MX346972B - Agonistas de guanilato ciclasa útiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatía coronaria, cálculo biliar, obesidad y otras enfermedades cardiovasculares. - Google Patents

Agonistas de guanilato ciclasa útiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatía coronaria, cálculo biliar, obesidad y otras enfermedades cardiovasculares.

Info

Publication number
MX346972B
MX346972B MX2015010413A MX2015010413A MX346972B MX 346972 B MX346972 B MX 346972B MX 2015010413 A MX2015010413 A MX 2015010413A MX 2015010413 A MX2015010413 A MX 2015010413A MX 346972 B MX346972 B MX 346972B
Authority
MX
Mexico
Prior art keywords
obesity
gallstone
hypercholesterolemia
atherosclerosis
agonists
Prior art date
Application number
MX2015010413A
Other languages
English (en)
Inventor
Kunwar Shailubhai
Original Assignee
Synergy Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synergy Pharmaceuticals Inc filed Critical Synergy Pharmaceuticals Inc
Publication of MX346972B publication Critical patent/MX346972B/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a una composición para usarse en la prevención o tratamiento de hipercolesterolemia, que comprende una dosis efectiva de una agonista del receptor de guanilato ciclasa que tiene la secuencia SEQ ID NO.9, en donde dicha secuencia es un biciclo [4, 12; 7,15].
MX2015010413A 2009-12-03 2010-12-03 Agonistas de guanilato ciclasa útiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatía coronaria, cálculo biliar, obesidad y otras enfermedades cardiovasculares. MX346972B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/630,654 US8969514B2 (en) 2007-06-04 2009-12-03 Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
PCT/US2010/058848 WO2011069038A2 (en) 2009-12-03 2010-12-03 Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases

Publications (1)

Publication Number Publication Date
MX346972B true MX346972B (es) 2017-04-07

Family

ID=43920728

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015010413A MX346972B (es) 2009-12-03 2010-12-03 Agonistas de guanilato ciclasa útiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatía coronaria, cálculo biliar, obesidad y otras enfermedades cardiovasculares.
MX2012006263A MX2012006263A (es) 2009-12-03 2010-12-03 Agonistas de guanilato ciclasa utiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatia coronaria, calculo biliar, obesidad y otras enfermedades cardiovasculares.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012006263A MX2012006263A (es) 2009-12-03 2010-12-03 Agonistas de guanilato ciclasa utiles para el tratamiento de hipercolesterolemia, arterioesclerosis, cardiopatia coronaria, calculo biliar, obesidad y otras enfermedades cardiovasculares.

Country Status (11)

Country Link
US (3) US8969514B2 (es)
EP (3) EP2923706A1 (es)
JP (6) JP5852005B2 (es)
CN (2) CN105963676B (es)
AU (2) AU2010325900B2 (es)
CA (2) CA2782691C (es)
ES (1) ES2540326T3 (es)
HK (1) HK1215387A1 (es)
IL (2) IL220090B (es)
MX (2) MX346972B (es)
WO (1) WO2011069038A2 (es)

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US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN103601792B (zh) 2007-06-04 2016-06-29 协同医药品公司 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂
AU2009256157B2 (en) 2008-06-04 2014-12-18 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2010065751A2 (en) 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase c agonists and methods of use
AU2011302006A1 (en) 2010-09-15 2013-03-07 Synergy Pharmaceuticals Inc. Formulations of guanylate cyclase C agonists and methods of use
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
MX357121B (es) * 2011-03-01 2018-06-27 Synergy Pharmaceuticals Inc Star Proceso de preparacion de agonistas c de guanilato ciclasa.
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US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
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JP6694385B2 (ja) 2013-08-09 2020-05-13 アーデリクス，インコーポレーテッド リン酸塩輸送阻害のための化合物及び方法
JP6661531B2 (ja) * 2013-10-10 2020-03-11 シナジー ファーマシューティカルズ インコーポレイテッド オピオイド誘発性機能障害の治療に有用なグアニル酸シクラーゼのアゴニスト
CN103694320B (zh) * 2013-12-11 2015-11-11 深圳翰宇药业股份有限公司 一种普利卡那肽的制备方法
CN111704543A (zh) 2014-11-14 2020-09-25 燿石治疗公司 用于制备α,ω-二羧酸封端的二烷醚的方法和中间体
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JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ
CN119613549A (zh) 2019-06-12 2025-03-14 诺华股份有限公司 利钠肽受体1抗体及使用方法
CN113481153A (zh) * 2021-07-25 2021-10-08 南通美韦德生命科学有限公司 一种脂肪间充质干细胞的分离培养方法

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US20120289460A1 (en) 2012-11-15
EP2506865B1 (en) 2015-04-01
CN105963676A (zh) 2016-09-28
CN105963676B (zh) 2020-02-18
US9814752B2 (en) 2017-11-14
JP6106313B2 (ja) 2017-03-29
ES2540326T3 (es) 2015-07-09
US20150283202A1 (en) 2015-10-08
CA2782691C (en) 2020-03-10
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JP2020023551A (ja) 2020-02-13
HK1215387A1 (en) 2016-08-26
JP6251432B2 (ja) 2017-12-20
JP2015199769A (ja) 2015-11-12
WO2011069038A3 (en) 2012-03-01
CN102858361A (zh) 2013-01-02
US20100152118A1 (en) 2010-06-17
US8969514B2 (en) 2015-03-03
WO2011069038A2 (en) 2011-06-09
CA2782691A1 (en) 2011-06-09
IL262838A (en) 2018-12-31
AU2016200545A1 (en) 2016-02-18
IL220090B (en) 2018-11-29
MX2012006263A (es) 2012-09-07
AU2010325900A1 (en) 2012-06-21
JP5942023B2 (ja) 2016-06-29
JP2013512923A (ja) 2013-04-18
EP2923706A1 (en) 2015-09-30
US9089612B2 (en) 2015-07-28
JP2016155861A (ja) 2016-09-01
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AU2010325900B2 (en) 2016-02-25

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