PL2912468T3 - Test papanicolaou pod kątem raka jajnika i endometrium - Google Patents

Test papanicolaou pod kątem raka jajnika i endometrium

Info

Publication number
PL2912468T3
PL2912468T3 PL13851273T PL13851273T PL2912468T3 PL 2912468 T3 PL2912468 T3 PL 2912468T3 PL 13851273 T PL13851273 T PL 13851273T PL 13851273 T PL13851273 T PL 13851273T PL 2912468 T3 PL2912468 T3 PL 2912468T3
Authority
PL
Poland
Prior art keywords
ovarian
endometrial cancers
papanicolaou test
papanicolaou
test
Prior art date
Application number
PL13851273T
Other languages
English (en)
Inventor
Isaac KINDE
Kenneth W. Kinzler
Bert Vogelstein
Nickolas Papadopoulos
Luis Diaz
Chetan Bettegowda
Yuxuan WANG
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50627940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2912468(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of PL2912468T3 publication Critical patent/PL2912468T3/pl

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5755Immunoassay; Biospecific binding assay; Materials therefor for cancer of the uterine cervix, uterine corpus or endometrium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Reproductive Health (AREA)
PL13851273T 2012-10-29 2013-10-17 Test papanicolaou pod kątem raka jajnika i endometrium PL2912468T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261719942P 2012-10-29 2012-10-29
EP13851273.6A EP2912468B1 (en) 2012-10-29 2013-10-17 Papanicolaou test for ovarian and endometrial cancers
PCT/US2013/065342 WO2014070462A1 (en) 2012-10-29 2013-10-17 Papanicolaou test for ovarian and endometrial cancers

Publications (1)

Publication Number Publication Date
PL2912468T3 true PL2912468T3 (pl) 2019-04-30

Family

ID=50627940

Family Applications (1)

Application Number Title Priority Date Filing Date
PL13851273T PL2912468T3 (pl) 2012-10-29 2013-10-17 Test papanicolaou pod kątem raka jajnika i endometrium

Country Status (8)

Country Link
US (2) US11525163B2 (pl)
EP (2) EP2912468B1 (pl)
CN (2) CN109457030B (pl)
AU (3) AU2013338393C1 (pl)
CA (1) CA2889937C (pl)
ES (2) ES2701742T3 (pl)
PL (1) PL2912468T3 (pl)
WO (1) WO2014070462A1 (pl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017220782A1 (en) * 2016-06-24 2017-12-28 Molecular Health Gmbh Screening method for endometrial cancer
TWI648403B (zh) * 2016-07-29 2019-01-21 Taipei Medical University (Tmu) 婦科腫瘤的診斷方法
CN109321654A (zh) * 2017-07-27 2019-02-12 张巍 用于多基因联合检测妇科肿瘤的引物组、试剂盒、文库及应用
US11230729B2 (en) 2018-04-20 2022-01-25 Inanna Diagnostics, Inc Methods and devices for obtaining cellular and DNA material from human female reproductive system
CN114410779B (zh) * 2021-12-29 2023-09-19 苏州方科生物科技有限公司 检测卵巢癌分子分型的探针池及制备,应用和使用方法

Family Cites Families (293)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040166A (en) 1985-03-28 2000-03-21 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences, including a probe
GB9323305D0 (en) 1993-11-11 1994-01-05 Medinnova Sf Isoaltion of nucleic acid
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5866330A (en) 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
EP0929694A4 (en) 1996-03-15 2002-05-02 Penn State Res Found DETECTION OF TUMOR-RELATED EXTRACELLULAR NUCLEIC ACID USING PLASMA OR BLOOD SERUM USING NUCLEIC ACID AMPLIFICATION TESTS
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
EP2327797B1 (en) 1997-04-01 2015-11-25 Illumina Cambridge Limited Method of nucleic acid sequencing
EP1000175A1 (en) 1997-07-22 2000-05-17 Rapigene, Inc. Amplification and other enzymatic reactions performed on nucleic acid arrays
DE19736691A1 (de) 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
DE19813317A1 (de) 1998-03-26 1999-09-30 Roche Diagnostics Gmbh Verbessertes Verfahren zur Primer Extension Präamplifikations-PCR
US6576420B1 (en) 1998-06-23 2003-06-10 Regents Of The University Of California Method for early diagnosis of, and determination of prognosis in, cancer
DE69940430D1 (de) 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US7510841B2 (en) 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US7683035B1 (en) 1999-02-23 2010-03-23 Qiagen, Gmbh Method of stabilizing and/or isolating nucleic acids
