HUP0303737A3 - Indolinones, substituted in position 6, and their use as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them - Google Patents
Indolinones, substituted in position 6, and their use as kinase inhibitors, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- HUP0303737A3 HUP0303737A3 HU0303737A HUP0303737A HUP0303737A3 HU P0303737 A3 HUP0303737 A3 HU P0303737A3 HU 0303737 A HU0303737 A HU 0303737A HU P0303737 A HUP0303737 A HU P0303737A HU P0303737 A3 HUP0303737 A3 HU P0303737A3
- Authority
- HU
- Hungary
- Prior art keywords
- indolinones
- substituted
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10117204A DE10117204A1 (de) | 2001-04-06 | 2001-04-06 | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2002/003583 WO2002081445A1 (de) | 2001-04-06 | 2002-03-30 | In 6-stellung substituierte indoline und ihre verwendung als kinase-inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303737A2 HUP0303737A2 (hu) | 2004-03-01 |
| HUP0303737A3 true HUP0303737A3 (en) | 2004-09-28 |
Family
ID=7680648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303737A HUP0303737A3 (en) | 2001-04-06 | 2002-03-30 | Indolinones, substituted in position 6, and their use as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6858641B2 (hu) |
| EP (1) | EP1379501A1 (hu) |
| JP (1) | JP2004525173A (hu) |
| KR (1) | KR20030090712A (hu) |
| CN (1) | CN1509270A (hu) |
| AR (1) | AR035813A1 (hu) |
| BG (1) | BG108220A (hu) |
| BR (1) | BR0208900A (hu) |
| CA (1) | CA2442695A1 (hu) |
| CZ (1) | CZ20032975A3 (hu) |
| DE (1) | DE10117204A1 (hu) |
| EA (1) | EA200301005A1 (hu) |
| EC (1) | ECSP034776A (hu) |
| EE (1) | EE200300491A (hu) |
| HU (1) | HUP0303737A3 (hu) |
| IL (1) | IL158254A0 (hu) |
| MX (1) | MXPA03008896A (hu) |
| NO (1) | NO20034434D0 (hu) |
| PE (1) | PE20021058A1 (hu) |
| PL (1) | PL366458A1 (hu) |
| SK (1) | SK12412003A3 (hu) |
| WO (1) | WO2002081445A1 (hu) |
| ZA (1) | ZA200307306B (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10233500A1 (de) * | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
| JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| BRPI0818543A2 (pt) | 2007-10-12 | 2018-10-23 | Ingenium Pharmaceuticals Gmbh | inibidores de proteína cinase |
| UY31506A1 (es) * | 2007-12-03 | 2009-08-03 | Derivados de indolinona y procedimiento para su preparacion | |
| US20170065529A1 (en) | 2015-09-09 | 2017-03-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical dosage form for immediate release of an indolinone derivative |
| CA2728228A1 (en) * | 2008-07-14 | 2010-01-21 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
| CA2731919A1 (en) | 2008-07-29 | 2010-02-04 | Boehringer Ingelheim International Gmbh | New compounds |
| NZ627520A (en) | 2010-03-10 | 2015-10-30 | Astrazeneca Ab | 4-phenyl pyridine analogues as protein kinase inhibitors |
| CN102267934B (zh) * | 2010-06-02 | 2013-04-17 | 金凯美(大连)医药科技有限公司 | 一种6-甲氧羰基吲哚酮的制备方法 |
| MX2018007852A (es) | 2015-12-24 | 2018-11-09 | Respivert Ltd | Compuestos de indolinona y su uso en el tratamiento de enfermedades fibróticas. |
| CA3017308A1 (en) * | 2016-03-08 | 2017-09-14 | Respivert Limited | Indole derivatives and their use as protein kinase inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503736A (ja) * | 1996-08-23 | 2001-03-21 | スージェン・インコーポレーテッド | 疾病の治療のためのインドリノンのコンビナトリアルライブラリーおよび関連する生成物および方法 |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6043254A (en) | 1998-04-03 | 2000-03-28 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase-inhibiting activity |
| DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6169106B1 (en) | 1998-04-15 | 2001-01-02 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase inhibitory activity |
| DE19824922A1 (de) | 1998-06-04 | 1999-12-09 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6319918B1 (en) * | 1998-06-04 | 2001-11-20 | Boehringer Ingelheim Pharma Kg | Substituted indolinones with kinase inhibitory activity |
| DE19924401A1 (de) | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE19940829A1 (de) | 1999-08-27 | 2001-03-01 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| ES2257313T3 (es) | 1999-08-27 | 2006-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Indolinonas sustituidas en calidad de inhibidores de tirosina quinasa. |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE10042696A1 (de) | 2000-08-31 | 2002-03-14 | Boehringer Ingelheim Pharma | In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
2001
- 2001-04-06 DE DE10117204A patent/DE10117204A1/de not_active Withdrawn
-
2002
- 2002-03-30 CN CNA028099184A patent/CN1509270A/zh active Pending
- 2002-03-30 HU HU0303737A patent/HUP0303737A3/hu unknown
- 2002-03-30 KR KR10-2003-7013027A patent/KR20030090712A/ko not_active Application Discontinuation
- 2002-03-30 MX MXPA03008896A patent/MXPA03008896A/es unknown
- 2002-03-30 IL IL15825402A patent/IL158254A0/xx unknown
- 2002-03-30 CA CA002442695A patent/CA2442695A1/en not_active Abandoned
- 2002-03-30 PL PL02366458A patent/PL366458A1/xx not_active Application Discontinuation
- 2002-03-30 EP EP02735201A patent/EP1379501A1/de not_active Withdrawn
- 2002-03-30 EE EEP200300491A patent/EE200300491A/xx unknown
- 2002-03-30 JP JP2002579433A patent/JP2004525173A/ja not_active Ceased
- 2002-03-30 SK SK1241-2003A patent/SK12412003A3/sk unknown
- 2002-03-30 EA EA200301005A patent/EA200301005A1/ru unknown
- 2002-03-30 WO PCT/EP2002/003583 patent/WO2002081445A1/de not_active Application Discontinuation
- 2002-03-30 BR BR0208900-9A patent/BR0208900A/pt active Pending
- 2002-03-30 CZ CZ20032975A patent/CZ20032975A3/cs unknown
- 2002-04-04 US US10/116,365 patent/US6858641B2/en not_active Expired - Lifetime
- 2002-04-05 PE PE2002000279A patent/PE20021058A1/es not_active Application Discontinuation
- 2002-04-05 AR ARP020101257A patent/AR035813A1/es not_active Withdrawn
-
2003
- 2003-09-18 ZA ZA200307306A patent/ZA200307306B/xx unknown
- 2003-09-24 EC EC2003004776A patent/ECSP034776A/es unknown
- 2003-10-01 BG BG108220A patent/BG108220A/bg active Pending
- 2003-10-03 NO NO20034434A patent/NO20034434D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL158254A0 (en) | 2004-05-12 |
| HUP0303737A2 (hu) | 2004-03-01 |
| SK12412003A3 (sk) | 2004-04-06 |
| ECSP034776A (es) | 2003-12-01 |
| EA200301005A1 (ru) | 2004-04-29 |
| US20030092756A1 (en) | 2003-05-15 |
| ZA200307306B (en) | 2004-08-31 |
| CZ20032975A3 (cs) | 2004-02-18 |
| NO20034434L (no) | 2003-10-03 |
| EP1379501A1 (de) | 2004-01-14 |
| US6858641B2 (en) | 2005-02-22 |
| PE20021058A1 (es) | 2003-01-20 |
| EE200300491A (et) | 2004-02-16 |
| CN1509270A (zh) | 2004-06-30 |
| JP2004525173A (ja) | 2004-08-19 |
| BR0208900A (pt) | 2004-04-20 |
| NO20034434D0 (no) | 2003-10-03 |
| KR20030090712A (ko) | 2003-11-28 |
| PL366458A1 (en) | 2005-02-07 |
| DE10117204A1 (de) | 2002-10-10 |
| CA2442695A1 (en) | 2002-10-17 |
| WO2002081445A1 (de) | 2002-10-17 |
| AR035813A1 (es) | 2004-07-14 |
| BG108220A (bg) | 2004-09-30 |
| MXPA03008896A (es) | 2003-12-08 |
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