DE69422061T2 - 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel - Google Patents
3-phenyl-2-isoxazoline derivate als entzündugshemmende mittelInfo
- Publication number
- DE69422061T2 DE69422061T2 DE69422061T DE69422061T DE69422061T2 DE 69422061 T2 DE69422061 T2 DE 69422061T2 DE 69422061 T DE69422061 T DE 69422061T DE 69422061 T DE69422061 T DE 69422061T DE 69422061 T2 DE69422061 T2 DE 69422061T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date
- inflammatory
- phenyl
- resistant agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15724193A | 1993-11-26 | 1993-11-26 | |
PCT/IB1994/000313 WO1995014680A1 (en) | 1993-11-26 | 1994-10-12 | 3-aryl-2-isoxazolines as antiinflammatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69422061D1 DE69422061D1 (de) | 2000-01-13 |
DE69422061T2 true DE69422061T2 (de) | 2000-03-30 |
Family
ID=22562909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69422061T Expired - Fee Related DE69422061T2 (de) | 1993-11-26 | 1994-10-12 | 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel |
Country Status (12)
Country | Link |
---|---|
US (1) | US5686434A (de) |
EP (1) | EP0730587B1 (de) |
JP (1) | JP2818820B2 (de) |
AT (1) | ATE187447T1 (de) |
CA (1) | CA2177375A1 (de) |
DE (1) | DE69422061T2 (de) |
DK (1) | DK0730587T3 (de) |
ES (1) | ES2139754T3 (de) |
FI (1) | FI945556A (de) |
GR (1) | GR3032506T3 (de) |
PT (1) | PT730587E (de) |
WO (1) | WO1995014680A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT920421E (pt) * | 1996-08-21 | 2003-03-31 | Upjohn Co | Derivados de isoxazolina uteis como agentes antimicrobianos |
US6172074B1 (en) * | 1996-11-11 | 2001-01-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Imidazopyridines and oxazolopyridines |
WO1998031676A1 (de) * | 1997-01-17 | 1998-07-23 | Basf Aktiengesellschaft | Verfahren zur herstellung von schwefelhaltigen 2-chlor-3-(4,5-dihydroisoxazol-3-yl)-benzoesäuren |
US6022977A (en) | 1997-03-26 | 2000-02-08 | Dupont Pharmaceuticals Company | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
JP2002503655A (ja) * | 1998-02-13 | 2002-02-05 | ファルマシア・アンド・アップジョン・カンパニー | 抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体 |
WO1999058509A1 (de) * | 1998-05-11 | 1999-11-18 | Basf Aktiengesellschaft | Verfahren zur herstellung von isoxazolin-3-yl-acylbenzolen |
DE19852095A1 (de) | 1998-11-12 | 2000-05-18 | Basf Ag | Verfahren zur Herstellung von 2-Alkyl-3-(4,5-dihydroisoxazol-3-yl)-acylbenzolen |
DE69914931T2 (de) * | 1998-10-09 | 2004-12-16 | Janssen Pharmaceutica N.V. | 4,5-dehydroisoxazole derivate und ihre pharmazeutische verwendung |
SK287231B6 (sk) | 1999-08-21 | 2010-04-07 | Nycomed Gmbh | Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora |
KR100399361B1 (ko) | 1999-11-04 | 2003-09-26 | 주식회사 엘지생명과학 | 캐스파제 억제제 함유 치료제 조성물 |
ATE273705T1 (de) * | 1999-09-17 | 2004-09-15 | Lg Chem Investment Ltd | Caspase-hemmer |
DE19953024A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Isoxazolderivate als Phosphodiesterase VII-Hemmer |
AU2002322720B2 (en) | 2001-07-25 | 2008-11-13 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
BRPI0409229A (pt) | 2003-04-01 | 2006-03-28 | Applied Research Systems | inibidores das fosfodiesterases na infertilidade |
KR100594544B1 (ko) * | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
AU2004268847A1 (en) | 2003-08-29 | 2005-03-10 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-IV |
WO2005051931A2 (en) * | 2003-11-26 | 2005-06-09 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
MXPA06010793A (es) * | 2004-03-26 | 2006-12-19 | Cytokine Pharmasciences Inc | Compuestos composiciones, procesos de elaboracion, y metodos de uso relacionados a la inhibicion del factor inhibidor de migracion de macrofago. |
PL1768966T3 (pl) * | 2004-06-17 | 2012-08-31 | Infinity Discovery Inc | Związki i sposoby hamowania oddziaływania białek BCL z partnerami wiążącymi |
ES2370788T3 (es) * | 2005-02-07 | 2011-12-22 | Aerocrine Ab | Controlar flujo de aliento exhalado durante análisis. |
KR101324451B1 (ko) * | 2005-03-15 | 2013-10-31 | 가니얼 이뮤노테라퓨틱스 인코포레이티드 | 면역 조절제 활성을 갖는 화합물 |
EP2392258B1 (de) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-Informatiksystem |
EP2258357A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
WO2007029077A1 (en) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Substituted indazoles as inhibitors of phosphodiesterase type-iv |
BRPI0617673C1 (pt) * | 2005-10-19 | 2012-05-22 | Ranbaxy Lab Ltd | composições de inibidores de fosfodiesterase do tipo iv |
AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536667A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | 5ht受容体介在性の神経新生 |
EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
US7998971B2 (en) * | 2006-09-08 | 2011-08-16 | Braincells Inc. | Combinations containing a 4-acylaminopyridine derivative |
MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
AU2007298549A1 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-IV |
US20100029728A1 (en) * | 2006-09-22 | 2010-02-04 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2688161C (en) | 2007-06-04 | 2020-10-20 | Kunwar Shailubhai | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
TR201908314T4 (tr) | 2009-02-20 | 2019-06-21 | 2 Bbb Medicines B V | Glutatyon bazlı ilaç dağıtım sistemi. |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
IL295075A (en) | 2009-05-06 | 2022-09-01 | Laboratory Skin Care Inc | Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them |
CN101781294B (zh) * | 2010-03-10 | 2012-02-01 | 天津药物研究院 | 一类咪唑的衍生物、其制备方法和用途 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
DK2691379T3 (en) | 2011-03-31 | 2017-02-13 | Bayer Ip Gmbh | HERBICID AND FUNGICID ACTIVE 3-PHENYLISOXAZOLINE-5-CARBOXAMIDES AND 3-PHENYLISOXAZOLIN-5-THIOAMIDES |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
EP2900644B1 (de) * | 2012-09-25 | 2016-09-21 | Bayer CropScience AG | Herbizid und fungizid wirksame 5-oxy-substituierte 3-phenylisoxazolin-5-carboxamide und 5-oxy-substituierte 3-phenylisoxazolin-5-thioamide |
BR112015006573B1 (pt) * | 2012-09-25 | 2020-11-03 | Bayer Cropscience Ag | derivados de 3-fenilisoxazolina, compoisições herbicidas, seus usos, e método para controle de plantas indesejáveis |
WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonisten der guanylatcyclase und deren verwendungen |
US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
MX2016001714A (es) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
ES2894277T3 (es) | 2017-06-13 | 2022-02-14 | Bayer Ag | 3-Fenilisoxazolin-5-carboxamidas de ácidos y ésteres tetrahidro y dihidrofuranocarboxílicos con efecto herbicida |
CN110799511B (zh) | 2017-06-13 | 2023-09-01 | 拜耳公司 | 除草活性的四氢和二氢呋喃甲酰胺的3-苯基异噁唑啉-5-甲酰胺 |
BR112020003266A2 (pt) | 2017-08-17 | 2020-10-13 | Bayer Aktiengesellschaft | 3-fenil-5-trifluorometilisoxazolina-5-carboxamidas herbicidamente ativas de ésteres e ácidos ciclopentilcarboxílicos |
UA127418C2 (uk) | 2018-01-25 | 2023-08-16 | Баєр Акціенгезельшафт | Гербіцидно активні 3-фенілізоксазолін-5-карбоксамідні похідні циклопентилкарбонової кислоти |
CA3133025A1 (en) | 2019-03-12 | 2020-09-17 | Bayer Aktiengesellschaft | Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenyl carboxylic acid esters |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