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
EP1212599A2 (en) 1999-08-30 2002-06-12 Illumina, Inc. Methods for improving signal detection from an array
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001023618A2 (en) 1999-09-30 2001-04-05 Qiagen Genomics, Inc. Compositions and methods for reducing oligonucleotide hybridization and priming specificity
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
DE10031236A1 (de) 2000-06-27 2002-01-10 Qiagen Gmbh Verwendung von Carbonsäuren und anderen Additiven in Kombination mit kationischen Verbindungen zur Stabilisierung von Nukleinsäuren in biologischen Materialien
US6686157B2 (en) 2000-06-30 2004-02-03 Molecular Staging Inc. Signal amplification with lollipop probes
CA2419058A1 (en) 2000-08-09 2002-02-14 Illumina, Inc. Automated information processing in randomly ordered arrays
WO2002016649A2 (en) 2000-08-25 2002-02-28 Illumina, Inc. Probes and decoder oligonucleotides
DE10063179A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur spezifischen Detektion von Tumorzellen und ihren Vorstufen in Gebärmutterhalsabstrichen durch simultane Messung von mindestens zwei verschiedenen molekularen Markern
JP4588976B2 (ja) 2001-01-25 2010-12-01 ルミネックス モレキュラー ダイアグノスティックス, インク. タグおよびタグ相補体としてのポリヌクレオチド、製品、ならびにその使用法
WO2002099982A2 (en) 2001-03-01 2002-12-12 Illumina, Inc. Methods for improving signal detection from an array
WO2003031591A2 (en) 2001-10-10 2003-04-17 Superarray Bioscience Corporation Detecting targets by unique identifier nucleotide tags
US7671349B2 (en) 2003-04-08 2010-03-02 Cymer, Inc. Laser produced plasma EUV light source
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
US20040259105A1 (en) 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7704687B2 (en) 2002-11-15 2010-04-27 The Johns Hopkins University Digital karyotyping
US9487823B2 (en) 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US6977153B2 (en) 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
AU2004209001B2 (en) 2003-01-29 2007-10-11 454 Life Sciences Corporation Bead emulsion nucleic acid amplification
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US8150626B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
CA2528577C (en) 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
ES2539784T3 (es) 2003-09-02 2015-07-06 Keygene N.V. Procedimientos basados en OLA para la detección de secuencias de ácidos nucleicos objetivo
KR20060120652A (ko) 2003-10-07 2006-11-27 밀레니엄 파머슈티컬스 인코퍼레이티드 난소암의 확인, 평가, 예방 및 치료를 위한 핵산 분자 및단백질
WO2005054435A2 (en) 2003-11-26 2005-06-16 Eppendorf Ag Methods and compositions for in vitro amplification of extrachromosomal nucleic acid
EP2361974A1 (fr) 2003-12-02 2011-08-31 Institut Pasteur Utilisation des proteines et des peptides codés par le genome d'une nouvelle souche de coronavirus associé au SRAS
US20050136405A1 (en) * 2003-12-17 2005-06-23 James Linder Novel method for the detection of cancer biomarkers in cervical specimens
DK3556866T3 (da) 2004-03-02 2021-05-03 Univ Johns Hopkins Mutationer af pik3ca-genet i humane cancere
US7776531B1 (en) 2004-03-25 2010-08-17 Illumina, Inc. Compositions and methods for stabilizing surface bound probes
EP1745150A4 (en) 2004-04-20 2008-02-27 Genaco Biomedial Products Inc METHOD FOR DETECTING NCRNA
EP1766061B1 (en) 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Single label comparative hybridization
US7745125B2 (en) 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
US7323310B2 (en) 2004-08-31 2008-01-29 Qiagen North American Holdings, Inc. Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
WO2006047787A2 (en) * 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
WO2006058031A2 (en) 2004-11-23 2006-06-01 Quest Diagnostics Incorporated Microarray quality control
US20060127918A1 (en) 2004-12-14 2006-06-15 Quest Diagnostics Investments Incorporated Nucleic acid arrays
EP1846760B1 (en) 2005-01-27 2010-12-15 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
