JP2008523098A - ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 - Google Patents

ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 Download PDF

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JP2008523098A
JP2008523098A JP2007545685A JP2007545685A JP2008523098A JP 2008523098 A JP2008523098 A JP 2008523098A JP 2007545685 A JP2007545685 A JP 2007545685A JP 2007545685 A JP2007545685 A JP 2007545685A JP 2008523098 A JP2008523098 A JP 2008523098A
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nucleoside
mmol
fluoro
cyclobutyl
pharmaceutically acceptable
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JP2008523098A5 (enExample
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リオツタ，デニス・シー
マオ，シヨリ
ヘイガー，マイケル
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エモリー・ユニバーシテイ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2007545685A 2004-12-10 2005-12-08 ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 Withdrawn JP2008523098A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63487504P 2004-12-10 2004-12-10
PCT/US2005/044709 WO2006063281A2 (en) 2004-12-10 2005-12-08 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation

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JP2008523098A true JP2008523098A (ja) 2008-07-03
JP2008523098A5 JP2008523098A5 (enExample) 2009-01-29

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JP2007545685A Withdrawn JP2008523098A (ja) 2004-12-10 2005-12-08 ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体

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US (2) US7495006B2 (enExample)
EP (1) EP1828145A4 (enExample)
JP (1) JP2008523098A (enExample)
CN (1) CN101115725A (enExample)
AU (1) AU2005313912A1 (enExample)
BR (1) BRPI0518984A2 (enExample)
CA (1) CA2590115A1 (enExample)
MX (1) MX2007006961A (enExample)
WO (1) WO2006063281A2 (enExample)

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TWI781960B (zh) * 2016-10-03 2022-11-01 美商阿克思生物科學有限公司 腺核苷5'-核苷酸酶之抑制劑及相關用途

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US8791237B2 (en) 1994-11-08 2014-07-29 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of non-hodgkins lymphoma
US8956621B2 (en) 1994-11-08 2015-02-17 The Trustees Of The University Of Pennsylvania Compositions and methods for treatment of cervical dysplasia
US9012141B2 (en) * 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
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US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
US7700344B2 (en) * 2001-03-26 2010-04-20 The Trustees Of The University Of Pennsylvania Compositions and methods for enhancing the immunogenicity of antigens
EP1828145A4 (en) 2004-12-10 2009-08-19 Univ Emory 2'- AND 3'-SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGUE FOR THE TREATMENT OF VIRAL INFECTIONS AND ANORMAL CELL PROLIFERATION
US20090318380A1 (en) * 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
US9017660B2 (en) 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
WO2010032147A2 (en) 2008-09-19 2010-03-25 Pfizer Inc. Hydroxamic acid derivatives useful as antibacterial agents
PT2512474E (pt) 2009-12-16 2014-12-23 Pfizer Derivados de ácido hidroxâmico n-ligado úteis como agentes antibacterianos
GEP20156370B (en) 2011-03-07 2015-09-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
EP2683400A4 (en) 2011-03-11 2014-09-17 Advaxis ADJUVANZIA ON LISTERIA BASE
SG193367A1 (en) 2011-04-08 2013-10-30 Pfizer Isoxazole derivatives useful as antibacterial agents
SG193458A1 (en) 2011-04-08 2013-10-30 Pfizer Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
ES2636448T3 (es) 2011-12-20 2017-10-05 Riboscience Llc Derivados de nucleósido 2',4'-difluoro-2'-metil sustituidos como inhibidores de la replicación del ARN del VHC
CA2869317C (en) 2011-12-20 2016-05-17 F. Hoffmann-La Roche Ag 4'-azido,3'-fluoro substituted nucleoside derivatives as inhibitors of hcv rna replication
US9895442B2 (en) 2013-05-16 2018-02-20 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
EA201592185A1 (ru) 2013-05-16 2016-05-31 Рибосайенс Ллк 4'-азидо, 3'-дезокси-3'-фторзамещенные нуклеозидные производные
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
UA118722C2 (uk) 2014-11-19 2019-02-25 Ідорсія Фармасьютікалз Лтд Антибактеріальні бензотіазольні похідні
CN107427530B (zh) 2015-03-06 2020-09-08 阿堤亚制药公司 用于HCV治疗的β-D-2’-脱氧-2’α-氟-2’-β-C-取代的-2-改性的-N6-取代的嘌呤核苷酸
LU100724B1 (en) 2016-07-14 2018-07-31 Atea Pharmaceuticals Inc Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
CN109689672B (zh) 2016-09-07 2023-05-30 阿堤亚制药公司 用于rna病毒治疗的2’-取代的-n6-取代的嘌呤核苷酸
GEP20227457B (en) 2017-02-01 2023-01-10 Atea Pharmaceuticals Inc Nucleotide hemi-sulfate salt for treatment of hepatitis c virus
AU2018335411B2 (en) 2017-09-21 2024-06-27 Riboscience Llc 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
JP2021521118A (ja) 2018-04-10 2021-08-26 アテア ファーマシューティカルズ， インコーポレイテッド 肝硬変を伴うｈｃｖ感染患者の治療
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KR20240022574A (ko) 2021-06-17 2024-02-20 아테아 파마슈티컬즈, 인크. 유리한 항-hcv 조합 요법
CN119431343A (zh) * 2024-11-04 2025-02-14 河南大学 一种m6A去甲基化酶ALKBH1小分子抑制剂、合成方法及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI781960B (zh) * 2016-10-03 2022-11-01 美商阿克思生物科學有限公司 腺核苷5'-核苷酸酶之抑制劑及相關用途

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CA2590115A1 (en) 2006-06-15
EP1828145A4 (en) 2009-08-19
US8114994B2 (en) 2012-02-14
BRPI0518984A2 (pt) 2008-12-16
EP1828145A2 (en) 2007-09-05
US20090149416A1 (en) 2009-06-11
US7495006B2 (en) 2009-02-24
WO2006063281A3 (en) 2006-10-12
CN101115725A (zh) 2008-01-30
WO2006063281A2 (en) 2006-06-15
AU2005313912A1 (en) 2006-06-15
US20060223835A1 (en) 2006-10-05
MX2007006961A (es) 2007-10-04

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