JP6309505B2 - 複素環式化合物及びその使用 - Google Patents
複素環式化合物及びその使用 Download PDFInfo
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- JP6309505B2 JP6309505B2 JP2015505792A JP2015505792A JP6309505B2 JP 6309505 B2 JP6309505 B2 JP 6309505B2 JP 2015505792 A JP2015505792 A JP 2015505792A JP 2015505792 A JP2015505792 A JP 2015505792A JP 6309505 B2 JP6309505 B2 JP 6309505B2
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- alkyl
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- heteroaryl
- cycloalkyl
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- 0 CC(C)C*C*N Chemical compound CC(C)C*C*N 0.000 description 48
- MZINZXIFJMLTOK-NSHDSACASA-N C[C@@H](C(N1c2ccccc2)=Cc(cccc2Cl)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Cc(cccc2Cl)c2C1=O)N MZINZXIFJMLTOK-NSHDSACASA-N 0.000 description 2
- PAPXDDXHFDTOSC-UHFFFAOYSA-N Bc(nccc1)c1C(O)=O Chemical compound Bc(nccc1)c1C(O)=O PAPXDDXHFDTOSC-UHFFFAOYSA-N 0.000 description 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N C1NCCOC1 Chemical compound C1NCCOC1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- QZASKKLEGWTLLD-UHFFFAOYSA-N CC(C(N(C(C12)=O)c3ccccc3)=CC1=CC=CC2c1ccccc1)NC(c1c2nccc[n]2nc1N)=O Chemical compound CC(C(N(C(C12)=O)c3ccccc3)=CC1=CC=CC2c1ccccc1)NC(c1c2nccc[n]2nc1N)=O QZASKKLEGWTLLD-UHFFFAOYSA-N 0.000 description 1
- HGMLHIZZMBNMDP-UHFFFAOYSA-N CC(C(N1c2ccccc2)=Cc([s]nc2C)c2C1=O)N Chemical compound CC(C(N1c2ccccc2)=Cc([s]nc2C)c2C1=O)N HGMLHIZZMBNMDP-UHFFFAOYSA-N 0.000 description 1
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- ZHGANLDJFKBMRH-UHFFFAOYSA-N CC(C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)NC(c1nc(cccc2)c2nc1N)=O Chemical compound CC(C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)NC(c1nc(cccc2)c2nc1N)=O ZHGANLDJFKBMRH-UHFFFAOYSA-N 0.000 description 1
- PTARWFPVOYNYPY-UHFFFAOYSA-N CC(C)C[n]1ncc(I)c1 Chemical compound CC(C)C[n]1ncc(I)c1 PTARWFPVOYNYPY-UHFFFAOYSA-N 0.000 description 1
- CFXNVDUEBJYAAZ-UHFFFAOYSA-N CC(C)[n]1ncc(I)c1 Chemical compound CC(C)[n]1ncc(I)c1 CFXNVDUEBJYAAZ-UHFFFAOYSA-N 0.000 description 1
- FPENIJXKHJNYGE-VZKVHNKZSA-N CCC/C=C\C(\C(N[C@@H](C)C(N1c2ccccc2)=Cc2cccc(Cl)c2C1=O)=O)=C(/N)\Br Chemical compound CCC/C=C\C(\C(N[C@@H](C)C(N1c2ccccc2)=Cc2cccc(Cl)c2C1=O)=O)=C(/N)\Br FPENIJXKHJNYGE-VZKVHNKZSA-N 0.000 description 1
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- OQHLYZTVUZZSRR-UHFFFAOYSA-N CN(C=C(C=C1)N)C1=O Chemical compound CN(C=C(C=C1)N)C1=O OQHLYZTVUZZSRR-UHFFFAOYSA-N 0.000 description 1
- FNBDLQHPJGCBDC-AIBWNMTMSA-N C[C@@H](C(N1C2C=CC=CC2)=Cc2cccc(C)c2C1=O)NC(c1c(N2CCOCC2)nccc1)=O Chemical compound C[C@@H](C(N1C2C=CC=CC2)=Cc2cccc(C)c2C1=O)NC(c1c(N2CCOCC2)nccc1)=O FNBDLQHPJGCBDC-AIBWNMTMSA-N 0.000 description 1
- NDSWDDWNFGZXMZ-AWEZNQCLSA-N C[C@@H](C(N1C2CC2)=Cc2cccc(Cl)c2C1=O)NC(c1c(N)ncc(-c2cc(NS(C)(=O)=O)ccc2)n1)=O Chemical compound C[C@@H](C(N1C2CC2)=Cc2cccc(Cl)c2C1=O)NC(c1c(N)ncc(-c2cc(NS(C)(=O)=O)ccc2)n1)=O NDSWDDWNFGZXMZ-AWEZNQCLSA-N 0.000 description 1
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- GZKJLOXLLATAQQ-ZDUSSCGKSA-N C[C@@H](C(N1C2CCCCC2)=Cc2cccc(C)c2C1=O)N Chemical compound C[C@@H](C(N1C2CCCCC2)=Cc2cccc(C)c2C1=O)N GZKJLOXLLATAQQ-ZDUSSCGKSA-N 0.000 description 1
- FNAKYJCXICHKDH-AWEZNQCLSA-N C[C@@H](C(N1C2CCCCC2)=Cc2cccc(Cl)c2C1=O)NC(c1c2nccc[n]2nc1N)=O Chemical compound C[C@@H](C(N1C2CCCCC2)=Cc2cccc(Cl)c2C1=O)NC(c1c2nccc[n]2nc1N)=O FNAKYJCXICHKDH-AWEZNQCLSA-N 0.000 description 1
- RZHDMSWSDJUQKS-INIZCTEOSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3ccccc3)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3ccccc3)c2C1=O)N RZHDMSWSDJUQKS-INIZCTEOSA-N 0.000 description 1
- RUQQCXITYHZNPM-ZDUSSCGKSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(C)c2C1=O)N RUQQCXITYHZNPM-ZDUSSCGKSA-N 0.000 description 1
- VSVWVGYHHDCFBR-NSHDSACASA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(F)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(F)c2C1=O)N VSVWVGYHHDCFBR-NSHDSACASA-N 0.000 description 1
- MYRGUBUZDDBRIU-KRWDZBQOSA-N C[C@@H](C(N1c2ccccc2)=Nc2cccc(-c3cc(OC)ncc3)c2C1=O)NC(c1c2nccc[n]2nc1N)=O Chemical compound C[C@@H](C(N1c2ccccc2)=Nc2cccc(-c3cc(OC)ncc3)c2C1=O)NC(c1c2nccc[n]2nc1N)=O MYRGUBUZDDBRIU-KRWDZBQOSA-N 0.000 description 1
- BRTIHPMUDVKVLP-JTQLQIEISA-N C[C@@H](C(N1c2ccccc2)=Nc2cccc(Cl)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Nc2cccc(Cl)c2C1=O)N BRTIHPMUDVKVLP-JTQLQIEISA-N 0.000 description 1
- XZTHJLHKZKLIPT-UHFFFAOYSA-N Cc1c(N)[n]2ncccc2n1 Chemical compound Cc1c(N)[n]2ncccc2n1 XZTHJLHKZKLIPT-UHFFFAOYSA-N 0.000 description 1
- TURJHURHSYPXPV-UHFFFAOYSA-N Nc(nccn1)c1I Chemical compound Nc(nccn1)c1I TURJHURHSYPXPV-UHFFFAOYSA-N 0.000 description 1
- WINJFUJIPMQGNL-UHFFFAOYSA-N Nc1c(C(O)=O)nc(cccc2)c2n1 Chemical compound Nc1c(C(O)=O)nc(cccc2)c2n1 WINJFUJIPMQGNL-UHFFFAOYSA-N 0.000 description 1
- ZAGZIOYVEIDDJA-UHFFFAOYSA-N Nc1c(C(O)=O)nccn1 Chemical compound Nc1c(C(O)=O)nccn1 ZAGZIOYVEIDDJA-UHFFFAOYSA-N 0.000 description 1
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
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- 2013-04-03 HK HK15107677.8A patent/HK1207069A1/xx unknown
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| US20150105385A1 (en) | 2015-04-16 |
| CN104703979A (zh) | 2015-06-10 |
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| AU2013205238A1 (en) | 2013-10-24 |
| WO2013154878A1 (en) | 2013-10-17 |
| JP2015512940A (ja) | 2015-04-30 |
| EP2836487B1 (en) | 2018-10-31 |
| US20160207940A1 (en) | 2016-07-21 |
| CA2870087A1 (en) | 2013-10-17 |
| CA2870087C (en) | 2021-02-02 |
| US20130267521A1 (en) | 2013-10-10 |
| US9255108B2 (en) | 2016-02-09 |
| AU2013205238B2 (en) | 2015-12-10 |
| EP2836487A1 (en) | 2015-02-18 |
| CN104703979B (zh) | 2018-11-27 |
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