BRPI0519709A2 - derivados de tetralina e indano e usos dos mesmos como antagonistas de 5-ht - Google Patents
derivados de tetralina e indano e usos dos mesmos como antagonistas de 5-htInfo
- Publication number
- BRPI0519709A2 BRPI0519709A2 BRPI0519709-0A BRPI0519709A BRPI0519709A2 BR PI0519709 A2 BRPI0519709 A2 BR PI0519709A2 BR PI0519709 A BRPI0519709 A BR PI0519709A BR PI0519709 A2 BRPI0519709 A2 BR PI0519709A2
- Authority
- BR
- Brazil
- Prior art keywords
- tetraline
- antagonists
- indane derivatives
- indane
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
- C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/12—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
DERIVADOS DE TETRALINA E INDANO E USOS DOS MESMOS COMO ANTAGONISTAS DE 5-HT. A presente invenção refere-se a compostos da fórmula i: ou um sal farmaceuticamente aceitável do mesmo, na qual m, p, q, Ar, R¹ e R² são como definidos aqui, neste pedido de patente. Também são providos métodos para a preparação, composição compreendendo e métodos para o uso dos compostos da fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63803104P | 2004-12-21 | 2004-12-21 | |
PCT/EP2005/013293 WO2006066748A1 (en) | 2004-12-21 | 2005-12-12 | Tetralin and indane derivatives and uses thereof as 5-ht antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0519709A2 true BRPI0519709A2 (pt) | 2009-03-10 |
Family
ID=36143294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0519709-0A BRPI0519709A2 (pt) | 2004-12-21 | 2005-12-12 | derivados de tetralina e indano e usos dos mesmos como antagonistas de 5-ht |
Country Status (15)
Country | Link |
---|---|
US (1) | US7576103B2 (pt) |
EP (1) | EP1831152B1 (pt) |
JP (1) | JP2008524277A (pt) |
KR (1) | KR100889185B1 (pt) |
CN (1) | CN101111472A (pt) |
AT (1) | ATE409179T1 (pt) |
AU (1) | AU2005318598B2 (pt) |
BR (1) | BRPI0519709A2 (pt) |
CA (1) | CA2591800A1 (pt) |
DE (1) | DE602005009977D1 (pt) |
ES (1) | ES2314749T3 (pt) |
MX (1) | MX2007007482A (pt) |
PL (1) | PL1831152T3 (pt) |
RU (1) | RU2388748C2 (pt) |
WO (1) | WO2006066748A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102099342B (zh) * | 2008-07-15 | 2013-07-10 | 霍夫曼-拉罗奇有限公司 | 氨基四氢吲唑基乙酸类 |
US8138208B2 (en) * | 2008-07-15 | 2012-03-20 | Hoffmann-La Roche Inc. | Aminotetrahydroindazoloacetic acids |
WO2010018112A2 (en) * | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Monoaryl aminotetralines |
CA2734104A1 (en) * | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Substituted aminotetralines |
CA2735392A1 (en) * | 2008-08-15 | 2010-02-18 | F. Hoffmann-La Roche Ag | Bi-aryl aminotetralines |
MX2011005200A (es) * | 2008-11-17 | 2011-06-01 | Hoffmann La Roche | Acidos naftilaceticos. |
CA2740863A1 (en) * | 2008-11-17 | 2010-05-20 | F. Hoffmann-La Roche Ag | Naphthylacetic acids |
CN102216273A (zh) * | 2008-11-17 | 2011-10-12 | 霍夫曼-拉罗奇有限公司 | 用作crth2拮抗剂或部分激动剂的萘乙酸 |
US8470884B2 (en) | 2011-11-09 | 2013-06-25 | Hoffmann-La Roche Inc. | Alkenyl naphthylacetic acids |
US9000044B2 (en) | 2012-02-28 | 2015-04-07 | Hoffmann-La Roche Inc. | Substituted naphthylacetic acids |
CN103998422B (zh) * | 2013-09-02 | 2016-11-30 | 北京英力科技发展有限公司 | 环戊二酮肟酯及其应用 |
WO2016082304A1 (zh) * | 2014-11-28 | 2016-06-02 | 北京英力科技发展有限公司 | 一种光固化阻焊油墨 |
CN110240537B (zh) * | 2019-05-22 | 2022-06-21 | 成都阿奇生物医药科技有限公司 | 一种茚氧乙酸类化合物及其制备方法和用途 |
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JPH08217694A (ja) * | 1995-02-09 | 1996-08-27 | Pola Chem Ind Inc | 抗掻痒皮膚外用剤 |
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PL324319A1 (en) | 1995-06-30 | 1998-05-25 | Upjohn Co | 1,6-disubstituted isochromates for fighting against sick headaches |
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JP2001501918A (ja) | 1996-08-21 | 2001-02-13 | スミスクライン・ビーチャム・コーポレイション | Il―8レセプターアンタゴニスト |
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-
2005
- 2005-12-12 KR KR1020077016595A patent/KR100889185B1/ko not_active IP Right Cessation
- 2005-12-12 AT AT05825521T patent/ATE409179T1/de active
- 2005-12-12 EP EP05825521A patent/EP1831152B1/en not_active Not-in-force
- 2005-12-12 ES ES05825521T patent/ES2314749T3/es active Active
- 2005-12-12 AU AU2005318598A patent/AU2005318598B2/en not_active Ceased
- 2005-12-12 PL PL05825521T patent/PL1831152T3/pl unknown
- 2005-12-12 CA CA002591800A patent/CA2591800A1/en not_active Abandoned
- 2005-12-12 JP JP2007547256A patent/JP2008524277A/ja not_active Ceased
- 2005-12-12 MX MX2007007482A patent/MX2007007482A/es active IP Right Grant
- 2005-12-12 BR BRPI0519709-0A patent/BRPI0519709A2/pt not_active IP Right Cessation
- 2005-12-12 WO PCT/EP2005/013293 patent/WO2006066748A1/en active IP Right Grant
- 2005-12-12 DE DE602005009977T patent/DE602005009977D1/de active Active
- 2005-12-12 CN CNA2005800472162A patent/CN101111472A/zh active Pending
- 2005-12-12 RU RU2007122406/04A patent/RU2388748C2/ru not_active IP Right Cessation
- 2005-12-21 US US11/316,003 patent/US7576103B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2006066748A1 (en) | 2006-06-29 |
US20060154965A1 (en) | 2006-07-13 |
RU2007122406A (ru) | 2009-01-27 |
KR100889185B1 (ko) | 2009-03-16 |
RU2388748C2 (ru) | 2010-05-10 |
DE602005009977D1 (de) | 2008-11-06 |
ATE409179T1 (de) | 2008-10-15 |
CN101111472A (zh) | 2008-01-23 |
EP1831152A1 (en) | 2007-09-12 |
JP2008524277A (ja) | 2008-07-10 |
ES2314749T3 (es) | 2009-03-16 |
CA2591800A1 (en) | 2006-06-29 |
KR20070087171A (ko) | 2007-08-27 |
MX2007007482A (es) | 2007-07-20 |
AU2005318598B2 (en) | 2010-08-26 |
EP1831152B1 (en) | 2008-09-24 |
AU2005318598A1 (en) | 2006-06-29 |
US7576103B2 (en) | 2009-08-18 |
PL1831152T3 (pl) | 2009-03-31 |
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