EA201001135A1 - Интратекальное лечение невропатической боли агонистами ar - Google Patents
Интратекальное лечение невропатической боли агонистами arInfo
- Publication number
- EA201001135A1 EA201001135A1 EA201001135A EA201001135A EA201001135A1 EA 201001135 A1 EA201001135 A1 EA 201001135A1 EA 201001135 A EA201001135 A EA 201001135A EA 201001135 A EA201001135 A EA 201001135A EA 201001135 A1 EA201001135 A1 EA 201001135A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- agonists
- neuropathic pain
- intratecal
- treatment
- relates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Abstract
Настоящее изобретение относится к способу лечения невропатической боли посредством интратекального введения агонистов аденозиновых рецепторов (АР).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1991208P | 2008-01-09 | 2008-01-09 | |
PCT/US2009/030565 WO2009089425A1 (en) | 2008-01-09 | 2009-01-09 | Intrathecal treatment of neuropathic pain with a2ar agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201001135A1 true EA201001135A1 (ru) | 2011-02-28 |
Family
ID=40851205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201001135A EA201001135A1 (ru) | 2008-01-09 | 2009-01-09 | Интратекальное лечение невропатической боли агонистами ar |
Country Status (10)
Country | Link |
---|---|
US (1) | US20090181920A1 (ru) |
EP (1) | EP2240020A4 (ru) |
JP (1) | JP2011509305A (ru) |
CN (1) | CN101938904A (ru) |
AU (1) | AU2009204084A1 (ru) |
BR (1) | BRPI0907248A2 (ru) |
CA (1) | CA2711495A1 (ru) |
EA (1) | EA201001135A1 (ru) |
IL (1) | IL206801A0 (ru) |
WO (1) | WO2009089425A1 (ru) |
Families Citing this family (60)
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GT200500281A (es) * | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
JP2008520744A (ja) | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
CA2647391C (en) | 2006-04-04 | 2015-12-29 | The Regents Of The University Of California | Kinase antagonists |
GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
KR20080110925A (ko) | 2006-04-21 | 2008-12-19 | 노파르티스 아게 | 아데노신 a2a 수용체 효능제로서 사용하기 위한 퓨린 유도체 |
US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
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EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
US7985754B2 (en) * | 2006-07-17 | 2011-07-26 | Trovis Pharmaceuticals, Llc | Selective antagonists of A2A adenosine receptors |
EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
JP2010508835A (ja) * | 2006-11-10 | 2010-03-25 | ノバルティス アーゲー | シクロペンテンジオールモノアセテート誘導体 |
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US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
US8703777B2 (en) | 2008-01-04 | 2014-04-22 | Intellikine Llc | Certain chemical entities, compositions and methods |
US8993580B2 (en) | 2008-03-14 | 2015-03-31 | Intellikine Llc | Benzothiazole kinase inhibitors and methods of use |
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WO2010006072A2 (en) | 2008-07-08 | 2010-01-14 | The Regents Of The University Of California | Mtor modulators and uses thereof |
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EP2358720B1 (en) | 2008-10-16 | 2016-03-02 | The Regents of The University of California | Fused ring heteroaryl kinase inhibitors |
US8476431B2 (en) | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン, エルエルシー | 複素環式化合物およびその使用 |
US8980899B2 (en) | 2009-10-16 | 2015-03-17 | The Regents Of The University Of California | Methods of inhibiting Ire1 |
US20130123208A1 (en) * | 2010-05-12 | 2013-05-16 | The Regents of the University of Colorado, a body corporation | Method of treating multiple sclerosis with adenosine receptor agonists |
JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
WO2012027695A1 (en) * | 2010-08-26 | 2012-03-01 | Northeastern University | Methods and compositions for preventing or treating obesity |
EP2621899B1 (en) | 2010-09-29 | 2015-10-21 | SK Biopharmaceuticals Co., Ltd. | Novel methylcyclohexane derivatives and uses thereof |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
MX2013006251A (es) | 2010-12-03 | 2013-10-01 | Epizyme Inc | Compuestos de purina y 7 - deazapurina substituidos como moduladores de enzimas epigeneticas. |
