CN112424224A - 抗白细胞介素-17a抗体、其药物组合物及其用途 - Google Patents

抗白细胞介素-17a抗体、其药物组合物及其用途 Download PDF

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CN112424224A
CN112424224A CN201980036614.6A CN201980036614A CN112424224A CN 112424224 A CN112424224 A CN 112424224A CN 201980036614 A CN201980036614 A CN 201980036614A CN 112424224 A CN112424224 A CN 112424224A
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seq
monoclonal antibody
variable region
chain variable
amino acid
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CN112424224B (zh
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李百勇
夏瑜
王忠民
张鹏
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Akeso Pharmaceuticals Inc
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Abstract

本发明属于自身免疫疾病治疗和分子免疫学领域，涉及一种抗IL‑17A抗体、其药物组合物及其用途。具体地，本发明涉及一种单克隆抗体或其抗原结合片段，其中，所述单克隆抗体的重链可变区包含：氨基酸序列分别如SEQ ID NOs:31－33所示的HCDR1－HCDR3或氨基酸序列分别如SEQ ID NOs:37－39所示的HCDR1－HCDR3，和所述单克隆抗体的轻链可变区包含：氨基酸序列分别如SEQ ID NOs:34－36所示的LCDR1－LCDR3或氨基酸序列分别如SEQ ID NOs:40－42所示的LCDR1－LCDR3。本发明的单克隆抗体能够很好地特异性与IL‑17A结合，特异拮抗IL‑17A与其配体的结合，抑制IL‑17A对成纤维细胞的激活。

Description

PCT国内申请，说明书已公开。

Claims (26)

  1. PCT国内申请，权利要求书已公开。
CN201980036614.6A 2018-05-30 2019-05-24 抗白细胞介素-17a抗体、其药物组合物及其用途 Active CN112424224B (zh)

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PCT/CN2019/088344 WO2019228266A1 (zh) 2018-05-30 2019-05-24 抗白细胞介素-17a抗体、其药物组合物及其用途

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CN117866903A (zh) * 2024-03-12 2024-04-12 北京贝来药业有限公司 单域抗体修饰的干细胞及其在疾病治疗中用途

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CN113024672B (zh) * 2019-12-24 2022-05-31 深圳华大生命科学研究院 一种抗Dig的抗体及其在测序中的应用
CN111040035B (zh) * 2019-12-31 2022-05-24 南京融捷康生物科技有限公司 针对il-17ra蛋白的抗体及其制备方法和应用
CN113150148B (zh) * 2020-06-19 2021-10-08 北京东方百泰生物科技股份有限公司 一种抗il-17ra单克隆抗体的纯化方法
CN114057871B (zh) * 2020-08-07 2023-08-01 沈阳何氏眼产业集团有限公司 抗人periostin单克隆嵌合抗体及应用
CN112142841B (zh) * 2020-09-27 2022-03-22 江苏荃信生物医药股份有限公司 一种新的抗人il-17a单克隆抗体、包含其的试剂盒及其检测方法
CN112250764B (zh) * 2020-10-22 2022-07-29 深圳市康瑞克生物科技有限责任公司 一种抗白细胞介素17a的单克隆抗体、其编码基因及应用
CN112300285B (zh) * 2020-11-06 2022-08-02 江苏荃信生物医药股份有限公司 一种定量检测血清中抗人白介素17单克隆抗体含量的酶联免疫分析方法
CN114685668B (zh) * 2020-12-28 2023-10-13 石药集团巨石生物制药有限公司 一种人gpc3单克隆抗体及其缀合物
CN115746132B (zh) * 2021-09-03 2023-09-08 三优生物医药(上海)有限公司 抗il-17a抗体及其用途
CN113817058B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CN113896793B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
WO2023060211A1 (en) * 2021-10-06 2023-04-13 The University Of Chicago Borealin targeting polypeptides for detection and treatment of cancer

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WO2019228266A1 (zh) 2019-12-05
EA202092844A1 (ru) 2021-03-16
CN110551215A (zh) 2019-12-10

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