ATE406463T1 (de) 2005-04-06 2008-09-15 Maurice Stroun Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf
SG2014011837A (en) 2005-04-18 2014-04-28 Mitomics Inc Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
US20060263789A1 (en) 2005-05-19 2006-11-23 Robert Kincaid Unique identifiers for indicating properties associated with entities to which they are attached, and methods for using
US20060292576A1 (en) 2005-06-23 2006-12-28 Quest Diagnostics Investments Incorporated Non-in situ hybridization method for detecting chromosomal abnormalities
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
US7977108B2 (en) 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
JP2009506759A (ja) 2005-09-01 2009-02-19 コーベット ライフ サイエンス ピーティーワイ リミテッド 核酸の増幅、定量化、及び同定の方法。
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
ES2558124T3 (es) 2005-12-22 2016-02-02 Keygene N.V. Procedimiento para detección de polimorfismos basada en AFLP de alto rendimiento
US7702468B2 (en) 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
SG140505A1 (en) 2006-09-05 2008-03-28 Univ Singapore Diagnostic biomolecule(s)
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
DE102006050037A1 (de) 2006-10-24 2008-04-30 Robert Bosch Gmbh Ultraschallwandler
EP2639578B1 (en) 2006-12-14 2016-09-14 Life Technologies Corporation Apparatus for measuring analytes using large scale fet arrays
US7899626B2 (en) 2007-01-10 2011-03-01 Illumina, Inc. System and method of measuring methylation of nucleic acids
EP2121983A2 (en) 2007-02-02 2009-11-25 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
JP2010528585A (ja) 2007-02-26 2010-08-26 ジョン ウェイン キャンサー インスティテュート 癌の診断および治療におけるb−rafdna変異の有用性
JP2010525301A (ja) * 2007-03-23 2010-07-22 ザ・トランスレーショナル・ジェノミクス・リサーチ・インスティチュート 子宮内膜癌および前癌の診断、分類および治療の方法
DE102007016707A1 (de) 2007-04-04 2008-10-09 Qiagen Gmbh Verfahren zur Aufreinigung von Biomolekülen
US8999634B2 (en) 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
DE102007025277A1 (de) 2007-05-31 2008-12-04 Qiagen Gmbh Verfahren zur Stabilisierung einer biologischen Probe
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
US7507539B2 (en) 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
US8871687B2 (en) 2007-09-28 2014-10-28 Quest Diagnostics Investments Incorporated Nucleic acid sequencing by single-base primer extension
EP2053132A1 (en) 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichment and sequence analysis of geomic regions
EP2220506B1 (en) 2007-10-29 2013-10-02 Vermillion, Inc. Biomarkers for the detection of early stage ovarian cancer
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US8211673B2 (en) 2008-02-04 2012-07-03 Life Technologies Corporation Composition and method for sequencing nucleic acid
WO2011025477A1 (en) 2009-08-25 2011-03-03 Illumina, Inc. Methods for selecting and amplifying polynucleotides
EP2262911B1 (en) 2008-04-17 2016-10-12 QIAGEN Gaithersburg, Inc. Compositions, methods, and kits using synthetic probes for determining the presence of a target nucleic acid
CN102076851A (zh) 2008-05-02 2011-05-25 Epi中心科技公司 Rna的选择性的5′连接标记
DE102008025656B4 (de) 2008-05-28 2016-07-28 Genxpro Gmbh Verfahren zur quantitativen Analyse von Nukleinsäuren, Marker dafür und deren Verwendung
US20100041048A1 (en) 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
US9410956B1 (en) 2008-08-01 2016-08-09 University Of South Florida Micro-RNA profiling in ovarian cancer
US20110319415A1 (en) 2008-08-18 2011-12-29 Universit+e,uml a+ee t zu K+e,uml o+ee ln Susceptibility to HSP90-Inhibitors
EP2326734B1 (en) 2008-09-03 2016-11-09 The Johns Hopkins University Pathways underlying pancreatic tumorigenesis and an hereditary pancreatic cancer gene
ES2755139T3 (es) 2008-09-03 2020-04-21 Univ Johns Hopkins Alteraciones genéticas en la citrato deshidrogenasa y otros genes en gliomas malignos
US8586310B2 (en) 2008-09-05 2013-11-19 Washington University Method for multiplexed nucleic acid patch polymerase chain reaction
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
JP2012506705A (ja) 2008-10-27 2012-03-22 キアジェン ゲイサーズバーグ インコーポレイテッド 迅速に結果を得るハイブリッドキャプチャー法による分析およびシステム
US9593366B2 (en) 2008-10-30 2017-03-14 Qiagen Gaithersburg, Inc. Individually synthesized primers to be used in whole genome amplification
US8399221B2 (en) 2008-11-04 2013-03-19 Sabiosciences Corporation Methods for detection and quantitation of small RNAs
WO2010055487A2 (en) 2008-11-13 2010-05-20 Koninklijke Philips Electronics N.V. Compositions and methods for micro-rna expession profiling of colorectal cancer
EP2193831A1 (de) 2008-12-05 2010-06-09 Qiagen GmbH Parallel-Extraktion von unterschiedlichen Biomolekülen aus Formalin-fixiertem Gewebe
CA2750820A1 (en) 2009-01-27 2010-08-05 Qiagen Gaithersburg Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
US8445412B2 (en) 2009-02-25 2013-05-21 Illumina, Inc. Separation of pyrophosphate release and pyrophosphate detection
US9347092B2 (en) 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
JP5457222B2 (ja) 2009-02-25 2014-04-02 エフ.ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
ES2706227T3 (es) 2009-03-30 2019-03-27 Illumina Inc Análisis de expresión génica en células individuales
EP2789694A1 (en) 2009-04-02 2014-10-15 Fluidigm Corporation Microfluidic device with reaction product recovery system
AU2010242073C1 (en) 2009-04-30 2015-12-24 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
WO2010127186A1 (en) 2009-04-30 2010-11-04 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
CN102414327B (zh) 2009-05-01 2015-04-08 奇亚根盖瑟斯堡股份有限公司 用于在样品中检测rna剪接形式的非靶向扩增方法
CN102459648A (zh) 2009-05-26 2012-05-16 奎斯特诊断投资公司 基因失调的检测方法
US20130143747A1 (en) 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
ES2544500T3 (es) 2009-06-05 2015-09-01 Myriad Genetics, Inc. Métodos de detección del cáncer
US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
ES2640776T3 (es) 2009-09-30 2017-11-06 Natera, Inc. Métodos para denominar de forma no invasiva ploidía prenatal
EP2494069B1 (en) 2009-10-30 2013-10-02 Roche Diagniostics GmbH Method for detecting balanced chromosomal aberrations in a genome
WO2011071923A2 (en) 2009-12-07 2011-06-16 Illumina, Inc. Multi-sample indexing for multiplex genotyping
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
EP2513340B1 (en) 2009-12-14 2016-06-29 North Carolina State University Mean dna copy number of chromosomal regions is of prognostic significance in cancer
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
JP6103941B2 (ja) 2010-01-29 2017-03-29 キアジェン ゲイサーズバーグ インコーポレイテッド 核酸の配列特異的精製および多重分析のための方法および組成物
AU2011223655A1 (en) * 2010-03-03 2012-06-28 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
US8951940B2 (en) 2010-04-01 2015-02-10 Illumina, Inc. Solid-phase clonal amplification and related methods
WO2011140827A1 (zh) 2010-05-12 2011-11-17 湖州树问生物技术有限公司 抗体与诊断试剂盒
US20130059741A1 (en) 2010-05-13 2013-03-07 Illumina, Inc. Binding assays for markers
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
CA2799200A1 (en) 2010-05-19 2011-11-24 Qiagen Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CA2841142C (en) 2010-06-23 2020-12-15 Ryan D. Morin Biomarkers for non-hodgkin lymphomas and uses thereof
US9029103B2 (en) 2010-08-27 2015-05-12 Illumina Cambridge Limited Methods for sequencing polynucleotides
WO2012034130A2 (en) 2010-09-10 2012-03-15 Qiagen Methods and compositions for nucleic acid detection
US8483969B2 (en) 2010-09-17 2013-07-09 Illuminia, Inc. Variation analysis for multiple templates on a solid support
ES2523140T3 (es) 2010-09-21 2014-11-21 Population Genetics Technologies Ltd. Aumento de la confianza en las identificaciones de alelos con el recuento molecular
WO2012047899A2 (en) 2010-10-04 2012-04-12 The Johns Hopkins University Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
DK2630263T4 (da) 2010-10-22 2022-02-14 Cold Spring Harbor Laboratory Varital tælling af nucleinsyrer for at opnå information om antal genomiske kopier
CN114678128B (zh) 2010-11-30 2026-01-09 香港中文大学 与癌症相关的遗传或分子畸变的检测
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
WO2012082841A2 (en) 2010-12-14 2012-06-21 University Of Maryland, Baltimore Universal anti-tag chimeric antigen receptor-expressing t cells and methods of treating cancer
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20150024952A1 (en) 2010-12-28 2015-01-22 Arlet Alarcon Molecular profiling for cancer
EP3564395B1 (en) 2010-12-30 2025-06-25 Foundation Medicine, Inc. Optimization of multigene analysis of tumor samples
WO2012095378A1 (en) 2011-01-11 2012-07-19 Roche Diagnostics Gmbh High resolution melting analysis as a prescreening tool
US9365897B2 (en) 2011-02-08 2016-06-14 Illumina, Inc. Selective enrichment of nucleic acids
US8728732B2 (en) 2011-03-01 2014-05-20 The Johns Hopkins University Global DNA hypomethylation and biomarkers for clinical indications in cancer
EP2495336B8 (en) 2011-03-04 2014-07-23 Roche Diagnostics GmbH A new type of universal probes for the detection of genomic variants
US8658572B2 (en) 2011-03-18 2014-02-25 Roche Nimblegen, Inc. Whole proteome tiling microarrays
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
WO2012170715A1 (en) 2011-06-07 2012-12-13 Caris Mpi, Inc. Molecular profiling for cancer
CA3104322C (en) 2011-09-23 2023-06-13 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US9410206B2 (en) 2011-11-30 2016-08-09 John Wayne Cancer Institute Long noncoding RNA (lncRNA) as a biomarker and therapeutic marker in cancer
EP2607495A1 (en) 2011-12-23 2013-06-26 Genomica S.A.U. Method for detection of KRAS mutations
EP2809801B1 (en) 2012-01-31 2018-07-25 Speiser, Paul Non-invasive cancer diagnosis
US20150011416A1 (en) 2012-02-23 2015-01-08 Qiagen Mansfield, Inc Multimodal pcr target detection
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
CA2867293C (en) 2012-03-13 2020-09-01 Abhijit Ajit PATEL Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing
FI2831279T3 (fi) 2012-03-26 2023-05-23 Univ Johns Hopkins Nopea aneuploidian havaitseminen
EP2653558B1 (en) 2012-04-18 2015-10-07 Roche Diagniostics GmbH A method of detecting nucleic acid targets using a statistical classifier
US9512477B2 (en) * 2012-05-04 2016-12-06 Boreal Genomics Inc. Biomarker anaylsis using scodaphoresis
EP4071253A1 (en) 2012-07-26 2022-10-12 Illumina, Inc. Compositions and methods for the amplification of nucleic acids
US20150197787A1 (en) 2012-08-02 2015-07-16 Qiagen Gmbh Recombinase mediated targeted dna enrichment for next generation sequencing
US8904664B2 (en) 2012-08-15 2014-12-09 Mimedx Group, Inc. Dehydration device and methods for drying biological materials
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
IL269097B2 (en) 2012-09-04 2024-01-01 Guardant Health Inc Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20140066317A1 (en) 2012-09-04 2014-03-06 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
WO2014044724A1 (en) 2012-09-18 2014-03-27 Qiagen Gmbh Method and kit for preparing a target rna depleted sample
US20150252415A1 (en) 2012-10-15 2015-09-10 The Children's Hospital Of Philadelphia Arid1b and neuroblastoma
US20140128270A1 (en) 2012-11-08 2014-05-08 Roche Molecular Systems, Inc. Method of improving microarray performance by strand elimination
US9218450B2 (en) 2012-11-29 2015-12-22 Roche Molecular Systems, Inc. Accurate and fast mapping of reads to genome
US20150307947A1 (en) 2012-12-04 2015-10-29 Caris Mpi, Inc. Molecular profiling for cancer
US9382581B2 (en) 2012-12-13 2016-07-05 Roche Molecular Systems, Inc. Primers with modified phosphate and base in allele-specific PCR
US9279146B2 (en) 2012-12-21 2016-03-08 Roche Molecular Systems, Inc. Compounds and methods for the enrichment of mutated nucleic acid from a mixture
US20140287937A1 (en) 2013-02-21 2014-09-25 Toma Biosciences, Inc. Methods for assessing cancer
TWI654206B (zh) 2013-03-16 2019-03-21 諾華公司 使用人類化抗-cd19嵌合抗原受體治療癌症
CA2912059A1 (en) 2013-05-10 2014-11-13 Foundation Medicine, Inc. Analysis of genetic variants
US9501449B2 (en) 2013-09-10 2016-11-22 Sviral, Inc. Method, apparatus, and computer-readable medium for parallelization of a computer program on a plurality of computing cores
WO2015073711A1 (en) 2013-11-13 2015-05-21 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
US9873908B2 (en) 2013-11-27 2018-01-23 Roche Molecular Systems, Inc. Methods for the enrichment of mutated nucleic acid from a mixture
CN106414765A (zh) 2013-12-20 2017-02-15 Illumina公司 在片段化的基因组dna样品中保留基因组连接信息
EP3378952B1 (en) 2013-12-28 2020-02-05 Guardant Health, Inc. Methods and systems for detecting genetic variants
US9944924B2 (en) 2014-01-16 2018-04-17 Illumina, Inc. Polynucleotide modification on solid support
WO2015116868A2 (en) 2014-01-29 2015-08-06 Caris Mpi, Inc. Molecular profiling of immune modulators
US9670530B2 (en) 2014-01-30 2017-06-06 Illumina, Inc. Haplotype resolved genome sequencing
EP3102699B1 (en) 2014-02-07 2018-10-31 Qiagen Sciences, LLC Pcr primers
JP6664332B2 (ja) 2014-03-18 2020-03-13 キアゲン ゲーエムベーハー 細胞外核酸の安定化および単離
CN106462669A (zh) 2014-03-25 2017-02-22 奎斯特诊断投资股份有限公司 通过使用平均循环阈值的基因内差异表达(ide)检测基因融合
WO2015173222A1 (en) 2014-05-12 2015-11-19 Roche Diagnostics Gmbh Rare variant calls in ultra-deep sequencing
WO2015181213A1 (en) 2014-05-27 2015-12-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of patients suffering from cancer
CA2950298C (en) 2014-06-03 2024-01-09 Illumina, Inc. Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores
GB201410646D0 (en) 2014-06-14 2014-07-30 Illumina Cambridge Ltd Methods of increasing sequencing accuracy
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
WO2015198074A1 (en) 2014-06-27 2015-12-30 Illumina Cambridge Limited Methods, applications and systems for processing and presenting gene sequencing information
US10658073B2 (en) 2014-08-15 2020-05-19 QIAGEN Redwood City, Inc. Methods and systems for interpretation and reporting of sequence-based genetic tests using pooled allele statistics
EP3626834B1 (en) 2014-07-15 2022-09-21 Qiagen Sciences, LLC Semi-random barcodes for nucleic acid analysis
JP6803327B2 (ja) 2014-08-06 2020-12-23 ニューゲン テクノロジーズ, インコーポレイテッド 標的化されたシークエンシングからのデジタル測定値
WO2016024346A1 (ja) 2014-08-13 2016-02-18 株式会社東京精密 プローバ及びプローブ検査方法
EP3191606B1 (en) 2014-09-12 2020-05-27 Illumina, Inc. Methods for detecting the presence of polymer subunits using chemiluminescence
CN104531854B (zh) 2014-11-10 2017-01-18 中国人民解放军第三〇七医院 检测西妥昔单抗治疗转移性结直肠癌耐药的试剂盒
DK3218511T3 (da) 2014-11-11 2020-07-20 Illumina Cambridge Ltd Fremgangsmåder og arrays til frembringelse og sekventering af monoklonale klynger af nukleinsyre
WO2016090273A1 (en) 2014-12-05 2016-06-09 Foundation Medicine, Inc. Multigene analysis of tumor samples
EP3882356A1 (en) 2014-12-15 2021-09-22 Illumina, Inc. Compositions and methods for single molecular placement on a substrate
US10792299B2 (en) 2014-12-26 2020-10-06 Nitto Denko Corporation Methods and compositions for treating malignant tumors associated with kras mutation
EP3240911B1 (en) 2014-12-31 2020-08-26 Guardant Health, Inc. Detection and treatment of disease exhibiting disease cell heterogeneity and systems and methods for communicating test results
EP3247804B1 (en) 2015-01-23 2020-08-05 Qiagen Sciences, LLC High multiplex pcr with molecular barcoding
SG11201706504RA (en) 2015-02-10 2017-09-28 Illumina Inc Methods and compositions for analyzing cellular components
WO2016134136A2 (en) 2015-02-20 2016-08-25 The Johns Hopkins University Genomic alterations in the tumor and circulation of pancreatic cancer patients
WO2016135300A1 (en) 2015-02-26 2016-09-01 Qiagen Gmbh Efficiency improving methods for gene library generation
WO2016140974A1 (en) 2015-03-01 2016-09-09 Novena Therapeutics Inc. Process for measuring tumor response to an initial oncology treatment
CA2978628A1 (en) 2015-03-03 2016-09-09 Caris Mpi, Inc. Molecular profiling for cancer
WO2016149261A1 (en) 2015-03-16 2016-09-22 Personal Genome Diagnostics, Inc. Systems and methods for analyzing nucleic acid
EP3274467A4 (en) 2015-03-24 2018-10-31 Eutropics Pharmaceuticals, Inc. Surrogate functional biomarker for solid tumor cancer
CA2980327A1 (en) 2015-03-26 2016-09-29 Quest Diagnostics Investments Incorporated Alignment and variant sequencing analysis pipeline
