MX2009003761A - Derivados biciclicos y triciclicos como antagonistas del receptor de trombina. - Google Patents
Derivados biciclicos y triciclicos como antagonistas del receptor de trombina.Info
- Publication number
- MX2009003761A MX2009003761A MX2009003761A MX2009003761A MX2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A MX 2009003761 A MX2009003761 A MX 2009003761A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- bond
- bicyclic
- receptor antagonists
- thrombin receptor
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
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Abstract
Los tricíclicos heterocíclicos-sustituidos de la fórmula (I): (ver fórmula (I)) o una sal o solvato farmacéuticamente aceptable de dicho compuesto, isómero o mezcla racémica, en donde representa un enlace doble opcional, la línea punteada es opcionalmente un enlace o no es un enlace, dando como resultado un enlace doble o un enlace sencillo, según lo permita el requerimiento de valencia y en donde E, A, G, M Het, B, X, R3, R10, R11, R32 y R33 son como se definen en la presente y los sustituyentes restantes son como se definen en la especificación, así como composiciones farmacéuticas que los contienen y un método para el tratamiento de enfermedades asociadas con trombosis, aterosclerosis, restenosis, hipertensión, angina de pecho, arritmia, paro cardíaco, cáncer, con la administración de dichos compuestos; también se reclama la terapia de combinación con otros agentes cardiovasculares.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84935406P | 2006-10-04 | 2006-10-04 | |
PCT/US2007/021277 WO2008042422A2 (en) | 2006-10-04 | 2007-10-02 | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003761A true MX2009003761A (es) | 2009-06-30 |
Family
ID=39269039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003761A MX2009003761A (es) | 2006-10-04 | 2007-10-02 | Derivados biciclicos y triciclicos como antagonistas del receptor de trombina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US8153664B2 (es) |
EP (1) | EP2069326B1 (es) |
JP (1) | JP2010505842A (es) |
KR (1) | KR20090074219A (es) |
CN (1) | CN101541782A (es) |
AR (1) | AR063123A1 (es) |
AU (1) | AU2007305269A1 (es) |
CA (1) | CA2667082A1 (es) |
IL (1) | IL198009A0 (es) |
MX (1) | MX2009003761A (es) |
TW (1) | TW200823205A (es) |
WO (1) | WO2008042422A2 (es) |
ZA (1) | ZA200902362B (es) |
Families Citing this family (26)
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US8227412B2 (en) * | 2007-03-29 | 2012-07-24 | Tsopanoglou Nikos E | Bioactive parstatin peptides and methods of use |
WO2009071661A1 (en) * | 2007-12-07 | 2009-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment and diagnosis of bone mineral density related diseases |
WO2010141525A1 (en) * | 2009-06-04 | 2010-12-09 | Schering Corporation | Active metabolite of a thrombin receptor antagonist |
NZ731621A (en) | 2009-12-04 | 2019-01-25 | Sunovion Pharmaceuticals Inc | Multicyclic compounds and methods of use thereof |
ES2527535T3 (es) | 2010-04-16 | 2015-01-26 | Sanofi | Piridil-vinil-pirazolo-quinolinas como inhibidores de PAR1 |
WO2011128421A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi | Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren |
