ATE407941T1 - Mit einer kohlenhydratgruppe chemisch modifizierte proteine - Google Patents

Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Info

Publication number
ATE407941T1
ATE407941T1 AT99937203T AT99937203T ATE407941T1 AT E407941 T1 ATE407941 T1 AT E407941T1 AT 99937203 T AT99937203 T AT 99937203T AT 99937203 T AT99937203 T AT 99937203T AT E407941 T1 ATE407941 T1 AT E407941T1
Authority
AT
Austria
Prior art keywords
protein
chemically modified
present
relates
cysteine residue
Prior art date
Application number
AT99937203T
Other languages
English (en)
Inventor
J Jones
Benjamin Davis
Original Assignee
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto filed Critical Univ Toronto
Application granted granted Critical
Publication of ATE407941T1 publication Critical patent/ATE407941T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Medical Informatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99937203T 1998-07-02 1999-07-02 Mit einer kohlenhydratgruppe chemisch modifizierte proteine ATE407941T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9168798P 1998-07-02 1998-07-02
US13144699P 1999-04-28 1999-04-28

Publications (1)

Publication Number Publication Date
ATE407941T1 true ATE407941T1 (de) 2008-09-15

Family

ID=26784230

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937203T ATE407941T1 (de) 1998-07-02 1999-07-02 Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Country Status (8)

Country Link
US (2) US6512098B2 (de)
EP (1) EP1093459B1 (de)
JP (1) JP2002519050A (de)
AT (1) ATE407941T1 (de)
AU (1) AU749383B2 (de)
CA (1) CA2331783C (de)
DE (1) DE69939538D1 (de)
WO (1) WO2000001712A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE407941T1 (de) 1998-07-02 2008-09-15 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine
JP4932990B2 (ja) * 1998-11-10 2012-05-16 ダニスコ・ユーエス・インコーポレイテッド 化学修飾突然変異体セリンヒドロラーゼは改良された触媒活性およびキラル選択性を示す
EP1185302B1 (de) * 1999-04-28 2013-07-24 Genencor International, Inc. Spezifischer zielrichtung von katalytische antagoniste und deren verwendungen
US6627744B2 (en) * 1999-07-02 2003-09-30 Genencor International, Inc. Synthesis of glycodendrimer reagents
AU2001240473A1 (en) 2000-03-08 2001-09-17 Novozymes A/S Variants with altered properties
US20040097720A1 (en) * 2001-04-02 2004-05-20 Bott Richard R. Use of glycodendrimer reagents for inhibiting adhesion by microorganisms
EP1578843B1 (de) 2002-12-31 2008-07-09 Nektar Therapeutics Al, Corporation Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
US20040180852A1 (en) * 2003-03-10 2004-09-16 Cara-Lynne Schengrund Use of multivalent glycodendrimers to inhibit the activity of human immunodeficiency virus
DE602004032345D1 (de) 2003-06-24 2011-06-01 Isis Innovation Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
GB0507123D0 (en) * 2005-04-08 2005-05-11 Isis Innovation Method
ATE461208T1 (de) * 2006-01-17 2010-04-15 Organon Nv Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern
US20080221027A1 (en) * 2007-03-09 2008-09-11 The Regents Of The University Of California Composition and Methods for the Treatment of Duchene Muscular Dystrophy
GB0801966D0 (en) * 2008-02-04 2008-03-12 Isis Innovation Process

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244791A (en) 1984-05-29 1993-09-14 Genecor International, Inc. Methods of ester hydrolysis
US5155033A (en) 1989-01-06 1992-10-13 Genencor, Inc. Subtilisins modified at position 225 resulting in a shift in catalytic activity
US5972682A (en) 1984-05-29 1999-10-26 Genencor International, Inc. Enzymatically active modified subtilisins
CN1056187C (zh) 1988-02-11 2000-09-06 金克克国际有限公司 新的蛋白水解酶及其在洗涤剂中的应用
DK97190D0 (da) 1990-04-19 1990-04-19 Novo Nordisk As Oxidationsstabile detergentenzymer
US5629173A (en) 1990-08-09 1997-05-13 Genentech, Inc. Methods of use of serine protease variants having peptide ligase activity
DE69131834T2 (de) 1990-08-09 2000-05-31 Genentech, Inc. Serinproteasevarianten mit peptidligase aktivität
US5340735A (en) 1991-05-29 1994-08-23 Cognis, Inc. Bacillus lentus alkaline protease variants with increased stability
US5316935A (en) 1992-04-06 1994-05-31 California Institute Of Technology Subtilisin variants suitable for hydrolysis and synthesis in organic media
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5837516A (en) 1995-03-03 1998-11-17 Genentech, Inc. Subtilisin variants capable of cleaving substrates containing basic residues
US6946280B1 (en) 1996-03-29 2005-09-20 Genencor International, Inc. Enzyme multimer and process of producing same
DE69737148T2 (de) 1996-11-26 2007-10-04 Genencor International, Inc., Palo Alto Chemisch modifizierte enzyme
AR016969A1 (es) 1997-10-23 2001-08-01 Procter & Gamble VARIANTE DE PROTEASA, ADN, VECTOR DE EXPRESIoN, MICROORGANISMO HUESPED, COMPOSICIoN DE LIMPIEZA, ALIMENTO PARA ANIMALES Y COMPOSICIoN PARA TRATAR UN TEXTIL
JP4475371B2 (ja) 1998-01-23 2010-06-09 ジェネンコア インターナショナル インコーポレーテッド 化学的に修飾された突然変異体酵素およびその産生方法とスクリーニング方法
WO1999037324A1 (en) 1998-01-23 1999-07-29 Genencor International, Inc. Modified enzymes and their use for peptide synthesis
ATE407941T1 (de) 1998-07-02 2008-09-15 Univ Toronto Mit einer kohlenhydratgruppe chemisch modifizierte proteine

Also Published As

Publication number Publication date
WO2000001712A3 (en) 2000-05-11
DE69939538D1 (de) 2008-10-23
EP1093459B1 (de) 2008-09-10
AU749383B2 (en) 2002-06-27
US20010018200A1 (en) 2001-08-30
US6512098B2 (en) 2003-01-28
WO2000001712A9 (en) 2000-06-22
US20020146803A1 (en) 2002-10-10
WO2000001712A2 (en) 2000-01-13
JP2002519050A (ja) 2002-07-02
AU5208199A (en) 2000-01-24
EP1093459A4 (de) 2002-02-06
CA2331783A1 (en) 2000-01-13
EP1093459A2 (de) 2001-04-25
US6930180B2 (en) 2005-08-16
CA2331783C (en) 2009-12-29

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Legal Events

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