EA202092844A1 - Анти-интерлейкин-17а антитело, фармацевтическая композиция и их применение - Google Patents

Анти-интерлейкин-17а антитело, фармацевтическая композиция и их применение

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EA202092844A1
EA202092844A1 EA202092844A EA202092844A EA202092844A1 EA 202092844 A1 EA202092844 A1 EA 202092844A1 EA 202092844 A EA202092844 A EA 202092844A EA 202092844 A EA202092844 A EA 202092844A EA 202092844 A1 EA202092844 A1 EA 202092844A1
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seq
amino acid
acid sequences
sequences shown
monoclonal antibody
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EA202092844A
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English (en)
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Байюн Ли
Юй Ся
Чжунминь Максвелл Ван
Пэн Чжан
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Акесо Байофарма, Инк.
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Publication of EA202092844A1 publication Critical patent/EA202092844A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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Abstract

Настоящее изобретение относится к области лечения аутоиммунных заболеваний и молекулярной иммунологии, а именно к анти-IL-17A антителу, содержащей его фармацевтической композиции и их применению. Более конкретно, настоящее изобретение относится к моноклональному антителу или его антигенсвязывающему фрагменту, в котором вариабельная область тяжелой цепи моноклонального антитела содержит HCDR1-HCDR3 с аминокислотными последовательностями, приведенными в SEQ ID NO: 31-33 соответственно, или HCDR1-HCDR3 с аминокислотными последовательностями, приведенными в SEQ ID NO: 37-39 соответственно, и вариабельная область легкой цепи моноклонального антитела содержит LCDR1-LCDR3 с аминокислотными последовательностями, приведенными в SEQ ID NO: 34-36 соответственно, или LCDR1-LCDR3 с аминокислотными последовательностями, приведенными в SEQ ID NO: 40-42 соответственно. Моноклональные антитела по настоящему изобретению могут специфически связываться с IL-17A, специфически противодействовать связыванию IL-17A с его лигандом и подавлять опосредованную IL-17A активацию фибробластов.
EA202092844A 2018-05-30 2019-05-24 Анти-интерлейкин-17а антитело, фармацевтическая композиция и их применение EA202092844A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810539405.0A CN110551215A (zh) 2018-05-30 2018-05-30 抗白细胞介素-17a抗体、其药物组合物及其用途
PCT/CN2019/088344 WO2019228266A1 (zh) 2018-05-30 2019-05-24 抗白细胞介素-17a抗体、其药物组合物及其用途

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US (1) US20210122815A1 (ru)
EP (1) EP3805264A4 (ru)
JP (1) JP2021526022A (ru)
KR (1) KR20210018336A (ru)
CN (2) CN110551215A (ru)
AU (1) AU2019276486A1 (ru)
BR (1) BR112020024512A2 (ru)
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EA (1) EA202092844A1 (ru)
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CN111690065B (zh) * 2020-06-19 2021-04-02 北京东方百泰生物科技股份有限公司 一种抗il-17ra单克隆抗体的纯化方法
CN114057871B (zh) * 2020-08-07 2023-08-01 沈阳何氏眼产业集团有限公司 抗人periostin单克隆嵌合抗体及应用
CN114276450B (zh) * 2020-09-27 2023-08-29 江苏荃信生物医药股份有限公司 抗人il-17a单克隆抗体及其用途
CN112250764B (zh) * 2020-10-22 2022-07-29 深圳市康瑞克生物科技有限责任公司 一种抗白细胞介素17a的单克隆抗体、其编码基因及应用
CN112300285B (zh) * 2020-11-06 2022-08-02 江苏荃信生物医药股份有限公司 一种定量检测血清中抗人白介素17单克隆抗体含量的酶联免疫分析方法
CN114685668B (zh) * 2020-12-28 2023-10-13 石药集团巨石生物制药有限公司 一种人gpc3单克隆抗体及其缀合物
CN115746132B (zh) * 2021-09-03 2023-09-08 三优生物医药(上海)有限公司 抗il-17a抗体及其用途
CN113817058B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CN113896793B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
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BR112020024512A2 (pt) 2021-03-02
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