KR100612981B1 - 다치환된 프로테아제 변이체 - Google Patents

다치환된 프로테아제 변이체 Download PDF

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Publication number
KR100612981B1
KR100612981B1 KR1020007004382A KR20007004382A KR100612981B1 KR 100612981 B1 KR100612981 B1 KR 100612981B1 KR 1020007004382 A KR1020007004382 A KR 1020007004382A KR 20007004382 A KR20007004382 A KR 20007004382A KR 100612981 B1 KR100612981 B1 KR 100612981B1
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South Korea
Prior art keywords
protease
residue
amino acid
positions
subtilisin
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Expired - Fee Related
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KR1020007004382A
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English (en)
Korean (ko)
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KR20010031374A (ko
Inventor
볼커 셀렌버거
제임스 티. 쥬니어 켈리스
크리스티안 패치
조안 나더니
도날드 피. 나키
아이루카란 제이. 풀로스
카테린 디. 콜리어
로버트 엠. 칼드웰
앙드레 씨. 백
Original Assignee
제넨코 인터내셔날 인코포레이티드
더 프락타 앤드 갬블 컴파니
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27420734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100612981(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 제넨코 인터내셔날 인코포레이티드, 더 프락타 앤드 갬블 컴파니 filed Critical 제넨코 인터내셔날 인코포레이티드
Publication of KR20010031374A publication Critical patent/KR20010031374A/ko
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Publication of KR100612981B1 publication Critical patent/KR100612981B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38681—Chemically modified or immobilised enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G4/123—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/189—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38609—Protease or amylase in solid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618—Protease or amylase in liquid compositions only
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3902—Organic or inorganic per-compounds combined with specific additives
    • C11D3/3905—Bleach activators or bleach catalysts
    • C11D3/3907—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39—Organic or inorganic per-compounds
    • C11D3/3945—Organic per-compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21062—Subtilisin (3.4.21.62)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/12—Soft surfaces, e.g. textile
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Fodder In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Slot Machines And Peripheral Devices (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Finish Polishing, Edge Sharpening, And Grinding By Specific Grinding Devices (AREA)
KR1020007004382A 1997-10-23 1998-10-23 다치환된 프로테아제 변이체 Expired - Fee Related KR100612981B1 (ko)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US95656497A 1997-10-23 1997-10-23
US95632497A 1997-10-23 1997-10-23
US95632397A 1997-10-23 1997-10-23
US8/956,323 1997-10-23
US08/956,564 1997-10-23
US08/956,324 1997-10-23
US8/956,324 1997-10-23
US8/956,564 1997-10-23
US08/956,323 1997-10-23
PCT/US1998/022572 WO1999020770A2 (en) 1997-10-23 1998-10-23 Multiply-substituted protease variants

Publications (2)

Publication Number Publication Date
KR20010031374A KR20010031374A (ko) 2001-04-16
KR100612981B1 true KR100612981B1 (ko) 2006-08-14

Family

ID=27420734

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020007004382A Expired - Fee Related KR100612981B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체
KR1020007004389A Ceased KR20010024554A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 포함하는 표백 조성물
KR1020007004388A Abandoned KR20010031380A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 함유하는 세정 조성물
KR1020007004391A Ceased KR20010024555A (ko) 1997-10-23 1998-10-23 다중 치환된 프로테아제 변이체 및 아밀라제 변이체를함유하는 세정 조성물
KR1020007004385A Expired - Fee Related KR100616143B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체
KR1020007004380A Expired - Fee Related KR100564039B1 (ko) 1997-10-23 1998-10-23 변경된 총전하를 갖는 세정제에 사용되기 위한 다중-치환된 프로테아제 변이체

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1020007004389A Ceased KR20010024554A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 포함하는 표백 조성물
KR1020007004388A Abandoned KR20010031380A (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체를 함유하는 세정 조성물
KR1020007004391A Ceased KR20010024555A (ko) 1997-10-23 1998-10-23 다중 치환된 프로테아제 변이체 및 아밀라제 변이체를함유하는 세정 조성물
KR1020007004385A Expired - Fee Related KR100616143B1 (ko) 1997-10-23 1998-10-23 다치환된 프로테아제 변이체
KR1020007004380A Expired - Fee Related KR100564039B1 (ko) 1997-10-23 1998-10-23 변경된 총전하를 갖는 세정제에 사용되기 위한 다중-치환된 프로테아제 변이체

Country Status (26)

Country Link
US (5) US6482628B1 (enExample)
EP (10) EP1027418B2 (enExample)
JP (7) JP2001520307A (enExample)
KR (6) KR100612981B1 (enExample)
CN (9) CN102021159A (enExample)
AR (10) AR015977A1 (enExample)
AT (9) ATE445002T1 (enExample)
AU (7) AU742632B2 (enExample)
BR (6) BRPI9813115B1 (enExample)
CA (9) CA2306894C (enExample)
CZ (6) CZ20001478A3 (enExample)
DE (7) DE69840335D1 (enExample)
DK (9) DK1025241T4 (enExample)
EG (2) EG21711A (enExample)
ES (7) ES2255189T3 (enExample)
HK (1) HK1039159B (enExample)
HU (3) HUP0103080A2 (enExample)
ID (4) ID28256A (enExample)
MA (2) MA25044A1 (enExample)
NO (3) NO326992B1 (enExample)
NZ (3) NZ520770A (enExample)
PL (1) PL191529B1 (enExample)
PT (8) PT1025239E (enExample)
TR (8) TR200001113T2 (enExample)
TW (2) TW585912B (enExample)
WO (5) WO1999020771A2 (enExample)

