DE29623744U1 - Indolinonverbindungen für die Behandlung von Krankheiten - Google Patents
Indolinonverbindungen für die Behandlung von KrankheitenInfo
- Publication number
- DE29623744U1 DE29623744U1 DE29623744U DE29623744U DE29623744U1 DE 29623744 U1 DE29623744 U1 DE 29623744U1 DE 29623744 U DE29623744 U DE 29623744U DE 29623744 U DE29623744 U DE 29623744U DE 29623744 U1 DE29623744 U1 DE 29623744U1
- Authority
- DE
- Germany
- Prior art keywords
- indolinone
- methylene
- nrr
- thiadiazole
- oxadiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- -1 4-alkylfuran Chemical compound 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims 4
- 125000005248 alkyl aryloxy group Chemical group 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004953 trihalomethyl group Chemical group 0.000 claims 4
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 3
- JZTKNVMVUVSGJF-UHFFFAOYSA-N 1,2,3,5-oxatriazole Chemical compound C=1N=NON=1 JZTKNVMVUVSGJF-UHFFFAOYSA-N 0.000 claims 2
- XLEDBLKSWOYHES-UHFFFAOYSA-N 1,2,3,5-thiatriazole Chemical compound C=1N=NSN=1 XLEDBLKSWOYHES-UHFFFAOYSA-N 0.000 claims 2
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical compound C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 claims 2
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical compound C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 2
- YGTAZGSLCXNBQL-UHFFFAOYSA-N 1,2,4-thiadiazole Chemical compound C=1N=CSN=1 YGTAZGSLCXNBQL-UHFFFAOYSA-N 0.000 claims 2
- UDGKZGLPXCRRAM-UHFFFAOYSA-N 1,2,5-thiadiazole Chemical compound C=1C=NSN=1 UDGKZGLPXCRRAM-UHFFFAOYSA-N 0.000 claims 2
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 claims 2
- MBIZXFATKUQOOA-UHFFFAOYSA-N 1,3,4-thiadiazole Chemical compound C1=NN=CS1 MBIZXFATKUQOOA-UHFFFAOYSA-N 0.000 claims 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 2
- KNSAWRXCIVESQC-UHFFFAOYSA-N 2-(1h-indol-7-yl)acetic acid Chemical compound OC(=O)CC1=CC=CC2=C1NC=C2 KNSAWRXCIVESQC-UHFFFAOYSA-N 0.000 claims 2
- YYOXBJRAUDWYMQ-UHFFFAOYSA-N 2-sulfonyl-3h-furan Chemical compound O=S(=O)=C1CC=CO1 YYOXBJRAUDWYMQ-UHFFFAOYSA-N 0.000 claims 2
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 125000004494 ethyl ester group Chemical group 0.000 claims 2
- JKFAIQOWCVVSKC-UHFFFAOYSA-N furazan Chemical compound C=1C=NON=1 JKFAIQOWCVVSKC-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 2
- CQDAMYNQINDRQC-UHFFFAOYSA-N oxatriazole Chemical compound C1=NN=NO1 CQDAMYNQINDRQC-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- YGNGABUJMXJPIJ-UHFFFAOYSA-N thiatriazole Chemical compound C1=NN=NS1 YGNGABUJMXJPIJ-UHFFFAOYSA-N 0.000 claims 2
- SEZFNTZQMWJIAI-UHFFFAOYSA-N 3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one Chemical compound O=C1NC2=CC=CC=C2C1=CC1=CC=CN1 SEZFNTZQMWJIAI-UHFFFAOYSA-N 0.000 claims 1