JPS62103070A (ja) * | 1985-10-29 | 1987-05-13 | Mitsui Toatsu Chem Inc | イソオキサゾリン誘導体および植物生長調節剤 |
US4912120A (en) * | 1986-03-14 | 1990-03-27 | Syntex (U.S.A.) Inc. | 3,5-substituted 4,5-dihydroisoxazoles as transglutaminase inhibitors |
WO1987006576A1 (en) * | 1986-04-29 | 1987-11-05 | Pfizer Inc. | Calcium independent camp phosphodiesterase inhibitor antidepressant |
ZA872997B (en) * | 1986-05-09 | 1988-12-28 | Warner Lambert Co | Novel styryl pyrazoles,isoxazoles and analogs thereof having activity as 5-lipoxygenase inhibitors,pharmaceutical compositions and methods of use therefor |
IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
DE3736113A1 (de) * | 1987-10-26 | 1989-05-03 | Hoechst Ag | Arzneimittel, darin enthaltene phosphorhaltige 2-isoxazoline und isoxazole, sowie herstellungsverfahren fuer diese heterocyclischen verbindungen |
US4952700A (en) * | 1988-04-25 | 1990-08-28 | W.R. Grace & Co.-Conn. | Preparation of isoxazolines and isoxazoles |
US4933464A (en) * | 1988-04-25 | 1990-06-12 | W. R. Grace & Co.-Conn. | Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles |
CA2017383A1 (en) * | 1989-06-08 | 1990-12-08 | Raymond R. Martodam | Use of vanilloids for the treatment of respiratory diseases or disorders |
WO1991007177A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders |
GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
EP0451790A1 (de) * | 1990-04-12 | 1991-10-16 | Hoechst Aktiengesellschaft | 3,5-disubstituierte 2-Isoxazoline und Isoxazole, Verfahren zu deren Herstellung, diese enthaltende Mittel und ihre Verwendung |
DE4026018A1 (de) * | 1990-08-17 | 1992-02-20 | Hoechst Ag | Isoxazoline oder isothiazoline enthaltende pflanzenschuetzende mittel und neue isoxazoline und isothiazoline |
KR930703262A (ko) * | 1990-11-06 | 1993-11-29 | 스튜어트 알. 슈터 | 이미다졸리디논 화합물 |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
AU2869092A (en) * | 1991-10-11 | 1993-05-03 | Smithkline Beecham Corporation | Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production |
-
1994
- 1994-10-12 EP EP94927778A patent/EP0730587B1/de not_active Expired - Lifetime
- 1994-10-12 AT AT94927778T patent/ATE187447T1/de not_active IP Right Cessation
- 1994-10-12 DK DK94927778T patent/DK0730587T3/da active
- 1994-10-12 WO PCT/IB1994/000313 patent/WO1995014680A1/en active IP Right Grant
- 1994-10-12 JP JP7514932A patent/JP2818820B2/ja not_active Expired - Fee Related
- 1994-10-12 ES ES94927778T patent/ES2139754T3/es not_active Expired - Lifetime
- 1994-10-12 CA CA002177375A patent/CA2177375A1/en not_active Abandoned
- 1994-10-12 DE DE69422061T patent/DE69422061T2/de not_active Expired - Fee Related
- 1994-10-12 US US08/640,945 patent/US5686434A/en not_active Expired - Fee Related
- 1994-10-12 PT PT94927778T patent/PT730587E/pt unknown
- 1994-11-25 FI FI945556A patent/FI945556A/fi not_active Application Discontinuation
-
2000
- 2000-01-27 GR GR20000400200T patent/GR3032506T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1995014680A1 (en) | 1995-06-01 |
JPH09500146A (ja) | 1997-01-07 |
GR3032506T3 (en) | 2000-05-31 |
EP0730587B1 (de) | 1999-12-08 |
FI945556A (fi) | 1995-05-27 |
CA2177375A1 (en) | 1995-06-01 |
PT730587E (pt) | 2000-05-31 |
DK0730587T3 (da) | 2000-04-10 |
ES2139754T3 (es) | 2000-02-16 |
JP2818820B2 (ja) | 1998-10-30 |
ATE187447T1 (de) | 1999-12-15 |
EP0730587A1 (de) | 1996-09-11 |
FI945556A0 (fi) | 1994-11-25 |
US5686434A (en) | 1997-11-11 |
DE69422061D1 (de) | 2000-01-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |