PE20021058A1 - Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos - Google Patents

Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos

Info

Publication number
PE20021058A1
PE20021058A1 PE2002000279A PE2002000279A PE20021058A1 PE 20021058 A1 PE20021058 A1 PE 20021058A1 PE 2002000279 A PE2002000279 A PE 2002000279A PE 2002000279 A PE2002000279 A PE 2002000279A PE 20021058 A1 PE20021058 A1 PE 20021058A1
Authority
PE
Peru
Prior art keywords
phenyl
amino
carbonyl
alkyl
methyl
Prior art date
Application number
PE2002000279A
Other languages
English (en)
Inventor
Armin Heckel
Frank Hilberg
Meel Jacobus Constantinus Antonius Van
Thorsten Lehmann-Lintz
Gerald Roth
Jorg Kley
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20021058A1 publication Critical patent/PE20021058A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A INDOLINONAS DE FORMULA I DONE X ES O, S; R1 ES H, PROFARMACO, R2 ES CARBOXI, ALCOXI C1-C6, CICLOALCOXI C4-C7, ARILOXICARBONILO; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, TRIFLUOROMETILO, HETEROARILO, FENILO, NAFTILO, R4 ES FENILO, PIRROLILO, FURANILO, ALQUIL C1-C3-AMINO-CARBONILO, ENTRE OTROS; R6 ES AMINO-CARBONILO, ALQUIL C1-C4-AMINO-CARBONILO, N-(ALQUIL C1-C5)-ALQUIL C1-C3-AMINO-CARBONILO, ENTRE OTROS; R5 ES H, ALQUILO C1-C3. SON COMPUESTOS PREFERIDOS 3-(Z)-ESTER METILICO DEL ACIDO[1-{4-[(PIPERAZIN-1-IL)-CARBONIL]FENIL-AMINO}-1-FENIL-METILIDEN]-2-INDOLINONA-6-CARBOXILICO; 3-(Z)-ESTER METILICO DEL ACIDO [1-{4-[N-(2-METIL-ETIL)-N-METIL-CARBAMOIL]FENIL-AMINO}-1-FENIL-METILIDEN]-2-INDOLINONA-6-CARBOXILICO; 3-(Z)-ESTER METILICO DEL ACIDO [1-{4-[(4-DIMETILAMINO-PIPERIDIN-1-IL)-CARBONIL]FENIL-METILIDEN}-2-INDOLINONA-6-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON INTERMEDIOS PARA LA PREPARACION DE COMPUESTOS INHIBIDORES DE CINASAS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE PROLIFERACION DE CELULAS ENDOTELIALES, TUMORES, PSORIASIS, ARTRITIS
PE2002000279A 2001-04-06 2002-04-05 Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos PE20021058A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10117204A DE10117204A1 (de) 2001-04-06 2001-04-06 In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20021058A1 true PE20021058A1 (es) 2003-01-20

Family

ID=7680648

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000279A PE20021058A1 (es) 2001-04-06 2002-04-05 Indolinonas sustituidas en posicion 6, su preparacion y su utilizacion como medicamentos

Country Status (23)

Country Link
US (1) US6858641B2 (es)
EP (1) EP1379501A1 (es)
JP (1) JP2004525173A (es)
KR (1) KR20030090712A (es)
CN (1) CN1509270A (es)
AR (1) AR035813A1 (es)
BG (1) BG108220A (es)
BR (1) BR0208900A (es)
CA (1) CA2442695A1 (es)
CZ (1) CZ20032975A3 (es)
DE (1) DE10117204A1 (es)
EA (1) EA200301005A1 (es)
EC (1) ECSP034776A (es)
EE (1) EE200300491A (es)
HU (1) HUP0303737A3 (es)
IL (1) IL158254A0 (es)
MX (1) MXPA03008896A (es)
NO (1) NO20034434D0 (es)
PE (1) PE20021058A1 (es)
PL (1) PL366458A1 (es)
SK (1) SK12412003A3 (es)
WO (1) WO2002081445A1 (es)
ZA (1) ZA200307306B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10233500A1 (de) * 2002-07-24 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20060154939A1 (en) * 2004-12-24 2006-07-13 Boehringer Ingelheim International Gmbh Medicaments for the Treatment or Prevention of Fibrotic Diseases
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2007057397A1 (en) * 2005-11-15 2007-05-24 Boehringer Ingelheim International Gmbh Treatment of cancer
JP5681855B2 (ja) 2007-10-12 2015-03-11 アストラゼネカ エービー プロテインキナーゼの阻害剤
PE20091445A1 (es) * 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
US20170065529A1 (en) 2015-09-09 2017-03-09 Boehringer Ingelheim International Gmbh Pharmaceutical dosage form for immediate release of an indolinone derivative
US8344018B2 (en) * 2008-07-14 2013-01-01 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
AU2009275964A1 (en) * 2008-07-29 2010-02-04 Boehringer Ingelheim International Gmbh New compounds
US8518948B2 (en) 2010-03-10 2013-08-27 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
CN102267934B (zh) * 2010-06-02 2013-04-17 金凯美(大连)医药科技有限公司 一种6-甲氧羰基吲哚酮的制备方法
US11046672B2 (en) * 2015-12-24 2021-06-29 Respivert Limited Indolinones compounds and their use in the treatment of fibrotic diseases
EA038773B1 (ru) 2016-03-08 2021-10-18 Респиверт Лимитед Индольные производные и их применение в качестве ингибиторов протеинкиназы

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1247803A3 (en) * 1996-08-23 2002-10-16 Sugen, Inc. Indolinone compounds suitable for modulation of protein kinases
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6043254A (en) 1998-04-03 2000-03-28 Boehringer Ingelheim Pharma Kg Indolinones having kinase-inhibiting activity
DE19816624A1 (de) 1998-04-15 1999-10-21 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6169106B1 (en) 1998-04-15 2001-01-02 Boehringer Ingelheim Pharma Kg Indolinones having kinase inhibitory activity
US6319918B1 (en) * 1998-06-04 2001-11-20 Boehringer Ingelheim Pharma Kg Substituted indolinones with kinase inhibitory activity
DE19824922A1 (de) * 1998-06-04 1999-12-09 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19924401A1 (de) 1999-05-27 2000-11-30 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19940829A1 (de) 1999-08-27 2001-03-01 Boehringer Ingelheim Pharma Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
ATE316527T1 (de) 1999-08-27 2006-02-15 Boehringer Ingelheim Pharma Substituierte indolinone als tyrosinkinase inhibitoren
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
DE10042696A1 (de) 2000-08-31 2002-03-14 Boehringer Ingelheim Pharma In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CA2442695A1 (en) 2002-10-17
DE10117204A1 (de) 2002-10-10
HUP0303737A2 (hu) 2004-03-01
US20030092756A1 (en) 2003-05-15
AR035813A1 (es) 2004-07-14
IL158254A0 (en) 2004-05-12
EP1379501A1 (de) 2004-01-14
NO20034434L (no) 2003-10-03
EA200301005A1 (ru) 2004-04-29
CN1509270A (zh) 2004-06-30
ZA200307306B (en) 2004-08-31
CZ20032975A3 (cs) 2004-02-18
KR20030090712A (ko) 2003-11-28
US6858641B2 (en) 2005-02-22
ECSP034776A (es) 2003-12-01
JP2004525173A (ja) 2004-08-19
BR0208900A (pt) 2004-04-20
HUP0303737A3 (en) 2004-09-28
PL366458A1 (en) 2005-02-07
BG108220A (bg) 2004-09-30
WO2002081445A1 (de) 2002-10-17
EE200300491A (et) 2004-02-16
NO20034434D0 (no) 2003-10-03
MXPA03008896A (es) 2003-12-08
SK12412003A3 (sk) 2004-04-06

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