PE20021058A1 - Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos - Google Patents
Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentosInfo
- Publication number
- PE20021058A1 PE20021058A1 PE2002000279A PE2002000279A PE20021058A1 PE 20021058 A1 PE20021058 A1 PE 20021058A1 PE 2002000279 A PE2002000279 A PE 2002000279A PE 2002000279 A PE2002000279 A PE 2002000279A PE 20021058 A1 PE20021058 A1 PE 20021058A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- amino
- carbonyl
- alkyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A INDOLINONAS DE FORMULA I DONE X ES O, S; R1 ES H, PROFARMACO, R2 ES CARBOXI, ALCOXI C1-C6, CICLOALCOXI C4-C7, ARILOXICARBONILO; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, TRIFLUOROMETILO, HETEROARILO, FENILO, NAFTILO, R4 ES FENILO, PIRROLILO, FURANILO, ALQUIL C1-C3-AMINO-CARBONILO, ENTRE OTROS; R6 ES AMINO-CARBONILO, ALQUIL C1-C4-AMINO-CARBONILO, N-(ALQUIL C1-C5)-ALQUIL C1-C3-AMINO-CARBONILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C3. SON COMPUESTOS PREFERIDOS 3-(Z)-ESTER METILICO DEL ACIDO[1-{4-[(PIPERAZIN-1-IL)-CARBONIL]FENIL-AMINO}-1-FENIL-METILIDEN]-2-INDOLINONA-6-CARBOXILICO; 3-(Z)-ESTER METILICO DEL ACIDO [1-{4-[N-(2-METIL-ETIL)-N-METIL-CARBAMOIL]FENIL-AMINO}-1-FENIL-METILIDEN]-2-INDOLINONA-6-CARBOXILICO; 3-(Z)-ESTER METILICO DEL ACIDO [1-{4-[(4-DIMETILAMINO-PIPERIDIN-1-IL)-CARBONIL]FENIL-METILIDEN}-2-INDOLINONA-6-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INTERMEDIOS PARA LA PREPARACION DE COMPUESTOS INHIBIDORES DE CINASAS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE PROLIFERACION DE CELULAS ENDOTELIALES, TUMORES, PSORIASIS, ARTRITIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10117204A DE10117204A1 (de) | 2001-04-06 | 2001-04-06 | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20021058A1 true PE20021058A1 (es) | 2003-01-20 |
Family
ID=7680648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000279A PE20021058A1 (es) | 2001-04-06 | 2002-04-05 | Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos |
Country Status (23)
Country | Link |
---|---|
US (1) | US6858641B2 (es) |
EP (1) | EP1379501A1 (es) |
JP (1) | JP2004525173A (es) |
KR (1) | KR20030090712A (es) |
CN (1) | CN1509270A (es) |
AR (1) | AR035813A1 (es) |
BG (1) | BG108220A (es) |
BR (1) | BR0208900A (es) |
CA (1) | CA2442695A1 (es) |
CZ (1) | CZ20032975A3 (es) |
DE (1) | DE10117204A1 (es) |
EA (1) | EA200301005A1 (es) |
EC (1) | ECSP034776A (es) |
EE (1) | EE200300491A (es) |
HU (1) | HUP0303737A3 (es) |
IL (1) | IL158254A0 (es) |
MX (1) | MXPA03008896A (es) |
NO (1) | NO20034434D0 (es) |
PE (1) | PE20021058A1 (es) |
PL (1) | PL366458A1 (es) |
SK (1) | SK12412003A3 (es) |
WO (1) | WO2002081445A1 (es) |
ZA (1) | ZA200307306B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
DK2212297T3 (da) | 2007-10-12 | 2011-09-05 | Ingenium Pharmaceuticals Gmbh | Inhibitorer af proteinkinaser |
UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
US8344018B2 (en) * | 2008-07-14 | 2013-01-01 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
CA2731919A1 (en) | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | New compounds |
KR20130016244A (ko) | 2010-03-10 | 2013-02-14 | 인게니움 파르마코이티칼스 게엠베하 | 단백질 키나아제의 억제제 |
CN102267934B (zh) * | 2010-06-02 | 2013-04-17 | 金凯美(大连)医药科技有限公司 | 一种6-甲氧羰基吲哚酮的制备方法 |
EP3394048B1 (en) * | 2015-12-24 | 2020-03-11 | Respivert Limited | Indolinones compounds and their use in the treatment of fibrotic diseases |
EP3426649B1 (en) * | 2016-03-08 | 2020-07-22 | Respivert Limited | Indole derivatives and their use as protein kinase inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2264220A1 (en) * | 1996-08-23 | 1998-02-26 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
