AU2869092A - Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production - Google Patents

Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production

Info

Publication number
AU2869092A
AU2869092A AU28690/92A AU2869092A AU2869092A AU 2869092 A AU2869092 A AU 2869092A AU 28690/92 A AU28690/92 A AU 28690/92A AU 2869092 A AU2869092 A AU 2869092A AU 2869092 A AU2869092 A AU 2869092A
Authority
AU
Australia
Prior art keywords
phenylpyrrolidin
heterocyclic
medicament
ones
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU28690/92A
Inventor
Paul Elliot Bender
Siegfried Benjamin Christensen Iv
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of AU2869092A publication Critical patent/AU2869092A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU28690/92A 1991-10-11 1992-10-02 Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production Abandoned AU2869092A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77650891A 1991-10-11 1991-10-11
US91673392A 1992-07-20 1992-07-20
US916733 1992-07-20
US776508 2004-02-12

Publications (1)

Publication Number Publication Date
AU2869092A true AU2869092A (en) 1993-05-03

Family

ID=27119195

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28690/92A Abandoned AU2869092A (en) 1991-10-11 1992-10-02 Heterocyclic 3-phenylpyrrolidin-2-ones, their preparation and use for the manufacture of a medicament for inhibiting tumor necrosis factor production

Country Status (4)

Country Link
AU (1) AU2869092A (en)
MX (1) MX9205875A (en)
PT (1) PT100947A (en)
WO (1) WO1993007141A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665754A (en) * 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
US5686434A (en) * 1993-11-26 1997-11-11 Pfizer Inc. 3-aryl-2-isoxazolines as antiinflammatory agents
US5612353A (en) * 1995-06-07 1997-03-18 Rhone-Poulenc Rorer Pharmaceuticals Inc. Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds
DE69637050T2 (en) * 1995-09-19 2008-06-19 Margolin, Solomon B., Dallas USE OF N-SUBSTITUTED PYRIDONES AS TUMOR NECROSIS FACTOR ALPHA HEMMER
DE19751062A1 (en) * 1997-11-18 1999-07-08 Univ Ludwigs Albert 4-substituted 2-pyrrolidinone derivatives to reduce extracellular glutamate levels
DE69915004T2 (en) * 1998-11-05 2004-09-09 Pfizer Products Inc., Groton 5-Oxo-pyrrolidine-2-carboxylic acid Hydroxamidderivate
CA2402384A1 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Benzylated pde4 inhibitors
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
IL161317A0 (en) * 2001-10-16 2004-09-27 Memory Pharm Corp 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
DE10222024A1 (en) * 2002-05-17 2003-11-27 Bayer Ag New N-substituted N'-((5-oxo-2-pyrrolidinyl)-phenyl)-(thio)ureas, are antiviral agents especially effective against human cytomegalovirus
US7495016B2 (en) 2002-10-21 2009-02-24 Irm Llc Pyrrolidones with anti-HIV activity
CA2507465C (en) 2002-11-26 2009-04-28 Pfizer Products Inc. Phenyl substituted piperidine compounds for use as ppar activators
DE10257786A1 (en) * 2002-12-11 2004-07-01 Bayer Healthcare Ag oxazolidinones
US7696198B2 (en) 2003-04-16 2010-04-13 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
CA2522687A1 (en) 2003-04-18 2004-11-04 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
JP2007513105A (en) * 2003-12-02 2007-05-24 ユ セ ベ ソシエテ アノニム Imidazole derivatives, their production and use
JP2008516964A (en) 2004-10-15 2008-05-22 メモリー ファーマシューティカルス コーポレーション Pyrazole derivatives as phosphodiesterase 4 inhibitors
CA2584328A1 (en) 2004-10-20 2006-04-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
JP2008542323A (en) 2005-06-01 2008-11-27 ユセベ ファルマ ソシエテ アノニム 2-Oxo-1-pyrrolidine derivatives, process for producing the same and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1350582A (en) * 1970-07-24 1974-04-18 Ucb Sa Cerivatives of 2-pyrrolidinone
JPS5182258A (en) * 1974-04-25 1976-07-19 Yoshitomi Pharmaceutical PIRORIJINON JUDOTAINO SEIZOHO
US4476311A (en) * 1980-03-12 1984-10-09 The Purdue Frederick Company Analgesic 4-carboxy-pyrrolidin-2-one compound
ATE37871T1 (en) * 1982-12-21 1988-10-15 Ciba Geigy Ag SUBSTITUTED AZABICYCLOALKANES, THEIR USE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF THESE COMPOUNDS.
FI875101A (en) * 1986-12-03 1988-06-04 Tanabe Seiyaku Co LAKTAMDERIVAT OCH PREPARAT INNEHAOLLANDE DESSA.
DE3823299A1 (en) * 1988-07-07 1990-01-11 Schering Ag SUBSTITUTED PHENYL-PYRROLIDIN-2-ONE, -OXAZOLIDIN-2-ONE AND -IMIDAZOLIDIN-2-ONE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
DD299058A5 (en) * 1990-01-31 1992-03-26 Arzneimittelwerk Dresden Gmbh,De PROCESS FOR THE PREPARATION OF N-ACYL-4-PHENYL-PYRROLIDIN-2-ONES WITH CEREBROPROTECTIVE EFFECT

Also Published As

Publication number Publication date
MX9205875A (en) 1993-07-01
PT100947A (en) 1994-02-28
WO1993007141A1 (en) 1993-04-15

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