ATE461208T1 - Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern - Google Patents
Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidesternInfo
- Publication number
- ATE461208T1 ATE461208T1 AT07703919T AT07703919T ATE461208T1 AT E461208 T1 ATE461208 T1 AT E461208T1 AT 07703919 T AT07703919 T AT 07703919T AT 07703919 T AT07703919 T AT 07703919T AT E461208 T1 ATE461208 T1 AT E461208T1
- Authority
- AT
- Austria
- Prior art keywords
- butyl
- enzymatic hydrolysis
- selective enzymatic
- terminal
- terminal tert
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000007071 enzymatic hydrolysis Effects 0.000 title abstract 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- DHHKPEUQJIEKOA-UHFFFAOYSA-N tert-butyl 2-[6-(nitromethyl)-6-bicyclo[3.2.0]hept-3-enyl]acetate Chemical group C1C=CC2C(CC(=O)OC(C)(C)C)(C[N+]([O-])=O)CC21 DHHKPEUQJIEKOA-UHFFFAOYSA-N 0.000 title 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000787 Subtilisin Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06100420 | 2006-01-17 | ||
| PCT/EP2007/050409 WO2007082890A1 (en) | 2006-01-17 | 2007-01-16 | SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE461208T1 true ATE461208T1 (de) | 2010-04-15 |
Family
ID=37025119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07703919T ATE461208T1 (de) | 2006-01-17 | 2007-01-16 | Selektive enzymatische hydrolyse von c-terminalen tert-butyl-peptidestern |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090093016A1 (de) |
| EP (1) | EP1979370B1 (de) |
| AT (1) | ATE461208T1 (de) |
| BR (1) | BRPI0706400A2 (de) |
| DE (1) | DE602007005349D1 (de) |
| DK (1) | DK1979370T3 (de) |
| ES (1) | ES2340885T3 (de) |
| WO (1) | WO2007082890A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100311130A1 (en) * | 2007-06-19 | 2010-12-09 | Dsm Ip Assets B.V. | Enzymatic ester hydrolysis |
| EP2198037B1 (de) * | 2007-10-12 | 2012-02-08 | DSM IP Assets B.V. | Chemisch-enzymatische Peptidsynthese mittels C-terminaler Ester-Umwandlung |
| KR20230158005A (ko) | 2021-03-18 | 2023-11-17 | 씨젠 인크. | 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3733222A1 (de) * | 1987-10-01 | 1989-04-13 | Hoechst Ag | Verfahren zur herstellung von optisch reinem homophenylalanin |
| ZW6189A1 (en) * | 1988-05-09 | 1990-05-09 | Smithkline Beckman Corp | Anti-aggregatory peptides |
| US5665587A (en) * | 1989-06-26 | 1997-09-09 | Novo Nordisk A/S | Modified subtilisins and detergent compositions containing same |
| US5204466A (en) * | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
| US5275950A (en) * | 1990-05-11 | 1994-01-04 | Abbott Laboratories | Process for the preparation of a renin inhibiting compound |
| US5256814A (en) * | 1990-12-07 | 1993-10-26 | Scios Nova Inc. | Excitatory amino acid antagonists |
| ES2051647B1 (es) * | 1992-12-10 | 1995-01-16 | Lipotec Sa | Procedimiento para la preparacion de calcitonina de salmon. |
| US6187579B1 (en) * | 1993-10-28 | 2001-02-13 | Carlsberg A/S | Customized proteases |
| US5981267A (en) * | 1996-01-24 | 1999-11-09 | The Scripps Research Institute | Enantioselection of amines using homocarbonates with hydrolase |
| TW505654B (en) * | 1996-07-30 | 2002-10-11 | Hoffmann La Roche | Synthesis of analogs of PTH and PTHrP |
| DE69939538D1 (de) * | 1998-07-02 | 2008-10-23 | Univ Toronto | Mit einer kohlenhydratgruppe chemisch modifizierte proteine |
| FR2814744B1 (fr) * | 2000-10-04 | 2002-11-29 | Commissariat Energie Atomique | Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese |
| NL1017258C2 (nl) * | 2001-02-01 | 2002-08-02 | Univ Delft Tech | Werkwijze voor het maken van vernette enzymaggregaten. |
| US20030032083A1 (en) * | 2001-05-23 | 2003-02-13 | Diversa Corporation | Peptide synthesis method |
| TWI243826B (en) * | 2001-07-19 | 2005-11-21 | Akzo Nobel Nv | Process for the preparation of peptides |
| TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
| US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
| US8124372B2 (en) * | 2007-06-25 | 2012-02-28 | N.V. Organon | Selective enzymatic amidation of C-terminal esters or acids of peptides |
-
2007
- 2007-01-16 AT AT07703919T patent/ATE461208T1/de not_active IP Right Cessation
- 2007-01-16 DE DE602007005349T patent/DE602007005349D1/de active Active
- 2007-01-16 DK DK07703919.6T patent/DK1979370T3/da active
- 2007-01-16 WO PCT/EP2007/050409 patent/WO2007082890A1/en not_active Ceased
- 2007-01-16 ES ES07703919T patent/ES2340885T3/es active Active
- 2007-01-16 US US12/087,849 patent/US20090093016A1/en not_active Abandoned
- 2007-01-16 EP EP07703919A patent/EP1979370B1/de active Active
- 2007-01-16 BR BRPI0706400-4A patent/BRPI0706400A2/pt active IP Right Grant
-
2012
- 2012-05-17 US US13/474,125 patent/US20120231497A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0706400A2 (pt) | 2011-03-29 |
| EP1979370A1 (de) | 2008-10-15 |
| DK1979370T3 (da) | 2010-06-28 |
| EP1979370B1 (de) | 2010-03-17 |
| US20120231497A1 (en) | 2012-09-13 |
| WO2007082890A1 (en) | 2007-07-26 |
| US20090093016A1 (en) | 2009-04-09 |
| ES2340885T3 (es) | 2010-06-10 |
| DE602007005349D1 (de) | 2010-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |