DE69939538D1 - Mit einer kohlenhydratgruppe chemisch modifizierte proteine - Google Patents

Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Info

Publication number
DE69939538D1
DE69939538D1 DE69939538T DE69939538T DE69939538D1 DE 69939538 D1 DE69939538 D1 DE 69939538D1 DE 69939538 T DE69939538 T DE 69939538T DE 69939538 T DE69939538 T DE 69939538T DE 69939538 D1 DE69939538 D1 DE 69939538D1
Authority
DE
Germany
Prior art keywords
protein
chemically modified
present
relates
cysteine residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69939538T
Other languages
English (en)
Inventor
J Bryan Jones
Benjamin G Davis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto
Original Assignee
University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto filed Critical University of Toronto
Application granted granted Critical
Publication of DE69939538D1 publication Critical patent/DE69939538D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
DE69939538T 1998-07-02 1999-07-02 Mit einer kohlenhydratgruppe chemisch modifizierte proteine Expired - Fee Related DE69939538D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9168798P 1998-07-02 1998-07-02
US13144699P 1999-04-28 1999-04-28
PCT/US1999/015138 WO2000001712A2 (en) 1998-07-02 1999-07-02 Chemically modified proteins with a carbohydrate moiety

Publications (1)

Publication Number Publication Date
DE69939538D1 true DE69939538D1 (de) 2008-10-23

Family

ID=26784230

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939538T Expired - Fee Related DE69939538D1 (de) 1998-07-02 1999-07-02 Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Country Status (8)

Country Link
US (2) US6512098B2 (de)
EP (1) EP1093459B1 (de)
JP (1) JP2002519050A (de)
AT (1) ATE407941T1 (de)
AU (1) AU749383B2 (de)
CA (1) CA2331783C (de)
DE (1) DE69939538D1 (de)
WO (1) WO2000001712A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69939538D1 (de) 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
CA2348014A1 (en) 1998-11-10 2000-05-18 John Bryan Jones Chemically modified mutant serine hydrolases
CA2368213C (en) * 1999-04-28 2013-08-06 Genencor International, Inc. Specifically targeted catalytic antagonists and uses thereof
US6627744B2 (en) * 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
EP2221365A1 (de) 2000-03-08 2010-08-25 Novozymes A/S Varianten mit veränderten Eigenschaften
US20040097720A1 (en) * 2001-04-02 2004-05-20 Bott Richard R. Use of glycodendrimer reagents for inhibiting adhesion by microorganisms
ATE400602T1 (de) * 2002-12-31 2008-07-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
US20040180852A1 (en) * 2003-03-10 2004-09-16 Cara-Lynne Schengrund Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus
JP4787155B2 (ja) * 2003-06-24 2011-10-05 イシス イノベーション リミテッド タンパク質のジスルフィド結合形成およびグリコシル化の方法とそれに用いられる試薬
GB0507123D0 (en) * 2005-04-08 2005-05-11 Isis Innovation Method
WO2007082890A1 (en) * 2006-01-17 2007-07-26 N.V. Organon SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES
US20080221027A1 (en) * 2007-03-09 2008-09-11 The Regents Of The University Of California Composition and Methods for the Treatment of Duchene Muscular Dystrophy
GB0801966D0 (en) * 2008-02-04 2008-03-12 Isis Innovation Process

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5972682A (en) * 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
US5244791A (en) 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5155033A (en) 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
PT89702B (pt) 1988-02-11 1994-04-29 Gist Brocades Nv Processo para a preparacao de novos enzimas proteoliticos e de detergentes que os contem
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
WO1992002615A1 (en) 1990-08-09 1992-02-20 Genentech, Inc. Serine protease variants having peptide ligase activity
US5629173A (en) 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
US5340735A (en) * 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
US5316935A (en) 1992-04-06 1994-05-31 California Institute Of Technology Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5837516A (en) 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
US6946280B1 (en) 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
ES2277364T3 (es) 1996-11-26 2007-07-01 Genencor International, Inc. Enzimas quimicamente modificadas.
MA24811A1 (fr) 1997-10-23 1999-12-31 Procter & Gamble Compositions de lavage contenant des variantes de proteases multisubstituees
DE69942910D1 (de) 1998-01-23 2010-12-16 Univ Toronto Chemisch modifizierte enzyme und methoden zu ihrer herstellung und zum screeningder enzyme
US6395532B1 (en) 1998-01-23 2002-05-28 Genencor International, Inc. Modified enzymes and their use for peptide synthesis
DE69939538D1 (de) 1998-07-02 2008-10-23 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Also Published As

Publication number Publication date
AU749383B2 (en) 2002-06-27
AU5208199A (en) 2000-01-24
WO2000001712A2 (en) 2000-01-13
EP1093459A4 (de) 2002-02-06
CA2331783A1 (en) 2000-01-13
US20020146803A1 (en) 2002-10-10
US6512098B2 (en) 2003-01-28
WO2000001712A9 (en) 2000-06-22
ATE407941T1 (de) 2008-09-15
CA2331783C (en) 2009-12-29
JP2002519050A (ja) 2002-07-02
WO2000001712A3 (en) 2000-05-11
US20010018200A1 (en) 2001-08-30
EP1093459B1 (de) 2008-09-10
EP1093459A2 (de) 2001-04-25
US6930180B2 (en) 2005-08-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee