BG104938A - Substituted indolinones, the production thereof and their use as medicaments - Google Patents

Substituted indolinones, the production thereof and their use as medicaments

Info

Publication number
BG104938A
BG104938A BG104938A BG10493800A BG104938A BG 104938 A BG104938 A BG 104938A BG 104938 A BG104938 A BG 104938A BG 10493800 A BG10493800 A BG 10493800A BG 104938 A BG104938 A BG 104938A
Authority
BG
Bulgaria
Prior art keywords
production
medicaments
substituted indolinones
relates
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BG104938A
Other languages
Bulgarian (bg)
Inventor
Armin Heckel
Rainer Walter
Wolfgang Grell
Meel Jacobus Van
Norbert Redemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BG104938A publication Critical patent/BG104938A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to substituted indolinones of general formula in which R1 to R5 and X are defined in the description, to the isomers thereof, and to their salts, especially to the physiologically compatible salts thereof, which exhibit valuable pharmacological characteristics, especially an inhibiting effect on different kinases and cyclin/CDK complexes, and on the proliferation of different tumor cells. The invention also relates to medicaments containing these compounds, to their use, and to a method for the production thereof. 13 claims
BG104938A 1998-06-04 2000-11-13 Substituted indolinones, the production thereof and their use as medicaments Pending BG104938A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19824922A DE19824922A1 (en) 1998-06-04 1998-06-04 Novel substituted indolinones, their preparation and their use as pharmaceuticals
PCT/EP1999/003692 WO1999062882A1 (en) 1998-06-04 1999-05-28 Substituted indolinones, the production thereof and their use as medicaments

Publications (1)

Publication Number Publication Date
BG104938A true BG104938A (en) 2001-06-29

Family

ID=7869856

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104938A Pending BG104938A (en) 1998-06-04 2000-11-13 Substituted indolinones, the production thereof and their use as medicaments

Country Status (23)

Country Link
EP (1) EP1100779A1 (en)
JP (1) JP2002516906A (en)
KR (1) KR20010043973A (en)
CN (1) CN1303374A (en)
AU (1) AU764782B2 (en)
BG (1) BG104938A (en)
BR (1) BR9910898A (en)
CA (1) CA2328291A1 (en)
CO (1) CO5050294A1 (en)
DE (1) DE19824922A1 (en)
EA (1) EA003514B1 (en)
EE (1) EE200000723A (en)
HR (1) HRP20000831A2 (en)
HU (1) HUP0102210A3 (en)
ID (1) ID27035A (en)
IL (1) IL138702A0 (en)
NO (1) NO20006138L (en)
PL (1) PL344467A1 (en)
SK (1) SK18222000A3 (en)
TR (1) TR200003515T2 (en)
WO (1) WO1999062882A1 (en)
YU (1) YU73900A (en)
ZA (1) ZA200005435B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816624A1 (en) * 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Novel substituted indolinones, their preparation and their use as pharmaceuticals
US6624171B1 (en) 1999-03-04 2003-09-23 Smithkline Beecham Corporation Substituted aza-oxindole derivatives
GB9904933D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
US6762180B1 (en) 1999-10-13 2004-07-13 Boehringer Ingelheim Pharma Kg Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (en) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Substituted in position 6 indolinones, producing and use thereof as medicament
AU2001288374A1 (en) * 2000-09-01 2002-03-22 Glaxo Group Limited Substituted oxindole derivatives as tyrosine kinase inhibitors
WO2002020513A1 (en) * 2000-09-01 2002-03-14 Glaxo Group Limited Oxindole derivatives
DE10117204A1 (en) * 2001-04-06 2002-10-10 Boehringer Ingelheim Pharma Indolinones substituted in the 6-position, their preparation and their use as medicaments
EP1401415B1 (en) 2001-06-29 2006-06-21 AB Science Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases
WO2003002109A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitors for treating autoimmune diseases
PT1401416E (en) * 2001-06-29 2007-02-28 Ab Science Use of c-kit inhibitors for treating inflammatory bowel diseases (ibd)
DE60216281T2 (en) 2001-06-29 2007-07-05 Ab Science THE USE OF TYROSINE KINASE INHIBITOR FOR THE TREATMENT OF ALLERGIC DISEASES
JP2005500041A (en) 2001-06-29 2005-01-06 アブ サイエンス Potent, selective and non-toxic C-KIT inhibitor
US20030225152A1 (en) * 2001-09-27 2003-12-04 Andrews Steven W. 3-(Arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
JP4879492B2 (en) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド Kinase inhibitors for the treatment of diseases
DE102004012070A1 (en) * 2004-03-12 2005-09-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments
PE20060777A1 (en) * 2004-12-24 2006-10-06 Boehringer Ingelheim Int INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES
JP5404414B2 (en) * 2006-12-05 2014-01-29 アリーナ ファーマシューティカルズ， インコーポレイテッド Method for preparing (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its intermediates
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CN101735071A (en) * 2009-12-04 2010-06-16 大连凯飞精细化工有限公司 Method for producing 4-N,N-dimethylamino methylaniline
CN103102352B (en) * 2011-11-15 2015-08-12 山东亨利医药科技有限责任公司 Tyrosine kinase inhibitor indolinone derivative
CN103130775B (en) * 2011-11-22 2015-09-30 山东亨利医药科技有限责任公司 As the dihydroindole ketone derivate of tyrosine kinase inhibitor
GB201208775D0 (en) * 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
CN103848814B (en) * 2012-12-06 2016-08-17 山东亨利医药科技有限责任公司 The full ketone derivatives of substituted indole as tyrosine kinase inhibitor
WO2024050297A1 (en) * 2022-09-02 2024-03-07 Deciphera Pharmaceuticals, Llc Ulk inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE838623A (en) * 1976-02-16 1976-06-16 3-HYDROXYMETHYLENE-2-INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
US4145422A (en) * 1977-09-06 1979-03-20 Abbott Laboratories Aminomethylene oxindoles
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
EP1247803A3 (en) * 1996-08-23 2002-10-16 Sugen, Inc. Indolinone compounds suitable for modulation of protein kinases
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives

Also Published As

Publication number Publication date
EA003514B1 (en) 2003-06-26
KR20010043973A (en) 2001-05-25
NO20006138L (en) 2001-02-01
PL344467A1 (en) 2001-11-05
IL138702A0 (en) 2001-10-31
TR200003515T2 (en) 2001-06-21
HUP0102210A3 (en) 2002-12-28
BR9910898A (en) 2001-02-13
EE200000723A (en) 2002-04-15
WO1999062882A1 (en) 1999-12-09
DE19824922A1 (en) 1999-12-09
HRP20000831A2 (en) 2001-12-31
AU764782B2 (en) 2003-08-28
JP2002516906A (en) 2002-06-11
CA2328291A1 (en) 1999-12-09
CN1303374A (en) 2001-07-11
AU4370799A (en) 1999-12-20
YU73900A (en) 2003-04-30
EP1100779A1 (en) 2001-05-23
CO5050294A1 (en) 2001-06-27
EA200100001A1 (en) 2001-08-27
ZA200005435B (en) 2002-01-07
HUP0102210A2 (en) 2001-11-28
ID27035A (en) 2001-02-22
NO20006138D0 (en) 2000-12-01
SK18222000A3 (en) 2001-08-06

Similar Documents

Publication Publication Date Title
BG104938A (en) Substituted indolinones, the production thereof and their use as medicaments
BG104813A (en) Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes
YU26602A (en) Indolinon substituted at position 6, its production process and use as medicament
PL346898A1 (en) Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes
WO1999057117A3 (en) Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation
BG105177A (en) Novel substituted pyrazole derivatives
BG105650A (en) Azepinoindole derivatives, the production and use thereof
AU3804500A (en) 2-amino-6-anilino-purines and their use as medicaments
PL350246A1 (en) Triazole compounds with dopamine-d3-receptor affinity
BG106444A (en) Benzodiazepin derivatives, the production and use thereof
WO2004026829A3 (en) Heterocyclically substituted indolinones and their use as receptor tyrosine kinase inhibitors
CA2396865A1 (en) Farnesyl protein transferase inhibitors for treating breast cancer
ZA975439B (en) New pyridyl alkane acid amides.
WO2001027080A3 (en) 5-substituted indolinones and use thereof as kinase and cyclin/cdk complex inhibitors
HU9201789D0 (en) Process for the production of substituted diamino-phtalimides and their analogues
PL336640A1 (en) Substituted 3,3-diamino-2- propenonitriles, their production and application
RS20050047A (en) Indoline derivatives substituted in position 6,production and use thereof as medicaments
BG106002A (en) Process for preparing pesticidal intermediates
ES2111492A1 (en) 1-[2-(substituted vinyl)]-3,4-dihydro-4-dihydro-5+E,uns H+EE -2,3-benzodiazepine derivatives
GR3001035T3 (en) Heterocyclic tetrahydro-3,4-diamine-n-n'-platinum complexes
EP1132383A4 (en) Novel agarofuan derivatives, their preparation, pharmaceutical composition containing them and their use as medicine
ZA986336B (en) Medicaments comprising polyhydroxybutylpyrazines novel polyhydroxybutylpyrazines and their preparation
AU2910800A (en) Novel substituted 3-phenoxy and 3-phenylalkyloxy-2-phenyl-propylamines
UY26308A1 (en) NEW SUBSTITUTED INDOLINONES, THEIR PREPARATION AND THEIR USE AS MEDICINES
IL140863A0 (en) Novel 2,3,3a,4,9,9a hexahydro-8-hydroxy-1h-benz [f] indoles, a method for the production thereof and their use as medicaments