- FDJJGAYOTZAUHK-UHFFFAOYSA-N 3-(4-ethyl-3,5-dimethyl-1h-pyrrol-2-yl)-1,3-dihydroindol-2-one Chemical compound CCC1=C(C)NC(C2C3=CC=CC=C3NC2=O)=C1C FDJJGAYOTZAUHK-UHFFFAOYSA-N 0.000 claims 1
- QMTIIBUDOBNABZ-UHFFFAOYSA-N 3-(thiophen-2-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2C1=CC1=CC=CS1 QMTIIBUDOBNABZ-UHFFFAOYSA-N 0.000 claims 1
- GXWWJQTWHQKQEJ-UHFFFAOYSA-N 3-[(1-methyl-5-nitroimidazol-2-yl)methylidene]-1h-indol-2-one Chemical compound C1=C([N+]([O-])=O)N(C)C(C=C2C3=CC=CC=C3NC2=O)=N1 GXWWJQTWHQKQEJ-UHFFFAOYSA-N 0.000 claims 1
- RSEXIUPHAVGKPO-UHFFFAOYSA-N 3-[(3,4-dimethyl-1h-pyrrol-2-yl)methylidene]-1h-indol-2-one Chemical compound CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1C RSEXIUPHAVGKPO-UHFFFAOYSA-N 0.000 claims 1
- WUWDLXZGHZSWQZ-UHFFFAOYSA-N 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one Chemical compound N1C(C)=CC(C)=C1C=C1C2=CC=CC=C2NC1=O WUWDLXZGHZSWQZ-UHFFFAOYSA-N 0.000 claims 1
- MWBZWKJOGWKJIO-UHFFFAOYSA-N 3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-5-nitro-1h-indol-2-one Chemical compound N1C(C)=CC(C)=C1C=C1C2=CC([N+]([O-])=O)=CC=C2NC1=O MWBZWKJOGWKJIO-UHFFFAOYSA-N 0.000 claims 1
- HKJUJLRPOAIDLV-UHFFFAOYSA-N 3-[(3-ethyl-4,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1h-indol-2-one Chemical compound CC1=C(C)NC(C=C2C3=CC=CC=C3NC2=O)=C1CC HKJUJLRPOAIDLV-UHFFFAOYSA-N 0.000 claims 1
- WTSKCANGBVHQSV-UHFFFAOYSA-N 3-[(3-methyl-1h-pyrrol-2-yl)methylidene]-1h-indol-2-one Chemical compound C1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1C WTSKCANGBVHQSV-UHFFFAOYSA-N 0.000 claims 1
- PLONGIHGLJAKNF-UHFFFAOYSA-N 3-[(3-methylthiophen-2-yl)methylidene]-1h-indol-2-one Chemical compound C1=CSC(C=C2C3=CC=CC=C3NC2=O)=C1C PLONGIHGLJAKNF-UHFFFAOYSA-N 0.000 claims 1
- QLHDFRHEOWTWQG-UHFFFAOYSA-N 3-[(5-chloro-3,4-dimethyl-1h-pyrrol-2-yl)methylidene]-1h-indol-2-one Chemical compound N1C(Cl)=C(C)C(C)=C1C=C1C2=CC=CC=C2NC1=O QLHDFRHEOWTWQG-UHFFFAOYSA-N 0.000 claims 1
- PHWIHJQQBCVMOT-UHFFFAOYSA-N 3-[(5-methyl-1h-imidazol-2-yl)methylidene]-1h-indol-2-one Chemical compound N1C(C)=CN=C1C=C1C2=CC=CC=C2NC1=O PHWIHJQQBCVMOT-UHFFFAOYSA-N 0.000 claims 1
- SLWNLXPWBFOSDW-UHFFFAOYSA-N 3-[(5-methylthiophen-2-yl)methylidene]-1h-indol-2-one Chemical compound S1C(C)=CC=C1C=C1C2=CC=CC=C2NC1=O SLWNLXPWBFOSDW-UHFFFAOYSA-N 0.000 claims 1
- XZLCDAKBNFQCMU-UHFFFAOYSA-N 3-[4-methyl-5-[(2-oxo-1h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl]propanoic acid Chemical compound OC(=O)CCC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1C XZLCDAKBNFQCMU-UHFFFAOYSA-N 0.000 claims 1
