DK1115704T3 - Substituerede indolinoner med inhiberende virkning for forskellige kinaser og cyclin/CDK komplekser - Google Patents
Substituerede indolinoner med inhiberende virkning for forskellige kinaser og cyclin/CDK komplekserInfo
- Publication number
- DK1115704T3 DK1115704T3 DK99947404T DK99947404T DK1115704T3 DK 1115704 T3 DK1115704 T3 DK 1115704T3 DK 99947404 T DK99947404 T DK 99947404T DK 99947404 T DK99947404 T DK 99947404T DK 1115704 T3 DK1115704 T3 DK 1115704T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclin
- inhibitory effect
- various kinases
- substituted indolinones
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/007040 WO2000018734A1 (de) | 1998-09-25 | 1999-09-22 | Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1115704T3 true DK1115704T3 (da) | 2003-09-29 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99947404T DK1115704T3 (da) | 1998-09-25 | 1999-09-22 | Substituerede indolinoner med inhiberende virkning for forskellige kinaser og cyclin/CDK komplekser |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (da) |
| EP (1) | EP1115704B1 (da) |
| JP (1) | JP2002525356A (da) |
| KR (1) | KR20010085841A (da) |
| CN (1) | CN1319090A (da) |
| AT (1) | ATE243195T1 (da) |
| AU (1) | AU763361B2 (da) |
| BG (1) | BG105327A (da) |
| BR (1) | BR9914065A (da) |
| CA (1) | CA2342622A1 (da) |
| DE (1) | DE59906030D1 (da) |
| DK (1) | DK1115704T3 (da) |
| EA (1) | EA200100320A1 (da) |
| EE (1) | EE200100184A (da) |
| ES (1) | ES2196860T3 (da) |
| HR (1) | HRP20010216A2 (da) |
| HU (1) | HUP0104973A3 (da) |
| ID (1) | ID27757A (da) |
| IL (1) | IL141622A0 (da) |
| NO (1) | NO20011477L (da) |
| NZ (1) | NZ510845A (da) |
| PL (1) | PL346898A1 (da) |
| PT (1) | PT1115704E (da) |
| SI (1) | SI1115704T1 (da) |
| SK (1) | SK4032001A3 (da) |
| TR (1) | TR200100854T2 (da) |
| WO (1) | WO2000018734A1 (da) |
| YU (1) | YU21301A (da) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| EP1430048A1 (en) * | 2001-09-27 | 2004-06-23 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| AU2003218342B8 (en) | 2002-03-26 | 2008-07-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| EP1539141B1 (en) * | 2002-08-29 | 2010-07-14 | Boehringer Ingelheim Pharmaceuticals Inc. | 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| WO2005033330A2 (en) * | 2003-10-03 | 2005-04-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Fluorescent probes for use in protein kinase inhibitor binding assay |
| RU2376286C2 (ru) | 2004-03-11 | 2009-12-20 | Актелион Фармасьютиклз Лтд | Производные индол-1-илуксусной кислоты |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1836166B1 (en) | 2004-12-27 | 2009-06-17 | Boehringer Ingelheim Pharmaceuticals Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EA013239B1 (ru) * | 2005-04-28 | 2010-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения для лечения воспалительных заболеваний |
| EP2102170A2 (en) | 2006-12-06 | 2009-09-23 | Boehringer Ingelheim International GmbH | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US20100086544A1 (en) * | 2006-12-11 | 2010-04-08 | Mass Robert D | Compositions and methods for treating a neoplasm |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| TR201802086T4 (tr) * | 2007-12-03 | 2018-03-21 | Boehringer Ingelheim Int | Bir indolinon türevinin imalatı için proses. |
| PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
| BRPI0908509A2 (pt) * | 2008-01-25 | 2015-08-18 | Boehringer Ingelheim Int | Formas de sal de um derivado de 6-flúor-1, 2-di-hidro-2-oxo-3h-indol-3-ilideno, processo para a produção das mesmas e composições farmacêuticas contendo as mesmas |
| SI2300472T1 (sl) | 2008-06-06 | 2012-05-31 | Boehringer Ingelheim Int | Glukokortikoidni mimetiki postopki za njihovo pripravo farmacevtski sestavki in njihove uporabe |
| PE20110213A1 (es) | 2008-07-29 | 2011-04-16 | Boehringer Ingelheim Int | Derivados de indolinona como inhibidores de quinasa |