RU2013130253A (ru) | 2010-12-03 | 2015-01-10 | Эпизайм, Инк. | 7-деазапуриновые регуляторы метилтрансферазы гистонов и способы их применения |
US8809349B2 (en) | 2011-01-10 | 2014-08-19 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
US9132131B2 (en) | 2011-04-21 | 2015-09-15 | Saint Louis University | Use of adenosine A3 receptor agonists for treatment of neuropathic pain |
AU2012284088B2 (en) | 2011-07-19 | 2015-10-08 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
AR088218A1 (es) | 2011-07-19 | 2014-05-21 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos utiles como inhibidores de pi3k |
EP2751093A1 (en) | 2011-08-29 | 2014-07-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
JP6342805B2 (ja) | 2011-09-02 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換ピラゾロ[3,4−d]ピリミジンおよびその用途 |
CN104363757B (zh) * | 2012-02-11 | 2017-05-24 | 中央研究院 | 治疗疼痛的方法及组合物 |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
EP2882750A4 (en) | 2012-08-10 | 2016-08-17 | Epizyme Inc | INHIBITORS OF THE PROTEIN METHYLTRANSFERASE DOT1L AND METHOD OF USE THEREOF |
AU2013312319B2 (en) | 2012-09-06 | 2018-04-19 | Epizyme, Inc. | Method of treating leukemia |
BR112015006828A8 (pt) | 2012-09-26 | 2019-09-17 | Univ California | composto, ou um sal farmaceuticamente aceitável do mesmo; composição farmacêutica; uso do composto; e método para modular a atividade de uma proteína ire1 |
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US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
PE20160685A1 (es) | 2013-10-04 | 2016-07-23 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
SG10201808053XA (en) | 2014-03-19 | 2018-10-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
WO2017048702A1 (en) | 2015-09-14 | 2017-03-23 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
US20190099404A1 (en) * | 2016-03-16 | 2019-04-04 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
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US5801188A (en) * | 1997-01-08 | 1998-09-01 | Medtronic Inc. | Clonidine therapy enhancement |
GB9723589D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
SG176313A1 (en) * | 2001-10-01 | 2011-12-29 | Univ Virginia Patent Found | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
GB0228723D0 (en) * | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
US7261882B2 (en) * | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
US20050004221A1 (en) * | 2003-07-01 | 2005-01-06 | Medtronic, Inc. | Intrathecal gabapentin compositions |
GB0405009D0 (en) * | 2004-03-05 | 2004-04-07 | Cambridge Biotechnology Ltd | Analgesics |
JP2007526291A (ja) * | 2004-03-05 | 2007-09-13 | ケンブリッジ・バイオテクノロジー・リミテッド | アデノシン受容体アゴニスト |
US7605143B2 (en) * | 2004-08-02 | 2009-10-20 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity |
US7589076B2 (en) * | 2006-05-18 | 2009-09-15 | Pgx Health, Llc | Substituted aryl piperidinylalkynyladenosines as A2AR agonists |
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-
2009
- 2009-01-09 EP EP09700821A patent/EP2240020A4/en not_active Withdrawn
- 2009-01-09 CA CA2711495A patent/CA2711495A1/en not_active Abandoned
- 2009-01-09 US US12/351,209 patent/US20090181920A1/en not_active Abandoned
- 2009-01-09 EA EA201001135A patent/EA201001135A1/ru unknown
- 2009-01-09 BR BRPI0907248-9A patent/BRPI0907248A2/pt not_active IP Right Cessation
- 2009-01-09 JP JP2010542368A patent/JP2011509305A/ja active Pending
- 2009-01-09 CN CN2009801042314A patent/CN101938904A/zh active Pending
- 2009-01-09 AU AU2009204084A patent/AU2009204084A1/en not_active Abandoned
- 2009-01-09 WO PCT/US2009/030565 patent/WO2009089425A1/en active Application Filing
-
2010
- 2010-07-04 IL IL206801A patent/IL206801A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009204084A1 (en) | 2009-07-16 |
EP2240020A1 (en) | 2010-10-20 |
US20090181920A1 (en) | 2009-07-16 |
WO2009089425A1 (en) | 2009-07-16 |
CA2711495A1 (en) | 2009-07-16 |
CN101938904A (zh) | 2011-01-05 |
EP2240020A4 (en) | 2011-05-11 |
BRPI0907248A2 (pt) | 2019-02-26 |
JP2011509305A (ja) | 2011-03-24 |
IL206801A0 (en) | 2010-12-30 |
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