JP7559059B2 - 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 - Google Patents

免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Download PDF

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JP7559059B2
JP7559059B2 JP2022520000A JP2022520000A JP7559059B2 JP 7559059 B2 JP7559059 B2 JP 7559059B2 JP 2022520000 A JP2022520000 A JP 2022520000A JP 2022520000 A JP2022520000 A JP 2022520000A JP 7559059 B2 JP7559059 B2 JP 7559059B2
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cancer
methyl
compound
amino
pyrido
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JP2022549375A (ja
JPWO2021067217A5 (https=
JP2022549375A5 (https=
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リィ，ジンウェイ
ウー，リアンシン
ヤオ，ウェンチン
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2022520000A 2019-09-30 2020-09-29 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物 Active JP7559059B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
US62/908,317 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (4)

Publication Number Publication Date
JP2022549375A JP2022549375A (ja) 2022-11-24
JPWO2021067217A5 JPWO2021067217A5 (https=) 2023-10-05
JP2022549375A5 JP2022549375A5 (https=) 2023-10-05
JP7559059B2 true JP7559059B2 (ja) 2024-10-01

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JP2022520000A Active JP7559059B2 (ja) 2019-09-30 2020-09-29 免疫調節剤としてのピリド［３，２－ｄ］ピリミジン化合物

Country Status (19)

Country Link
US (2) US11401279B2 (https=)
EP (1) EP4037773A1 (https=)
JP (1) JP7559059B2 (https=)
KR (1) KR20220075382A (https=)
CN (1) CN115175734B (https=)
AR (1) AR120109A1 (https=)
AU (1) AU2020357514A1 (https=)
BR (1) BR112022005826A2 (https=)
CA (1) CA3155852A1 (https=)
CL (1) CL2022000787A1 (https=)
CO (1) CO2022005378A2 (https=)
CR (1) CR20220190A (https=)
EC (1) ECSP22034236A (https=)
IL (1) IL291471B2 (https=)
MX (1) MX2022003578A (https=)
PE (1) PE20221038A1 (https=)
PH (1) PH12022550754A1 (https=)
TW (1) TWI879811B (https=)
WO (1) WO2021067217A1 (https=)

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AU2016379372A1 (en) * 2015-12-22 2018-08-02 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2906460T3 (es) 2016-05-06 2022-04-18 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
BR112018076534A2 (pt) 2016-06-20 2019-04-02 Incyte Corporation compostos heterocíclicos como imunomoduladores
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ES2941716T3 (es) 2016-08-29 2023-05-25 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
ES2874756T3 (es) 2016-12-22 2021-11-05 Incyte Corp Derivados de triazolo[1,5-A]piridina como inmunomoduladores
AU2017382870B2 (en) 2016-12-22 2022-03-24 Incyte Corporation Benzooxazole derivatives as immunomodulators
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WO2018119286A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
BR122023024273A2 (pt) 2018-02-27 2024-02-20 Incyte Corporation Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos
CR20200520A (es) 2018-03-30 2021-03-09 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
WO2019217821A1 (en) 2018-05-11 2019-11-14 Incyte Corporation Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators
WO2019222677A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
GEP20237548B (en) 2018-07-05 2023-10-10 Incyte Corp Fused pyrazine derivatives as a2a /a2b inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN114222737B (zh) 2019-05-31 2024-07-26 詹森药业有限公司 NF-κB诱导激酶的小分子抑制剂
EP4010342A1 (en) 2019-08-09 2022-06-15 Incyte Corporation Salts of a pd-1/pd-l1 inhibitor
WO2021067217A1 (en) 2019-09-30 2021-04-08 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
BR112022009031A2 (pt) 2019-11-11 2022-10-11 Incyte Corp Sais e formas cristalinas de um inibidor de pd-1/pd-l1
CA3182595A1 (en) * 2020-06-17 2021-12-23 Mingming Zhang Immunosuppressant, and preparation method therefor and use thereof
US11866434B2 (en) 2020-11-06 2024-01-09 Incyte Corporation Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
WO2022099075A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Crystalline form of a pd-1/pd-l1 inhibitor
WO2023169373A1 (zh) * 2022-03-07 2023-09-14 上海和誉生物医药科技有限公司 一种全对称联苯基衍生物及其制备方法和应用
CN117384088A (zh) * 2023-09-27 2024-01-12 上海凌凯医药科技有限公司 一种3-硝基吡啶甲腈类化合物以及3-氨基-吡啶甲酰胺类化合物的制备方法
US20250186450A1 (en) 2023-12-06 2025-06-12 Incyte Corporation COMBINATION THERAPY COMPRISING DGK INHIBITORS and PD-1/PD-L1 INHIBITORS
CN120204228B (zh) * 2025-04-17 2026-01-30 重庆医科大学附属第一医院 化合物或其盐在制备癌症治疗药物中的用途

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CN115175734A (zh) 2022-10-11
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