JP2008523098A5 - - Google Patents
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- Publication number
- JP2008523098A5 JP2008523098A5 JP2007545685A JP2007545685A JP2008523098A5 JP 2008523098 A5 JP2008523098 A5 JP 2008523098A5 JP 2007545685 A JP2007545685 A JP 2007545685A JP 2007545685 A JP2007545685 A JP 2007545685A JP 2008523098 A5 JP2008523098 A5 JP 2008523098A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleoside
- prodrug
- pharmaceutically acceptable
- base
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63487504P | 2004-12-10 | 2004-12-10 | |
| PCT/US2005/044709 WO2006063281A2 (en) | 2004-12-10 | 2005-12-08 | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008523098A JP2008523098A (ja) | 2008-07-03 |
| JP2008523098A5 true JP2008523098A5 (enExample) | 2009-01-29 |
Family
ID=36578634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007545685A Withdrawn JP2008523098A (ja) | 2004-12-10 | 2005-12-08 | ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7495006B2 (enExample) |
| EP (1) | EP1828145A4 (enExample) |
| JP (1) | JP2008523098A (enExample) |
| CN (1) | CN101115725A (enExample) |
| AU (1) | AU2005313912A1 (enExample) |
| BR (1) | BRPI0518984A2 (enExample) |
| CA (1) | CA2590115A1 (enExample) |
| MX (1) | MX2007006961A (enExample) |
| WO (1) | WO2006063281A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US7820180B2 (en) * | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US8791237B2 (en) * | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| US8114414B2 (en) * | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US9012141B2 (en) * | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| JP2004500405A (ja) * | 2000-03-29 | 2004-01-08 | ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルヴァニア | 抗原の免疫原性を増強するための組成物および方法 |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| US7700344B2 (en) * | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| EP1828145A4 (en) * | 2004-12-10 | 2009-08-19 | Univ Emory | 2'- AND 3'-SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS AND ANORMAL CELL PROLIFERATION |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| JP5793766B2 (ja) | 2009-12-16 | 2015-10-14 | ファイザー・インク | 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体 |
| AP3336A (en) | 2011-03-07 | 2015-07-31 | Pfizer | Fluoro-pyridinone derivatives useful as antibacterial agents |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| WO2012137099A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| WO2012137094A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
| EA024297B1 (ru) | 2011-12-20 | 2016-09-30 | Рибосайенс Ллк | 2',4'-дифтор-2'-метилзамещенные нуклеозидные производные в качестве ингибиторов репликации рнк вируса гепатита с |
| IN2014CN04530A (enExample) | 2011-12-20 | 2015-09-11 | Hoffmann La Roche | |
| US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
| AU2014265293B2 (en) | 2013-05-16 | 2019-07-18 | Riboscience Llc | 4'-Fluoro-2'-methyl substituted nucleoside derivatives |
| MX2015015781A (es) | 2013-05-16 | 2016-06-02 | Riboscience Llc | Derivados de nucleósido 4'-azido, 3'-deoxi-3'-fluoro sustituido. |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| BR112017010474A2 (pt) | 2014-11-19 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados antibacterianos de benzotiazol |
| FI3265102T3 (fi) | 2015-03-06 | 2025-10-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
| WO2018067424A1 (en) | 2016-10-03 | 2018-04-12 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5'-nucleotidase |
| CN115477679A (zh) | 2017-02-01 | 2022-12-16 | 阿堤亚制药公司 | 用于治疗丙型肝炎病毒的核苷酸半硫酸盐 |
| EP3684374B1 (en) | 2017-09-21 | 2025-07-30 | Riboscience LLC | 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication |
| CN112351799A (zh) | 2018-04-10 | 2021-02-09 | 阿堤亚制药公司 | 具有硬化的hcv感染患者的治疗 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2022164941A1 (en) | 2021-01-26 | 2022-08-04 | Atea Pharmaceuticals, Inc. | Advantageous morphic form of at-527 hemi-sulfate salt |
| AU2022291927A1 (en) | 2021-06-17 | 2024-01-04 | Atea Pharmaceuticals, Inc. | Advantageous anti-hcv combination therapy |
| CN119431343B (zh) * | 2024-11-04 | 2026-04-10 | 河南大学 | 一种m6A去甲基化酶ALKBH1小分子抑制剂、合成方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855466A (en) * | 1987-12-28 | 1989-08-08 | E. R. Squibb & Sons, Inc. | Purinyl cyclobutanes |
| EP0330992A3 (en) * | 1988-02-29 | 1991-11-06 | Nippon Kayaku Kabushiki Kaisha | Novel cyclobutane derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| US5185459A (en) | 1988-03-30 | 1993-02-09 | E. R. Squibb & Sons Inc. | Bis protected (hydroxymethyl)cyclobutanols |
| US5130462A (en) | 1988-03-30 | 1992-07-14 | E. R. Squibb & Sons, Inc. | Cyclobutane derivatives |
| US5126345A (en) | 1988-03-30 | 1992-06-30 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl triazolopyrimidines |
| IL92096A0 (en) * | 1988-10-25 | 1990-07-12 | Abbott Lab | Carboxylic nucleoside analogs |
| US4918075A (en) * | 1988-12-20 | 1990-04-17 | E. R. Squibb & Sons, Inc. | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents |
| US5324730A (en) | 1990-05-24 | 1994-06-28 | Nippon Kayaku Kabushiki Kaisha | Phenoxyphosphoryloxymethyl cyclobutyl purines |
| CA2042931A1 (en) * | 1990-05-24 | 1991-11-25 | Robert Zahler | Fluorinated bis (hydroxymethyl) cyclobutyl purines and pyrimidines |
| US5166397A (en) | 1990-09-20 | 1992-11-24 | Nippon Kayaku Kabushiki Kaisha | Process for producing optically active cyclobutylamines |
| US20040229839A1 (en) * | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| EP1828145A4 (en) | 2004-12-10 | 2009-08-19 | Univ Emory | 2'- AND 3'-SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS AND ANORMAL CELL PROLIFERATION |
-
2005
- 2005-12-08 EP EP05853591A patent/EP1828145A4/en not_active Withdrawn
- 2005-12-08 CN CNA2005800477715A patent/CN101115725A/zh active Pending
- 2005-12-08 US US11/301,326 patent/US7495006B2/en not_active Expired - Lifetime
- 2005-12-08 WO PCT/US2005/044709 patent/WO2006063281A2/en not_active Ceased
- 2005-12-08 JP JP2007545685A patent/JP2008523098A/ja not_active Withdrawn
- 2005-12-08 CA CA002590115A patent/CA2590115A1/en not_active Abandoned
- 2005-12-08 BR BRPI0518984-5A patent/BRPI0518984A2/pt not_active IP Right Cessation
- 2005-12-08 MX MX2007006961A patent/MX2007006961A/es active IP Right Grant
- 2005-12-08 AU AU2005313912A patent/AU2005313912A1/en not_active Abandoned
-
2009
- 2009-02-10 US US12/368,876 patent/US8114994B2/en not_active Expired - Fee Related
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