NO20011303L - Fremgangsmåter for nukleinsyreoppformering og sekvensering - Google Patents

Fremgangsmåter for nukleinsyreoppformering og sekvensering

Info

Publication number
NO20011303L
NO20011303L NO20011303A NO20011303A NO20011303L NO 20011303 L NO20011303 L NO 20011303L NO 20011303 A NO20011303 A NO 20011303A NO 20011303 A NO20011303 A NO 20011303A NO 20011303 L NO20011303 L NO 20011303L
Authority
NO
Norway
Prior art keywords
sequencing
methods
nucleic acid
acid propagation
propagation
Prior art date
Application number
NO20011303A
Other languages
English (en)
Norwegian (no)
Other versions
NO20011303D0 (no
Inventor
Celine Adessi
Eric Kawashima
Pascal Mayer
Jean-Jacques Mermod
Gerardo Turcatti
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20011303D0 publication Critical patent/NO20011303D0/no
Publication of NO20011303L publication Critical patent/NO20011303L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO20011303A 1998-09-30 2001-03-14 Fremgangsmåter for nukleinsyreoppformering og sekvensering NO20011303L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98307985 1998-09-30
PCT/GB1999/003248 WO2000018957A1 (en) 1998-09-30 1999-09-30 Methods of nucleic acid amplification and sequencing

Publications (2)

Publication Number Publication Date
NO20011303D0 NO20011303D0 (no) 2001-03-14
NO20011303L true NO20011303L (no) 2001-05-22

Family

ID=8235083

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20011303A NO20011303L (no) 1998-09-30 2001-03-14 Fremgangsmåter for nukleinsyreoppformering og sekvensering

Country Status (25)

Country Link
US (4) US7115400B1 (de)
EP (2) EP1634963B1 (de)
JP (1) JP2002525125A (de)
KR (1) KR20010085860A (de)
CN (1) CN1325458A (de)
AR (1) AR021833A1 (de)
AT (1) ATE311474T1 (de)
AU (1) AU771073B2 (de)
BG (1) BG105363A (de)
BR (1) BR9914159A (de)
CA (1) CA2344575A1 (de)
CZ (1) CZ20011183A3 (de)
DE (1) DE69928683T2 (de)
EA (1) EA004271B1 (de)
EE (1) EE200100195A (de)
HK (1) HK1042525A1 (de)
HU (1) HUP0105052A3 (de)
IL (1) IL142178A0 (de)
NO (1) NO20011303L (de)
NZ (1) NZ510599A (de)
PL (1) PL347125A1 (de)
SK (1) SK4292001A3 (de)
TR (1) TR200100911T2 (de)
WO (1) WO2000018957A1 (de)
ZA (1) ZA200102420B (de)

Families Citing this family (783)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837913T2 (de) 1997-04-01 2008-02-07 Solexa Ltd., Saffron Walden Verfahren zur vervielfältigung von nukleinsäure
US20100130368A1 (en) * 1998-07-30 2010-05-27 Shankar Balasubramanian Method and system for sequencing polynucleotides
AR021833A1 (es) * 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
DE10027040A1 (de) * 2000-06-02 2001-12-06 Basf Lynx Bioscience Ag Verfahren zur Herstellung von DNA-Arrays
AR031640A1 (es) * 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
ATE397095T1 (de) 2001-04-20 2008-06-15 Penn State Res Found Verfahren zur manipulation von nukleinsäuren
US7195908B2 (en) * 2002-10-31 2007-03-27 Corning Incorporated Supports treated with triamine for immobilizing biomolecules
WO2004083443A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
JP4473878B2 (ja) 2003-01-29 2010-06-02 ４５４ コーポレーション 核酸を増幅および配列決定する方法
JP2007525571A (ja) 2004-01-07 2007-09-06 ソレクサ リミテッド 修飾分子アレイ
EP1758981A4 (de) 2004-05-28 2013-01-16 Wafergen Inc Vorrichtungen und verfahren für multiplex-analysen
GB0427236D0 (en) * 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
EP1828412B2 (de) † 2004-12-13 2019-01-09 Illumina Cambridge Limited Verbessertes nukleotidnachweisverfahren
EP2233582A1 (de) 2005-02-01 2010-09-29 AB Advanced Genetic Analysis Corporation Nukleinsäuresequenzierung durch schrittweise Duplexverlängerung
AU2006210553A1 (en) 2005-02-01 2006-08-10 Ab Advanced Genetic Analysis Corporation Reagents, methods and libraries for bead-based sequencing
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0514935D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Methods for sequencing a polynucleotide template
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
GB0524069D0 (en) 2005-11-25 2006-01-04 Solexa Ltd Preparation of templates for solid phase amplification
AU2006331512B2 (en) * 2005-12-22 2012-02-23 Pacific Biosciences Of California, Inc. Active surface coupled polymerases
CN101415839B (zh) 2006-02-08 2012-06-27 亿明达剑桥有限公司 对多核苷酸模板进行测序的方法
EP2021503A1 (de) * 2006-03-17 2009-02-11 Solexa Ltd. Isothermische methoden zur entstehung von arrays von einzelnen molekülen
WO2007111937A1 (en) 2006-03-23 2007-10-04 Applera Corporation Directed enrichment of genomic dna for high-throughput sequencing
US8921073B2 (en) 2006-06-23 2014-12-30 Illumina, Inc. Devices and systems for creation of DNA cluster arrays
US9328378B2 (en) * 2006-07-31 2016-05-03 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
US8334099B2 (en) * 2006-07-31 2012-12-18 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
JPWO2008018355A1 (ja) * 2006-08-08 2009-12-24 シャープ株式会社 バイオセンサ及びその製造方法並びに当該バイオセンサを用いた検出方法
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2008045158A1 (en) 2006-10-10 2008-04-17 Illumina, Inc. Compositions and methods for representational selection of nucleic acids fro complex mixtures using hybridization
WO2008069906A2 (en) * 2006-11-14 2008-06-12 The Regents Of The University Of California Digital expression of gene analysis
US8315817B2 (en) 2007-01-26 2012-11-20 Illumina, Inc. Independently removable nucleic acid sequencing system and method
CA2676570C (en) * 2007-01-26 2016-05-03 Illumina, Inc. Nucleic acid sequencing system and method
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
US9598724B2 (en) 2007-06-01 2017-03-21 Ibis Biosciences, Inc. Methods and compositions for multiple displacement amplification of nucleic acids
EP2167519A4 (de) * 2007-06-16 2011-04-13 Scarab Genomics Llc Nukleinsäureverpackungssystem
WO2008157640A2 (en) 2007-06-18 2008-12-24 Illumina, Inc. Microfabrication methods for the optimal patterning of substrates
JP2009000070A (ja) * 2007-06-22 2009-01-08 Hitachi Ltd 大規模並列核酸分析方法
US8759077B2 (en) 2007-08-28 2014-06-24 Lightspeed Genomics, Inc. Apparatus for selective excitation of microparticles
US8222040B2 (en) * 2007-08-28 2012-07-17 Lightspeed Genomics, Inc. Nucleic acid sequencing by selective excitation of microparticles
EP2191011B1 (de) * 2007-08-29 2017-03-29 Illumina Cambridge Limited Verfahren zur sequenzierung einer polynukleotidmatrize
WO2009029728A1 (en) 2007-08-29 2009-03-05 Applied Biosystems Inc. Alternative nucleic acid sequencing methods
US8716190B2 (en) 2007-09-14 2014-05-06 Affymetrix, Inc. Amplification and analysis of selected targets on solid supports
US9388457B2 (en) 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7767441B2 (en) * 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
JP2009178159A (ja) * 2007-11-05 2009-08-13 Hitachi Plant Technologies Ltd 核酸配列の検出方法及び核酸配列検出基板
US8202691B2 (en) * 2008-01-25 2012-06-19 Illumina, Inc. Uniform fragmentation of DNA using binding proteins
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
WO2009137521A2 (en) * 2008-05-07 2009-11-12 Illumina, Inc. Compositions and methods for providing substances to and from an array
US8407012B2 (en) * 2008-07-03 2013-03-26 Cold Spring Harbor Laboratory Methods and systems of DNA sequencing
EP2302028B1 (de) 2008-07-09 2013-09-11 Panasonic Corporation Sequenzer
US20100069250A1 (en) * 2008-08-16 2010-03-18 The Board Of Trustees Of The Leland Stanford Junior University Digital PCR Calibration for High Throughput Sequencing
GB2467691A (en) 2008-09-05 2010-08-11 Aueon Inc Methods for stratifying and annotating cancer drug treatment options
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
WO2010038042A1 (en) 2008-10-02 2010-04-08 Illumina Cambridge Ltd. Nucleic acid sample enrichment for sequencing applications
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
AU2009319907B2 (en) 2008-11-03 2015-10-01 The Regents Of The University Of California Methods for detecting modification resistant nucleic acids
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
AU2009311588B2 (en) 2008-11-07 2016-07-28 Adaptive Biotechnologies Corp. Methods of monitoring conditions by sequence analysis
EP2373817A4 (de) * 2008-12-10 2013-01-02 Illumina Inc Verfahren und zusammensetzungen zur hybridisierung von nukleinsäuren
EP2379748A4 (de) * 2008-12-23 2012-08-29 Illumina Inc Multibase-freisetzung für lange auslesevorgänge bei squenzierungen mittels syntheseprotokollen
HUE029424T2 (en) 2009-01-15 2017-02-28 Adaptive Biotechnologies Corp Adaptive immunity profiling and a method for producing monoclonal antibodies
US20100216648A1 (en) 2009-02-20 2010-08-26 Febit Holding Gmbh Synthesis of sequence-verified nucleic acids
JP5600880B2 (ja) * 2009-03-03 2014-10-08 東洋紡株式会社 改良された増幅試薬
JP5239978B2 (ja) * 2009-03-23 2013-07-17 パナソニック株式会社 センサおよびシーケンサー
US20100285970A1 (en) * 2009-03-31 2010-11-11 Rose Floyd D Methods of sequencing nucleic acids
WO2010115100A1 (en) * 2009-04-03 2010-10-07 L&C Diagment, Inc. Multiplex nucleic acid detection methods and systems
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
JP2012525147A (ja) 2009-04-30 2012-10-22 グッド スタート ジェネティクス， インコーポレイテッド 遺伝マーカーを評価するための方法および組成物
EP2248914A1 (de) 2009-05-05 2010-11-10 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Die Verwendung von IIB-Restriktionsendonukleasen in Sequenzierungsanwendungen der zweiten Generation
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
KR20120044941A (ko) 2009-06-25 2012-05-08 프레드 헛친슨 켄서 리서치 센터 적응 면역의 측정방법
US10036063B2 (en) 2009-07-24 2018-07-31 Illumina, Inc. Method for sequencing a polynucleotide template
WO2011014811A1 (en) 2009-07-31 2011-02-03 Ibis Biosciences, Inc. Capture primers and capture sequence linked solid supports for molecular diagnostic tests
EP2464729B9 (de) 2009-08-14 2014-12-31 Epicentre Technologies Corporation Verfahren, zusammensetzungen und kits zur erzeugung rrna-armer proben oder zur isolierung von rrna aus proben
PL2669387T3 (pl) 2009-08-25 2016-12-30 Sposoby selekcji i amplifikacji polinukleotydów
US8182994B2 (en) * 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
US10385391B2 (en) * 2009-09-22 2019-08-20 President And Fellows Of Harvard College Entangled mate sequencing
ES2628739T3 (es) 2009-10-15 2017-08-03 Ibis Biosciences, Inc. Amplificación por desplazamiento múltiple
US8524450B2 (en) 2009-10-30 2013-09-03 Illumina, Inc. Microvessels, microparticles, and methods of manufacturing and using the same
CN102648295B (zh) 2009-12-07 2017-08-08 伊鲁米那股份有限公司 用于多重基因分型的多样品索引
EP2848703A1 (de) 2010-01-19 2015-03-18 Verinata Health, Inc Gleichzeitige Bestimmung von Aneupolidie- und Fötus-DNA-Fraktion
AU2011207544A1 (en) 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
WO2011090556A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Methods for determining fraction of fetal nucleic acid in maternal samples
WO2011091063A1 (en) 2010-01-19 2011-07-28 Verinata Health, Inc. Partition defined detection methods
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US9499814B2 (en) * 2010-01-22 2016-11-22 The Regents Of The University Of California Methods for identifying drug effects on a cell by determining changes in the cell's spliced message profile
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8759037B2 (en) 2010-02-23 2014-06-24 Illumina Cambridge Limited Amplification methods to minimise sequence specific bias
CN202281746U (zh) 2010-03-06 2012-06-20 伊鲁米那股份有限公司 检测来自样品光信号的测定设备及其光学组件和光学系统
US8502867B2 (en) 2010-03-19 2013-08-06 Lightspeed Genomics, Inc. Synthetic aperture optics imaging method using minimum selective excitation patterns
US9465228B2 (en) 2010-03-19 2016-10-11 Optical Biosystems, Inc. Illumination apparatus optimized for synthetic aperture optics imaging using minimum selective excitation patterns
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
JP6158080B2 (ja) 2010-05-06 2017-07-05 アダプティヴ バイオテクノロジーズ コーポレーション クロノタイププロファイルを用いた健康状態および疾患状態のモニタリング
WO2011140489A2 (en) * 2010-05-06 2011-11-10 Ibis Biosciences, Inc. Integrated sample preparation systems and stabilized enzyme mixtures
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
CA3037126C (en) 2010-05-18 2023-09-12 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
CN103069005A (zh) 2010-06-07 2013-04-24 艾索特里克斯遗传实验室有限责任公司 核酸计数
US9353412B2 (en) 2010-06-18 2016-05-31 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
CN103069006A (zh) 2010-07-23 2013-04-24 艾索特里克斯遗传实验室有限责任公司 区别表达的胚胎或母源基因组区的鉴定及其用途
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
EP2426214A1 (de) 2010-09-01 2012-03-07 Koninklijke Philips Electronics N.V. Verfahren zur Amplifikation von Nukleinsäuren
AU2011301935B2 (en) 2010-09-16 2015-06-11 Ibis Biosciences, Inc. Stabilization of ozone-labile fluorescent dyes by thiourea
EP2619329B1 (de) 2010-09-24 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer
US8759038B2 (en) 2010-09-29 2014-06-24 Illumina Cambridge Limited Compositions and methods for sequencing nucleic acids
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
EA022475B1 (ru) * 2010-10-19 2016-01-29 Ооо "Центр Инновационных Технологий-Нано" Способ секвенирования днк
EP2633069B1 (de) 2010-10-26 2015-07-01 Illumina, Inc. Sequenzierungsverfahren
WO2012058096A1 (en) 2010-10-27 2012-05-03 Illumina, Inc. Microdevices and biosensor cartridges for biological or chemical analysis and systems and methods for the same
US8575071B2 (en) 2010-11-03 2013-11-05 Illumina, Inc. Reducing adapter dimer formation
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
EP2643484A4 (de) 2010-11-22 2014-04-16 Univ California Verfahren zur identifizierung eines rna-transkripts zellulären ursprungs
US20120152743A1 (en) * 2010-12-17 2012-06-21 General Electric Company Method for electroeluting genetic material from dried samples
CN103370425B (zh) 2010-12-17 2019-03-19 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
JP5616773B2 (ja) 2010-12-21 2014-10-29 株式会社日立ハイテクノロジーズ 核酸分析用反応デバイス、及び核酸分析装置
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012092265A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9217132B2 (en) 2011-01-20 2015-12-22 Ibis Biosciences, Inc. Microfluidic transducer
WO2012106546A2 (en) 2011-02-02 2012-08-09 University Of Washington Through Its Center For Commercialization Massively parallel continguity mapping
WO2012106072A2 (en) * 2011-02-03 2012-08-09 Illumina, Inc. Methods for minimizing sequence specific bias
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
JP6211931B2 (ja) 2011-03-09 2017-10-11 セル・シグナリング・テクノロジー・インコーポレイテツド モノクローナル抗体を作製するための方法および試薬
RS57837B1 (sr) 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
CN103748236B (zh) 2011-04-15 2018-12-25 约翰·霍普金斯大学 安全测序系统
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
CN104126191A (zh) 2011-07-13 2014-10-29 多发性骨髓瘤研究基金会公司 数据采集和分发方法
WO2013022778A1 (en) 2011-08-05 2013-02-14 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
HUE056246T2 (hu) 2011-09-23 2022-02-28 Illumina Inc Készítmények nukleinsav-szekvenáláshoz
WO2013049135A1 (en) 2011-09-26 2013-04-04 Gen-Probe Incorporated Algorithms for sequence determinations
EP2768983A4 (de) 2011-10-17 2015-06-03 Good Start Genetics Inc Analyseverfahren
CN104080958A (zh) 2011-10-19 2014-10-01 纽亘技术公司 用于定向核酸扩增和测序的组合物和方法
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
WO2013063308A1 (en) 2011-10-25 2013-05-02 University Of Massachusetts An enzymatic method to enrich for capped rna, kits for performing same, and compositions derived therefrom
CA2856163C (en) 2011-10-28 2019-05-07 Illumina, Inc. Microarray fabrication system and method
WO2013065499A1 (ja) 2011-10-31 2013-05-10 株式会社 日立ハイテクノロジーズ 核酸増幅法、核酸基板、核酸分析方法及び核酸分析装置
ES2683037T3 (es) 2011-12-09 2018-09-24 Adaptive Biotechnologies Corporation Diagnóstico de tumores malignos linfoides y detección de enfermedad residual mínima
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
EP2795333A4 (de) 2011-12-20 2016-02-17 Univ Michigan Pseudogene und verwendungen davon
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
US20150329855A1 (en) 2011-12-22 2015-11-19 Ibis Biosciences, Inc. Amplification primers and methods
WO2013096799A1 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
WO2013096819A2 (en) 2011-12-22 2013-06-27 Ibis Biosciences, Inc. Macromolecule positioning by electrical potential
US20140349858A1 (en) 2011-12-22 2014-11-27 Ibis Bioscience, Inc. Amplification of a sequence from a ribonucleic acid
WO2013102091A1 (en) 2011-12-28 2013-07-04 Ibis Biosciences, Inc. Nucleic acid ligation systems and methods
US9823246B2 (en) 2011-12-28 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon
US9803231B2 (en) 2011-12-29 2017-10-31 Ibis Biosciences, Inc. Macromolecule delivery to nanowells
EP2872523B1 (de) 2011-12-30 2018-01-17 Abbott Molecular Inc. Mikroorganismus-nukleinsäurereinigung von wirtsproben
EP2802673B1 (de) 2012-01-09 2019-07-03 Oslo Universitetssykehus HF Verfahren und biomarker zur analyse von kolorektalkarzinomen
EP3434789A1 (de) 2012-01-13 2019-01-30 Data2Bio Genotypisierung durch eine sequenzierung der nächsten generation
CN104093890B (zh) 2012-01-26 2016-04-20 纽亘技术公司 用于靶向核酸序列富集和高效文库产生的组合物和方法
WO2013117595A2 (en) 2012-02-07 2013-08-15 Illumina Cambridge Limited Targeted enrichment and amplification of nucleic acids on a support
PL3363901T3 (pl) 2012-02-17 2021-07-05 Fred Hutchinson Cancer Research Center Kompozycje i sposoby dokładnej identyfikacji mutacji
US9506117B2 (en) 2012-02-21 2016-11-29 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
DK2823060T3 (en) 2012-03-05 2018-05-28 Adaptive Biotechnologies Corp Determination of associated immune receptor chains from frequency-matched subunits
EP2823059A2 (de) 2012-03-06 2015-01-14 Oslo Universitetssykehus HF Gensignaturen in zusammenhang mit der wirksamkeit einer postmastektomie-strahlentherapie bei brustkrebs
NO2694769T3 (de) 2012-03-06 2018-03-03
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US20130261984A1 (en) 2012-03-30 2013-10-03 Illumina, Inc. Methods and systems for determining fetal chromosomal abnormalities
EP2834622B1 (de) 2012-04-03 2023-04-12 Illumina, Inc. Integrierter optoelektronischer lesekopf und fluidkartusche zur nucleinsäuresequenzierung
US9732387B2 (en) 2012-04-03 2017-08-15 The Regents Of The University Of Michigan Biomarker associated with irritable bowel syndrome and Crohn's disease
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US8812422B2 (en) 2012-04-09 2014-08-19 Good Start Genetics, Inc. Variant database
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
EP2844775B1 (de) 2012-05-02 2018-07-18 Ibis Biosciences, Inc. Dna-sequenzierung
WO2013166305A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
WO2013166303A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
US20150133310A1 (en) 2012-05-02 2015-05-14 Ibis Biosciences, Inc. Nucleic acid sequencing systems and methods
EP2831276B1 (de) 2012-05-08 2016-04-20 Adaptive Biotechnologies Corporation Zusammensetzungen und verfahren zum vermessen und kalibrieren eines amplifizierungs-bias in multiplexierten pcr-reaktionen
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
JP6181751B2 (ja) 2012-06-18 2017-08-16 ニューゲン テクノロジーズ， インコーポレイテッド 望まれない核酸配列のネガティブ選択のための組成物および方法
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
EP2870264A4 (de) 2012-07-03 2016-03-02 Sloan Kettering Inst Cancer Quantitative beurteilung der wiederherstellung eines menschlichen t-zellen-repertoires nach der transplantation allogener blutbildender stammzellen
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
EP2875173B1 (de) 2012-07-17 2017-06-28 Counsyl, Inc. System und verfahren zur erkennung von genetischen variationen
US9092401B2 (en) 2012-10-31 2015-07-28 Counsyl, Inc. System and methods for detecting genetic variation
US9977861B2 (en) 2012-07-18 2018-05-22 Illumina Cambridge Limited Methods and systems for determining haplotypes and phasing of haplotypes
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP4397767A3 (de) 2012-08-14 2024-07-31 10X Genomics, Inc. Mikrokapselzusammensetzungen und verfahren
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US9422602B2 (en) 2012-08-15 2016-08-23 Bio-Rad Laboratories, Inc. Methods and compositions for determining nucleic acid degradation
NL2017959B1 (en) 2016-12-08 2018-06-19 Illumina Inc Cartridge assembly
CA3178340A1 (en) 2012-08-20 2014-02-27 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
DK2897978T3 (en) 2012-09-19 2017-05-15 Abbvie Biotherapeutics Inc PROCEDURES FOR IDENTIFYING ANTIBODIES WITH REDUCED IMMUNOGENICITY
WO2014055561A1 (en) 2012-10-01 2014-04-10 Adaptive Biotechnologies Corporation Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization
EP2909343B1 (de) 2012-10-16 2018-10-10 Abbott Molecular Inc. Verfahren zum sequenzieren einer nukleinsäure
US9365896B2 (en) 2012-10-19 2016-06-14 Agilent Technologies, Inc. Addition of an adaptor by invasive cleavage
EP2912197B1 (de) 2012-10-24 2019-08-07 Takara Bio USA, Inc. Auf vorlagenwechseln basierende verfahren zur herstellung einer produktnukleinsäure
PL2912468T3 (pl) 2012-10-29 2019-04-30 Univ Johns Hopkins Test papanicolaou pod kątem raka jajnika i endometrium
CA3140836A1 (en) 2012-11-21 2014-05-30 Courtagen Life Sciences Inc. A method of removing amplicons of a non-target nucleic acid having one or more methylated cytosines from a sample
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2894694C (en) 2012-12-14 2023-04-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
WO2014113204A1 (en) 2013-01-17 2014-07-24 Personalis, Inc. Methods and systems for genetic analysis
EP3998342A1 (de) 2013-02-08 2022-05-18 10X Genomics, Inc. Partitionierung und verarbeitung von analyten und andere arten
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
WO2014135223A1 (en) 2013-03-08 2014-09-12 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
ES2620423T3 (es) 2013-03-08 2017-06-28 Illumina Cambridge Limited Compuestos de polimetina y su uso como marcadores fluorescentes
US10557133B2 (en) 2013-03-13 2020-02-11 Illumina, Inc. Methods and compositions for nucleic acid sequencing
EP2969479B1 (de) 2013-03-13 2021-05-05 Illumina, Inc. Mehrschichtige fluidvorrichtungen und verfahren zu deren herstellung
EP2971169A4 (de) 2013-03-13 2016-10-26 Abbott Molecular Inc Systeme und verfahren zur isolierung von nukleinsäuren
US20140274736A1 (en) 2013-03-14 2014-09-18 Abbott Molecular Inc. Minimizing errors using uracil-dna-n-glycosylase
WO2014152421A1 (en) 2013-03-14 2014-09-25 Good Start Genetics, Inc. Methods for analyzing nucleic acids
EP2971154A4 (de) 2013-03-14 2017-03-01 Ibis Biosciences, Inc. Nukleinsäurekontrollpanels
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
EP3533884A1 (de) 2013-03-15 2019-09-04 Ibis Biosciences, Inc. Dna-sequenzen zur beurteilung der kontamination in der dna-sequenzierung
US9890425B2 (en) 2013-03-15 2018-02-13 Abbott Molecular Inc. Systems and methods for detection of genomic copy number changes
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
US20140274738A1 (en) 2013-03-15 2014-09-18 Nugen Technologies, Inc. Sequential sequencing
WO2014142981A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Enzyme-linked nucleotides
EP2970366B1 (de) 2013-03-15 2019-01-16 Ibis Biosciences, Inc. Nukleotidanaloga zur sequenzierung
WO2014171898A2 (en) 2013-04-17 2014-10-23 Agency For Science, Technology And Research Method for generating extended sequence reads
WO2014172288A2 (en) 2013-04-19 2014-10-23 Raindance Technologies, Inc. Digital analyte analysis
EP3005200A2 (de) 2013-06-03 2016-04-13 Good Start Genetics, Inc. Verfahren und systeme zur speicherung von sequenzlesedaten
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
DK3431614T3 (da) 2013-07-01 2021-12-06 Illumina Inc Katalysator fri overfladefunktionalisering og polymerpodning
EP3017063B1 (de) 2013-07-03 2017-04-05 Illumina, Inc. Sequenzierung durch orthogonale synthese
CA2917430C (en) 2013-07-25 2020-10-06 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
WO2015021080A2 (en) 2013-08-05 2015-02-12 Twist Bioscience Corporation De novo synthesized gene libraries
MX370560B (es) 2013-08-08 2019-12-17 Illumina Inc Sistema de fluidos para distribución de reactivo a una celda de flujo.
EP3626866B1 (de) 2013-08-19 2021-03-24 Abbott Molecular Inc. Sequenzierungsbibliotheken der nächsten generation
WO2015031849A1 (en) 2013-08-30 2015-03-05 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
WO2015051275A1 (en) 2013-10-03 2015-04-09 Personalis, Inc. Methods for analyzing genotypes
EP4389888A2 (de) 2013-10-17 2024-06-26 Takara Bio USA, Inc. Verfahren zum hinzufügen von adaptern zu nukleinsäuren und zusammensetzungen zur durchführung davon
HUE045954T2 (hu) 2013-10-17 2020-01-28 Illumina Inc Eljárások és készítmények nukleinsavkönyvtárak elõállítására
US11041203B2 (en) 2013-10-18 2021-06-22 Molecular Loop Biosolutions, Inc. Methods for assessing a genomic region of a subject
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
US10415083B2 (en) 2013-10-28 2019-09-17 The Translational Genomics Research Institute Long insert-based whole genome sequencing
JP6525473B2 (ja) 2013-11-13 2019-06-05 ニューゲン テクノロジーズ， インコーポレイテッド 複製物配列決定リードを同定するための組成物および方法
WO2015088913A1 (en) 2013-12-09 2015-06-18 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
BR112016013353B1 (pt) 2013-12-10 2020-11-24 Illumina, Inc Biossensor e metodo para produzir um biossensor
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
EP3083700B1 (de) 2013-12-17 2023-10-11 The Brigham and Women's Hospital, Inc. Bestimmung eines antikörpers gegen ein pathogen
US9719136B2 (en) 2013-12-17 2017-08-01 Takara Bio Usa, Inc. Methods for adding adapters to nucleic acids and compositions for practicing the same
EP3084523B1 (de) 2013-12-19 2019-07-03 Illumina, Inc. Substrate mit nanostrukturierungsoberflächen und verfahren zur herstellung davon
CN106414765A (zh) 2013-12-20 2017-02-15 Illumina公司 在片段化的基因组dna样品中保留基因组连接信息
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
AU2014377537B2 (en) 2014-01-16 2021-02-25 Illumina, Inc. Amplicon preparation and sequencing on solid supports
WO2015107430A2 (en) 2014-01-16 2015-07-23 Oslo Universitetssykehus Hf Methods and biomarkers for detection and prognosis of cervical cancer
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
LT3108009T (lt) 2014-02-18 2021-07-12 Illumina, Inc. Būdai ir kompozicijos, skirti dnr profiliavimui
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
US20170292149A1 (en) 2014-03-05 2017-10-12 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
EP3134541B1 (de) 2014-04-21 2020-08-19 Natera, Inc. Nachweis von ploidien in chromosomalen segmenten in krebs
WO2015175530A1 (en) 2014-05-12 2015-11-19 Gore Athurva Methods for detecting aneuploidy
WO2015175832A1 (en) 2014-05-16 2015-11-19 Illumina, Inc. Nucleic acid synthesis techniques
US10427155B2 (en) 2014-05-27 2019-10-01 Illumina, Inc. Systems and methods for biochemical analysis including a base instrument and a removable cartridge
GB201410022D0 (en) 2014-06-05 2014-07-16 Orion Diagnostica Oy Method
KR102499300B1 (ko) 2014-06-05 2023-02-10 일루미나, 인코포레이티드 시료 또는 시료 분석 중 적어도 하나를 위한 회전 밸브를 포함하는 시스템들 및 방법들
US10760109B2 (en) 2014-06-06 2020-09-01 The Regents Of The University Of Michigan Compositions and methods for characterizing and diagnosing periodontal disease
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
EP3155125A1 (de) 2014-06-13 2017-04-19 Illumina Cambridge Limited Verfahren und zusammensetzungen zur herstellung von sequenzierungsbibliotheken
GB201410646D0 (en) 2014-06-14 2014-07-30 Illumina Cambridge Ltd Methods of increasing sequencing accuracy
IL286474B2 (en) 2014-06-23 2023-11-01 Massachusetts Gen Hospital Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
EP3161157B1 (de) 2014-06-24 2024-03-27 Bio-Rad Laboratories, Inc. Digitales pcr-barcoding
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
JP2017526046A (ja) 2014-06-26 2017-09-07 １０エックス ゲノミクス，インコーポレイテッド 核酸配列アセンブルのプロセス及びシステム
JP2017521654A (ja) 2014-06-27 2017-08-03 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法
DK3161152T3 (en) 2014-06-30 2019-03-25 Illumina Inc Methods and compositions using one-sided transposition
RU2697502C2 (ru) 2014-07-24 2019-08-14 Эбботт Молекьюлар Инк. Композиции и способы обнаружения и анализа микобактерии туберкулеза (mycobacterium tuberculosis)
EP4219710A3 (de) 2014-08-01 2023-08-16 Dovetail Genomics, LLC Markierung von nukleinsäuren für sequenzassemblierung
US10102337B2 (en) 2014-08-06 2018-10-16 Nugen Technologies, Inc. Digital measurements from targeted sequencing
CA2956723C (en) 2014-08-12 2023-04-11 Nextgen Jane, Inc. System and method for monitoring health based on collected bodily fluid
US10174383B2 (en) 2014-08-13 2019-01-08 Vanadis Diagnostics Method of estimating the amount of a methylated locus in a sample
US9982250B2 (en) 2014-08-21 2018-05-29 Illumina Cambridge Limited Reversible surface functionalization
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
WO2016044391A1 (en) 2014-09-17 2016-03-24 Ibis Biosciences, Inc. Sequencing by synthesis using pulse read optics
WO2016044233A1 (en) 2014-09-18 2016-03-24 Illumina, Inc. Methods and systems for analyzing nucleic acid sequencing data
WO2016048829A1 (en) 2014-09-24 2016-03-31 Good Start Genetics, Inc. Process control for increased robustness of genetic assays
US10040048B1 (en) 2014-09-25 2018-08-07 Synthego Corporation Automated modular system and method for production of biopolymers
SG11201701974XA (en) 2014-10-09 2017-04-27 Illumina Inc Method and device for separating immiscible liquids to effectively isolate at least one of the liquids
WO2016061517A2 (en) 2014-10-17 2016-04-21 Illumina Cambridge Limited Contiguity preserving transposition
ES2784343T3 (es) 2014-10-29 2020-09-24 Adaptive Biotechnologies Corp Detección simultánea altamente multiplexada de ácidos nucleicos que codifican heterodímeros de receptores inmunes adaptativos emparejados de muchas muestras
AU2015339148B2 (en) 2014-10-29 2022-03-10 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
EP4026913A1 (de) 2014-10-30 2022-07-13 Personalis, Inc. Verfahren zur verwendung von mosaizismus in nukleinsäuren, die distal zu ihrem ursprung entnommen wurden
PL3212684T3 (pl) 2014-10-31 2020-10-19 Illumina Cambridge Limited Polimery i powłoki z kopolimeru DNA
EP3215846B1 (de) 2014-11-05 2020-03-11 Nirmidas Biotech, Inc. Metallverbundstoffe zur verbesserten bildgebung
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US10030268B2 (en) 2014-11-11 2018-07-24 Abbott Molecular Inc. Hybridization probes and methods
CN114438174A (zh) 2014-11-11 2022-05-06 伊鲁米那股份有限公司 使用crispr-cas系统的多核苷酸扩增
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US11789906B2 (en) 2014-11-19 2023-10-17 Arc Bio, Llc Systems and methods for genomic manipulations and analysis
US10233490B2 (en) 2014-11-21 2019-03-19 Metabiotech Corporation Methods for assembling and reading nucleic acid sequences from mixed populations
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
WO2016090266A1 (en) 2014-12-05 2016-06-09 Amyris, Inc. High-throughput sequencing of polynucleotides
EP3271480B8 (de) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Abtastung auf strukturelle varianten
KR102321863B1 (ko) 2015-01-12 2021-11-08 10엑스 제노믹스, 인크. 핵산 시퀀싱 라이브러리의 제조 방법 및 시스템 및 이를 이용하여 제조한 라이브러리
KR20170106979A (ko) 2015-01-13 2017-09-22 10엑스 제노믹스, 인크. 구조 변이 및 위상 조정 정보를 시각화하기 위한 시스템 및 방법
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
US10669304B2 (en) 2015-02-04 2020-06-02 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
CN107208156B (zh) 2015-02-09 2021-10-08 10X基因组学有限公司 用于使用变异识别数据来确定结构变异和定相的系统和方法
WO2016133764A1 (en) 2015-02-17 2016-08-25 Complete Genomics, Inc. Dna sequencing using controlled strand displacement
US10208339B2 (en) 2015-02-19 2019-02-19 Takara Bio Usa, Inc. Systems and methods for whole genome amplification
WO2016134342A1 (en) 2015-02-20 2016-08-25 Wafergen, Inc. Method for rapid accurate dispensing, visualization and analysis of single cells
AU2016222719B2 (en) 2015-02-24 2022-03-31 10X Genomics, Inc. Methods for targeted nucleic acid sequence coverage
CA2976580A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
EP4286516A3 (de) 2015-02-24 2024-03-06 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
AU2016235288B2 (en) 2015-03-24 2019-02-28 Illumina Cambridge Limited Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
CN107532205B (zh) 2015-03-31 2021-06-08 伊卢米纳剑桥有限公司 模板的表面连环化
US11041202B2 (en) 2015-04-01 2021-06-22 Adaptive Biotechnologies Corporation Method of identifying human compatible T cell receptors specific for an antigenic target
JP6828007B2 (ja) 2015-04-10 2021-02-10 スペーシャル トランスクリプトミクス アクチボラグ 生物学的試料の空間識別されるマルチプレックスな核酸分析
KR20170136555A (ko) 2015-04-15 2017-12-11 더 제너럴 하스피탈 코포레이션 Lna-기반 돌연변이체 농축 차세대 서열분석 검정
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
ES2961374T3 (es) 2015-04-24 2024-03-11 Atila Biosystems Incorporated Amplificación con cebadores de composición de nucleótidos limitada
WO2016170182A1 (en) 2015-04-24 2016-10-27 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on a solid support
WO2016170179A1 (en) 2015-04-24 2016-10-27 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on solid support
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
BR112017023188B1 (pt) 2015-05-11 2023-11-14 Illumina, Inc Plataforma para descoberta e análise de agentes terapêuticos
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
CN107532218A (zh) * 2015-05-18 2018-01-02 10X基因组学有限公司 稳定化还原剂及其使用方法
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
CN107849598B (zh) 2015-05-29 2021-12-14 伊卢米纳剑桥有限公司 簇中的表面引物的增强利用
WO2016196210A2 (en) 2015-05-29 2016-12-08 Illumina, Inc. Sample carrier and assay system for conducting designated reactions
US11274333B2 (en) 2015-05-29 2022-03-15 Molecular Cloning Laboratories (MCLAB) LLC Compositions and methods for preparing sequencing libraries
US10808282B2 (en) 2015-07-07 2020-10-20 Illumina, Inc. Selective surface patterning via nanoimprinting
EP3322805B1 (de) 2015-07-14 2021-10-20 Abbott Molecular Inc. Reinigung von nukleinsäuren unter verwendung von kupfer-titan-oxiden oder magnesium-titan-oxiden
CN108184327A (zh) 2015-07-14 2018-06-19 雅培分子公司 用于鉴定耐药性结核的组合物和方法
EP3325648B1 (de) 2015-07-17 2023-03-29 Illumina, Inc. Polymerfolien zur sequenzierung von anwendungen
EP3325654B1 (de) 2015-07-23 2020-06-10 Asuragen, Inc. Verfahren, zusammensetzungen, kits und verwendungen zur analyse von nukleinsäuren mit sich wiederholenden a/t-reichen segmenten
IL294145B2 (en) 2015-07-30 2024-02-01 Illumina Inc Removal of orthogonal blocking of nucleotides
WO2017024138A1 (en) 2015-08-06 2017-02-09 Arc Bio, Llc Systems and methods for genomic analysis
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
CN116338219A (zh) 2015-08-24 2023-06-27 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制系统
CN107921432A (zh) 2015-09-02 2018-04-17 伊卢米纳剑桥有限公司 改善流控系统中的液滴操作的系统和方法
WO2017042040A1 (en) 2015-09-09 2017-03-16 Qiagen Gmbh Polymerase enzyme
WO2017044843A1 (en) 2015-09-11 2017-03-16 The General Hospital Corporation Full interrogation of nuclease dsbs and sequencing (find-seq)
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
CN113604546A (zh) 2015-09-22 2021-11-05 特韦斯特生物科学公司 用于核酸合成的柔性基底
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
WO2017059313A1 (en) 2015-09-30 2017-04-06 The General Hospital Corporation Comprehensive in vitro reporting of cleavage events by sequencing (circle-seq)
WO2017087724A1 (en) 2015-11-17 2017-05-26 Omniome, Inc. Methods for determining sequence profiles
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
EP3384077A4 (de) 2015-12-01 2019-05-08 Twist Bioscience Corporation Funktionalisierte oberflächen und herstellung davon
DK3882357T3 (da) 2015-12-04 2022-08-29 10X Genomics Inc Fremgangsmåder og sammensætninger til analyse af nukleinsyrer
CA3090392C (en) 2015-12-07 2021-06-01 Zymergen Inc. Microbial strain improvement by a htp genomic engineering platform
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
CA3007635A1 (en) 2015-12-07 2017-06-15 Zymergen Inc. Promoters from corynebacterium glutamicum
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform
CN108431223A (zh) 2016-01-08 2018-08-21 生物辐射实验室股份有限公司 每液滴分辨率下的多个珠
CA3008031A1 (en) 2016-01-11 2017-07-20 Illumina Singapore Pte Ltd Detection apparatus having a microfluorometer, a fluidic system, and a flow cell latch clamp module
US10626390B2 (en) 2016-02-08 2020-04-21 RGENE, Inc. Multiple ligase compositions, systems, and methods
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
WO2017160788A2 (en) 2016-03-14 2017-09-21 RGENE, Inc. HYPER-THERMOSTABLE LYSINE-MUTANT ssDNA/RNA LIGASES
EP4071250A1 (de) 2016-03-22 2022-10-12 Myriad Women's Health, Inc. Kombinatorisches dna-screening
WO2017172798A1 (en) 2016-03-28 2017-10-05 Illumina, Inc. Multi-plane microarrays
EP3442706A4 (de) 2016-04-13 2020-02-19 NextGen Jane, Inc. Probensammel- und konservierungsvorrichtungen, systeme und verfahren
DK3455372T3 (da) 2016-05-11 2020-01-06 Illumina Inc Polynukleotidberigelse og -amplifikation ved anvendelse af argonautsystemer
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
WO2017201302A1 (en) 2016-05-18 2017-11-23 The University Of Chicago Btk mutation and ibrutinib resistance
CN109313396B (zh) 2016-05-18 2022-11-22 Illumina公司 使用图案化疏水性表面进行的自组装图案化
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
FI3464628T3 (fi) 2016-06-06 2024-05-03 Redvault Biosciences Lp Kohdereportterikonstruktit ja niiden käyttö
WO2017214557A1 (en) 2016-06-10 2017-12-14 Counsyl, Inc. Nucleic acid sequencing adapters and uses thereof
EP3472354A4 (de) 2016-06-17 2020-01-01 California Institute of Technology Nukleinsäurereaktionen sowie zugehörige verfahren und zusammensetzungen
WO2018005793A1 (en) 2016-06-30 2018-01-04 Zymergen Inc. Methods for generating a glucose permease library and uses thereof
EP3478833A4 (de) 2016-06-30 2019-10-02 Zymergen, Inc. Verfahren zum erzeugen einer bakteriellen hämoglobin-bibliothek und deren verwendung
US11091795B2 (en) 2016-07-11 2021-08-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
US10676734B2 (en) 2016-07-12 2020-06-09 Life Technologies Corporation Compositions and methods for detecting nucleic acid regions
CN106086203A (zh) * 2016-07-12 2016-11-09 深圳绿倍生态科技有限公司 一种小球藻核酸模板的制备方法及其应用
EP3487616B1 (de) 2016-07-21 2023-08-09 Takara Bio USA, Inc. Multi-z-bildgebung von wells von multi-well-geräten und flüssigkeitsabgabe in die wells
CA3026773C (en) 2016-07-22 2022-10-18 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
AU2017315252B2 (en) 2016-08-22 2023-03-16 Biolumic Limited System, device and methods of seed treatment
GB2568444A (en) 2016-08-22 2019-05-15 Twist Bioscience Corp De novo synthesized nucleic acid libraries
WO2018042251A1 (en) 2016-08-29 2018-03-08 Oslo Universitetssykehus Hf Chip-seq assays
WO2018057526A2 (en) 2016-09-21 2018-03-29 Twist Bioscience Corporation Nucleic acid based data storage
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
US11530352B2 (en) 2016-10-03 2022-12-20 Illumina, Inc. Fluorescent detection of amines and hydrazines and assaying methods thereof
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
CN111781139B (zh) 2016-10-14 2023-09-12 亿明达股份有限公司 夹盒组件
WO2018093780A1 (en) 2016-11-16 2018-05-24 Illumina, Inc. Validation methods and systems for sequence variant calls
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
AU2017378492B2 (en) 2016-12-16 2022-06-16 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
CN110139932B (zh) 2016-12-19 2024-05-17 生物辐射实验室股份有限公司 液滴加标的相邻性保留的标签化dna
EP4257596A3 (de) 2016-12-22 2023-12-06 Illumina Cambridge Limited Cumarinverbindungen und deren verwendungen als fluoreszente marker
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
PL3565905T3 (pl) 2017-01-04 2022-09-26 Mgi Tech Co., Ltd. Sekwencjonowanie kwasów nukleinowych z zastosowaniem odczynników powinowactwa
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
CA3050247A1 (en) 2017-01-18 2018-07-26 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
EP3354746B1 (de) 2017-01-30 2019-05-29 Gregor Mendel Institute of Molecular Plant Biology GmbH Neuartige spike-in-oligonukleotide zur normalisierung von sequenzdaten
WO2018144217A1 (en) 2017-01-31 2018-08-09 Counsyl, Inc. Methods and compositions for enrichment of target polynucleotides
WO2018144216A1 (en) 2017-01-31 2018-08-09 Counsyl, Inc. Methods and compositions for enrichment of target polynucleotides
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
WO2018148727A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from 9°n
WO2018148723A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from pyrococcus abyssi
WO2018148724A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from pyrococcus furiosus
US20200002689A1 (en) 2017-02-13 2020-01-02 Qiagen Sciences, Llc Polymerase enzyme from 9°n
WO2018148726A1 (en) 2017-02-13 2018-08-16 Qiagen Waltham Inc. Polymerase enzyme from phage t4
US11492666B2 (en) 2017-02-15 2022-11-08 Pacific Biosciences Of California, Inc. Distinguishing sequences by detecting polymerase dissociation
CA3054303A1 (en) 2017-02-22 2018-08-30 Twist Bioscience Corporation Nucleic acid based data storage
WO2018170169A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018175399A1 (en) 2017-03-24 2018-09-27 Bio-Rad Laboratories, Inc. Universal hairpin primers
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
US10737267B2 (en) 2017-04-04 2020-08-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
DK3872187T3 (da) 2017-04-23 2022-12-05 Illumina Cambridge Ltd Sammensætninger og fremgangsmåder til forbedring af prøveidentificering i indekserede nukleinsyrebiblioteker
SG11201909394PA (en) 2017-04-23 2019-11-28 Illumina Inc Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018259202B2 (en) 2017-04-23 2022-03-24 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
AU2018259206B2 (en) 2017-04-23 2024-07-11 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
CN110799653A (zh) 2017-05-01 2020-02-14 伊鲁米那股份有限公司 用于多重大规模平行测序的最佳索引序列
SG11201910070PA (en) 2017-05-08 2019-11-28 Illumina Inc Universal short adapters for indexing of polynucleotide samples
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
CA3061731A1 (en) 2017-05-19 2018-11-22 Zymergen Inc. Genomic engineering of biosynthetic pathways leading to increased nadph
CN110870018A (zh) 2017-05-19 2020-03-06 10X基因组学有限公司 用于分析数据集的系统和方法
SG11201901822QA (en) 2017-05-26 2019-03-28 10X Genomics Inc Single cell analysis of transposase accessible chromatin
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
US20200370058A1 (en) 2017-06-06 2020-11-26 Zymergen Inc. A htp genomic engineering platform for improving escherichia coli
US20200102554A1 (en) 2017-06-06 2020-04-02 Zymergen Inc. High throughput transposon mutagenesis
EP3635112A2 (de) 2017-06-06 2020-04-15 Zymergen, Inc. Genomische htp-engineering-plattform zur verbesserung von pilzstämmen
CN110914425B (zh) 2017-06-06 2024-06-25 齐默尔根公司 用于改良刺糖多孢菌的高通量(htp)基因组工程改造平台
NZ759895A (en) 2017-06-07 2023-05-26 Illumina Inc Single cell whole genome libraries for methylation sequencing
AU2018279728B2 (en) 2017-06-08 2023-07-20 The Brigham And Women's Hospital, Inc. Methods and compositions for identifying epitopes
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
AU2018284227B2 (en) 2017-06-12 2024-05-02 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
WO2018236918A1 (en) 2017-06-20 2018-12-27 Bio-Rad Laboratories, Inc. MDA USING A BALL OLIGONUCLEOTIDE
JP7390285B2 (ja) 2017-06-26 2023-12-01 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン 老化細胞を検出するための新規バイオマーカー
GB201711219D0 (en) 2017-07-12 2017-08-23 Illumina Cambridge Ltd Short pendant arm linkers for nucleotides in sequencing applications
AU2018302034B2 (en) 2017-07-18 2021-05-20 Pacific Biosciences Of California, Inc. Method of chemically modifying plastic surfaces
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
ES2941083T3 (es) * 2017-08-01 2023-05-16 Mgi Tech Co Ltd Método de secuenciación de ácidos nucleicos
AU2018312560B2 (en) 2017-08-01 2022-03-10 Illumina, Inc. Hydrogel beads for nucleotide sequencing
SG11201911869XA (en) 2017-08-01 2020-01-30 Illumina Inc Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
AU2018313286A1 (en) 2017-08-11 2020-03-12 Atila Biosystems Incorporated Digital amplification with primers of limited nucleotide composition
CN111182972B (zh) 2017-08-15 2022-03-08 欧姆尼奥姆股份有限公司 用于检测化学和生物分析物的扫描装置和方法
WO2019038594A2 (en) 2017-08-21 2019-02-28 Biolumic Limited TRANSGENIC PLANTS WITH HIGH GROWTH AND HIGH RUSTICITY
CA3075505A1 (en) 2017-09-11 2019-03-14 Twist Bioscience Corporation Gpcr binding proteins and synthesis thereof
US11447818B2 (en) 2017-09-15 2022-09-20 Illumina, Inc. Universal short adapters with variable length non-random unique molecular identifiers
CN111357054B (zh) 2017-09-20 2024-07-16 夸登特健康公司 用于区分体细胞变异和种系变异的方法和系统
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
AU2018346765A1 (en) 2017-10-06 2020-04-16 Oncotherapy Science, Inc. Screening of T lymphocytes for cancer-specific antigens
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
SG10202108020VA (en) 2017-10-16 2021-09-29 Illumina Inc Deep learning-based techniques for training deep convolutional neural networks
NZ759880A (en) 2017-10-16 2022-04-29 Illumina Inc Aberrant splicing detection using convolutional neural networks (cnns)
EP3697932A1 (de) 2017-10-19 2020-08-26 Omniome, Inc. Gleichzeitige hintergrundreduktion und komplexstabilisierung in bindungsassayarbeitsflüssen
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
SG11202003574TA (en) 2017-10-20 2020-05-28 Twist Bioscience Corp Heated nanowells for polynucleotide synthesis
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
EP3700672B1 (de) 2017-10-27 2022-12-28 10X Genomics, Inc. Verfahren zur probenvorbereitung und -analyse
EP3704247B1 (de) 2017-11-02 2023-01-04 Bio-Rad Laboratories, Inc. Genomische analyse auf transposasebasis
AU2018327221A1 (en) 2017-11-13 2019-05-30 The Multiple Myeloma Research Foundation, Inc. Integrated, molecular, omics, immunotherapy, metabolic, epigenetic, and clinical database
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
EP3714043A4 (de) 2017-11-22 2021-08-11 The Regents of The University of Michigan Zusammensetzungen und verfahren zur behandlung von krebs
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
JP2021509024A (ja) 2018-01-02 2021-03-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 多数の液滴の捕捉
GB2585506A (en) 2018-01-04 2021-01-13 Twist Bioscience Corp DNA-based digital information storage
US11561196B2 (en) 2018-01-08 2023-01-24 Illumina, Inc. Systems and devices for high-throughput sequencing with semiconductor-based detection
KR102494589B1 (ko) 2018-01-08 2023-02-07 일루미나, 인코포레이티드 반도체-기반 검출을 사용한 고-처리율 서열분석
US11705219B2 (en) 2018-01-15 2023-07-18 Illumina, Inc. Deep learning-based variant classifier
EP3747189A4 (de) 2018-01-30 2021-11-10 Rebus Biosystems, Inc. Verfahren zur detektion von teilchen mit strukturierter beleuchtung
WO2019152543A1 (en) 2018-01-31 2019-08-08 Dovetail Genomics, Llc Sample prep for dna linkage recovery
US20190241944A1 (en) 2018-01-31 2019-08-08 Bio-Rad Laboratories, Inc. Methods and compositions for deconvoluting partition barcodes
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
CA3067140C (en) 2018-02-13 2023-03-21 Illumina, Inc. Dna sequencing using hydrogel beads
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
KR20200132870A (ko) 2018-03-20 2020-11-25 지머젠 인코포레이티드 중국 햄스터 난소 세포의 유전자 조작을 위한 htp 플랫폼
WO2019183188A1 (en) 2018-03-22 2019-09-26 Illumina, Inc. Preparation of nucleic acid libraries from rna and dna
WO2019195225A1 (en) 2018-04-02 2019-10-10 Illumina, Inc. Compositions and methods for making controls for sequence-based genetic testing
CA3095292A1 (en) 2018-04-02 2019-10-10 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
EP3553182A1 (de) 2018-04-11 2019-10-16 Université de Bourgogne Verfahren zum nachweis von somatischen genetischen anomalien, kombination von fangsonden und nachweiskit
US20190318806A1 (en) 2018-04-12 2019-10-17 Illumina, Inc. Variant Classifier Based on Deep Neural Networks
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
AU2019255987A1 (en) 2018-04-19 2020-12-10 Pacific Biosciences Of California, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
JP7511344B2 (ja) 2018-04-20 2024-07-05 イルミナ インコーポレイテッド 単一細胞を封入する方法、封入された細胞およびその使用
JP2021521820A (ja) 2018-04-26 2021-08-30 オムニオム インコーポレイテッドＯｍｎｉｏｍｅ， Ｉｎｃ． 核酸−ヌクレオチド−ポリメラーゼ複合体を安定化するための方法及び組成物
EP3788377A1 (de) 2018-05-04 2021-03-10 Abbott Laboratories Hbv-diagnostische, prognostische und therapeutische verfahren und produkte
JP7100069B2 (ja) 2018-05-15 2022-07-12 イルミナ インコーポレイテッド 表面結合オリゴヌクレオチドを化学開裂および脱保護するための組成物および方法
JP7234146B2 (ja) 2018-05-17 2023-03-07 イルミナ インコーポレイテッド 低減した増幅バイアスによるハイスループット単一細胞シークエンシング
GB2590196A (en) 2018-05-18 2021-06-23 Twist Bioscience Corp Polynucleotides, reagents, and methods for nucleic acid hybridization
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
CA3101337A1 (en) 2018-05-31 2019-12-05 Omniome, Inc. Increased signal to noise in nucleic acid sequencing
AU2019282158B2 (en) 2018-06-04 2021-08-12 Illumina, Inc. High-throughput single-cell transcriptome libraries and methods of making and of using
WO2019236478A1 (en) 2018-06-04 2019-12-12 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free nucleic acids
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CN110684829A (zh) * 2018-07-05 2020-01-14 深圳华大智造科技有限公司 一种高通量的单细胞转录组测序方法和试剂盒
US20200251183A1 (en) 2018-07-11 2020-08-06 Illumina, Inc. Deep Learning-Based Framework for Identifying Sequence Patterns that Cause Sequence-Specific Errors (SSEs)
SG11202100344WA (en) 2018-07-23 2021-02-25 Guardant Health Inc Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
US11421262B2 (en) 2018-07-24 2022-08-23 Pacific Biosciences Of California, Inc. Serial formation of ternary complex species
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CN112955568A (zh) 2018-08-15 2021-06-11 Illumina公司 用于改善文库富集的组合物和方法
US11479816B2 (en) 2018-08-20 2022-10-25 Bio-Rad Laboratories, Inc. Nucleotide sequence generation by barcode bead-colocalization in partitions
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
SG11202102029TA (en) 2018-08-28 2021-03-30 10X Genomics Inc Methods for generating spatially barcoded arrays
SG11202101403YA (en) 2018-08-30 2021-03-30 Guardant Health Inc Methods and systems for detecting contamination between samples
CN112930569A (zh) 2018-08-31 2021-06-08 夸登特健康公司 无细胞dna中的微卫星不稳定性检测
WO2020096691A2 (en) 2018-09-04 2020-05-14 Guardant Health, Inc. Methods and systems for detecting allelic imbalance in cell-free nucleic acid samples
DK3814533T3 (da) 2018-09-20 2021-11-15 Tamirna Gmbh Mikro-RNA-signaturer til forudsigelse af leverdysfunktion
SG11201911777QA (en) 2018-10-15 2020-05-28 Illumina Inc Deep learning-based techniques for pre-training deep convolutional neural networks
AU2019364418A1 (en) 2018-10-25 2021-04-22 Illumina, Inc. Methods and compositions for identifying ligands on arrays using indexes and barcodes
US11085036B2 (en) 2018-10-26 2021-08-10 Illumina, Inc. Modulating polymer beads for DNA processing
EP3874060A1 (de) 2018-10-31 2021-09-08 Guardant Health, Inc. Verfahren, zusammensetzungen und systeme zur kalibrierung epigenetischer partitionstests
US10704094B1 (en) 2018-11-14 2020-07-07 Element Biosciences, Inc. Multipart reagents having increased avidity for polymerase binding
US10768173B1 (en) * 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US10876148B2 (en) 2018-11-14 2020-12-29 Element Biosciences, Inc. De novo surface preparation and uses thereof
WO2020101795A1 (en) 2018-11-15 2020-05-22 Omniome, Inc. Electronic detection of nucleic acid structure
AU2019390388A1 (en) 2018-11-30 2021-05-06 Illumina, Inc. Analysis of multiple analytes using a single assay
CN211311438U (zh) 2018-12-04 2020-08-21 欧姆尼欧美公司 流动池
AU2019391274A1 (en) 2018-12-05 2021-01-07 Illumina Cambridge Limited Methods and compositions for cluster generation by bridge amplification
CN113366120B (zh) * 2018-12-07 2024-05-14 深圳华大生命科学研究院 纳米孔测序方法
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
CN112639126A (zh) 2018-12-14 2021-04-09 伊卢米纳剑桥有限公司 降低测序期间用未标记的核苷酸的定相
WO2020126593A1 (en) 2018-12-17 2020-06-25 Illumina Cambridge Limited Compositions for use in polyunucleotide sequencing
AU2019411267A1 (en) 2018-12-17 2021-01-07 Illumina Cambridge Limited Primer oligonucleotide for sequencing
CA3103633A1 (en) 2018-12-18 2020-06-25 Illumina Cambridge Limited Methods and compositions for paired end sequencing using a single surface primer
DK3899037T3 (da) 2018-12-19 2023-11-06 Illumina Inc Fremgangsmåder til forbedring af polynukleotidklyngeklonalitetsprioritet
SG11202104701XA (en) 2018-12-20 2021-06-29 Guardant Health Inc Methods, compositions, and systems for improving recovery of nucleic acid molecules
EP3899032A2 (de) 2018-12-20 2021-10-27 Omniome, Inc. Temperaturkontrolle zur analyse von nukleinsäuren und anderen analyten
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US20220081714A1 (en) 2019-01-04 2022-03-17 Northwestern University Storing temporal data into dna
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
EP3908678A1 (de) 2019-01-10 2021-11-17 Iovance Biotherapeutics, Inc. System und verfahren zur überwachung der klonalität und persistenz von adoptiven zelltherapien
US11643693B2 (en) 2019-01-31 2023-05-09 Guardant Health, Inc. Compositions and methods for isolating cell-free DNA
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11584953B2 (en) 2019-02-12 2023-02-21 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
EP3924513B1 (de) 2019-02-14 2023-04-12 Pacific Biosciences of California, Inc. Verminderung von negativen auswirkungen von detektionssystemen auf nukleinsäuren und anderen biologischen analyten
US11680950B2 (en) 2019-02-20 2023-06-20 Pacific Biosciences Of California, Inc. Scanning apparatus and methods for detecting chemical and biological analytes
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
US11492728B2 (en) 2019-02-26 2022-11-08 Twist Bioscience Corporation Variant nucleic acid libraries for antibody optimization
WO2020176678A1 (en) 2019-02-26 2020-09-03 Twist Bioscience Corporation Variant nucleic acid libraries for glp1 receptor
WO2020176659A1 (en) 2019-02-27 2020-09-03 Guardant Health, Inc. Methods and systems for determining the cellular origin of cell-free dna
EP3931263A1 (de) 2019-03-01 2022-01-05 Illumina Cambridge Limited Exocyclische aminsubstituierte cumarinverbindungen und deren verwendungen als fluoreszente marker
CN113302300A (zh) 2019-03-01 2021-08-24 伊路敏纳公司 高通量单细胞核和单细胞文库及其制备和使用方法
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
AU2020233166A1 (en) 2019-03-01 2021-01-07 Illumina Cambridge Limited Tertiary amine substituted coumarin compounds and their uses as fluorescent labels
SG11202111242PA (en) 2019-03-11 2021-11-29 10X Genomics Inc Systems and methods for processing optically tagged beads
US11347965B2 (en) 2019-03-21 2022-05-31 Illumina, Inc. Training data generation for artificial intelligence-based sequencing
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
WO2020191390A2 (en) 2019-03-21 2020-09-24 Illumina, Inc. Artificial intelligence-based quality scoring
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
WO2020206170A1 (en) 2019-04-02 2020-10-08 Progenity, Inc. Methods, systems, and compositions for counting nucleic acid molecules
US11609208B2 (en) 2019-04-12 2023-03-21 Western Digital Technologies, Inc. Devices and methods for molecule detection based on thermal stabilities of magnetic nanoparticles
US11327073B2 (en) 2019-04-12 2022-05-10 Western Digital Technologies, Inc. Thermal sensor array for molecule detection and related detection schemes
US11738336B2 (en) 2019-04-12 2023-08-29 Western Digital Technologies, Inc. Spin torque oscillator (STO) sensors used in nucleic acid sequencing arrays and detection schemes for nucleic acid sequencing
US11579217B2 (en) 2019-04-12 2023-02-14 Western Digital Technologies, Inc. Devices and methods for frequency- and phase-based detection of magnetically-labeled molecules using spin torque oscillator (STO) sensors
US11112468B2 (en) 2019-04-12 2021-09-07 Western Digital Technologies, Inc. Magnetoresistive sensor array for molecule detection and related detection schemes
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
EP4394778A2 (de) 2019-05-16 2024-07-03 Illumina Inc. Systeme und verfahren zur charakterisierung und erfolgsanalyse von pixel-basierter sequenzierung
US11423306B2 (en) 2019-05-16 2022-08-23 Illumina, Inc. Systems and devices for characterization and performance analysis of pixel-based sequencing
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
WO2020243722A1 (en) 2019-05-31 2020-12-03 Guardant Health, Inc. Methods and systems for improving patient monitoring after surgery
WO2020252186A1 (en) 2019-06-11 2020-12-17 Omniome, Inc. Calibrated focus sensing
WO2020257612A1 (en) 2019-06-21 2020-12-24 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
JP2022540268A (ja) 2019-07-12 2022-09-15 イルミナ ケンブリッジ リミテッド 固体支持体上で固定化されたｃｒｉｓｐｒ／ｃａｓ９を使用する核酸シークエンシングライブラリを調製するための組成物及び方法
WO2021011803A1 (en) 2019-07-16 2021-01-21 Omniome, Inc. Synthetic nucleic acids having non-natural structures
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
CA3147077A1 (en) 2019-08-05 2021-02-11 David Ruff Method and apparatus for single-cell analysis for determining a cell trajectory
WO2021050681A1 (en) 2019-09-10 2021-03-18 Omniome, Inc. Reversible modification of nucleotides
US11208682B2 (en) 2019-09-13 2021-12-28 Western Digital Technologies, Inc. Enhanced optical detection for nucleic acid sequencing using thermally-dependent fluorophore tags
CA3142535A1 (en) 2019-09-20 2021-03-25 Illumina, Inc. Methods and compositions for identifying ligands on arrays using indexes and barcodes
US11111507B2 (en) 2019-09-23 2021-09-07 Zymergen Inc. Method for counterselection in microorganisms
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
US11788137B2 (en) 2019-09-30 2023-10-17 Diagenode S.A. Diagnostic and/or sequencing method and kit
CN118186063A (zh) 2019-10-18 2024-06-14 加利福尼亚太平洋生物科学股份有限公司 用于对核酸加帽的方法和组合物
DK3812472T3 (da) 2019-10-21 2023-02-20 Univ Freiburg Albert Ludwigs Virkelig uvildig in vitro-undersøgelse til profilering af off-target-aktivitet af en eller flere målspecifikke programmerbare nukleaser i celler (abnoba-seq)
EP4055185A1 (de) 2019-11-08 2022-09-14 10X Genomics, Inc. Räumlich markierte analytfänger für analyt-multiplexing
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
US11747329B2 (en) 2019-11-22 2023-09-05 Western Digital Technologies, Inc. Magnetic gradient concentrator/reluctance detector for molecule detection
EP4065725A1 (de) 2019-11-26 2022-10-05 Guardant Health, Inc. Verfahren, zusammensetzungen und systeme zum verbessern der bindung von methylierten polynukleotiden
EP4065646A1 (de) 2019-11-27 2022-10-05 Illumina Cambridge Limited Cyclooctatetraen enthaltende farbstoffe und zusammensetzungen
US20220356461A1 (en) 2019-12-19 2022-11-10 Illumina, Inc. High-throughput single-cell libraries and methods of making and of using
US11747262B2 (en) 2019-12-23 2023-09-05 Singular Genomics Systems, Inc. Flow cell carrier and methods of use
US20210189483A1 (en) 2019-12-23 2021-06-24 Mgi Tech Co. Ltd. Controlled strand-displacement for paired end sequencing
US11498078B2 (en) 2019-12-23 2022-11-15 Singular Genomics Systems, Inc. Flow cell receiver and methods of use
