DE602007005349D1 - SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN - Google Patents

SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN

Info

Publication number
DE602007005349D1
DE602007005349D1 DE602007005349T DE602007005349T DE602007005349D1 DE 602007005349 D1 DE602007005349 D1 DE 602007005349D1 DE 602007005349 T DE602007005349 T DE 602007005349T DE 602007005349 T DE602007005349 T DE 602007005349T DE 602007005349 D1 DE602007005349 D1 DE 602007005349D1
Authority
DE
Germany
Prior art keywords
tert
enzymatic hydrolysis
butyl
peptidestern
terminales
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007005349T
Other languages
English (en)
Inventor
Ivo Franci Eggen
Carmen G Boeriu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of DE602007005349D1 publication Critical patent/DE602007005349D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/023—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution using racemisation inhibiting agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE602007005349T 2006-01-17 2007-01-16 SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN Active DE602007005349D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100420 2006-01-17
PCT/EP2007/050409 WO2007082890A1 (en) 2006-01-17 2007-01-16 SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL tert-BUTYL ESTERS OF PEPTIDES

Publications (1)

Publication Number Publication Date
DE602007005349D1 true DE602007005349D1 (de) 2010-04-29

Family

ID=37025119

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007005349T Active DE602007005349D1 (de) 2006-01-17 2007-01-16 SELEKTIVE ENZYMATISCHE HYDROLYSE VON C-TERMINALEN tert-BUTYL-PEPTIDESTERN

Country Status (8)

Country Link
US (2) US20090093016A1 (de)
EP (1) EP1979370B1 (de)
AT (1) ATE461208T1 (de)
BR (1) BRPI0706400A2 (de)
DE (1) DE602007005349D1 (de)
DK (1) DK1979370T3 (de)
ES (1) ES2340885T3 (de)
WO (1) WO2007082890A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2155884A1 (de) * 2007-06-19 2010-02-24 DSM IP Assets B.V. Verfahren zur selektiven enzymatischen hydrolyse von hängenden estern eines polymers
JP2011500010A (ja) * 2007-10-12 2011-01-06 ディーエスエム アイピー アセッツ ビー．ブイ． Ｃ末端エステル転換による化学酵素的ペプチド合成
KR20230158005A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3733222A1 (de) * 1987-10-01 1989-04-13 Hoechst Ag Verfahren zur herstellung von optisch reinem homophenylalanin
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5665587A (en) * 1989-06-26 1997-09-09 Novo Nordisk A/S Modified subtilisins and detergent compositions containing same
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5256814A (en) * 1990-12-07 1993-10-26 Scios Nova Inc. Excitatory amino acid antagonists
ES2051647B1 (es) * 1992-12-10 1995-01-16 Lipotec Sa Procedimiento para la preparacion de calcitonina de salmon.
US6187579B1 (en) * 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
US5981267A (en) * 1996-01-24 1999-11-09 The Scripps Research Institute Enantioselection of amines using homocarbonates with hydrolase
TW505654B (en) * 1996-07-30 2002-10-11 Hoffmann La Roche Synthesis of analogs of PTH and PTHrP
CA2331783C (en) * 1998-07-02 2009-12-29 Genencor International, Inc. Chemically modified proteins with a carbohydrate moiety
FR2814744B1 (fr) * 2000-10-04 2002-11-29 Commissariat Energie Atomique Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
NL1017258C2 (nl) * 2001-02-01 2002-08-02 Univ Delft Tech Werkwijze voor het maken van vernette enzymaggregaten.
US20030032083A1 (en) * 2001-05-23 2003-02-13 Diversa Corporation Peptide synthesis method
IL150601A (en) * 2001-07-19 2010-06-30 Organon Nv Process for rapid synthesis of peptides within a solution using the back of an activated carboxyl component and destruction of the residual activated carboxyl component
TWI243826B (en) * 2001-07-19 2005-11-21 Akzo Nobel Nv Process for the preparation of peptides
US7084247B2 (en) * 2004-03-11 2006-08-01 Peptimmune, Inc. Identification of self and non-self antigens implicated in autoimmune diseases
US8124372B2 (en) * 2007-06-25 2012-02-28 N.V. Organon Selective enzymatic amidation of C-terminal esters or acids of peptides

Also Published As

Publication number Publication date
WO2007082890A1 (en) 2007-07-26
EP1979370A1 (de) 2008-10-15
ES2340885T3 (es) 2010-06-10
DK1979370T3 (da) 2010-06-28
US20090093016A1 (en) 2009-04-09
ATE461208T1 (de) 2010-04-15
US20120231497A1 (en) 2012-09-13
EP1979370B1 (de) 2010-03-17
BRPI0706400A2 (pt) 2011-03-29

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