JP2010532747A5 - - Google Patents
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- Publication number
- JP2010532747A5 JP2010532747A5 JP2010502196A JP2010502196A JP2010532747A5 JP 2010532747 A5 JP2010532747 A5 JP 2010532747A5 JP 2010502196 A JP2010502196 A JP 2010502196A JP 2010502196 A JP2010502196 A JP 2010502196A JP 2010532747 A5 JP2010532747 A5 JP 2010532747A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- compound
- hepatitis
- stereoisomer
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 6
- 241000700605 Viruses Species 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 3
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 3
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims 2
- 241000725619 Dengue virus Species 0.000 claims 2
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000991587 Enterovirus C Species 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 241000709721 Hepatovirus A Species 0.000 claims 2
- 241000710842 Japanese encephalitis virus Species 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 241000710886 West Nile virus Species 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- XVVLESMRYHJYLT-RFQRIQSBSA-N CC(C)OC(=O)[C@H](C)N=P(=O)OC1=CC=CC=C1OC[C@@H]1[C@@H](O)[C@@](C)(F)[C@H](N2C(NC(=O)C=C2)=O)O1 Chemical compound CC(C)OC(=O)[C@H](C)N=P(=O)OC1=CC=CC=C1OC[C@@H]1[C@@H](O)[C@@](C)(F)[C@H](N2C(NC(=O)C=C2)=O)O1 XVVLESMRYHJYLT-RFQRIQSBSA-N 0.000 claims 1
- 229940127073 nucleoside analogue Drugs 0.000 claims 1
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 claims 1
- 0 CC(C)CCC([C@](C)*(*(Oc1ccccc1)=O)=I)=O Chemical compound CC(C)CCC([C@](C)*(*(Oc1ccccc1)=O)=I)=O 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90931507P | 2007-03-30 | 2007-03-30 | |
| US60/909,315 | 2007-03-30 | ||
| US98230907P | 2007-10-24 | 2007-10-24 | |
| US60/982,309 | 2007-10-24 | ||
| US12/053,015 US7964580B2 (en) | 2007-03-30 | 2008-03-21 | Nucleoside phosphoramidate prodrugs |
| US12/053,015 | 2008-03-21 | ||
| PCT/US2008/058183 WO2008121634A2 (en) | 2007-03-30 | 2008-03-26 | Nucleoside phosphoramidate prodrugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012032352A Division JP5539419B2 (ja) | 2007-03-30 | 2012-02-17 | ヌクレオシドホスホロアミデートプロドラッグ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532747A JP2010532747A (ja) | 2010-10-14 |
| JP2010532747A5 true JP2010532747A5 (enExample) | 2012-04-12 |
| JP5318085B2 JP5318085B2 (ja) | 2013-10-16 |
Family
ID=39808855
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502196A Active JP5318085B2 (ja) | 2007-03-30 | 2008-03-26 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2012032352A Active JP5539419B2 (ja) | 2007-03-30 | 2012-02-17 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2014093905A Active JP5774749B2 (ja) | 2007-03-30 | 2014-04-30 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2014186366A Pending JP2015024998A (ja) | 2007-03-30 | 2014-09-12 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2015139458A Withdrawn JP2016023187A (ja) | 2007-03-30 | 2015-07-13 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2017000051A Active JP6377781B2 (ja) | 2007-03-30 | 2017-01-04 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2018138161A Pending JP2018197245A (ja) | 2007-03-30 | 2018-07-24 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2019223231A Pending JP2020100617A (ja) | 2007-03-30 | 2019-12-10 | ヌクレオシドホスホロアミデートプロドラッグ |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012032352A Active JP5539419B2 (ja) | 2007-03-30 | 2012-02-17 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2014093905A Active JP5774749B2 (ja) | 2007-03-30 | 2014-04-30 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2014186366A Pending JP2015024998A (ja) | 2007-03-30 | 2014-09-12 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2015139458A Withdrawn JP2016023187A (ja) | 2007-03-30 | 2015-07-13 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2017000051A Active JP6377781B2 (ja) | 2007-03-30 | 2017-01-04 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2018138161A Pending JP2018197245A (ja) | 2007-03-30 | 2018-07-24 | ヌクレオシドホスホロアミデートプロドラッグ |
| JP2019223231A Pending JP2020100617A (ja) | 2007-03-30 | 2019-12-10 | ヌクレオシドホスホロアミデートプロドラッグ |
Country Status (37)
Families Citing this family (270)
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| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
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| JP2004532184A (ja) | 2001-01-22 | 2004-10-21 | メルク エンド カムパニー インコーポレーテッド | Ｒｎａ依存性ｒｎａウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体 |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| KR100883703B1 (ko) | 2003-05-30 | 2009-02-12 | 파마셋 인코포레이티드 | 변형 불소화 뉴클레오시드 유사체 |
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