Families Citing this family (620)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA23346A1 (fr) * 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
DE69839076T2 (de) * 1997-08-29 2009-01-22 Novozymes A/S Proteasevarianten und zusammensetzungen
ES2367505T3 (es) * 1997-10-23 2011-11-04 Danisco Us Inc. Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes.
AR015977A1 (es) * 1997-10-23 2001-05-30 Genencor Int Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes
DE69939538D1 (de) 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
WO2000024924A2 (en) * 1998-10-23 2000-05-04 The Procter & Gamble Company Methods for screening protease variants for use in detergent compositions
EP1129180B1 (en) 1998-11-10 2009-06-10 The Governing Council Of The University Of Toronto Chemically modified mutant serine hydrolases
JP5180417B2 (ja) * 1999-04-28 2013-04-10 ジェネンコー・インターナショナル・インク 特異的に標的化された触媒性アンタゴニストおよびその使用
US6627744B2 (en) 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
AU5928400A (en) * 1999-07-22 2001-02-13 Procter & Gamble Company, The Protease conjugates having sterically protected clip sites
BR0012660A (pt) * 1999-07-22 2002-04-09 Procter & Gamble Variante de protease tipo subtilisina; composição de limpeza; e composição de cuidado pessoal
CA2382870A1 (en) * 1999-09-09 2001-03-15 Ryohei Ohtani A detergent composition containing a protease
US6899961B2 (en) * 1999-12-15 2005-05-31 Samsung Sdi Co., Ltd. Organic electroluminescence device
US7067049B1 (en) * 2000-02-04 2006-06-27 Exxonmobil Oil Corporation Formulated lubricant oils containing high-performance base oils derived from highly paraffinic hydrocarbons
DE10007608A1 (de) * 2000-02-18 2001-08-30 Henkel Kgaa Protease und Percarbonat enthaltende Wasch- und Reinigungsmittel
WO2001064852A1 (en) * 2000-03-03 2001-09-07 Novozymes A/S Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same
US6777218B1 (en) * 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
AU4981101A (en) * 2000-04-03 2001-10-15 Maxygen Inc Subtilisin variants
EP2258852A1 (en) * 2000-04-28 2010-12-08 Novozymes A/S Lipolytic enzyme variant
EP1294844A1 (en) * 2000-06-30 2003-03-26 The Procter & Gamble Company Detergent compositions comprising a cyclodextrin glucanotransferase enzyme
BR0017276A (pt) * 2000-06-30 2003-05-06 Procter & Gamble Composições detergentes compreendendo uma enzima alfa-amilase maltogênica
WO2002010356A2 (de) 2000-07-28 2002-02-07 Henkel Kommanditgesellschaft Auf Aktien Neues amylolytisches enzym aus bacillus sp. a 7-7 (dsm 12368) sowie wasch- und reinigungsmittel mit diesem neuen amylolytischen enzym
US20020155574A1 (en) 2000-08-01 2002-10-24 Novozymes A/S Alpha-amylase mutants with altered properties
US6893855B2 (en) * 2000-10-13 2005-05-17 Novozymes A/S Subtilase variants
US6803222B2 (en) * 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
EP1241112A3 (en) 2001-03-15 2003-02-26 The Procter & Gamble Company Flexible multiple compartment pouch
WO2002077187A2 (en) * 2001-03-23 2002-10-03 Genencor International, Inc. Proteins producing an altered immunogenic response and methods of making and using the same
EP3000881A3 (en) 2001-05-15 2016-07-20 Novozymes A/S Alpha-amylase variant with altered properties
DK200101090A (da) * 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE10153792A1 (de) 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
AU2002360745B2 (en) * 2001-12-31 2007-05-17 Genencor International, Inc. Proteases producing an altered immunogenic response and methods of making and using the same
WO2003062380A2 (en) * 2002-01-16 2003-07-31 Genencor International, Inc. Multiply-substituted protease variants
CA2472725C (en) * 2002-01-16 2015-08-11 Genencor International, Inc. Multiply-substituted protease variants
US20030180281A1 (en) * 2002-03-11 2003-09-25 Bott Richard R. Preparations for topical skin use and treatment
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AU1199499A (en) 1999-05-10
WO1999020769A3 (en) 1999-08-26
DE69829577D1 (de) 2005-05-04
EP1025241A2 (en) 2000-08-09
DE69839057D1 (de) 2008-03-13
CN1306577A (zh) 2001-08-01
AR052453A2 (es) 2007-03-21
DE69841226D1 (de) 2009-11-19
DK1025240T3 (da) 2006-05-22
TR200101861T2 (tr) 2002-06-21
HUP0103080A2 (hu) 2001-12-28
JP2001520045A (ja) 2001-10-30
NO326992B1 (no) 2009-03-30
BR9814097A (pt) 2000-10-03
BR9813266A (pt) 2001-11-20
HUP0104539A2 (hu) 2002-04-29
US6815193B2 (en) 2004-11-09
KR20010031374A (ko) 2001-04-16
DK1025194T3 (da) 2009-04-06
DK1624050T3 (da) 2010-02-15
DK1025194T4 (da) 2012-04-02
DK1398367T3 (da) 2009-04-06
KR100616143B1 (ko) 2006-08-25
WO1999020771A3 (en) 1999-07-01
EG21711A (en) 2002-02-27
CA2306794C (en) 2009-07-07
NO20001899L (no) 2000-06-19
CA2307640A1 (en) 1999-04-29
WO1999020723A3 (en) 2001-01-04

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