| WO2013137371A1 (ja) * | 2012-03-15 | 2013-09-19 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| EP3749697A4 (en) | 2018-02-05 | 2021-11-03 | Bio-Rad Laboratories, Inc. | CHROMATOGRAPHIC RESIN WITH A LIGAND WITH ANION EXCHANGE-HYDROPHOBIC MIXED MODE |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Application Discontinuation
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Application Discontinuation
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx active Pending
- 2001-03-21 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011477A patent/NO20011477L/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20010216A2 (en) | 2002-04-30 |
| DE59906030D1 (de) | 2003-07-24 |
| NO20011477D0 (no) | 2001-03-22 |
| HUP0104973A2 (hu) | 2002-04-29 |
| JP2002525356A (ja) | 2002-08-13 |
| TR200100854T2 (tr) | 2001-12-21 |
| ID27757A (id) | 2001-04-26 |
| US6855710B2 (en) | 2005-02-15 |
| EP1115704A1 (de) | 2001-07-18 |
| EE200100184A (et) | 2002-08-15 |
| BR9914065A (pt) | 2001-06-19 |
| EP1115704B1 (de) | 2003-06-18 |
| AU6086399A (en) | 2000-04-17 |
| ES2196860T3 (es) | 2003-12-16 |
| IL141622A0 (en) | 2002-03-10 |
| ATE243195T1 (de) | 2003-07-15 |
| BG105327A (en) | 2001-12-29 |
| CA2342622A1 (en) | 2000-04-06 |
| AU763361B2 (en) | 2003-07-17 |
| PT1115704E (pt) | 2003-11-28 |
| US20040058978A1 (en) | 2004-03-25 |
| YU21301A (sh) | 2003-04-30 |
| HUP0104973A3 (en) | 2002-06-28 |
| KR20010085841A (ko) | 2001-09-07 |
| EA200100320A1 (ru) | 2001-10-22 |
| NZ510845A (en) | 2003-10-31 |
| WO2000018734A1 (de) | 2000-04-06 |
| SI1115704T1 (en) | 2003-12-31 |
| CN1319090A (zh) | 2001-10-24 |
| SK4032001A3 (en) | 2001-11-06 |
| PL346898A1 (en) | 2002-03-11 |
| NO20011477L (no) | 2001-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1115704T3 (da) | Substituerede indolinoner med inhiberende virkning for forskellige kinaser og cyclin/CDK komplekser | |
| MY127956A (en) | Substituted indolines which inhibit receptor tyrosine kinases | |
| MY122357A (en) | Indolinones having kinase inhibitory activity | |
| BG104938A (en) | Substituted indolinones, the production thereof and their use as medicaments | |
| DK1109785T3 (da) | Indolderivater og deres anvendelse til behandling af ondartede og andre sygdomme forårsaget af patologisk celleproliferation | |
| NO994016L (no) | Heterocykliske forbindelser og deres anvendelse for inhibering av <beta>amyloidpeptid | |
| MXPA05007115A (es) | Nuevos agonistas inversos del receptor cb 1. | |
| MXPA02010627A (es) | Derivados de 2-acil-indol y su uso como farmaco antitumoral. | |
| DK0865498T3 (da) | Fremgangsmåde til fremstilling af substituerede arylmælkesyreholdige cyclodepsipeptider med 24 ringatomer | |
| DK0900214T3 (da) | Fremgangsmåde til fremstilling af pyrmidin-derivater | |
| RS20050047A (en) | Indoline derivatives substituted in position 6,production and use thereof as medicaments | |
| UA97837C2 (ru) | Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6 | |
| DE60112091D1 (de) | Verfahren zur herstellung von azacycloalkanoylaminothiazolen | |
| BR0214488A (pt) | Derivados de benzotiazol | |
| AU2003273675A1 (en) | Protein tyrosine kinase inhibitors | |
| HUP0000854A2 (hu) | 4-[6-Fluor-(1H)-indol-3-il]-1,2,3,6-tetrahidropiridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás mindezek előállítására | |
| YU3701A (sh) | Supstituisani fenilamidini sa antitrombskim dejstvom | |
| UY26308A1 (es) | Nuevas indolinonas sustituidas, su preparación y su empleo como medicamentos | |
| DK0737187T3 (da) | Benzoxazinderivater, fremgangsmåder til fremstilling deraf og deres anvendelse som lægemidler | |
| DK1192191T3 (da) | Fremgangsmåde til fremstilling af kondensationsforbindelser | |
| DK0998461T3 (da) | Fremgangsmåde til fremstilling af imidazoloner | |
| TH57154B (th) | ซับสทิทิวเทด อินโดลิโนน ชนิดใหม่, การเตรียมสารเหล่านี้และการใช้สารเหล่านี้เป็นสารผสมทางเภสัช | |
| TH59387B (th) | อนุพันธ์ n-ไตรอะโซลอิลเมทธิล-พิเพอราซิน เป็น นิวโรไคนิน-รีเซปเตอร์แอนทาโกนิสท์ |