AR051149A1 - Compuestos de benzotiadiazina, un proceso para su preparacion y composiciones farmaceuticas que los contienen - Google Patents
Compuestos de benzotiadiazina, un proceso para su preparacion y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR051149A1 AR051149A1 ARP050104582A ARP050104582A AR051149A1 AR 051149 A1 AR051149 A1 AR 051149A1 AR P050104582 A ARP050104582 A AR P050104582A AR P050104582 A ARP050104582 A AR P050104582A AR 051149 A1 AR051149 A1 AR 051149A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- group
- alkyl
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- -1 (trifluoromethylsulfonyl) amino Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101100134929 Gallus gallus COR9 gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Reivindicacion 1: Compuestos de formula (1), en la cual: R1 representa un grupo alquilo C1-6 lineal o ramificado, sustituido por uno o más átomos de halogeno; R2 representa un átomo de hidrogeno, un átomo de halogeno o un grupo hidroxi; R3 representa un grupo arilo no sustituido o un grupo arilo sustituido por uno o más grupos, idénticos o diferentes, seleccionados entre: alquilo C1-6 lineal o ramificado; alcoxi C1-6 lineal o ramificado; polihaloalquilo C1-6 lineal o ramificado; átomos de halogeno; alcoxicarbonilo C1-6 lineal o ramificado; alquiltio C1-6 lineal o ramificado; carboxi; acilo C1-6 lineal o ramificado; polihaloalcoxi C1-6 lineal o ramificado; hidroxi; ciano; nitro; amidino (opcionalmente sustituido por uno o dos grupos idénticos o diferentes seleccionados entre alquilo C1-6 lineal o ramificado, hidroxi, alcoxi C1-6 lineal o ramificado y -O-C(=O)-R12); amino (opcionalmente sustituido por uno o dos grupos alquilo C1-6 lineal o ramificado; aminocarbonilo (opcionalmente sustituido por uno o dos grupos alquilo C1-6 lineal o ramificado); benciloxi; alquilsulfonilamino C1-6 (opcionalmente sustituido en el nitrogeno por un grupo alquilo C1-6 lineal o ramificado); (trifluorometilsulfonil)amino; un grupo heterocíclico; y un alquilo C1-6 sustituido por una parte por uno o más grupos, idénticos o diferentes, seleccionados entre átomos de hidrogeno y halogeno y grupo alquilo 1-6 lineal o ramificado y, por otra parte, sustituidos por un grupo seleccionado entre NR4R5, S(O)nR6, OR7, amidino (opcionalmente sustituido por uno o dos grupos idénticos o diferentes, seleccionados entre alquilo C1-6 lineal o ramificado, hidroxi, alcoxi C1-6 lineal o ramificado y -O-C(=O)-R12), y un grupo heterocíclico, en el cual: R4 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, o un grupo S(O)pR8, COR9 o P(O)(OR10)(OR11); R5 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado; o R4 y R5, junto con el átomo de nitrogeno que los lleva, forma un grupo heterocíclico, R6, R8, R9, R10, R11 y R12, que pueden ser iguales o diferentes, y cada uno representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado, opcionalmente sustituido por uno o más átomos de halogeno; un grupo arilalquilo C1-6 en el cual la parte alquilo es lineal o ramificado; o un grupo arilo; R7 representa un grupo alquilo C1-6 lineal o ramificado o un grupo acilo C1-6 lineal o ramificado, n y p, que puede ser iguales o diferentes, representan, cada uno, 0, 1 o 2; a sus enantiomeros y diastereoisomeros, y también a las sales de adicion de éstos con un ácido o con una base farmacéuticamente aceptable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0411690A FR2877338B1 (fr) | 2004-11-03 | 2004-11-03 | Nouveaux derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR051149A1 true AR051149A1 (es) | 2006-12-20 |
Family
ID=34950935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104582A AR051149A1 (es) | 2004-11-03 | 2005-11-02 | Compuestos de benzotiadiazina, un proceso para su preparacion y composiciones farmaceuticas que los contienen |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7268130B2 (es) |
| EP (1) | EP1655030B1 (es) |
| JP (1) | JP2006151972A (es) |
| KR (1) | KR100818431B1 (es) |
| CN (1) | CN100396673C (es) |
| AR (1) | AR051149A1 (es) |
| AT (1) | ATE381338T1 (es) |
| AU (1) | AU2005229698A1 (es) |
| BR (1) | BRPI0504780A (es) |
| CA (1) | CA2524859A1 (es) |
| DE (1) | DE602005003907D1 (es) |
| DK (1) | DK1655030T3 (es) |
| EA (1) | EA011212B1 (es) |
| ES (1) | ES2298970T3 (es) |
| FR (1) | FR2877338B1 (es) |
| GE (1) | GEP20074256B (es) |
| HR (1) | HRP20080119T5 (es) |
| MA (1) | MA27917A1 (es) |
| MX (1) | MXPA05011820A (es) |
| NO (1) | NO20055167L (es) |
| NZ (1) | NZ543358A (es) |
| PL (1) | PL1655030T3 (es) |
| PT (1) | PT1655030E (es) |
| SG (1) | SG121999A1 (es) |
| SI (1) | SI1655030T1 (es) |
| ZA (1) | ZA200508911B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2404605B1 (en) * | 2004-08-25 | 2015-04-22 | Essentialis, Inc. | Pharmaceutical formulations of potassium ATP channel openers and uses thereof |
| EP2404604B1 (en) | 2006-01-05 | 2019-02-06 | Essentialis, Inc. | Salts of potassium ATP channel openers and uses thereof |
| WO2009006483A1 (en) * | 2007-07-02 | 2009-01-08 | Essentialis, Inc. | Salts of potassium atp channel openers and uses thereof |
| US8124793B2 (en) * | 2007-11-27 | 2012-02-28 | Gail Marie Cronyn, legal representative | Derivatives of ethylene methanedisulfonate as cancer chemotherapeutic agents |
| FR2943342B1 (fr) * | 2009-03-20 | 2011-03-04 | Servier Lab | Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO2010111518A1 (en) * | 2009-03-27 | 2010-09-30 | Yale University | Treatment and prevention of white matter injury with katp channel activators |
| FR2955106B1 (fr) * | 2010-01-08 | 2011-12-23 | Servier Lab | Nouveaux derives de benzothiadiazines cyclopropylees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR101633632B1 (ko) | 2015-09-30 | 2016-06-27 | 김동용 | 방사능 차폐재 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722502B1 (fr) | 1994-07-12 | 1996-08-23 | Adir | Nouveau derive de benzothiadiazine, son procede depreparation et les compositions pharmaceutiques qui le contiennent |
| WO1998012185A1 (en) * | 1996-09-17 | 1998-03-26 | The Regents Of The University Of California | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| HUP0101280A3 (en) | 1998-02-18 | 2003-02-28 | Neurosearch As | Positive ampa receptor modulator compounds and their use |
| FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2833950B1 (fr) * | 2001-12-21 | 2005-12-16 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2833956B1 (fr) * | 2001-12-21 | 2004-01-30 | Servier Lab | Nouveaux derives de benzothiazine et de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2004
- 2004-11-03 FR FR0411690A patent/FR2877338B1/fr not_active Expired - Fee Related
-
2005
- 2005-10-17 MA MA28554A patent/MA27917A1/fr unknown
- 2005-10-17 SG SG200506773A patent/SG121999A1/en unknown
- 2005-10-28 EA EA200501530A patent/EA011212B1/ru not_active IP Right Cessation
- 2005-10-31 CA CA002524859A patent/CA2524859A1/fr not_active Abandoned
- 2005-11-01 BR BRPI0504780-3A patent/BRPI0504780A/pt not_active IP Right Cessation
- 2005-11-02 KR KR1020050104300A patent/KR100818431B1/ko not_active IP Right Cessation
- 2005-11-02 NZ NZ543358A patent/NZ543358A/en unknown
- 2005-11-02 DE DE602005003907T patent/DE602005003907D1/de active Active
- 2005-11-02 GE GEAP20059036A patent/GEP20074256B/en unknown
- 2005-11-02 PT PT05292310T patent/PT1655030E/pt unknown
- 2005-11-02 PL PL05292310T patent/PL1655030T3/pl unknown
- 2005-11-02 ES ES05292310T patent/ES2298970T3/es active Active
- 2005-11-02 DK DK05292310T patent/DK1655030T3/da active
- 2005-11-02 AR ARP050104582A patent/AR051149A1/es unknown
- 2005-11-02 US US11/265,011 patent/US7268130B2/en not_active Expired - Fee Related
- 2005-11-02 AT AT05292310T patent/ATE381338T1/de not_active IP Right Cessation
- 2005-11-02 SI SI200530159T patent/SI1655030T1/sl unknown
- 2005-11-02 EP EP05292310A patent/EP1655030B1/fr active Active
- 2005-11-03 MX MXPA05011820A patent/MXPA05011820A/es unknown
- 2005-11-03 CN CNB2005101316002A patent/CN100396673C/zh not_active Expired - Fee Related
- 2005-11-03 AU AU2005229698A patent/AU2005229698A1/en not_active Abandoned
- 2005-11-03 NO NO20055167A patent/NO20055167L/no not_active Application Discontinuation
- 2005-11-03 ZA ZA200508911A patent/ZA200508911B/en unknown
- 2005-11-04 JP JP2005320478A patent/JP2006151972A/ja active Pending
-
2007
- 2007-07-27 US US11/881,438 patent/US20070270415A1/en not_active Abandoned
-
2008
- 2008-03-19 HR HR20080119T patent/HRP20080119T5/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |