ECSP034776A - Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos - Google Patents

Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos

Info

Publication number
ECSP034776A
ECSP034776A EC2003004776A ECSP034776A ECSP034776A EC SP034776 A ECSP034776 A EC SP034776A EC 2003004776 A EC2003004776 A EC 2003004776A EC SP034776 A ECSP034776 A EC SP034776A EC SP034776 A ECSP034776 A EC SP034776A
Authority
EC
Ecuador
Prior art keywords
preparation
indolinones
medications
replaced
salts
Prior art date
Application number
EC2003004776A
Other languages
English (en)
Inventor
Gerald Juergen Roth
Frank Hilberg
Armin Heckel
Joerg Kley
Thorsten Lehmann-Lintz
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ECSP034776A publication Critical patent/ECSP034776A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

El presente invento se refiere a indolinonas sustituidas en posición 6 de la fórmula general en la que (Grafico) R1 hasta R5 y X están definidos como en la reivindicación1, sus isomeros y sus sales, en particular sus sales fisiológicamente compatibles, que presentan valiosas propiedades farmacológicas, en particular un efecto inhibidor sobre diferentes tirosina-cinasas de receptores y complejos de sislinas y CDK, así como sobre ka proliferación de células endoteliales diferentes células tumorales, medicamentos que contienen estos compuestos, su utilización y procedimientos para su preparación
EC2003004776A 2001-04-06 2003-09-24 Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos ECSP034776A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10117204A DE10117204A1 (de) 2001-04-06 2001-04-06 In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ECSP034776A true ECSP034776A (es) 2003-12-01

Family

ID=7680648

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2003004776A ECSP034776A (es) 2001-04-06 2003-09-24 Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos

Country Status (23)

Country Link
US (1) US6858641B2 (es)
EP (1) EP1379501A1 (es)
JP (1) JP2004525173A (es)
KR (1) KR20030090712A (es)
CN (1) CN1509270A (es)
AR (1) AR035813A1 (es)
BG (1) BG108220A (es)
BR (1) BR0208900A (es)
CA (1) CA2442695A1 (es)
CZ (1) CZ20032975A3 (es)
DE (1) DE10117204A1 (es)
EA (1) EA200301005A1 (es)
EC (1) ECSP034776A (es)
EE (1) EE200300491A (es)
HU (1) HUP0303737A3 (es)
IL (1) IL158254A0 (es)
MX (1) MXPA03008896A (es)
NO (1) NO20034434L (es)
PE (1) PE20021058A1 (es)
PL (1) PL366458A1 (es)
SK (1) SK12412003A3 (es)
WO (1) WO2002081445A1 (es)
ZA (1) ZA200307306B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
US20060154939A1 (en) * 2004-12-24 2006-07-13 Boehringer Ingelheim International Gmbh Medicaments for the Treatment or Prevention of Fibrotic Diseases
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2007057397A1 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer
WO2009047359A1 (en) 2007-10-12 2009-04-16 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
PE20091445A1 (es) * 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
CA2728228A1 (en) * 2008-07-14 2010-01-21 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
JP5651110B2 (ja) 2008-07-29 2015-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規化合物
US8518948B2 (en) 2010-03-10 2013-08-27 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
CN102267934B (zh) * 2010-06-02 2013-04-17 金凯美(大连)医药科技有限公司 一种6-甲氧羰基吲哚酮的制备方法
MY195904A (en) 2015-12-24 2023-02-27 Respivert Ltd Indolinones Compounds and Their use in the Treatment Of Fibrotic Diseases
JP7039480B2 (ja) * 2016-03-08 2022-03-22 レスピバート・リミテツド プロテインキナーゼ阻害剤としてのインドール誘導体およびそれらの使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4155697A (en) * 1996-08-23 1998-03-06 Sugen, Inc. Indolinone combinatorial libraries and related products and methods for the treatment of disease
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6043254A (en) 1998-04-03 2000-03-28 Boehringer Ingelheim Pharma Kg Indolinones having kinase-inhibiting activity
US6169106B1 (en) 1998-04-15 2001-01-02 Boehringer Ingelheim Pharma Kg Indolinones having kinase inhibitory activity
DE19816624A1 (de) 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6319918B1 (en) * 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
DE19824922A1 (de) 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19924401A1 (de) 1999-05-27 2000-11-30 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19940829A1 (de) 1999-08-27 2001-03-01 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
JP3952369B2 (ja) 1999-08-27 2007-08-01 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規な置換インドリノン類、その製造及びその薬剤としての使用
DE10042696A1 (de) 2000-08-31 2002-03-14 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу

Also Published As

Publication number Publication date
US6858641B2 (en) 2005-02-22
IL158254A0 (en) 2004-05-12
WO2002081445A1 (de) 2002-10-17
DE10117204A1 (de) 2002-10-10
SK12412003A3 (sk) 2004-04-06
EA200301005A1 (ru) 2004-04-29
EE200300491A (et) 2004-02-16
NO20034434D0 (no) 2003-10-03
CA2442695A1 (en) 2002-10-17
HUP0303737A3 (en) 2004-09-28
CN1509270A (zh) 2004-06-30
AR035813A1 (es) 2004-07-14
BR0208900A (pt) 2004-04-20
PL366458A1 (en) 2005-02-07
HUP0303737A2 (hu) 2004-03-01
JP2004525173A (ja) 2004-08-19
NO20034434L (no) 2003-10-03
US20030092756A1 (en) 2003-05-15
PE20021058A1 (es) 2003-01-20
CZ20032975A3 (cs) 2004-02-18
MXPA03008896A (es) 2003-12-08
ZA200307306B (en) 2004-08-31
KR20030090712A (ko) 2003-11-28
EP1379501A1 (de) 2004-01-14
BG108220A (bg) 2004-09-30

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