CN114885610A (zh) 2019-12-23 2022-08-09 10X基因组学有限公司 使用rna模板化连接进行空间分析的方法
CA3166578A1 (en) 2019-12-31 2021-07-08 Singular Genomics Systems, Inc. Polynucleotide barcodes for long read sequencing
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
CN115243792A (zh) 2020-02-04 2022-10-25 加利福尼亚太平洋生物科学股份有限公司 流通池及其制造和使用方法
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
US11835462B2 (en) 2020-02-11 2023-12-05 10X Genomics, Inc. Methods and compositions for partitioning a biological sample
JP2023513314A (ja) 2020-02-13 2023-03-30 ザイマージェン インコーポレイテッド メタゲノムライブラリーおよび天然物発見プラットフォーム
WO2021162028A1 (ja) * 2020-02-14 2021-08-19 東レ株式会社 バイオチップの製造方法
BR112022016415A2 (pt) 2020-02-20 2022-10-11 Illumina Inc Múltiplas chamadas de base à base de inteligência artificial
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
US11926863B1 (en) 2020-02-27 2024-03-12 10X Genomics, Inc. Solid state single cell method for analyzing fixed biological cells
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
AU2021233133A1 (en) 2020-03-09 2022-01-06 Illumina, Inc. Improvements in nucleic acid sequencing
PT3969618T (pt) 2020-03-09 2023-11-15 Illumina Inc Métodos para sequenciação de polinucleótidos
WO2021185320A1 (en) 2020-03-18 2021-09-23 Mgi Tech Co., Ltd. Restoring phase in massively parallel sequencing
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
ES2965354T3 (es) 2020-04-22 2024-04-12 10X Genomics Inc Métodos para análisis espacial que usan eliminación de ARN elegido como diana
EP4143338A1 (de) 2020-04-30 2023-03-08 Guardant Health, Inc. Verfahren zur sequenzbestimmung unter verwendung partitionierter nukleinsäuren
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
CN115836135A (zh) 2020-05-05 2023-03-21 加利福尼亚太平洋生物科学股份有限公司 用于修饰聚合酶-核酸复合物的组合物和方法
WO2021224677A1 (en) 2020-05-05 2021-11-11 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
US20210355518A1 (en) 2020-05-12 2021-11-18 Illumina, Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
WO2021231921A1 (en) 2020-05-14 2021-11-18 Guardant Health, Inc. Homologous recombination repair deficiency detection
EP4153776A1 (de) 2020-05-22 2023-03-29 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
EP4153775B1 (de) 2020-05-22 2024-07-24 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
CN116249785A (zh) 2020-06-02 2023-06-09 10X基因组学有限公司 用于抗原-受体的空间转录组学
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
WO2021252591A1 (en) 2020-06-10 2021-12-16 10X Genomics, Inc. Methods for determining a location of an analyte in a biological sample
MX2022016492A (es) 2020-06-22 2023-03-06 Illumina Cambridge Ltd Nucleosidos y nucleotidos con grupo de bloqueo de acetal 3'.
WO2021263111A1 (en) 2020-06-25 2021-12-30 10X Genomics, Inc. Spatial analysis of dna methylation
WO2022006081A1 (en) 2020-06-30 2022-01-06 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
AU2021300252A1 (en) 2020-07-02 2023-01-05 Illumina, Inc. A method to calibrate nucleic acid library seeding efficiency in flowcells
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
WO2022010965A1 (en) 2020-07-08 2022-01-13 Illumina, Inc. Beads as transposome carriers
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
WO2022015600A2 (en) 2020-07-13 2022-01-20 Singular Genomics Systems, Inc. Methods of sequencing complementary polynucleotides
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
WO2022026761A1 (en) 2020-07-30 2022-02-03 Guardant Health, Inc. Methods for isolating cell-free dna
KR20230041725A (ko) 2020-08-06 2023-03-24 일루미나, 인코포레이티드 비드-연결된 트랜스포좀을 사용한 rna 및 dna 시퀀싱 라이브러리의 제작
EP4193363A1 (de) 2020-08-07 2023-06-14 Oxford Nanopore Technologies plc Verfahren zur identifizierung von nukleinsäurebarcodes
WO2022040176A1 (en) 2020-08-18 2022-02-24 Illumina, Inc. Sequence-specific targeted transposition and selection and sorting of nucleic acids
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
JP2023540221A (ja) 2020-08-25 2023-09-22 ガーダント ヘルス， インコーポレイテッド バリアントの起源を予測するための方法およびシステム
KR20230069135A (ko) 2020-09-11 2023-05-18 일루미나 케임브리지 리미티드 헤어핀 어댑터를 사용하여 시퀀싱 라이브러리에서 표적 서열을 농축시키는 방법
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
WO2022073011A1 (en) 2020-09-30 2022-04-07 Guardant Health, Inc. Methods and systems to improve the signal to noise ratio of dna methylation partitioning assays
IL302207A (en) 2020-10-21 2023-06-01 Illumina Inc Sequencing templates that include several additions and compositions and methods to improve sequencing output
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
EP4121555A1 (de) 2020-12-21 2023-01-25 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
EP4267757A1 (de) 2020-12-23 2023-11-01 Guardant Health, Inc. Verfahren und systeme zur analyse methylierter polynukleotide
EP4284944A1 (de) 2021-01-29 2023-12-06 Illumina, Inc. Verfahren, zusammensetzungen und kits zur verbesserung der saateffizienz von durchflusszellen mit polynukleotiden
CN116829731A (zh) 2021-02-04 2023-09-29 Illumina公司 转座体结合珠粒上的长带索引连接的读段生成
US11486001B2 (en) 2021-02-08 2022-11-01 Singular Genomics Systems, Inc. Methods and compositions for sequencing complementary polynucleotides
US20240043915A1 (en) 2021-02-13 2024-02-08 The General Hospital Corporation Methods and compositions for in situ macromolecule detection and uses thereof
AU2022227563A1 (en) 2021-02-23 2023-08-24 10X Genomics, Inc. Probe-based analysis of nucleic acids and proteins
CA3210101A1 (en) 2021-03-05 2022-09-09 Katie Julia QUINN Methods and related aspects for analyzing molecular response
JP2024512372A (ja) 2021-03-09 2024-03-19 ガーダント ヘルス， インコーポレイテッド オフターゲットポリヌクレオチド配列決定データに基づく腫瘍の存在の検出
WO2022197754A1 (en) 2021-03-16 2022-09-22 Illumina Software, Inc. Neural network parameter quantization for base calling
WO2022198068A1 (en) 2021-03-18 2022-09-22 10X Genomics, Inc. Multiplex capture of gene and protein expression from a biological sample
AU2022245985A1 (en) 2021-03-22 2023-09-21 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
MX2023010814A (es) 2021-03-29 2023-09-27 Illumina Inc Metodos mejorados de preparacion de genotecas.
CA3214282A1 (en) 2021-03-29 2022-10-06 Illumina, Inc. Compositions and methods for assessing dna damage in a library and normalizing amplicon size bias
MX2023010495A (es) 2021-03-30 2023-09-18 Illumina Inc Metodos mejorados de preparacion de genoteca y adn complementarios isotermicos.
MX2023011218A (es) 2021-03-31 2023-10-02 Illumina Inc Métodos de preparación de genotecas de secuenciación de tagmentación direccional usando tecnología basada en transposón con identificadores moleculares únicos para la corrección de errores.
US20220336054A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures
CA3215598A1 (en) 2021-05-05 2022-11-10 Michael Callingham Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
US20220396832A1 (en) 2021-05-20 2022-12-15 Illumina Cambridge Limited Compositions and methods for sequencing by synthesis
EP4355476A1 (de) 2021-06-15 2024-04-24 Illumina, Inc. Hydrogelfreie oberflächenfunktionalisierung zur sequenzierung
US11427855B1 (en) 2021-06-17 2022-08-30 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US11859241B2 (en) 2021-06-17 2024-01-02 Element Biosciences, Inc. Compositions and methods for pairwise sequencing
US20220411864A1 (en) 2021-06-23 2022-12-29 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
WO2023278609A1 (en) 2021-06-29 2023-01-05 Illumina, Inc. Self-learned base caller, trained using organism sequences
WO2023278184A1 (en) 2021-06-29 2023-01-05 Illumina, Inc. Methods and systems to correct crosstalk in illumination emitted from reaction sites
WO2023287617A1 (en) 2021-07-13 2023-01-19 Illumina, Inc. Methods and systems for real time extraction of crosstalk in illumination emitted from reaction sites
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
EP4374343A1 (de) 2021-07-19 2024-05-29 Illumina, Inc. Intensitätsextraktion mit interpolation und anpassung für basisanrufe
GB202110485D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CA3226451A1 (en) 2021-07-21 2023-01-26 Sam Reed Method and system comprising a cartridge for sequencing target polynucleotides
GB202110479D0 (en) 2021-07-21 2021-09-01 Dnae Diagnostics Ltd Compositions, kits and methods for sequencing target polynucleotides
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
IL309786A (en) 2021-07-28 2024-02-01 Illumina Inc Quality score calibration of BASECALLING systems
KR20240035413A (ko) 2021-08-03 2024-03-15 일루미나, 인코포레이티드 다중 염기 호출자 모델을 사용한 염기 호출
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
EP4395933A1 (de) 2021-09-03 2024-07-10 Elegen Corporation Vorrichtungen, systeme und verfahren zur mehrweg-wulstsortierung unter verwendung von druckquellen
US20230096386A1 (en) 2021-09-30 2023-03-30 Illumina Cambridge Limited Polynucleotide sequencing
WO2023056328A2 (en) 2021-09-30 2023-04-06 Illumina, Inc. Solid supports and methods for depleting and/or enriching library fragments prepared from biosamples
CN118355128A (zh) 2021-10-20 2024-07-16 因美纳有限公司 用于捕获测序用文库dna的方法
WO2023086847A1 (en) 2021-11-10 2023-05-19 Encodia, Inc. Methods for barcoding macromolecules in individual cells
WO2023086635A1 (en) 2021-11-15 2023-05-19 Vir Biotechnology, Inc. Virological and molecular surrogates of response to sars-cov-2 neutralizing antibody sotrovimab
CN117813396A (zh) 2021-12-16 2024-04-02 因美纳有限公司 混合聚类
WO2023114896A1 (en) 2021-12-16 2023-06-22 Illumina Cambridge Limited Methods for metal directed cleavage of surface-bound polynucleotides
WO2023114394A1 (en) 2021-12-17 2023-06-22 Illumina, Inc. Orthogonal hybridization
WO2023122499A1 (en) 2021-12-20 2023-06-29 Illumina Cambridge Limited Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
AU2022419500A1 (en) 2021-12-20 2024-01-18 Illumina, Inc. Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides
CA3222937A1 (en) 2021-12-29 2023-07-06 Jonathan Mark Boutell Methods of nucleic acid sequencing using surface-bound primers
WO2023135485A1 (en) 2022-01-13 2023-07-20 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
WO2023141154A1 (en) 2022-01-20 2023-07-27 Illumina Cambridge Limited Methods of detecting methylcytosine and hydroxymethylcytosine by sequencing
WO2023152568A2 (en) 2022-02-10 2023-08-17 Oslo Universitetssykehus Hf Compositions and methods for characterizing lung cancer
CA3223653A1 (en) 2022-03-15 2023-09-21 Aathavan KARUNAKARAN Concurrent sequencing of forward and reverse complement strands on separate polynucleotides for methylation detection
WO2023175021A1 (en) 2022-03-15 2023-09-21 Illumina, Inc. Methods of preparing loop fork libraries
US20230304086A1 (en) 2022-03-28 2023-09-28 Illumina Cambridge Limited Labeled avidin and methods for sequencing
WO2023192163A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Systems and methods of sequencing polynucleotides
WO2023186872A1 (en) 2022-03-30 2023-10-05 Illumina Cambridge Limited Methods for chemical cleavage of surface-bound polynucleotides
CA3222797A1 (en) 2022-03-31 2023-10-05 Ramesh NEELAKANDAN Nucleosides and nucleotides with 3' vinyl blocking group
US20230357845A1 (en) 2022-03-31 2023-11-09 Illumina, Inc. Compositions and methods for improving sequencing signals
WO2023187061A1 (en) 2022-03-31 2023-10-05 Illumina Cambridge Limited Paired-end re-synthesis using blocked p5 primers
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
WO2023209606A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
US20230360725A1 (en) 2022-05-09 2023-11-09 Guardant Health, Inc. Detecting degradation based on strand bias
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
WO2023240093A1 (en) 2022-06-06 2023-12-14 Element Biosciences, Inc. Methods for assembling and reading nucleic acid sequences from mixed populations
WO2024003087A1 (en) 2022-06-28 2024-01-04 Illumina, Inc. Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024057280A1 (en) 2022-09-16 2024-03-21 Illumina Cambridge Limited Nanoparticle with polynucleotide binding site and method of making thereof
WO2024061799A1 (en) 2022-09-19 2024-03-28 Illumina, Inc. Deformable polymers comprising immobilised primers
US20240102067A1 (en) 2022-09-26 2024-03-28 Illumina, Inc. Resynthesis Kits and Methods
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
US20240124914A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Thermophilic compositions for nucleic acid amplification
US20240110234A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Amplification Compositions and Methods
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
US20240124929A1 (en) 2022-09-30 2024-04-18 Illumina, Inc. Mesophilic compositions for nucleic acid amplification
US20240110221A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of modulating clustering kinetics
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
GB202215624D0 (en) 2022-10-21 2022-12-07 Dnae Diagnostics Ltd Clonal amplification
WO2024107599A1 (en) 2022-11-15 2024-05-23 Guardant Health, Inc. Method of predicting non-small cell lung cancer (nsclc) patient drug response or time until death or cancer progression from circulating tumor dna (ctdna) utilizing signals from both baseline ctdna level and longitudinal change of ctdna level over time
WO2024118903A1 (en) 2022-11-30 2024-06-06 Illumina, Inc. Chemoenzymatic correction of false positive uracil transformations
US20240209429A1 (en) 2022-12-07 2024-06-27 Illumina, Inc. Monoclonal clustering using double stranded dna size exclusion with patterned seeding
WO2024123866A1 (en) 2022-12-09 2024-06-13 Illumina, Inc. Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers
WO2024129672A1 (en) 2022-12-12 2024-06-20 The Broad Institute, Inc. Trafficked rnas for assessment of cell-cell connectivity and neuroanatomy
US20240209419A1 (en) 2022-12-14 2024-06-27 Illumina, Inc. Systems and Methods for Capture and Enrichment of Clustered Beads on Flow Cell Substrates
WO2024137682A1 (en) 2022-12-21 2024-06-27 Guardant Health, Inc. Detecting homologous recombination deficiences based on methylation status of cell-free nucleic acid molecules
WO2024137765A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240247311A1 (en) 2022-12-22 2024-07-25 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
WO2024145154A1 (en) 2022-12-27 2024-07-04 Illumina, Inc. Methods of sequencing using 3´ allyl blocked nucleotides
WO2024147904A1 (en) 2023-01-06 2024-07-11 Illumina, Inc. Reducing uracils by polymerase

