NO20006138D0 - Substituted indolinones, preparation and use thereof as drugs - Google Patents
Substituted indolinones, preparation and use thereof as drugsInfo
- Publication number
- NO20006138D0 NO20006138D0 NO20006138A NO20006138A NO20006138D0 NO 20006138 D0 NO20006138 D0 NO 20006138D0 NO 20006138 A NO20006138 A NO 20006138A NO 20006138 A NO20006138 A NO 20006138A NO 20006138 D0 NO20006138 D0 NO 20006138D0
- Authority
- NO
- Norway
- Prior art keywords
- drugs
- preparation
- substituted indolinones
- indolinones
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19824922A DE19824922A1 (en) | 1998-06-04 | 1998-06-04 | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
PCT/EP1999/003692 WO1999062882A1 (en) | 1998-06-04 | 1999-05-28 | Substituted indolinones, the production thereof and their use as medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20006138D0 true NO20006138D0 (en) | 2000-12-01 |
NO20006138L NO20006138L (en) | 2001-02-01 |
Family
ID=7869856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20006138A NO20006138L (en) | 1998-06-04 | 2000-12-01 | Substituted indolinones, preparation and use thereof as medicaments |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP1100779A1 (en) |
JP (1) | JP2002516906A (en) |
KR (1) | KR20010043973A (en) |
CN (1) | CN1303374A (en) |
AU (1) | AU764782B2 (en) |
BG (1) | BG104938A (en) |
BR (1) | BR9910898A (en) |
CA (1) | CA2328291A1 (en) |
CO (1) | CO5050294A1 (en) |
DE (1) | DE19824922A1 (en) |
EA (1) | EA003514B1 (en) |
EE (1) | EE200000723A (en) |
HR (1) | HRP20000831A2 (en) |
HU (1) | HUP0102210A3 (en) |
ID (1) | ID27035A (en) |
IL (1) | IL138702A0 (en) |
NO (1) | NO20006138L (en) |
PL (1) | PL344467A1 (en) |
SK (1) | SK18222000A3 (en) |
TR (1) | TR200003515T2 (en) |
WO (1) | WO1999062882A1 (en) |
YU (1) | YU73900A (en) |
ZA (1) | ZA200005435B (en) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19816624A1 (en) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Novel substituted indolinones, their preparation and their use as pharmaceuticals |
GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
US6624171B1 (en) | 1999-03-04 | 2003-09-23 | Smithkline Beecham Corporation | Substituted aza-oxindole derivatives |
UA75054C2 (en) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Substituted in position 6 indolinones, producing and use thereof as medicament |
US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
WO2002020513A1 (en) * | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Oxindole derivatives |
WO2002020479A1 (en) | 2000-09-01 | 2002-03-14 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
DE10117204A1 (en) | 2001-04-06 | 2002-10-10 | Boehringer Ingelheim Pharma | Indolinones substituted in the 6-position, their preparation and their use as medicaments |
JP2004537542A (en) | 2001-06-29 | 2004-12-16 | アブ サイエンス | Use of a tyrosine kinase inhibitor for treating inflammatory bowel disease (IBD) |
EP1401413B1 (en) | 2001-06-29 | 2006-11-22 | AB Science | Use of tyrosine kinase inhibitions for treating allergic diseases |
DE60212627T2 (en) * | 2001-06-29 | 2007-06-14 | Ab Science | Use of tyrosine kinase inhibitors for the treatment of inflammatory diseases |
DE60227709D1 (en) * | 2001-06-29 | 2008-08-28 | Ab Science | THE USE OF C-CRITERIA FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
JP2005500041A (en) | 2001-06-29 | 2005-01-06 | アブ サイエンス | Potent, selective and non-toxic C-KIT inhibitor |
WO2003027102A1 (en) | 2001-09-27 | 2003-04-03 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
JP4879492B2 (en) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | Kinase inhibitors for the treatment of diseases |
DE102004012070A1 (en) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New cycloalkyl-containing 5-acylindolinones, their preparation and their use as medicaments |
PE20060777A1 (en) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES |
EP2099743B1 (en) * | 2006-12-05 | 2014-08-27 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
GB0706072D0 (en) * | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
CN101735071A (en) * | 2009-12-04 | 2010-06-16 | 大连凯飞精细化工有限公司 | Method for producing 4-N,N-dimethylamino methylaniline |
CN103102352B (en) * | 2011-11-15 | 2015-08-12 | 山东亨利医药科技有限责任公司 | Tyrosine kinase inhibitor indolinone derivative |
CN103130775B (en) * | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | As the dihydroindole ketone derivate of tyrosine kinase inhibitor |
GB201208775D0 (en) * | 2012-05-18 | 2012-07-04 | Uni I Oslo | Chemical compounds |
CN103848814B (en) * | 2012-12-06 | 2016-08-17 | 山东亨利医药科技有限责任公司 | The full ketone derivatives of substituted indole as tyrosine kinase inhibitor |
WO2024050297A1 (en) * | 2022-09-02 | 2024-03-07 | Deciphera Pharmaceuticals, Llc | Ulk inhibitors and methods of use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE838623A (en) * | 1976-02-16 | 1976-06-16 | 3-HYDROXYMETHYLENE-2-INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | |
US4145422A (en) * | 1977-09-06 | 1979-03-20 | Abbott Laboratories | Aminomethylene oxindoles |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
EP1247803A3 (en) * | 1996-08-23 | 2002-10-16 | Sugen, Inc. | Indolinone compounds suitable for modulation of protein kinases |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
-
1998
- 1998-06-04 DE DE19824922A patent/DE19824922A1/en not_active Withdrawn
-
1999
- 1999-05-28 AU AU43707/99A patent/AU764782B2/en not_active Ceased
- 1999-05-28 PL PL99344467A patent/PL344467A1/en unknown
- 1999-05-28 SK SK1822-2000A patent/SK18222000A3/en unknown
- 1999-05-28 BR BR9910898-4A patent/BR9910898A/en not_active IP Right Cessation
- 1999-05-28 TR TR2000/03515T patent/TR200003515T2/en unknown
- 1999-05-28 WO PCT/EP1999/003692 patent/WO1999062882A1/en not_active Application Discontinuation
- 1999-05-28 IL IL13870299A patent/IL138702A0/en unknown
- 1999-05-28 ID IDW20002523A patent/ID27035A/en unknown
- 1999-05-28 YU YU73900A patent/YU73900A/en unknown
- 1999-05-28 HU HU0102210A patent/HUP0102210A3/en unknown
- 1999-05-28 CA CA002328291A patent/CA2328291A1/en not_active Abandoned
- 1999-05-28 EA EA200100001A patent/EA003514B1/en not_active IP Right Cessation
- 1999-05-28 KR KR1020007013597A patent/KR20010043973A/en not_active Application Discontinuation
- 1999-05-28 EE EEP200000723A patent/EE200000723A/en unknown
- 1999-05-28 CN CN99806884A patent/CN1303374A/en active Pending
- 1999-05-28 EP EP99926454A patent/EP1100779A1/en not_active Withdrawn
- 1999-05-28 JP JP2000552094A patent/JP2002516906A/en active Pending
- 1999-06-04 CO CO99035396A patent/CO5050294A1/en unknown
-
2000
- 2000-10-05 ZA ZA200005435A patent/ZA200005435B/en unknown
- 2000-11-13 BG BG104938A patent/BG104938A/en active Pending
- 2000-12-01 NO NO20006138A patent/NO20006138L/en not_active Application Discontinuation
- 2000-12-01 HR HR20000831A patent/HRP20000831A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1303374A (en) | 2001-07-11 |
EP1100779A1 (en) | 2001-05-23 |
TR200003515T2 (en) | 2001-06-21 |
WO1999062882A1 (en) | 1999-12-09 |
EA003514B1 (en) | 2003-06-26 |
PL344467A1 (en) | 2001-11-05 |
JP2002516906A (en) | 2002-06-11 |
HUP0102210A2 (en) | 2001-11-28 |
AU764782B2 (en) | 2003-08-28 |
BR9910898A (en) | 2001-02-13 |
EE200000723A (en) | 2002-04-15 |
NO20006138L (en) | 2001-02-01 |
CA2328291A1 (en) | 1999-12-09 |
ZA200005435B (en) | 2002-01-07 |
AU4370799A (en) | 1999-12-20 |
CO5050294A1 (en) | 2001-06-27 |
BG104938A (en) | 2001-06-29 |
EA200100001A1 (en) | 2001-08-27 |
SK18222000A3 (en) | 2001-08-06 |
KR20010043973A (en) | 2001-05-25 |
IL138702A0 (en) | 2001-10-31 |
ID27035A (en) | 2001-02-22 |
DE19824922A1 (en) | 1999-12-09 |
HRP20000831A2 (en) | 2001-12-31 |
YU73900A (en) | 2003-04-30 |
HUP0102210A3 (en) | 2002-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |