CR8530A - Intermediarios de quinolona como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos - Google Patents

Intermediarios de quinolona como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos

Info

Publication number
CR8530A
CR8530A CR8530A CR8530A CR8530A CR 8530 A CR8530 A CR 8530A CR 8530 A CR8530 A CR 8530A CR 8530 A CR8530 A CR 8530A CR 8530 A CR8530 A CR 8530A
Authority
CR
Costa Rica
Prior art keywords
inhibitors
quinolona
intermediaries
synthesis
same
Prior art date
Application number
CR8530A
Other languages
English (en)
Inventor
Wang Youchu
Warren Chew
Papamichelakis Maria
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8530A publication Critical patent/CR8530A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Metodos de preparacion de compuestos de quinolina 4-sustituida como intermediarios en la elaboracion de inhibidores de tirosina quinasas de receptores y los compuestos intermediarios utilizados en dichos metodos, donde dicho compuesto quinolina 4-sustituida presenta la siguiente formula general (I): y donde las sustituciones en LG", PG, A, G, R1 y R4 son las que se describieron en la memoria descriptiva.
CR8530A 2004-01-16 2006-07-24 Intermediarios de quinolona como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos CR8530A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53732904P 2004-01-16 2004-01-16

Publications (1)

Publication Number Publication Date
CR8530A true CR8530A (es) 2008-09-23

Family

ID=34807094

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8530A CR8530A (es) 2004-01-16 2006-07-24 Intermediarios de quinolona como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos

Country Status (20)

Country Link
US (2) US7432377B2 (es)
EP (1) EP1711467A2 (es)
KR (1) KR20060123545A (es)
CN (1) CN1930128A (es)
AR (1) AR047424A1 (es)
AU (1) AU2005206541A1 (es)
BR (1) BRPI0520812A2 (es)
CA (1) CA2553729A1 (es)
CR (1) CR8530A (es)
EC (1) ECSP066773A (es)
GT (1) GT200500008A (es)
MY (1) MY136959A (es)
NO (1) NO20063501L (es)
PA (1) PA8621501A1 (es)
PE (1) PE20050896A1 (es)
RU (1) RU2006127414A (es)
SG (1) SG149817A1 (es)
TW (1) TW200526219A (es)
UA (1) UA85698C2 (es)
WO (1) WO2005070890A2 (es)

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GT200500008A (es) 2004-01-16 2005-08-16 Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la sintesis de los mismos
WO2006127203A2 (en) * 2005-05-25 2006-11-30 Wyeth Methods of synthesizing 6-alkylaminoquinoline derivatives
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RU2007139544A (ru) * 2005-05-25 2009-06-27 Вайет (Us) Способ получения 3-цианохинолинов и промежуточные соединения, полученные согласно данному способу
TW200808728A (en) * 2006-05-23 2008-02-16 Wyeth Corp Method of preparing 4-halogenated quinoline intermediates
US8093246B2 (en) * 2006-12-14 2012-01-10 Lexicon Pharmaceuticals, Inc. O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
US8063220B2 (en) 2007-06-22 2011-11-22 Richter Gedeon Nyrt. Sulfonyl-quinoline derivatives
ES2645689T3 (es) 2008-05-21 2017-12-07 Ariad Pharmaceuticals, Inc. Derivados de fósforo como inhibidores de quinasas
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
NZ589843A (en) 2008-06-27 2012-12-21 Avila Therapeutics Inc Pyrimidine heteroaryl compounds and uses thereof as protein kinase inhibitors
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
JP5590040B2 (ja) 2008-11-12 2014-09-17 アリアド・ファーマシューティカルズ・インコーポレイテッド キナーゼ阻害剤としてのピラジノピラジンおよび誘導体
DK2603081T3 (en) 2010-08-10 2017-01-16 Celgene Avilomics Res Inc COLLECTED BY A BTK INHIBITOR
TWI545115B (zh) 2010-11-01 2016-08-11 阿維拉製藥公司 雜環化合物及其用途
JP5956999B2 (ja) 2010-11-01 2016-07-27 セルジーン アヴィロミクス リサーチ， インコーポレイテッド ヘテロアリール化合物およびその使用
US8796255B2 (en) 2010-11-10 2014-08-05 Celgene Avilomics Research, Inc Mutant-selective EGFR inhibitors and uses thereof
EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
EP2770830A4 (en) 2011-10-28 2015-05-27 Celgene Avilomics Res Inc METHODS OF TREATING A DISEASE OR DISEASE ASSOCIATED WITH TYROSINE KINASE BTK (BRUTON'S TYROSINE KINASE)
ES2698298T3 (es) 2012-03-15 2019-02-04 Celgene Car Llc Sales de un inhibidor de quinasa receptor de factor de crecimiento epidérmico
EP2825041B1 (en) 2012-03-15 2021-04-21 Celgene CAR LLC Solid forms of an epidermal growth factor receptor kinase inhibitor
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
EP2935226A4 (en) 2012-12-21 2016-11-02 Celgene Avilomics Res Inc HETEROARYL COMPOUNDS AND USES THEREOF
CA2900012A1 (en) 2013-02-08 2014-08-14 Celgene Avilomics Research, Inc. Erk inhibitors and uses thereof
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
EP3179858B1 (en) 2014-08-13 2019-05-15 Celgene Car Llc Forms and compositions of an erk inhibitor
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
WO2016034202A1 (en) * 2014-09-01 2016-03-10 Electrolux Appliances Aktiebolag Support assembly
AU2016333987A1 (en) 2015-10-05 2018-05-10 Ny State Psychiatric Institute Activators of autophagic flux and phospholipase D and clearance of protein aggregates including tau and treatment of proteinopathies
CN105503720B (zh) * 2015-12-31 2018-07-03 重庆威鹏药业有限公司 来那替尼中间体的制备方法
CN107501175A (zh) * 2017-07-25 2017-12-22 广州大学 一种喹啉衍生物的合成方法
CN107417612A (zh) * 2017-07-25 2017-12-01 广州大学 一种喹啉衍生物的合成方法
CN107501174A (zh) * 2017-07-25 2017-12-22 广州大学 一种喹啉衍生物的合成方法
KR20210003160A (ko) 2018-04-18 2021-01-11 콘스텔레이션 파마슈티칼스, 인크. 메틸 변형 효소 조절제, 이의 조성물 및 용도
CN112262143A (zh) 2018-05-21 2021-01-22 星座制药公司 甲基修饰酶的调节剂、其组合物和用途

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Also Published As

Publication number Publication date
WO2005070890A2 (en) 2005-08-04
SG149817A1 (en) 2009-02-27
KR20060123545A (ko) 2006-12-01
GT200500008A (es) 2005-08-16
US20090030197A1 (en) 2009-01-29
UA85698C2 (ru) 2009-02-25
WO2005070890A3 (en) 2005-11-03
RU2006127414A (ru) 2008-02-27
PE20050896A1 (es) 2005-11-14
MY136959A (en) 2008-12-31
ECSP066773A (es) 2006-11-16
AR047424A1 (es) 2006-01-18
US20050159446A1 (en) 2005-07-21
CN1930128A (zh) 2007-03-14
PA8621501A1 (es) 2005-08-10
CA2553729A1 (en) 2005-08-04
AU2005206541A1 (en) 2005-08-04
NO20063501L (no) 2006-09-28
TW200526219A (en) 2005-08-16
BRPI0520812A2 (pt) 2009-10-06
EP1711467A2 (en) 2006-10-18
US7432377B2 (en) 2008-10-07

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Legal Events

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FA Abandonment or withdrawal (granting procedure)