US9340530B2 (en) | 2012-03-06 | 2016-05-17 | Merck Sharp & Dohme Corp. | Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists |
EP3035930A4 (en) | 2013-08-22 | 2017-03-08 | Merck Sharp & Dohme Corp. | 7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives |
WO2015026693A1 (en) | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | 7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives |
EP3035928B1 (en) | 2013-08-22 | 2023-10-18 | Merck Sharp & Dohme LLC | 3'-pyridyl substituted- 6,6-difluoro bicyclic himbacine derivatives |
WO2016060940A1 (en) * | 2014-10-15 | 2016-04-21 | Merck Sharp & Dohme Corp. | Preparation and use of cyclic sulfonamide derivatives as par-1 receptor antagonists |
WO2016058144A1 (en) * | 2014-10-15 | 2016-04-21 | Merck Sharp & Dohme Corp. | Preparation and use of cyclic sulfonamide derivatives as par-1 receptor antagonists |
CN105985303B (zh) * | 2015-02-13 | 2020-08-14 | 上海彩迩文生化科技有限公司 | 抗凝血剂的制备方法、中间体及其制备方法 |
CN105732595B (zh) | 2015-12-22 | 2018-08-28 | 山东大学 | 基于萜类衍生物的par-1抑制剂及其制备方法和在治疗血栓性疾病中的用途 |
CN107129477A (zh) * | 2016-02-26 | 2017-09-05 | 上海星泰医药科技有限公司 | ((1R,3aR,4aR,6R,8aR,9S,9aR)-9-甲酰基-1-甲基-3-氧杂十二氢萘[2,3-c]-6-呋喃基)羧酸乙酯的制备方法 |
KR20190065246A (ko) | 2016-07-29 | 2019-06-11 | 선오비온 파마슈티컬스 인코포레이티드 | 화합물 및 조성물 및 이들의 용도 |
IL264446B1 (en) | 2016-07-29 | 2024-05-01 | Pgi Drug Discovery Llc | Compounds and compositions and their use |
IL268694B2 (en) | 2017-02-16 | 2023-10-01 | Sunovion Pharmaceuticals Inc | Treatment of schizophrenia |
EP3661929B1 (en) | 2017-08-02 | 2021-07-14 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
WO2019161238A1 (en) | 2018-02-16 | 2019-08-22 | Sunovion Pharmaceuticals Inc. | Salts, crystal forms, and production methods thereof |
CN110559294A (zh) * | 2018-06-06 | 2019-12-13 | 杨仑 | 脂肪性肝病及其相关疾病的预防和治疗性药物 |
AU2020236225A1 (en) | 2019-03-14 | 2021-09-16 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
CN110627710B (zh) * | 2019-09-29 | 2020-06-05 | 山东大学 | 一种新型par-1抑制剂及其制备方法和在预防和/或治疗血栓性疾病中的用途 |
US11738002B2 (en) | 2020-04-14 | 2023-08-29 | Sunovion Pharmaceuticals Inc. | Methods of treating neurological and psychiatric disorders |
CN112759548B (zh) * | 2020-12-31 | 2021-11-02 | 山东大学 | 一种par-1抑制剂及其制备方法 |
CN115043820B (zh) * | 2022-05-27 | 2024-03-22 | 山东大学 | Par-1抑制剂及其类似物的制备方法和在血栓性疾病防治中的应用 |
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US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
PE133799A1 (es) | 1997-11-25 | 2000-01-10 | Schering Corp | Antagonistas del receptor de trombina |
FR2807040B1 (fr) * | 2000-03-31 | 2002-05-17 | Oreal | Procede de preparation de composes 3-(4-hydroxy-1h-indol-5- ylmethyl)-pyridiniums utilisant une reaction d'aldolisation |
CA2410177C (en) * | 2000-06-15 | 2010-05-11 | Schering Corporation | Thrombin receptor antagonists |
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MXPA04003610A (es) * | 2001-10-18 | 2004-07-27 | Schering Corp | Analogos de himbacina como antagonistas del receptor de trombina. |
JP2003183278A (ja) * | 2001-12-25 | 2003-07-03 | Sagami Chem Res Center | 芳香族複素環を有するヒンバシン類縁体 |
ATE378330T1 (de) | 2002-04-16 | 2007-11-15 | Schering Corp | Trizyklische thrombin rezeptor antagonisten |
CA2572750A1 (en) * | 2003-09-10 | 2005-03-17 | Anil Koul | Heterobicyclic compounds as pharmaceutically active agents |
