. |
Profiling peptides and methods for sensitivity profiling
|
RS62456B1
(sr)
|
2016-12-22 |
2021-11-30 |
Amgen Inc |
Derivati benzizotiazola, izotiazolo[3,4-b]piridina, hinazolina, ftalazina, pirido[2,3-d]piridazina i pirido[2,3-d]pirimidina kao kras g12c inhibitori za tretman raka pluća, pankreasa ili debelog creva
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
SG11202001499WA
(en)
|
2017-09-08 |
2020-03-30 |
Amgen Inc |
Inhibitors of kras g12c and methods of using the same
|
WO2019055579A1
(en)
|
2017-09-12 |
2019-03-21 |
Tolero Pharmaceuticals, Inc. |
TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR
|
US20200237766A1
(en)
|
2017-10-13 |
2020-07-30 |
Tolero Pharmaceuticals, Inc. |
Pkm2 activators in combination with reactive oxygen species for treatment of cancer
|
EP3697425A1
(en)
|
2017-10-18 |
2020-08-26 |
Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus |
Methods and compounds for improved immune cell therapy
|
JP7021356B2
(ja)
|
2017-12-21 |
2022-02-16 |
ヘフェイ インスティテューツ オブ フィジカル サイエンス, チャイニーズ アカデミー オブ サイエンシーズ |
ピリミジン誘導体系キナーゼ阻害剤類
|
US11045484B2
(en)
|
2018-05-04 |
2021-06-29 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
EP3788038B1
(en)
|
2018-05-04 |
2023-10-11 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
US11096939B2
(en)
|
2018-06-01 |
2021-08-24 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
EP3802537A1
(en)
|
2018-06-11 |
2021-04-14 |
Amgen Inc. |
Kras g12c inhibitors for treating cancer
|
MX2020012261A
(es)
|
2018-06-12 |
2021-03-31 |
Amgen Inc |
Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer.
|
CA3103995A1
(en)
|
2018-07-26 |
2020-01-30 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
JP2020090482A
(ja)
|
2018-11-16 |
2020-06-11 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
CA3117222A1
(en)
|
2018-11-19 |
2020-05-28 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
CN109912490B
(zh)
*
|
2018-11-30 |
2020-10-16 |
深圳大学 |
一种吲哚类化合物Plancyindole E及其制备方法
|
MX2021006544A
(es)
|
2018-12-04 |
2021-07-07 |
Sumitomo Pharma Oncology Inc |
Inhibidores de cinasa dependiente de ciclina 9 (cdk9) y polimorfos de los mismos para uso como agentes para el tratamiento de cancer.
|
MA54547A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
|
MA54546A
(fr)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
|
PE20211475A1
(es)
|
2018-12-20 |
2021-08-05 |
Amgen Inc |
Inhibidores de kif18a
|
ES2953821T3
(es)
|
2018-12-20 |
2023-11-16 |
Amgen Inc |
Inhibidores de KIF18A
|
EP3924351A4
(en)
|
2019-02-12 |
2022-12-21 |
Sumitomo Pharma Oncology, Inc. |
FORMULATIONS COMPRISING HETEROCYCLIC PROTEIN KINASE INHIBITORS
|
US20230096028A1
(en)
|
2019-03-01 |
2023-03-30 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
JP2022522777A
(ja)
|
2019-03-01 |
2022-04-20 |
レボリューション メディシンズ インコーポレイテッド |
二環式ヘテロアリール化合物及びその使用
|
WO2020191326A1
(en)
|
2019-03-20 |
2020-09-24 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Treatment of acute myeloid leukemia (aml) with venetoclax failure
|
AU2020245437A1
(en)
|
2019-03-22 |
2021-09-30 |
Sumitomo Pharma Oncology, Inc. |
Compositions comprising PKM2 modulators and methods of treatment using the same
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
EP3972973A1
(en)
|
2019-05-21 |
2022-03-30 |
Amgen Inc. |
Solid state forms
|
WO2021026098A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
AU2020324963A1
(en)
|
2019-08-02 |
2022-02-24 |
Amgen Inc. |
KIF18A inhibitors
|
US20220372018A1
(en)
|
2019-08-02 |
2022-11-24 |
Amgen Inc. |
Kif18a inhibitors
|
RU2734495C1
(ru)
*
|
2019-09-13 |
2020-10-19 |
Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) |
Способ лечения сахарного диабета
|
WO2021081212A1
(en)
|
2019-10-24 |
2021-04-29 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
CA3159559A1
(en)
|
2019-11-04 |
2021-05-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
TW202132314A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
PE20230249A1
(es)
|
2019-11-08 |
2023-02-07 |
Revolution Medicines Inc |
Compuestos de heteroarilo biciclicos y usos de estos
|
WO2021097212A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
AR120456A1
(es)
|
2019-11-14 |
2022-02-16 |
Amgen Inc |
Síntesis mejorada del compuesto inhibidor de g12c de kras
|
US20220395553A1
(en)
|
2019-11-14 |
2022-12-15 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|
JP2023505100A
(ja)
|
2019-11-27 |
2023-02-08 |
レボリューション メディシンズ インコーポレイテッド |
共有ras阻害剤及びその使用
|
BR112022010086A2
(pt)
|
2020-01-07 |
2022-09-06 |
Revolution Medicines Inc |
Dosagem do inibidor de shp2 e métodos de tratamento de câncer
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|
CN115916194A
(zh)
|
2020-06-18 |
2023-04-04 |
锐新医药公司 |
用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
|
US11945809B2
(en)
|
2020-07-19 |
2024-04-02 |
King Saud University |
Isatin derivatives
|
AU2021344830A1
(en)
|
2020-09-03 |
2023-04-06 |
Revolution Medicines, Inc. |
Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
|
KR20230067635A
(ko)
|
2020-09-15 |
2023-05-16 |
레볼루션 메디슨즈, 인크. |
암의 치료에서 ras 억제제로서 인돌 유도체
|
CN117396472A
(zh)
|
2020-12-22 |
2024-01-12 |
上海齐鲁锐格医药研发有限公司 |
Sos1抑制剂及其用途
|
WO2022235870A1
(en)
|
2021-05-05 |
2022-11-10 |
Revolution Medicines, Inc. |
Ras inhibitors for the treatment of cancer
|
CN117500811A
(zh)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
共价ras抑制剂及其用途
|
CR20230570A
(es)
|
2021-05-05 |
2024-01-22 |
Revolution Medicines Inc |
Inhibidores de ras
|
IT202100023357A1
(it)
|
2021-09-09 |
2023-03-09 |
Cheirontech S R L |
Peptidi con attività anti-angiogenica
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
WO2023081923A1
(en)
|
2021-11-08 |
2023-05-11 |
Frequency Therapeutics, Inc. |
Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
|
TW202340214A
(zh)
|
2021-12-17 |
2023-10-16 |
美商健臻公司 |
做為shp2抑制劑之吡唑并吡𠯤化合物
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
US20230263771A1
(en)
*
|
2022-02-21 |
2023-08-24 |
University Of Houston System |
Small molecules that treat or prevent viral infections
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
WO2024081916A1
(en)
|
2022-10-14 |
2024-04-18 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|