WO2009060945A1 - 血管新生阻害物質と抗腫瘍性白金錯体との併用 - Google Patents

血管新生阻害物質と抗腫瘍性白金錯体との併用 Download PDF

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Publication number
WO2009060945A1
WO2009060945A1 PCT/JP2008/070321 JP2008070321W WO2009060945A1 WO 2009060945 A1 WO2009060945 A1 WO 2009060945A1 JP 2008070321 W JP2008070321 W JP 2008070321W WO 2009060945 A1 WO2009060945 A1 WO 2009060945A1
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WO
WIPO (PCT)
Prior art keywords
combination
platinum complex
tumor platinum
angiogenic substance
tumor
Prior art date
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PCT/JP2008/070321
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English (en)
French (fr)
Inventor
Yuji Yamamoto
Original Assignee
Eisai R & D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Eisai R & D Management Co., Ltd. filed Critical Eisai R & D Management Co., Ltd.
Priority to CA2704000A priority Critical patent/CA2704000C/en
Priority to EP08846814.5A priority patent/EP2218712B1/en
Priority to KR1020107011023A priority patent/KR101513326B1/ko
Priority to JP2009540099A priority patent/JP5638244B2/ja
Priority to CN2008801150117A priority patent/CN101848895B/zh
Priority to AU2008325608A priority patent/AU2008325608B2/en
Priority to US12/741,682 priority patent/US8952035B2/en
Publication of WO2009060945A1 publication Critical patent/WO2009060945A1/ja
Priority to IL205512A priority patent/IL205512A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)

Abstract

　本発明の課題は、優れた抗腫瘍効果を示す医薬組成物および癌の治療方法を見出すことにある。 　４－（３－クロロ－４－（シクロプロピルアミノカルボニル）アミノフェノキシ）－７－メトキシ－６－キノリンカルボキサミドおよびその類似化合物、またはその薬理学的に許容される塩、またはそれらの溶媒和物は、抗腫瘍性白金錯体と併用することにより優れた抗腫瘍効果を示すことができる。
PCT/JP2008/070321 2007-11-09 2008-11-07 血管新生阻害物質と抗腫瘍性白金錯体との併用 WO2009060945A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2704000A CA2704000C (en) 2007-11-09 2008-11-07 Combination of anti-angiogenic substance and anti-tumor platinum complex
EP08846814.5A EP2218712B1 (en) 2007-11-09 2008-11-07 Combination of anti-angiogenic substance and anti-tumor platinum complex
KR1020107011023A KR101513326B1 (ko) 2007-11-09 2008-11-07 혈관 신생 저해 물질과 항종양성 백금 착물의 병용
JP2009540099A JP5638244B2 (ja) 2007-11-09 2008-11-07 血管新生阻害物質と抗腫瘍性白金錯体との併用
CN2008801150117A CN101848895B (zh) 2007-11-09 2008-11-07 血管新生抑制物质和抗肿瘤性铂络合物的组合使用
AU2008325608A AU2008325608B2 (en) 2007-11-09 2008-11-07 Combination of anti-angiogenic substance and anti-tumor platinum complex
US12/741,682 US8952035B2 (en) 2007-11-09 2008-11-07 Combination of anti-angiogenic substance and anti-tumor platinum complex
IL205512A IL205512A (en) 2007-11-09 2010-05-03 Pharmaceutical preparations, kits, and combinations for the treatment of non-small cell lung cancer containing 4- (3-chloro-4- (cyclopropylaminocarbonyl) aminophenoxy) -7-methoxy-6-quinolinecarboxamide and one or more anticancer conjugates containing platinum and cisplatin.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98664107P 2007-11-09 2007-11-09
US60/986,641 2007-11-09

Publications (1)

Publication Number Publication Date
WO2009060945A1 true WO2009060945A1 (ja) 2009-05-14

Family

ID=40625831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070321 WO2009060945A1 (ja) 2007-11-09 2008-11-07 血管新生阻害物質と抗腫瘍性白金錯体との併用

Country Status (9)

Country Link
US (1) US8952035B2 (ja)
EP (1) EP2218712B1 (ja)
JP (1) JP5638244B2 (ja)
KR (1) KR101513326B1 (ja)
CN (1) CN101848895B (ja)
AU (1) AU2008325608B2 (ja)
CA (1) CA2704000C (ja)
IL (1) IL205512A (ja)
WO (1) WO2009060945A1 (ja)

Cited By (18)

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WO2011162343A1 (ja) * 2010-06-25 2011-12-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 キナーゼ阻害作用を有する化合物の併用による抗腫瘍剤
WO2012144463A1 (ja) * 2011-04-18 2012-10-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療剤
US8759530B2 (en) 2011-03-29 2014-06-24 Eisai R&D Management Co., Ltd. Method for producing phenoxypyridine derivative
US8815241B2 (en) 2005-11-07 2014-08-26 Eisai R&D Management Co., Ltd. Use of combination of anti-angiogenic substance and c-kit kinase inhibitor
US8865737B2 (en) 2006-08-28 2014-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for undifferentiated gastric cancer
US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
JPWO2012164954A1 (ja) * 2011-06-01 2015-02-23 株式会社ツムラ 集合データの類似性評価方法、類似性評価プログラム、及び類似性評価装置
US8962655B2 (en) 2007-01-29 2015-02-24 Eisai R&D Management Co., Ltd. Composition for treatment of undifferentiated gastric cancer
US8969379B2 (en) 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
US8969344B2 (en) 2005-08-02 2015-03-03 Eisai R&D Management Co., Ltd. Method for assay on the effect of vascularization inhibitor
US9006256B2 (en) 2006-05-18 2015-04-14 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
US9334239B2 (en) 2012-12-21 2016-05-10 Eisai R&D Management Co., Ltd. Amorphous form of quinoline derivative, and method for producing same
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US10259791B2 (en) 2014-08-28 2019-04-16 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
US10517861B2 (en) 2013-05-14 2019-12-31 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
US11090386B2 (en) 2015-02-25 2021-08-17 Eisai R&D Management Co., Ltd. Method for suppressing bitterness of quinoline derivative
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
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ES2318649T3 (es) 2000-10-20 2009-05-01 EISAI R&D MANAGEMENT CO., LTD. Procedimiento de preparacion de derivados de 4-fenoxi quinolinas.
US20100105031A1 (en) * 2005-08-01 2010-04-29 Esai R & D Management Co., Ltd. Method for prediction of the efficacy of vascularization inhibitor
ES2705698T3 (es) 2013-06-26 2019-03-26 Eisai R&D Man Co Ltd Terapia de combinación para el tratamiento del cáncer que comprende eribulina y lenvatinib
US20190000797A1 (en) * 2015-08-20 2019-01-03 Eisai R&D Management Co., Ltd. Tumor therapeutic agent
SG11202006617RA (en) 2018-01-10 2020-08-28 Eisai R&D Man Co Ltd Combination therapies for the treatment of hepatocellular carcinoma
CN113679720A (zh) * 2020-05-19 2021-11-23 江苏苏中药业集团股份有限公司 一种取代丁烯酰胺联合铂类化合物的药物组合物及其用途

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AU2008325608B2 (en) 2013-03-14
US20100239688A1 (en) 2010-09-23
CN101848895B (zh) 2013-10-23
EP2218712B1 (en) 2015-07-01
AU2008325608A1 (en) 2009-05-14
CA2704000C (en) 2016-12-13
EP2218712A4 (en) 2012-07-18
US8952035B2 (en) 2015-02-10
IL205512A0 (en) 2010-12-30
CN101848895A (zh) 2010-09-29
EP2218712A1 (en) 2010-08-18
CA2704000A1 (en) 2009-05-14
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