MA54547A - Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a - Google Patents

Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Info

Publication number
MA54547A
MA54547A MA054547A MA54547A MA54547A MA 54547 A MA54547 A MA 54547A MA 054547 A MA054547 A MA 054547A MA 54547 A MA54547 A MA 54547A MA 54547 A MA54547 A MA 54547A
Authority
MA
Morocco
Prior art keywords
amides useful
heteroaryl amides
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054547A
Other languages
English (en)
Inventor
John Gordon Allen
Abhisek Banerjee
Matthew Paul Bourbeau
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Matthew Richard Kaller
Kexue Li
Thomas T Nguyen
Nobuko Nishimura
Nuria A Tamayo
Qiufen May Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54547A publication Critical patent/MA54547A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA054547A 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a MA54547A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783053P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54547A true MA54547A (fr) 2022-03-30

Family

ID=69374368

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054547A MA54547A (fr) 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Country Status (9)

Country Link
US (1) US12441736B2 (fr)
EP (1) EP3898592B1 (fr)
JP (1) JP7676308B2 (fr)
AU (1) AU2019401495B2 (fr)
CA (1) CA3123044A1 (fr)
ES (1) ES2997190T3 (fr)
MA (1) MA54547A (fr)
MX (1) MX2021007157A (fr)
WO (1) WO2020132653A1 (fr)

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IL283639B2 (en) * 2018-12-20 2024-06-01 Amgen Inc Kif18a inhibitors
MA54547A (fr) 2018-12-20 2022-03-30 Amgen Inc Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a
MX2022001296A (es) * 2019-08-02 2022-02-22 Amgen Inc Inhibidores de kif18a.
WO2021026101A1 (fr) * 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
US20220289724A1 (en) * 2019-08-02 2022-09-15 Amgen Inc. Kif18a inhibitors
CA3147276A1 (fr) 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
CA3198809A1 (fr) 2020-10-20 2022-04-28 Amgen Inc. Composes spiro heterocycliques et methodes d'utilisation
JP2023549055A (ja) 2020-10-27 2023-11-22 アムジエン・インコーポレーテツド 複素環式スピロ化合物及びその使用方法
WO2022232332A1 (fr) 2021-04-29 2022-11-03 Amgen Inc. Composés de 2-aminobenzothiazole et leurs procédés d'utilisation
JP7773801B2 (ja) * 2021-06-25 2025-11-20 ハンジョウ イノゲート ファーマ カンパニー リミテッド Ｋｉｆ１８ａ阻害剤としての化合物
CA3230123A1 (fr) * 2021-08-26 2023-03-02 Derek A. Cogan Inhibiteurs spiro-indoliniques de la kif18a
WO2023041055A1 (fr) * 2021-09-16 2023-03-23 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
EP4434979A4 (fr) * 2021-11-19 2025-10-29 Wigen Biomedicine Tech Shanghai Co Ltd Inhibiteur de kif18a
EP4472966A4 (fr) * 2022-02-04 2026-01-14 Latigo Biotherapeutics Inc Composés bloquant les canaux de sodium, leurs dérivés et leurs procédés d'utilisation
EP4479398A1 (fr) 2022-02-16 2024-12-25 Amgen Inc. Composés quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
WO2023159086A1 (fr) 2022-02-16 2023-08-24 Amgen Inc. Composés de quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
US20250197382A1 (en) * 2022-03-17 2025-06-19 Wigen Biomedicine Technology (shanghai) Co., Ltd. Kif18a inhibitor
TW202346288A (zh) * 2022-04-28 2023-12-01 美商佛拉斯托醫療公司 用於抑制ｋｉｆ１８ａ之化合物
CN116554151B (zh) * 2022-05-13 2024-09-20 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
EP4524135A4 (fr) * 2022-05-13 2025-08-20 Shanghai Apeiron Therapeutics Company Ltd Inhibiteur de kinésine kif18a et son utilisation
CN119487026A (zh) * 2022-06-30 2025-02-18 勤浩医药（苏州）有限公司 一种含氮化合物及其应用
WO2024022508A1 (fr) * 2022-07-29 2024-02-01 武汉人福创新药物研发中心有限公司 Inhibiteur de la kif18a et utilisation
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
EP4572855A1 (fr) 2022-08-18 2025-06-25 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
WO2024083208A1 (fr) * 2022-10-21 2024-04-25 杭州邦顺制药有限公司 Inhibiteur de protéine kif18a
WO2024099398A1 (fr) * 2022-11-10 2024-05-16 南京明德新药研发有限公司 Classe de composés sulfonamide contenant un hétérocycle ortho-condensé et leur utilisation
JP2025539080A (ja) 2022-11-14 2025-12-03 アムジエン・インコーポレーテツド 大環状ｋｒａｓ阻害剤及び使用方法
EP4628486A1 (fr) * 2022-12-02 2025-10-08 Shenzhen Zhongge Biological Technology Co., Ltd. Composé amide ou urée
WO2024125488A1 (fr) * 2022-12-14 2024-06-20 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation pharmaceutique
WO2024137984A1 (fr) * 2022-12-22 2024-06-27 Accent Therapeutics, Inc. Inhibiteurs de kif18a et utilisations associées
WO2024146593A1 (fr) * 2023-01-05 2024-07-11 浙江海正药业股份有限公司 Dérivé d'amide aromatique, son procédé de préparation et son utilisation médicale
WO2024156288A1 (fr) * 2023-01-29 2024-08-02 Shanghai Kygent Pharmaceutical Co., Ltd Inhibiteurs de dnmt1, compositions pharmaceutiques et applications thérapeutiques
TW202438053A (zh) * 2023-02-23 2024-10-01 美商佛拉斯托醫療公司 Ｋｉｆ１８ａ吲哚啉抑制劑之固體調配物及多晶形式
WO2024217348A1 (fr) * 2023-04-18 2024-10-24 南京同诺康医药科技有限公司 Inhibiteur de kif18a, son procédé de préparation et son utilisation
CN121693499A (zh) * 2023-08-16 2026-03-17 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
WO2025194057A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025194054A1 (fr) 2024-03-14 2025-09-18 Amgen Inc. Composés spirocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025217247A1 (fr) 2024-04-10 2025-10-16 Amgen Inc. Inhibiteurs spiro-hétérocycliques ancrés de protéines mutantes kras g12c et leurs utilisations
WO2025230878A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025230862A1 (fr) 2024-04-29 2025-11-06 Amgen Inc. Composés aminés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2025240582A1 (fr) 2024-05-14 2025-11-20 Amgen Inc. Composés macrocycliques utilisés en tant que modulateurs de kras et leurs utilisations
WO2026055477A1 (fr) 2024-09-06 2026-03-12 Amgen Inc. Composés macrocycliques constituant des modulateurs de kras et leurs utilisations

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EP3898592C0 (fr) 2024-10-09
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ES2997190T3 (en) 2025-02-14
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