MX358499B - Moduladores de dihidropirazol del receptor acoplado a la proteína g (gpr40). - Google Patents

Moduladores de dihidropirazol del receptor acoplado a la proteína g (gpr40).

Info

Publication number
MX358499B
MX358499B MX2015005735A MX2015005735A MX358499B MX 358499 B MX358499 B MX 358499B MX 2015005735 A MX2015005735 A MX 2015005735A MX 2015005735 A MX2015005735 A MX 2015005735A MX 358499 B MX358499 B MX 358499B
Authority
MX
Mexico
Prior art keywords
gpr40 modulators
dihydropyrazole
dihydropyrazole gpr40
modulators
compounds
Prior art date
Application number
MX2015005735A
Other languages
English (en)
Other versions
MX2015005735A (es
Inventor
R Ewing William
s hernandez Andres
A Allsworth Bruce
Shi Jun
A Jurica Elizabeth
Wu Ximao
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MX2015005735A publication Critical patent/MX2015005735A/es
Publication of MX358499B publication Critical patent/MX358499B/es

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    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

La presente invención proporciona compuestos de la Fórmula (I): o un estereoisómero o una sal farmacéuticamente aceptable del mismo, en donde todas las variables son como se definen en la presente. Estos compuestos son moduladores del receptor acoplado a la proteína GPR4O G, que se pueden usar como medicamentos.
MX2015005735A 2012-11-16 2013-11-15 Moduladores de dihidropirazol del receptor acoplado a la proteína g (gpr40). MX358499B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261727262P 2012-11-16 2012-11-16
US201361777294P 2013-03-12 2013-03-12
PCT/US2013/070215 WO2014078610A1 (en) 2012-11-16 2013-11-15 Dihydropyrazole gpr40 modulators

Publications (2)

Publication Number Publication Date
MX2015005735A MX2015005735A (es) 2015-09-16
MX358499B true MX358499B (es) 2018-08-23

Family

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MX2015005735A MX358499B (es) 2012-11-16 2013-11-15 Moduladores de dihidropirazol del receptor acoplado a la proteína g (gpr40).

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US (1) US9133163B2 (es)
EP (1) EP2920165B1 (es)
JP (1) JP6322203B2 (es)
KR (1) KR102204804B1 (es)
CN (1) CN104812748B (es)
AU (1) AU2013344604B2 (es)
BR (1) BR112015010779A2 (es)
CA (1) CA2891574A1 (es)
CY (1) CY1118365T1 (es)
DK (1) DK2920165T3 (es)
EA (1) EA026913B1 (es)
ES (1) ES2606685T3 (es)
HR (1) HRP20161631T1 (es)
HU (1) HUE032401T2 (es)
IL (1) IL238741A0 (es)
LT (1) LT2920165T (es)
MX (1) MX358499B (es)
PL (1) PL2920165T3 (es)
PT (1) PT2920165T (es)
RS (1) RS55363B1 (es)
SG (1) SG11201503558SA (es)
SI (1) SI2920165T1 (es)
SM (1) SMT201600410B (es)
TW (1) TW201427971A (es)
UY (1) UY35143A (es)
WO (1) WO2014078610A1 (es)

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CY1118365T1 (el) 2017-06-28
CA2891574A1 (en) 2014-05-22
KR20150082616A (ko) 2015-07-15
HRP20161631T1 (hr) 2017-01-13
US9133163B2 (en) 2015-09-15
RS55363B1 (sr) 2017-03-31
DK2920165T3 (en) 2017-01-16
UY35143A (es) 2014-05-30
US20140142139A1 (en) 2014-05-22
ES2606685T3 (es) 2017-03-27
PT2920165T (pt) 2016-12-20
KR102204804B1 (ko) 2021-01-18
PL2920165T3 (pl) 2017-04-28
EA026913B1 (ru) 2017-05-31
SMT201600410B (it) 2017-01-10
JP2016500063A (ja) 2016-01-07
WO2014078610A1 (en) 2014-05-22
AU2013344604B2 (en) 2017-07-27
MX2015005735A (es) 2015-09-16
LT2920165T (lt) 2016-12-12
SG11201503558SA (en) 2015-06-29
EA201590954A1 (ru) 2015-08-31
CN104812748A (zh) 2015-07-29
TW201427971A (zh) 2014-07-16
JP6322203B2 (ja) 2018-05-09
IL238741A0 (en) 2015-06-30
BR112015010779A2 (pt) 2017-07-11
HUE032401T2 (en) 2017-09-28
EP2920165A1 (en) 2015-09-23
SI2920165T1 (sl) 2017-02-28
CN104812748B (zh) 2017-10-24
EP2920165B1 (en) 2016-09-28
AU2013344604A1 (en) 2015-07-02

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