NO20011477D0 - Nye substituerte indolinoner med inhiberende virkning pÕ forskjellige kinaser og cyclin/CDK-komplekser - Google Patents
Nye substituerte indolinoner med inhiberende virkning pÕ forskjellige kinaser og cyclin/CDK-komplekserInfo
- Publication number
- NO20011477D0 NO20011477D0 NO20011477A NO20011477A NO20011477D0 NO 20011477 D0 NO20011477 D0 NO 20011477D0 NO 20011477 A NO20011477 A NO 20011477A NO 20011477 A NO20011477 A NO 20011477A NO 20011477 D0 NO20011477 D0 NO 20011477D0
- Authority
- NO
- Norway
- Prior art keywords
- cyclin
- inhibitory effect
- various kinases
- novel substituted
- substituted indolinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP1999/007040 WO2000018734A1 (de) | 1998-09-25 | 1999-09-22 | Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20011477L NO20011477L (no) | 2001-03-22 |
| NO20011477D0 true NO20011477D0 (no) | 2001-03-22 |
Family
ID=26049076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20011477A NO20011477D0 (no) | 1998-09-25 | 2001-03-22 | Nye substituerte indolinoner med inhiberende virkning pÕ forskjellige kinaser og cyclin/CDK-komplekser |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6855710B2 (no) |
| EP (1) | EP1115704B1 (no) |
| JP (1) | JP2002525356A (no) |
| KR (1) | KR20010085841A (no) |
| CN (1) | CN1319090A (no) |
| AT (1) | ATE243195T1 (no) |
| AU (1) | AU763361B2 (no) |
| BG (1) | BG105327A (no) |
| BR (1) | BR9914065A (no) |
| CA (1) | CA2342622A1 (no) |
| DE (1) | DE59906030D1 (no) |
| DK (1) | DK1115704T3 (no) |
| EA (1) | EA200100320A1 (no) |
| EE (1) | EE200100184A (no) |
| ES (1) | ES2196860T3 (no) |
| HR (1) | HRP20010216A2 (no) |
| HU (1) | HUP0104973A3 (no) |
| ID (1) | ID27757A (no) |
| IL (1) | IL141622A0 (no) |
| NO (1) | NO20011477D0 (no) |
| NZ (1) | NZ510845A (no) |
| PL (1) | PL346898A1 (no) |
| PT (1) | PT1115704E (no) |
| SI (1) | SI1115704T1 (no) |
| SK (1) | SK4032001A3 (no) |
| TR (1) | TR200100854T2 (no) |
| WO (1) | WO2000018734A1 (no) |
| YU (1) | YU21301A (no) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
| US6765012B2 (en) * | 2001-09-27 | 2004-07-20 | Allergan, Inc. | 3-(Arylamino)methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors |
| US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| ES2298508T3 (es) | 2002-03-26 | 2008-05-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos. |
| DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
| US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
| US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| BR0313923A (pt) * | 2002-08-29 | 2005-07-12 | Boehringer Ingelheim Pharma | Derivados de 3-(sulfonamidoetil)-indol para uso como miméticos de glicocorticóide no tratamento de doenças inflamatórias, alérgicas e proliferativas |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| JP4949845B2 (ja) * | 2003-10-03 | 2012-06-13 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼインヒビター結合アッセイにおける使用のための蛍光プローブ |
| EP1740171B1 (en) | 2004-03-11 | 2010-06-09 | Actelion Pharmaceuticals Ltd. | Indol-1-yl-acetic acid derivatives |
| US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| JP2008525525A (ja) | 2004-12-27 | 2008-07-17 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | グルココルチコイドミメティクス、その製法、医薬組成物及び使用 |
| EA013239B1 (ru) | 2005-04-28 | 2010-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Новые соединения для лечения воспалительных заболеваний |
| KR20090097908A (ko) | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
| WO2008073509A2 (en) * | 2006-12-11 | 2008-06-19 | Genentech, Inc. | Compositions and methods for treating a neoplasm |
| CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
| UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
| RU2525114C2 (ru) * | 2007-12-03 | 2014-08-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ получения производного индолинона |
| MX2010007950A (es) * | 2008-01-25 | 2010-08-04 | Boehringer Ingelheim Int | Formas salinas de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-ind ol-3-ilideno, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| SI2300472T1 (sl) | 2008-06-06 | 2012-05-31 | Boehringer Ingelheim Int | Glukokortikoidni mimetiki postopki za njihovo pripravo farmacevtski sestavki in njihove uporabe |
| US8853420B2 (en) | 2008-07-29 | 2014-10-07 | Boehringer Ingelheim International Gmbh | Compounds |
| JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
| WO2019152977A2 (en) | 2018-02-05 | 2019-08-08 | Bio-Rad Laboratories, Inc. | Chromatography resin having an anionic exchange-hydrophobic mixed mode ligand |
| CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Application Discontinuation
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Application Discontinuation
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx active Pending
- 2001-03-21 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011477A patent/NO20011477D0/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2196860T3 (es) | 2003-12-16 |
| BG105327A (en) | 2001-12-29 |
| CN1319090A (zh) | 2001-10-24 |
| EP1115704B1 (de) | 2003-06-18 |
| DK1115704T3 (da) | 2003-09-29 |
| IL141622A0 (en) | 2002-03-10 |
| US6855710B2 (en) | 2005-02-15 |
| TR200100854T2 (tr) | 2001-12-21 |
| BR9914065A (pt) | 2001-06-19 |
| YU21301A (sh) | 2003-04-30 |
| SK4032001A3 (en) | 2001-11-06 |
| PT1115704E (pt) | 2003-11-28 |
| NO20011477L (no) | 2001-03-22 |
| HUP0104973A3 (en) | 2002-06-28 |
| AU763361B2 (en) | 2003-07-17 |
| DE59906030D1 (de) | 2003-07-24 |
| NZ510845A (en) | 2003-10-31 |
| HRP20010216A2 (en) | 2002-04-30 |
| PL346898A1 (en) | 2002-03-11 |
| WO2000018734A1 (de) | 2000-04-06 |
| HUP0104973A2 (hu) | 2002-04-29 |
| KR20010085841A (ko) | 2001-09-07 |
| JP2002525356A (ja) | 2002-08-13 |
| ATE243195T1 (de) | 2003-07-15 |
| EA200100320A1 (ru) | 2001-10-22 |
| AU6086399A (en) | 2000-04-17 |
| SI1115704T1 (en) | 2003-12-31 |
| ID27757A (id) | 2001-04-26 |
| EE200100184A (et) | 2002-08-15 |
| EP1115704A1 (de) | 2001-07-18 |
| US20040058978A1 (en) | 2004-03-25 |
| CA2342622A1 (en) | 2000-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20011477D0 (no) | Nye substituerte indolinoner med inhiberende virkning pÕ forskjellige kinaser og cyclin/CDK-komplekser | |
| MY127956A (en) | Substituted indolines which inhibit receptor tyrosine kinases | |
| AU727013B2 (en) | Heterocyclic compound and antitumor agent comprising the same as effective component | |
| BG104813A (en) | Substituted indolinones having an inhibiting effect on kinases and cycline/cdk complexes | |
| BG104938A (en) | Substituted indolinones, the production thereof and their use as medicaments | |
| IL139056A0 (en) | Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation | |
| DE69131581T2 (de) | 2-Oxindolderivate als Tyrosinekinaseinhibitoren | |
| NO20054952L (no) | 2,3,6-trisubstituerte 4-pyrimidonderivater | |
| MXPA05007115A (es) | Nuevos agonistas inversos del receptor cb 1. | |
| WO2004026829A3 (de) | Heterocyclisch substituierte indolinone und deren verwendung als rezeptor-tyrosinkinasen inhibitoren | |
| DE69734773D1 (de) | Nicht-peptidische bombesin rezeptor antagonisten | |
| MXPA02010627A (es) | Derivados de 2-acil-indol y su uso como farmaco antitumoral. | |
| IL186777A0 (en) | (3,4-dihydro-quinazolin-2-yl) - (2-aryloxy-ethyl) - amines having an activity on the 5 - ht receptor | |
| HUP0002300A2 (hu) | 4-Kinolinkarboxamid-származékok, előállításuk, e vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
| ECSP034776A (es) | Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos | |
| DK0900214T3 (da) | Fremgangsmåde til fremstilling af pyrmidin-derivater | |
| NO178397C (no) | Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter | |
| HUP0301587A2 (hu) | Foszfodiészteráz V gátló hatású 5-amino-alkil-pirazolo[4,3-d]pirimidinek, ezeket tartalmazó gyógyszerkészítmények és eljárások az elżállításaikra | |
| UA97837C2 (ru) | Соединения хинолина для лечения нарушений, которые реагируют на модуляцию рецептора серотонина 5-ht6 | |
| DK1303514T3 (da) | Fremgangsmåde til fremstilling af azacycloalkanoylaminothiazoler | |
| ATE380810T1 (de) | Protein-tyrosine-kinase-inhibitoren | |
| NZ508852A (en) | 2-aminothiazol-fused 2-aminoindans and 2-aminotetralins and their use in treating CNS and circulation disorders | |
| HUP0000854A2 (hu) | 4-[6-Fluor-(1H)-indol-3-il]-1,2,3,6-tetrahidropiridin-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás mindezek előállítására | |
| UY26308A1 (es) | Nuevas indolinonas sustituidas, su preparación y su empleo como medicamentos | |
| HUP0203543A2 (hu) | Eljárás aril-triazolinonok előállítására és új intermedierek az eljáráshoz |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |