JP2012514982A5 - - Google Patents
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- JP2012514982A5 JP2012514982A5 JP2011545537A JP2011545537A JP2012514982A5 JP 2012514982 A5 JP2012514982 A5 JP 2012514982A5 JP 2011545537 A JP2011545537 A JP 2011545537A JP 2011545537 A JP2011545537 A JP 2011545537A JP 2012514982 A5 JP2012514982 A5 JP 2012514982A5
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Claims (21)
- 活性化可能な抗体であって、前記活性化可能な抗体は:
標的分子への結合に関して約100nM以下の平衡解離定数を有する抗体またはその抗原結合断片(AB)と;
切断されていない状態で、前記標的分子への前記ABの結合を阻害することができるマスキング部分(MM)であって、ここで、
(A)前記MMは、長さ約2アミノ酸〜約40アミノ酸のポリペプチドであり、
(B)前記MMは、前記ABへの結合に関して、前記標的分子に対する前記ABの平衡解離定数よりも大きい平衡解離定数を有し、
(C)前記MMのポリペプチド配列は、前記標的分子の配列とは異なり、かつ前記MMのポリペプチド配列は、前記ABの天然の結合パートナーに対して50%以下同一であり、かつ
(D)前記MMは、切断された状態で、前記標的への結合に関して、前記ABを妨害も競合もしない、マスキング部分(MM)と;
長さ最大15アミノ酸のポリペプチドである切断可能な部分(CM)であって、前記CMは、第1の組織中において前記標的分子と共に共局在化し、前記活性化可能な抗体中の前記CMを切断することができるプロテアーゼの基質として役割を果たし、ここで、前記切断されていない状態で、前記標的への前記活性化可能な抗体の結合が、前記標的への改変されていないABの結合の平衡解離定数よりも少なくとも100倍大きい平衡解離定数で生じるように低減され、かつ一方で、前記切断された状態で、前記ABが、前記標的の存在下で、前記標的分子に結合することができるように、前記CMが、前記活性化可能な抗体中に位置づけられている、切断可能な部分(CM)と;ならびに、
各々長さ約1アミノ酸〜約20アミノ酸のペプチドである、2つの連結ペプチド(LP1、LP2)であって、ここで、LP1およびLP2は、互いに同一である必要はない、連結ペプチドと;
を含み、
前記活性化可能な抗体は、前記切断されていない状態で、以下のような、N末端からC末端までの構造上の配置を有する:
(MM)−LP1−(CM)−LP2−(AB)または(AB)−LP2−(CM)−L1(MM)
ここで、前記MMのカップリングは、前記標的に対する、前記MMとカップリングした場合の前記ABの解離定数(Kd)が、前記標的に対する、前記MMとカップリングしていない場合の前記ABのKdよりも少なくとも100倍大きいように、前記ABがその標的に結合する能力を低下させる、
活性化可能な抗体。 - 標的置換アッセイを用いてin vitroでアッセイした場合に、前記CMが切断された場合と比較して、標的分子の存在下で、前記CMが切断されていない場合、前記MMが、前記ABが前記標的分子と結合する能力を少なくとも90%低下させる、請求項1に記載の活性化可能な抗体。
- 前記その抗原結合断片が、Fab断片、F(ab’)2断片、scFv、scAB、dAb、単一ドメイン重鎖抗体、および単一ドメイン軽鎖抗体からなる群より選択される、請求項1に記載の活性化可能な抗体。
- 前記ABが、セツキシマブ、アダリムマブ、パニツムマブ、インフリキシマブ、エファリズマブ、イピリムマブ、トレメリムマブ、アデカツムマブ、Hu5c8、アレムツズマブ、ラニビズマブ、トシツモマブ、イブリツモマブチウキセタン、リツキシマブ、トシリズマブ、ベバシズマブ、またはフィギツムマブであるか、あるいはそれらに由来する、請求項1に記載の活性化可能な抗体。
- 前記標的が、EGFR、Jagged1、Jagged2、gp130、TNFアルファ、CD11a、CSFR、CTLA−4、EpCAM、VEGF、CD40、CD20、Notch1、Notch2、Notch3、Notch4、CD52、MUC1、IGF1R、トランスフェリン、VCAM−1、CD44、DLL4、またはIL4である、請求項1に記載の活性化可能な抗体。
- 前記標的が細胞表面受容体である、請求項1に記載の活性化可能な抗体。
- 前記標的が、トシリズマブの標的である、インターロイキン6受容体(IL−6R)である、請求項1に記載の活性化可能な抗体。
- 前記CMが、uPA、MT−SP1、レグマイン、プラスミン、TMPRSS−3/4、MMP−9、MT1−MMP、カテプシン、カスパーゼ、ヒト好中球エラスターゼ、ベータ−セクレターゼ、またはPSAからなる群より選択される酵素の基質である、請求項1に記載の活性化可能な抗体。
- 前記MMが、前記ABの前記標的分子に対して25%超のアミノ酸配列同一性または10%超のアミノ酸配列同一性を含まず、必要に応じて、前記MMが、CISPRGC(配列番号1)、C(N/P)H(HVF)(Y/T)(F/W/T/L)(Y/G/T/S)(T/S/Y/H)CGCISPRGCG(配列番号2)、xCxxYQCLxxxxxx(配列番号3)、XXQPxPPRVXX(配列番号4)、PxPGFPYCxxxx(配列番号5)、xxxxQxxPWPP(配列番号6)、GxGxCYTILExxCxxxR(配列番号7)、GxxxCYxIxExxCxxxx(配列番号8)、GxxxCYxIxExWCxxxx(配列番号9)、xxxCCxxYxIxxCCxxx(配列番号10)、およびxxxxxYxILExxxxx(配列番号11)から選択されるコンセンサス配列を含む、請求項1に記載の活性化可能な抗体。
- 前記MMのカップリングにより、前記標的に対する前記MMとカップリングした場合の前記ABの解離定数(Kd)が前記標的に対する前記MMとカップリングしていない場合の前記ABのKdよりも少なくとも1000倍大きい、または少なくとも10,000倍大きいように、前記ABがその標的と結合する能力が低下する、請求項1に記載の活性化可能な抗体。
- 前記第1の組織中での前記活性化可能な抗体とその標的との結合の親和性が、第2の組織中での前記活性化可能な抗体とその標的との結合と比較した場合により高く、前記第1の組織が罹患した組織であり、必要に応じて、前記罹患した組織が、乳房の組織、頭部の組織、頸部の組織、肺の組織、膵臓の組織、神経系の組織、肝臓の組織、前立腺の組織、泌尿生殖器の組織、または子宮頸部の組織である、請求項1に記載の活性化可能な抗体。
- 以下のうちの少なくとも1つを含む、請求項1に記載の活性化可能な抗体:
(i)第2のABであって、前記第2のABの標的は、Notch1、EGFR、TNFアルファ、CD11a、CSFR、CTLA−4、EpCAM、VEGF、CD40、CD20、Notch2、Notch3、Notch4、Jagged1、Jagged2、CD52、MUC1、IGF1R、トランスフェリン、gp130、VCAM−1、CD44、DLL4、およびIL4からなる群より選択される、第2のAB;または
(ii)少なくとも1つの第1のCMおよび第2のCMであって、ここで、前記第1のCMは、標的組織中の第1の切断剤によって切断可能であり、前記第2のCMは、標的組織中の第2の切断剤によって切断可能である、第1のCMおよび第2のCM、
活性化可能な抗体。 - 前記第1のCM、前記第2のCM、前記第1の切断剤または前記第2の切断剤が、以下の特徴のうちの少なくとも1つを含む、請求項12に記載の活性化可能な抗体:
(i)前記第1の切断剤および前記第2の切断剤は同じ酵素であり、かつ前記第1のCMおよび前記第2のCMは前記酵素の異なる基質である;
(ii)前記第1の切断剤および前記第2の切断剤は異なる酵素である;
(iii)前記第1の切断剤および前記第2の切断剤は前記第1の組織中において共局在化している;あるいは
(iv)前記第1のCMおよび前記第2のCMは前記第1の組織中における少なくとも1つの切断剤によって切断可能である、
活性化可能な抗体。 - LP1およびLP2のうちの少なくとも1つが、(GS)n、(GSGGS)n(配列番号12)、(GGGS)n(配列番号13)、GGSG(配列番号14)、GGSGG(配列番号15)、GSGSG(配列番号16)、GSGGG(配列番号17)、GGGSG(配列番号18)およびGSSSG(配列番号19)から選択されるアミノ酸配列を含み、式中、nは少なくとも1の整数である、請求項1に記載の活性化可能な抗体。
- 検出可能な部分、必要に応じて診断剤を含むか、または前記ABに結合体化された治療剤、必要に応じて、抗腫瘍剤をさらに含む、請求項1に記載の活性化可能な抗体。
- 被験体における新生物、自己免疫疾患または炎症性疾患を処置するため、あるいは被験体における血管形成を阻害するための組成物であって、請求項1〜15のいずれか一項に記載の活性化可能な抗体を含む、組成物。
- 被験体における新生物、自己免疫疾患または炎症性疾患を処置するための医薬の製造における、あるいは被験体における血管形成を阻害するための医薬の製造における、請求項1〜15のいずれか一項に記載の活性化可能な抗体の使用。
- 活性化可能な抗体を製造する方法であって、前記方法は:
(a)前記活性化可能な抗体の発現を誘導する条件下で前記活性化可能な抗体をコードする核酸構築物を含む細胞を培養する工程であって、ここで、前記活性化可能な抗体は、マスキング部分(MM)、切断可能な部分(CM)、および標的に特異的に結合する抗体またはその抗原結合断片(AB)を含み、ここで、
(i)前記MMは、長さ約2アミノ酸〜約40アミノ酸のポリペプチドであり、前記MMは、前記ABへの結合に関して、前記標的への結合についての前記ABの平衡解離定数よりも大きい平衡解離定数を有し、そして前記MMのアミノ酸配列は、前記標的のアミノ酸配列とは異なり、かつ前記MMのアミノ酸配列は、前記ABの天然の結合パートナーのアミノ酸配列に対して50%以下同一であり;
(ii)前記CMは、組織中において前記標的と共に共局在化するプロテアーゼの基質として機能するポリペプチドであり、前記プロテアーゼは、前記活性化可能な抗体が前記プロテアーゼに曝露された場合に前記活性化可能な抗体中の前記CMを切断し;
(iii)前記活性化可能な抗体は、切断されていない状態で、以下:
MM−CM−ABまたはAB−CM−MM
のような、N末端からC末端までの構造上の配置を有し;そして
(iv)切断されていない状態で、前記MMは、前記標的への前記ABの特異的結合を妨害し、そして切断された状態で、前記MMは、前記標的への前記ABの特異的結合を妨害も競合もしない;
工程;
(b)前記活性化可能な抗体を回収する工程
を包含する、方法。 - 請求項1に記載の活性化可能な抗体を製造する方法であって、前記方法は:
(a)抗体またはその抗原結合断片(AB)、マスキング部分(MM)、切断可能な部分(CM)、第1の連結ペプチド(LP1)および第2の連結ペプチド(LP2)を提供するステップと;
(b)前記第1の連結ペプチド(LP1)を介して、前記MMを前記CMにカップリングさせるステップと;
(c)前記第2の連結ペプチド(LP2)を介して、前記ABを前記CMにカップリングさせるステップと;
を含み、ここで、
前記活性化可能な抗体は、切断されていない状態で、以下のような、N末端からC末端までの構造上の配置を有する:
(MM)−LP1−(CM)−LP2−(AB)または(AB)−LP2−(CM)−L1(MM)、
方法。 - 請求項1に記載の活性化可能な抗体をコードする、単離された核酸分子。
- 請求項1に記載の活性化可能な抗体の発現を誘導する条件下で、細胞を培養することによって、請求項1に記載の活性化可能な抗体を生成する方法であって、前記細胞は、前記活性化可能な抗体をコードする単離された核酸分子を含むベクターを含む、方法。
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JP7036860B2 (ja) | 2013-07-25 | 2022-03-15 | シトムクス セラピューティクス,インコーポレイティド | 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法 |
JP7472183B2 (ja) | 2016-11-03 | 2024-04-22 | ブリストル-マイヤーズ スクイブ カンパニー | 活性化可能な抗ctla-4抗体およびその使用 |
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