US6043254A (en) | 1998-04-03 | 2000-03-28 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase-inhibiting activity |
DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
US6169106B1 (en) | 1998-04-15 | 2001-01-02 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase inhibitory activity |
DE19824922A1 (de) * | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
US6319918B1 (en) * | 1998-06-04 | 2001-11-20 | Boehringer Ingelheim Pharma Kg | Substituted indolinones with kinase inhibitory activity |
DE19924401A1 (de) | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19940829A1 (de) | 1999-08-27 | 2001-03-01 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
JP3952369B2 (ja) | 1999-08-27 | 2007-08-01 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 新規な置換インドリノン類、その製造及びその薬剤としての使用 |
UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
DE10042696A1 (de) | 2000-08-31 | 2002-03-14 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
2001
- 2001-04-06 DE DE10117204A patent/DE10117204A1/de not_active Withdrawn
-
2002
- 2002-03-30 EE EEP200300491A patent/EE200300491A/xx unknown
- 2002-03-30 KR KR10-2003-7013027A patent/KR20030090712A/ko not_active Application Discontinuation
- 2002-03-30 BR BR0208900-9A patent/BR0208900A/pt active Pending
- 2002-03-30 WO PCT/EP2002/003583 patent/WO2002081445A1/de not_active Application Discontinuation
- 2002-03-30 EA EA200301005A patent/EA200301005A1/ru unknown
- 2002-03-30 SK SK1241-2003A patent/SK12412003A3/sk unknown
- 2002-03-30 JP JP2002579433A patent/JP2004525173A/ja not_active Ceased
- 2002-03-30 PL PL02366458A patent/PL366458A1/xx not_active Application Discontinuation
- 2002-03-30 IL IL15825402A patent/IL158254A0/xx unknown
- 2002-03-30 CZ CZ20032975A patent/CZ20032975A3/cs unknown
- 2002-03-30 CN CNA028099184A patent/CN1509270A/zh active Pending
- 2002-03-30 CA CA002442695A patent/CA2442695A1/en not_active Abandoned
- 2002-03-30 MX MXPA03008896A patent/MXPA03008896A/es unknown
- 2002-03-30 EP EP02735201A patent/EP1379501A1/de not_active Withdrawn
- 2002-03-30 HU HU0303737A patent/HUP0303737A3/hu unknown
- 2002-04-04 US US10/116,365 patent/US6858641B2/en not_active Expired - Lifetime
- 2002-04-05 PE PE2002000279A patent/PE20021058A1/es not_active Application Discontinuation
- 2002-04-05 AR ARP020101257A patent/AR035813A1/es not_active Withdrawn
-
2003
- 2003-09-18 ZA ZA200307306A patent/ZA200307306B/xx unknown
- 2003-09-24 EC EC2003004776A patent/ECSP034776A/es unknown
- 2003-10-01 BG BG108220A patent/BG108220A/bg active Pending
- 2003-10-03 NO NO20034434A patent/NO20034434D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
BG108220A (bg) | 2004-09-30 |
DE10117204A1 (de) | 2002-10-10 |
SK12412003A3 (sk) | 2004-04-06 |
HUP0303737A2 (hu) | 2004-03-01 |
US6858641B2 (en) | 2005-02-22 |
ZA200307306B (en) | 2004-08-31 |
AR035813A1 (es) | 2004-07-14 |
NO20034434L (no) | 2003-10-03 |
US20030092756A1 (en) | 2003-05-15 |
CN1509270A (zh) | 2004-06-30 |
EE200300491A (et) | 2004-02-16 |
BR0208900A (pt) | 2004-04-20 |
MXPA03008896A (es) | 2003-12-08 |
WO2002081445A1 (de) | 2002-10-17 |
JP2004525173A (ja) | 2004-08-19 |
CZ20032975A3 (cs) | 2004-02-18 |
ECSP034776A (es) | 2003-12-01 |
EP1379501A1 (de) | 2004-01-14 |
IL158254A0 (en) | 2004-05-12 |
KR20030090712A (ko) | 2003-11-28 |
EA200301005A1 (ru) | 2004-04-29 |
PL366458A1 (en) | 2005-02-07 |
NO20034434D0 (no) | 2003-10-03 |
HUP0303737A3 (en) | 2004-09-28 |
CA2442695A1 (en) | 2002-10-17 |
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Legal Events
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FC | Refusal |