US9828672B2 (en) 2015-03-26 2017-11-28 Lam Research Corporation Minimizing radical recombination using ALD silicon oxide surface coating with intermittent restoration plasma
WO2016156529A1 (en) 2015-03-31 2016-10-06 Qiagen Gmbh Efficiency improving ligation methods
WO2016170147A1 (en) 2015-04-22 2016-10-27 Qiagen Gmbh Efficiency improving ligation methods
US10844428B2 (en) 2015-04-28 2020-11-24 Illumina, Inc. Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
ES2969767T3 (es) 2015-05-01 2024-05-22 Guardant Health Inc Métodos de diagnóstico
WO2016190897A1 (en) 2015-05-27 2016-12-01 Quest Diagnostics Investments Incorporated Compositions and methods for screening solid tumors
KR102828319B1 (ko) 2015-06-03 2025-07-02 일루미나, 인코포레이티드 나노기공에 인접한 중합효소에 고정된 테터를 이용하여 폴리뉴클레오타이드를 서열결정하기 위한 조성물, 시스템 및 방법
JP7007197B2 (ja) 2015-06-05 2022-01-24 キアゲン ゲーエムベーハー サイズによってdnaを分離する方法
EP3307886B1 (en) 2015-06-10 2021-03-24 Qiagen GmbH Method for isolating extracellular nucleic acids using anion exchange particles
IL318703A (en) 2015-06-29 2025-03-01 Caris Science Inc Therapeutic oligonucleotides
US12157910B2 (en) 2015-07-06 2024-12-03 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
US10640823B2 (en) 2015-07-08 2020-05-05 Quest Diagnostics Investments Incorporated Detecting genetic copy number variation
JP7074661B2 (ja) 2015-07-21 2022-05-25 ガーダント ヘルス, インコーポレイテッド 融合遺伝子を捕捉するためのロックド核酸
CA3242290A1 (en) 2015-07-27 2017-02-02 Illumina, Inc. Spatial mapping of nucleic acid sequence information
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US11248262B2 (en) 2015-08-24 2022-02-15 Qiagen Gmbh Method for generating a RNA-sequencing library
US12540351B2 (en) 2015-09-02 2026-02-03 Guardant Health, Inc. Identification of somatic mutations versus germline variants for cell-free DNA variant calling applications
US11302416B2 (en) 2015-09-02 2022-04-12 Guardant Health Machine learning for somatic single nucleotide variant detection in cell-free tumor nucleic acid sequencing applications
US20180268937A1 (en) 2015-09-24 2018-09-20 Caris Science, Inc. Method, apparatus, and computer program product for analyzing biological data
US10577643B2 (en) 2015-10-07 2020-03-03 Illumina, Inc. Off-target capture reduction in sequencing techniques
US20180300449A1 (en) 2015-10-10 2018-10-18 Guardant Health, Inc. Methods and applications of gene fusion detection in cell-free dna analysis
US20170141793A1 (en) 2015-11-13 2017-05-18 Microsoft Technology Licensing, Llc Error correction for nucleotide data stores
CA3005694A1 (en) 2015-11-20 2017-05-26 Qiagen Gmbh Method of preparing sterilized compositions for stabilization of extracellular nucleic acids
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
CN108463559A (zh) 2016-01-15 2018-08-28 文塔纳医疗系统公司 肿瘤的深度测序概况分析
CN108603229A (zh) 2016-01-22 2018-09-28 格瑞尔公司 用于高保真测序的方法和系统
AU2017211236B2 (en) 2016-01-26 2023-04-20 Ventana Medical Systems, Inc. Predictive diagnostic workflow for tumors using automated dissection, next generation sequencing, and automated slide stainers
US12359250B2 (en) 2016-01-29 2025-07-15 The Johns Hopkins University Bottleneck sequencing
WO2017136603A1 (en) 2016-02-02 2017-08-10 Guardant Health, Inc. Cancer evolution detection and diagnostic
AU2017225876B2 (en) 2016-02-29 2021-03-04 Foundation Medicine, Inc. Methods and systems for evaluating tumor mutational burden
ES3002715T3 (en) 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
WO2017181202A2 (en) 2016-04-15 2017-10-19 Natera, Inc. Methods for lung cancer detection
US12351875B2 (en) 2016-04-15 2025-07-08 Roche Sequencing Solutions, Inc. Detecting cancer driver genes and pathways
US20170316149A1 (en) 2016-04-28 2017-11-02 Quest Diagnostics Investments Inc. Classification of genetic variants
WO2017197027A1 (en) 2016-05-11 2017-11-16 Illumina, Inc. Polynucleotide enrichment and amplification using argonaute systems
ES2929367T3 (es) 2016-05-18 2022-11-28 Hoffmann La Roche Amplificación por PCR ultrarrápida cuantitativa usando un dispositivo basado en electrohumectación
