AR030676A1 - Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden - Google Patents

Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden

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Publication number
AR030676A1
AR030676A1 ARP000103892A ARP000103892A AR030676A1 AR 030676 A1 AR030676 A1 AR 030676A1 AR P000103892 A ARP000103892 A AR P000103892A AR P000103892 A ARP000103892 A AR P000103892A AR 030676 A1 AR030676 A1 AR 030676A1
Authority
AR
Argentina
Prior art keywords
formula
methylene
substituted
aryl
alkylene
Prior art date
Application number
ARP000103892A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR030676A1 publication Critical patent/AR030676A1/es

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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  • Pyridine Compounds (AREA)
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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivado de aminas y amidas de la formula (A) que son ligandos para el receptor del neuropéptido Y Y5 caracterizados porque R1 se selecciona en forma independiente del grupo que consiste en hidrogeno, hidroxi, halo, alquilo de C1-8; alquilo sustituido de C1-8; alcoxi de C1-8, alcoxi sustituido de C1-8, trifluoroalquilo; alquiltio de C1-8 y alquiltio de C1-8 sustituido; cicloalquilo de C3-6; cicloalcoxi de C3-8, nitro; amino, alquilamino de C1-6, dialquilamino de C1-8, cicloalquilamino de C4-8; ciano; carboxi; alcoxicarbonilo de C1-5; alquilcarboniloxi de C1-5; formilo; carbamoilo; fenilo y fenilo sustituido; n es 1-2, B1 es hidrogeno; B2 es hidrogeno; o B1 y B2 puede ser metileno y unidos forman un anillo de cinco o seis elementos; m es 0-3; R2 se selecciona en forma independiente del grupo que consiste en hidrogeno; hidroxi, alquilo de C1-6; alquenilo de C2-6, halo; cicloalquilo de C3-7; fenilo sustituido; naftilo, naftilo sustituido; fenoxi; fenoxi heteroarilo; heteroarilo y heterocicloalquilo; L se selecciona del grupo que consiste en alquileno de C1-8; alquenileno de C2-10; alquinileno de C2-10; cicloalquileno de C3-7; cicloalquilC3-7alquilenoC1-4; alquilenoC1-4arilo; alquilenoC4-7a-amino de formula (1); (N-metilen) piperidin-4-ilo de formula (2); (N-metilen) piperacin-4-ilo de formula (3); (N-metilen) pirrolidin-3-ilo de formula (4); (N-metilen) p-4-acetil-piperidin-4-ilo de formula (5); y (N-metilen) piperidin-4,4-biilo de formula (6); Y es metileno o carbonilo; Z se selecciona del grupo que consiste en: arilo de formula (7); N-sulfonamido de formula (8); N-(aril) sulfonamido de formula (9); arilamido de formula (10); arilureido de formula (11); arilacetamido de formula (12); (ariloxi) carbonilamino de formula (13); 2,3-dihidro-2-oxo-1H-bencimidazol-1-ilo de formula (14); y 1-aril-2,3-dihidro-4-oxo-imidazol-5,5-diilo de formula (15); R3 es seleccionado en forma independiente del grupo que consiste en alquilo de C1-6; alquilo sustituido de C1-8; cicloalquilo; cicloalquilo sustituido; naftililo, naftililo sustituido; heteroarilo; y heteroarilo sustituido; R4 se selecciona en forma independientemente del grupo que consiste en hidrogeno; alquilo de C1-8; alcoxi de C1-8; alcoxi sustituido de C1-8; hidroxi; halogeno; ciano, nitro, amino y alquilamino de C1-8 y dialquilamino de C1-8; R5 se selecciona en forma independiente del grupo que consiste en hidrogeno; alquilo de C1-8; alquilcarbonilo de C1-8; aroilo, carbamoilo, amidino, alquilamino carbonilo de C1-8; (arilamino) carbonilo y alquilcarbonilo de C1-8 arilo; R6 se selecciona en forma independiente del grupo que consiste en hidrogeno y alquilo de C1-8; p es 1-3; q es 1-3; y enantiomeros, diasteromeros y sales de ellos aceptables farmacéuticamente; siempre que: cuando L es alquileno de C1-6, alquenileno de C2-10, alquinileno de C2-10, cicloalquileno de C3-7, alquileno de C1-4 cicloalquil de C3-7, alquileno de C1-4 arilo o a- aminoalquileno; entonces Z es fenilo, N-sulfonamido o N-(aril)sulfonamido; cuando L es (N-metilen) piperacin-4-ilo; entonces Z es fenilo o naftilo; cuando L es (N-metilen) pirrolidin-3-il o (N-metilen) piperidin-4-il; entonces Z es N-sulfonamido, N- (aril) sulfonamido; 2,3-dihidro-2-oxo-1H-becimidazol-1-ilo; benzamido, fenilureido, fenilacetamido o (fenoxi) carbonilamino; cuando L es (N-metilen)-4-acetil-piperidin-4-ilo; entonces Z es fenilo o naftilo e Y es carbonilo; cuando L es (N-metilen) piperidin-4,4-diilo, entonces Z es 1-arilo-2,3-dihidro-4-oxo-imidazol-5,5-diilo e Y es carbonilo; y cuando B1 y B2 son ambos metileno, entonces forman un anillo de seis elementos y cuando L se selecciona del grupo que consiste en alquileno de C1-10; alquenileno de C2-10; alquinileno de C2-10; o alquileno de C1-4 arilo; entonces Z no puede ser N-sulfonamido, N-(aril) sulfonamido o fenilo. Estos derivados son ligandos para el receptor del neuropéptido Y Y5 (NPY5). Las aminas y amidas de la formula (A) son utiles en el tratamiento de trastornos y enfermedades asociadas con el receptor de NPY subtipo Y5. Además, se da a conocer el uso de dichos derivados para la elaboracion de medicamentos para el tratamiento de dichos trastornos y enfermedades, y composiciones farmacéuticas que comprenden dichos derivados.
ARP000103892A 1999-07-28 2000-07-27 Derivados de aminas y amidas como ligandos para el receptor del neuropeptido y y5 utiles en el tratamiento de la obesidad y otros trastornos, uso de los mismos para la elaboracion de medicamentos y composiciones farmaceuticas que los comprenden AR030676A1 (es)

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US20020115715A1 (en) 2002-08-22
EP1202986A1 (en) 2002-05-08
HUP0202143A2 (hu) 2002-11-28
ZA200201660B (en) 2003-08-27
RU2228927C2 (ru) 2004-05-20
ATE306482T1 (de) 2005-10-15
NZ516782A (en) 2004-12-24
DK1202986T3 (da) 2006-02-20
EP1493742A1 (en) 2005-01-05
DE60023148T2 (de) 2006-07-06
CA2380032A1 (en) 2001-02-08
NO20020384L (no) 2002-03-22
US7071195B2 (en) 2006-07-04
AU783223B2 (en) 2005-10-06
MXPA02000927A (es) 2003-07-14
EP1202986B1 (en) 2005-10-12
HUP0202143A3 (en) 2003-12-29
US6380224B1 (en) 2002-04-30
US20060052388A1 (en) 2006-03-09
JP2003506367A (ja) 2003-02-18
AU6496900A (en) 2001-02-19

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