EA010488B1 (ru) * | 2003-12-05 | 2008-10-30 | Янссен Фармацевтика Н.В. | 6-замещённые 2-хинолиноны и 2-хиноксалиноны как ингибиторы поли (адф-рибоза) полимеразы |
JP2008500998A (ja) * | 2004-05-28 | 2008-01-17 | シュペーデル・エクスペリメンタ・アーゲー | 複素環式化合物およびアルドステロンシンターゼ阻害薬としてのそれらの使用 |
US7429666B2 (en) * | 2004-06-10 | 2008-09-30 | Merck Frosst Canada Ltd. | Pyridine analogs as C5a antagonists |
CN100581837C (zh) * | 2004-07-29 | 2010-01-20 | 株式会社艾迪科 | 光学记录材料和光学记录介质 |
KR20070060156A (ko) * | 2004-10-04 | 2007-06-12 | 미리어드 제네틱스, 인크. | 알츠하이머병 치료용 화합물 |
WO2006041872A2 (en) | 2004-10-08 | 2006-04-20 | Schering Corporation | Thrombin receptor antagonists |
JP4705367B2 (ja) * | 2004-12-24 | 2011-06-22 | 花王株式会社 | 染毛剤組成物 |
RU2007143049A (ru) * | 2005-04-21 | 2009-05-27 | Ниппон Синяку Ко., Лтд. (Jp) | Производное фталазинона и содержащая его фармацевтическая композиция |
DE102005049953A1 (de) * | 2005-10-19 | 2007-04-26 | Sanofi-Aventis Deutschland Gmbh | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
KR20080110886A (ko) * | 2006-04-04 | 2008-12-19 | 미리어드 제네틱스, 인크. | 질병 및 장애용 화합물 |
AU2007240450B2 (en) * | 2006-04-21 | 2011-12-22 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
AR061664A1 (es) * | 2006-06-29 | 2008-09-10 | Schering Corp | Derivados de himbacina como antagonistas del receptor de trombina biciclicos y triciclicos sustituidos. composiciones farmaceuticas. |
AU2007334436A1 (en) * | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
-
2007
- 2007-10-02 US US11/865,793 patent/US8153664B2/en active Active
- 2007-10-02 MX MX2009003761A patent/MX2009003761A/es not_active Application Discontinuation
- 2007-10-02 EP EP07867202.9A patent/EP2069326B1/en active Active
- 2007-10-02 WO PCT/US2007/021277 patent/WO2008042422A2/en active Application Filing
- 2007-10-02 AU AU2007305269A patent/AU2007305269A1/en not_active Abandoned
- 2007-10-02 KR KR1020097008442A patent/KR20090074219A/ko not_active Application Discontinuation
- 2007-10-02 JP JP2009531448A patent/JP2010505842A/ja not_active Withdrawn
- 2007-10-02 CA CA002667082A patent/CA2667082A1/en not_active Abandoned
- 2007-10-02 CN CNA2007800433716A patent/CN101541782A/zh active Pending
- 2007-10-03 TW TW096137080A patent/TW200823205A/zh unknown
- 2007-10-03 AR ARP070104391A patent/AR063123A1/es not_active Application Discontinuation
-
2009
- 2009-04-03 ZA ZA200902362A patent/ZA200902362B/xx unknown
- 2009-04-05 IL IL198009A patent/IL198009A0/en unknown
-
2012
- 2012-02-24 US US13/404,462 patent/US20120157403A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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IL198009A0 (en) | 2009-12-24 |
WO2008042422A3 (en) | 2009-03-26 |
TW200823205A (en) | 2008-06-01 |
AU2007305269A1 (en) | 2008-04-10 |
CN101541782A (zh) | 2009-09-23 |
AR063123A1 (es) | 2008-12-30 |
EP2069326A2 (en) | 2009-06-17 |
JP2010505842A (ja) | 2010-02-25 |
US20080090830A1 (en) | 2008-04-17 |
KR20090074219A (ko) | 2009-07-06 |
US8153664B2 (en) | 2012-04-10 |
CA2667082A1 (en) | 2008-04-10 |
EP2069326B1 (en) | 2015-03-18 |
WO2008042422A2 (en) | 2008-04-10 |
ZA200902362B (en) | 2010-10-27 |
US20120157403A1 (en) | 2012-06-21 |
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