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957858A (en) 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
EP0224126A3 (de) 1985-11-25 1989-02-01 The University of Calgary Kovalent gekoppelte komplementäre Oligodeoxynukleotide zur Verwendung als "Primer Linkers" bei Sequenzierung von Nukleinsäuren
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
IE72468B1 (en) 1987-07-31 1997-04-09 Univ Leland Stanford Junior Selective amplification of target polynucleotide sequences
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
US6107023A (en) * 1988-06-17 2000-08-22 Genelabs Technologies, Inc. DNA amplification and subtraction techniques
GB8818020D0 (en) 1988-07-28 1988-09-01 Ici Plc Method for amplification of nucleotide sequences
CA2004326A1 (en) 1988-12-23 1990-06-23 Nanibushan Dattagupta Assay of sequences using amplified genes
US5629158A (en) * 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5547839A (en) * 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
EP0450060A1 (de) 1989-10-26 1991-10-09 Sri International Dns-sequenzierung
CA2036946C (en) * 1990-04-06 2001-10-16 Kenneth V. Deugau Indexing linkers
US5326692B1 (en) * 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
DE69228247T2 (de) 1991-08-10 1999-07-08 Medical Research Council, London Behandlung von Zellpopulationen
WO1993004199A2 (en) 1991-08-20 1993-03-04 Scientific Generics Limited Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids
EP0543484B1 (de) * 1991-08-30 2001-01-31 Research Development Corporation of Japan Verfahren zur Amplifikation von DNA
CA2130562A1 (en) * 1992-02-19 1993-09-02 Alexander B. Chetverin Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
DE69327326T2 (de) * 1992-07-24 2001-08-16 Diatech Pty. Ltd., Brisbane Vervielfältigungs- und detektionsprozess
RU2048522C1 (ru) * 1992-10-14 1995-11-20 Институт белка РАН Способ размножения нуклеиновых кислот, способ их экспрессии и среда для их осуществления
US5436142A (en) * 1992-11-12 1995-07-25 Cold Spring Harbor Laboratory Methods for producing probes capable of distingushing variant genomic sequences
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
JPH07203998A (ja) * 1994-01-26 1995-08-08 Hamamatsu Photonics Kk 核酸塩基配列決定方法
JPH10500862A (ja) * 1994-05-28 1998-01-27 テプネル・メディカル・リミテッド 核酸のコピーの産生
US5641658A (en) * 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US6060288A (en) * 1994-08-03 2000-05-09 Mosaic Technologies Method for performing amplification of nucleic acid on supports
CA2218188A1 (en) 1995-04-11 1996-10-17 Trustees Of Boston University Solid phase sequencing of biopolymers
US5753439A (en) * 1995-05-19 1998-05-19 Trustees Of Boston University Nucleic acid detection methods
EP0862656B1 (de) 1995-11-21 2001-03-07 Yale University Unimolekulare segmentamplifikation und bestimmung
US5939291A (en) * 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US6218142B1 (en) * 1997-03-05 2001-04-17 Michael Wassenegger Nucleic acid molecules encoding polypeptides having the enzymatic activity of an RNA-directed RNA polymerase (RDRP)
DE69837913T2 (de) * 1997-04-01 2008-02-07 Solexa Ltd., Saffron Walden Verfahren zur vervielfältigung von nukleinsäure
ATE269908T1 (de) * 1997-04-01 2004-07-15 Manteia S A Methode zur sequenzierung von nukleinsäuren
EP0917590A1 (de) 1997-04-04 1999-05-26 Innogenetics N.V. Isothermale polymerase kettenreaktion mit zyklisierenden konzentrationen divalenter metallionen
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
EP2258846A3 (de) 1997-07-07 2012-03-21 Medical Research Council Verfahren zur Erhöhung der Konzentration eines Nucleinsäuremoleküls
US6326489B1 (en) * 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US6124120A (en) * 1997-10-08 2000-09-26 Yale University Multiple displacement amplification
US6511803B1 (en) * 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
US6248558B1 (en) * 1998-03-31 2001-06-19 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
EP1098996A1 (de) * 1998-07-20 2001-05-16 Yale University Verfahren zum nachweis von nukleinsäuren unter verwendung zielgerichteter ligation von zweiteiligen primern
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
WO2000041524A2 (en) 1999-01-11 2000-07-20 President And Fellows Of Harvard College Isothermal amplification of dna
US6300070B1 (en) * 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
JP6049051B2 (ja) 2011-07-29 2016-12-21 日東電工株式会社 両面真空成膜方法

Also Published As

Publication number Publication date
PL347125A1 (en) 2002-03-25
HUP0105052A3 (en) 2003-12-29
DE69928683T2 (de) 2006-08-24
EA004271B1 (ru) 2004-02-26
EP1634963A1 (de) 2006-03-15
BG105363A (bg) 2001-12-31
IL142178A0 (en) 2002-03-10
JP2002525125A (ja) 2002-08-13
HUP0105052A2 (hu) 2002-04-29
BR9914159A (pt) 2001-06-26
US7115400B1 (en) 2006-10-03
NZ510599A (en) 2003-06-30
ATE311474T1 (de) 2005-12-15
AR021833A1 (es) 2002-08-07
US10370652B2 (en) 2019-08-06
US20140228254A1 (en) 2014-08-14
US20080160580A1 (en) 2008-07-03
EP1117827B8 (de) 2010-06-02
WO2000018957A1 (en) 2000-04-06
NO20011303D0 (no) 2001-03-14
EP1117827A1 (de) 2001-07-25
ZA200102420B (en) 2001-09-26
EP1117827B1 (de) 2005-11-30
AU6108899A (en) 2000-04-17
EP1634963B1 (de) 2013-06-19
EA200100402A1 (ru) 2001-10-22
SK4292001A3 (en) 2001-12-03
EE200100195A (et) 2002-06-17
US8652810B2 (en) 2014-02-18
CA2344575A1 (en) 2000-04-06
CN1325458A (zh) 2001-12-05
DE69928683D1 (de) 2006-01-05
CZ20011183A3 (cs) 2001-09-12
US9297006B2 (en) 2016-03-29
KR20010085860A (ko) 2001-09-07
US20160319274A1 (en) 2016-11-03
AU771073B2 (en) 2004-03-11
HK1042525A1 (zh) 2002-08-16
TR200100911T2 (tr) 2001-07-23

Similar Documents

Publication Publication Date Title
NO20011303L (no) Fremgangsmåter for nukleinsyreoppformering og sekvensering
NO994009D0 (no) Gensekvensator og metoder
DE69841895D1 (de) Nukleinsäuretestverfahren
DK2325317T3 (da) Receptornukleinsyrer og polypeptidr
AU3199699A (en) Modified nucleotides and methods useful for nucleic acid sequencing
NO20002849D0 (no) Sammensetninger og metoder for Õ indusere genekspersjon
DE69635744D1 (de) Modifizierte Nukleinsäuresonden
NO960408D0 (no) DNA sekvenseringsenzymer
NO20001323D0 (no) Dipeptid-apoptose inhibitorer og deres anvendelse
NO20003067L (no) Antipicornavirus-forbindelser og fremgangsmÕter for deres anvendelse og fremstilling
NO20001554L (no) FremgangsmÕter og mellomprodukter nyttige for Õ fremstille antifolater
IS6401A (is) Efnafræðilegar aðferðir og milliefni
NO20011195L (no) System og fremgangsmate for raffinormalinger
EE200000790A (et) Geeniteraapia meetod
DK1330525T3 (da) NOD2-nukleinsyrer og proteiner
DK1094986T3 (da) Vandrensningssystem og fremgangsmåde
NO20015089L (no) System og fremgangsmåte for konvertert-bölge-analyse
DK1228026T3 (da) 15-Hydroxyicosatetraensyrerelaterede forbindelser og fremgangsmåde til anvendelse
DK1036319T3 (da) Fremgangsmåde til opnåelse af L-dihydroorotsyre og anvendelse deraf
IL143486A0 (en) Array and method for analysing nucleic acid sequences
GB9827908D0 (en) Nucleic acid sequencing method
GB0021008D0 (en) Protein and nucleic acid sequence
DK1307761T3 (da) Fremgangsmåde til retningsbestemmelse og bestemmelsesapparat
SE9704063D0 (sv) Method and kit for nucleic ACID (PROBE) purification
IS2104B (is) Aðferð til að endurforma kjöt

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application