- BKVUIEOPCYWYAT-UHFFFAOYSA-N 5-chloro-3-[(5-methylthiophen-2-yl)methylidene]-1h-indol-2-one Chemical compound S1C(C)=CC=C1C=C1C2=CC(Cl)=CC=C2NC1=O BKVUIEOPCYWYAT-UHFFFAOYSA-N 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- XLBQNZICMYZIQT-GHXNOFRVSA-N SU5614 Chemical compound N1C(C)=CC(C)=C1\C=C/1C2=CC(Cl)=CC=C2NC\1=O XLBQNZICMYZIQT-GHXNOFRVSA-N 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000012876 carrier material Substances 0.000 claims 1
- GJEFYBYFHDVNIW-UHFFFAOYSA-N ethyl 2,4-dimethyl-5-(2-oxo-1,3-dihydroindol-3-yl)-1h-pyrrole-3-carboxylate Chemical compound CCOC(=O)C1=C(C)NC(C2C3=CC=CC=C3NC2=O)=C1C GJEFYBYFHDVNIW-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- CNGIYKVXXNBDFW-UHFFFAOYSA-N methyl 3-[4-methyl-2-[(2-oxo-1h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl]propanoate Chemical compound CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1CCC(=O)OC CNGIYKVXXNBDFW-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
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Description
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Claims (6)
1. Eine Verbindung der Formel:
und pharmazeutisch annehmbare Salze davon, wobei:
R1 H ist;
R2 O oder S ist;
R3 Wasserstoff ist;
R4, R5, R6 und R7 jeweils unabhängig voneinander ausgewählt werden, aus der Gruppe, die aus Wasserstoff, Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, SO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, und CONRR' besteht;
A ein fünfgliedriger Heteroarylring ist, der ausgewählt wird aus der Gruppe, die aus Thiophen, Pyrrol, Pyrazol, Imidazol, 1,2,3-Triazol, 1,2,4-Triazol, Oxazol, Isoxazol, Thiazol, Isothiazol, 2-Sulfonylfuran, 4-Alkylfuran, 1,2,3- Oxadiazol, 1,2,4-Oxadiazol, 1,2,5-Oxadiazol, 1,3,4-Oxadiazol, 1,2,3,4-Oxatriazol, 1,2,3,5-Oxatriazol, 1,2,3-Thiadiazol, 1,2,4-Thiadiazol, 1,2,5-Thiadiazol, 1,3,4-Thiadiazol, 1,2,3,4- Thiatriazol, 1,2,3,5-Thiatriazol und Tetrazol, gegebenenfalls substituiert an einer oder mehreren Positionen mit Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, NO2NRR' SO3R, SR, NO2, NRR' OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R und CONRR' besteht;
n 0-3 ist;
R H, Alkyl oder Aryl ist und R' H, Alkyl oder Aryl ist, mit der Maßgabe, dass die folgenden Verbindungen ausgenommen sind:
3-(Pyrrol-2-ylmethylen)-2-indolinon;
3-(5-Chlor-3,4-dimethylpyrrol-2-ylmethylen)-2-indolinon;
3-(3,5-Dimethyl-4-ethylpyrrol-2-yl)-2-indolinon;
3-(3,5-Dimethyl-4-ethoxycarbonylpyrrol-2-yl)-2-indolinon;
Benzoesäure, 2-[[[1-Ethyl-2,3-dihydro-2-oxo-3-(1H-pyrrol-2- ylmethylen)-1H-indol-5-yl]oxy]methyl]-;
3-[(1-Methyl-5-nitro-imidazol-2-yl)methylen]-2-indolinon;
3-(Thien-2-ylmethylen)-2-indolinon;
1H-Indol-7-essigsäure, 3-[(2-butyl-1H-imidazol-4- yl)methylen]-2,3-dihydro-2-oxo-, Ethylester; und
1H-Indol-7-essigsäure, 3-[[2-butyl-1-[(1,1- dimethylethoxy)carbonyl]-1H-imidazol-4-yl]methylen]-2,3- dihydro-2-oxo-, Ethylester.
und pharmazeutisch annehmbare Salze davon, wobei:
R1 H ist;
R2 O oder S ist;
R3 Wasserstoff ist;
R4, R5, R6 und R7 jeweils unabhängig voneinander ausgewählt werden, aus der Gruppe, die aus Wasserstoff, Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, SO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, und CONRR' besteht;
A ein fünfgliedriger Heteroarylring ist, der ausgewählt wird aus der Gruppe, die aus Thiophen, Pyrrol, Pyrazol, Imidazol, 1,2,3-Triazol, 1,2,4-Triazol, Oxazol, Isoxazol, Thiazol, Isothiazol, 2-Sulfonylfuran, 4-Alkylfuran, 1,2,3- Oxadiazol, 1,2,4-Oxadiazol, 1,2,5-Oxadiazol, 1,3,4-Oxadiazol, 1,2,3,4-Oxatriazol, 1,2,3,5-Oxatriazol, 1,2,3-Thiadiazol, 1,2,4-Thiadiazol, 1,2,5-Thiadiazol, 1,3,4-Thiadiazol, 1,2,3,4- Thiatriazol, 1,2,3,5-Thiatriazol und Tetrazol, gegebenenfalls substituiert an einer oder mehreren Positionen mit Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, NO2NRR' SO3R, SR, NO2, NRR' OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R und CONRR' besteht;
n 0-3 ist;
R H, Alkyl oder Aryl ist und R' H, Alkyl oder Aryl ist, mit der Maßgabe, dass die folgenden Verbindungen ausgenommen sind:
3-(Pyrrol-2-ylmethylen)-2-indolinon;
3-(5-Chlor-3,4-dimethylpyrrol-2-ylmethylen)-2-indolinon;
3-(3,5-Dimethyl-4-ethylpyrrol-2-yl)-2-indolinon;
3-(3,5-Dimethyl-4-ethoxycarbonylpyrrol-2-yl)-2-indolinon;
Benzoesäure, 2-[[[1-Ethyl-2,3-dihydro-2-oxo-3-(1H-pyrrol-2- ylmethylen)-1H-indol-5-yl]oxy]methyl]-;
3-[(1-Methyl-5-nitro-imidazol-2-yl)methylen]-2-indolinon;
3-(Thien-2-ylmethylen)-2-indolinon;
1H-Indol-7-essigsäure, 3-[(2-butyl-1H-imidazol-4- yl)methylen]-2,3-dihydro-2-oxo-, Ethylester; und
1H-Indol-7-essigsäure, 3-[[2-butyl-1-[(1,1- dimethylethoxy)carbonyl]-1H-imidazol-4-yl]methylen]-2,3- dihydro-2-oxo-, Ethylester.
2. Eine Verbindung der Formel:
und pharmazeutisch annehmbare Salze davon, wobei:
R1 H ist;
R2 O oder S ist;
R3 Wasserstoff ist;
R4, R5, R6 und R7 jeweils unabhängig voneinander ausgewählt werden, aus der Gruppe, die aus Wasserstoff, Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, SO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, und CONRR' besteht;
A ein fünfgliedriger Heteroarylring ist, der ausgewählt wird aus der Gruppe, die aus Pyrazol, Zmidazol, 1,2,3-Triazol, 1,2,4-Triazol, Oxazol, Isoxazol, Thiazol, Isothiazol, 2- Sulfonylfuran, 4-Alkylfuran, 1,2,3-Oxadiazol, 1,2,4-Oxadiazol, 1,2,5-Oxadiazol, 1,3,4-Oxadiazol, 1,2,3,4-Oxatriazol, 1,2,3,5- Oxatriazol, 1,2,3-Thiadiazol, 1,2,4-Thiadiazol, 1,2,5- Thiadiazol, 1,3,4-Thiadiazol, 1,2,3,4-Thiatriazol, 1,2,3,5- Thiatriazol und Tetrazol, gegebenenfalls substituiert an einer oder mehreren Positionen mit Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, NO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R und CONRR' besteht;
n 0-3 ist;
R H, Alkyl oder Aryl ist und R H, Alkyl oder Aryl ist.
und pharmazeutisch annehmbare Salze davon, wobei:
R1 H ist;
R2 O oder S ist;
R3 Wasserstoff ist;
R4, R5, R6 und R7 jeweils unabhängig voneinander ausgewählt werden, aus der Gruppe, die aus Wasserstoff, Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, SO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R, und CONRR' besteht;
A ein fünfgliedriger Heteroarylring ist, der ausgewählt wird aus der Gruppe, die aus Pyrazol, Zmidazol, 1,2,3-Triazol, 1,2,4-Triazol, Oxazol, Isoxazol, Thiazol, Isothiazol, 2- Sulfonylfuran, 4-Alkylfuran, 1,2,3-Oxadiazol, 1,2,4-Oxadiazol, 1,2,5-Oxadiazol, 1,3,4-Oxadiazol, 1,2,3,4-Oxatriazol, 1,2,3,5- Oxatriazol, 1,2,3-Thiadiazol, 1,2,4-Thiadiazol, 1,2,5- Thiadiazol, 1,3,4-Thiadiazol, 1,2,3,4-Thiatriazol, 1,2,3,5- Thiatriazol und Tetrazol, gegebenenfalls substituiert an einer oder mehreren Positionen mit Alkyl, Alkoxy, Aryl, Aryloxy, Alkaryl, Alkaryloxy, Halogen, Trihalomethyl, S(O)R, NO2NRR', SO3R, SR, NO2, NRR', OH, CN, C(O)R, OC(O)R, NHC(O)R, (CH2)nCO2R und CONRR' besteht;
n 0-3 ist;
R H, Alkyl oder Aryl ist und R H, Alkyl oder Aryl ist.
3. Eine Verbindung nach Anspruch 1 oder 2, ausgewählt aus der
Gruppe, die besteht aus 3-[(3-Methylpyrrol-2-yl)methylen]-2-
indolinon; 3-[(3,4-Dimethylpyrrol-2-yl)methylen]-2-indolinon;
3-[(2-Methylthien-5-yl)methylen]-2-indolinon; 3-[(3-
Methylthien-2-yl)methylen]-2-indolinon; 3-{[4-(2-
methoxycarbonylethyl)-3-methylpyrrol-5-yl]methylen}-2-
indolinon; 3-[(4,5-Dimethyl-3-ethylpyrrol-2-yl)methylen]-2-
indolinon; 3-[(5-Methylimidazol-2-yl)methylen]-2-indolinon; 5-
Chlor-3-[(5-methylthien-2-yl)methylen]-2-indolinon; 3-[(3,5-
Dimethylpyrrol-2-yl)methylen]-5-nitro-2-indolinon; 3-[(3-(2-
Carboxyethyl)-4-methylpyrrol-5-yl)methylen]-2-indolinon; 5-
Chlor-3-[(3,5-dimethylpyrrol-2-yl)methylen]-2-indolinon; und
3-[(2; 4-Dimethylpyrrol-5-yl)methylen]-2-indolinon, oder einem
pharmazeutisch annehmbaren Salz davon.
4. 3-[(2,4-Dimethylpyrrol-5-yl)methylen]-2-indolinon, oder ein
pharmazeutisch annehmbares Salz davon.
5. Eine pharmazeutische Zusammensetzung, die eine Verbindung
nach einem der Ansprüche 1 bis 4, oder eine pharmazeutisch
annehmbares Salz davon und einen pharmazeutisch annehmbares
Trägermaterial umfaßt.
6. Pharmazeutische Zusammensetzung nach Anspruch 5, zur
parenteralen oder subkutanen Anwendung oder in Form einer
Depotformulierung.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/485,323 US5880141A (en) | 1995-06-07 | 1995-06-07 | Benzylidene-Z-indoline compounds for the treatment of disease |
EP96918093A EP0769947B1 (de) | 1995-06-07 | 1996-06-05 | Indolinonverbindungen zur behandlung von krankheiten |
Publications (1)
Publication Number | Publication Date |
---|---|
DE29623744U1 true DE29623744U1 (de) | 1999-09-30 |
Family
ID=23927713
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69612649T Expired - Lifetime DE69612649T2 (de) | 1995-06-07 | 1996-06-05 | Indolinonverbindungen zur behandlung von krankheiten |
DE29623744U Expired - Lifetime DE29623744U1 (de) | 1995-06-07 | 1996-06-05 | Indolinonverbindungen für die Behandlung von Krankheiten |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69612649T Expired - Lifetime DE69612649T2 (de) | 1995-06-07 | 1996-06-05 | Indolinonverbindungen zur behandlung von krankheiten |
Country Status (20)
Country | Link |
---|---|
US (9) | US5880141A (de) |
EP (2) | EP0769947B1 (de) |
JP (2) | JP3231044B2 (de) |
CN (1) | CN1268333C (de) |
AR (2) | AR003088A1 (de) |
AT (1) | ATE200863T1 (de) |
AU (1) | AU706597C (de) |
BR (1) | BR9606410A (de) |
CA (1) | CA2192797C (de) |
DE (2) | DE69612649T2 (de) |
DK (1) | DK0769947T3 (de) |
ES (1) | ES2159741T3 (de) |
GR (1) | GR3036315T3 (de) |
HK (2) | HK1001121A1 (de) |
HU (1) | HU226755B1 (de) |
MX (1) | MX9606401A (de) |
NO (1) | NO311355B1 (de) |
NZ (1) | NZ310109A (de) |
PT (1) | PT769947E (de) |
WO (1) | WO1996040116A1 (de) |
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1995
- 1995-06-07 US US08/485,323 patent/US5880141A/en not_active Expired - Lifetime
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- 1996-06-05 EP EP99103667A patent/EP0934931A3/de not_active Withdrawn
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6525072B1 (en) | 1998-08-31 | 2003-02-25 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
US6642251B1 (en) | 1998-08-31 | 2003-11-04 | Sugen, Inc. | Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity |
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