IL298701B2 (en) 2016-05-25 2024-03-01 Caris Science Inc Oligonucleotide probes and uses thereof
EP3469079B1 (en) 2016-06-13 2020-08-05 Grail, Inc. Enrichment of mutated cell free nucleic acids for cancer detection
WO2018005811A1 (en) 2016-06-30 2018-01-04 Grail, Inc. Differential tagging of rna for preparation of a cell-free dna/rna sequencing library
KR102610098B1 (ko) 2016-07-06 2023-12-04 가던트 헬쓰, 인크. 무세포 핵산의 프래그멘톰 프로파일링을 위한 방법
EP3485033B1 (en) 2016-07-12 2022-09-28 Qiagen Sciences, LLC Single end duplex dna sequencing
ES2873723T3 (es) 2016-07-22 2021-11-03 Univ Oregon Health & Science Colecciones de genoma completo de células individuales y métodos de indexación combinatoria para prepararlas
KR102416441B1 (ko) 2016-09-22 2022-07-04 일루미나, 인코포레이티드 체세포 복제수 변이 검출
WO2018057928A1 (en) 2016-09-23 2018-03-29 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
EP3299471B1 (en) 2016-09-23 2019-10-23 Roche Diagniostics GmbH Methods for determining the amount of a nucleic acid of interest in an unprocessed sample
US20200032265A1 (en) 2016-09-27 2020-01-30 Caris Science, Inc. Oligonucleotide Probes and Uses Thereof
KR20240155386A (ko) 2016-09-30 2024-10-28 가던트 헬쓰, 인크. 무세포 핵산의 다중-해상도 분석 방법
US10810213B2 (en) 2016-10-03 2020-10-20 Illumina, Inc. Phenotype/disease specific gene ranking using curated, gene library and network based data structures
KR102384832B1 (ko) 2016-10-07 2022-04-08 일루미나, 인코포레이티드 뉴클레오타이드 서열분석 데이터의 이차 분석을 위한 시스템 및 방법
SG11201903509QA (en) 2016-10-24 2019-05-30 Univ Hong Kong Chinese Methods and systems for tumor detection
US10822651B2 (en) 2016-10-28 2020-11-03 Grail, Inc. Methods for single-stranded nucleic acid library preparation
EP3532635B1 (en) 2016-10-31 2021-06-09 F. Hoffmann-La Roche AG Barcoded circular library construction for identification of chimeric products
WO2018085862A2 (en) 2016-11-07 2018-05-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
CN110023509A (zh) 2016-11-15 2019-07-16 私人基因诊断公司 基因型分型测定中的非独特条形码
AU2017360993A1 (en) 2016-11-16 2019-06-13 Illumina, Inc. Validation methods and systems for sequence variant calls
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
US20180163201A1 (en) 2016-12-12 2018-06-14 Grail, Inc. Methods for tagging and amplifying rna template molecules for preparing sequencing libraries
WO2018119452A2 (en) 2016-12-22 2018-06-28 Guardant Health, Inc. Methods and systems for analyzing nucleic acid molecules
EP3559841B1 (en) 2016-12-22 2025-08-06 Grail, Inc. Base coverage normalization and use thereof in detecting copy number variation
WO2018119399A1 (en) 2016-12-23 2018-06-28 Grail, Inc. Methods for high efficiency library preparation using double-stranded adapters
CN110741096B (zh) 2016-12-28 2023-07-14 奎斯特诊断投资有限责任公司 用于检测循环肿瘤dna的组合物和方法
JP6806909B2 (ja) 2017-01-17 2021-01-06 イルミナ インコーポレイテッド 腫瘍形成性スプライスバリアントの判定
CA3050247A1 (en) 2017-01-18 2018-07-26 Illumina, Inc. Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
CA3051509A1 (en) 2017-01-25 2018-08-02 The Chinese University Of Hong Kong Diagnostic applications using nucleic acid fragments
CA3063364A1 (en) 2017-01-26 2018-08-02 Qiagen Gmbh Method for enriching template nucleic acids
EP3382978A1 (en) 2017-03-31 2018-10-03 Nagravision SA Distributed denial of service analysis
WO2018204657A1 (en) 2017-05-04 2018-11-08 The Johns Hopkins University Detection of cancer
KR20200011474A (ko) 2017-05-26 2020-02-03 노벨리스 인크. 코팅 제거 킬른을 위한 유체 온도 제어 시스템 및 방법
EP3665308A1 (en) 2017-08-07 2020-06-17 The Johns Hopkins University Methods and materials for assessing and treating cancer
KR102356323B1 (ko) 2017-11-30 2022-01-26 일루미나, 인코포레이티드 서열 변이체 콜에 대한 검증방법 및 시스템
CN108181992A (zh) 2018-01-22 2018-06-19 北京百度网讯科技有限公司 基于手势的语音唤醒方法、装置、设备及计算机可读介质
EP3765017B1 (en) 2018-03-15 2025-05-21 The Board of Trustees of the Leland Stanford Junior University Methods using nucleic acid signals for revealing biological attributes
US20210292851A1 (en) 2018-07-27 2021-09-23 Roche Sequencing Solutions, Inc. Method of monitoring effectiveness of immunotherapy of cancer patients

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