BRPI0518984A2 - anÁlogos de nucleosÍdeo de ciclobutil substituÍdos em 2' e 3' para tratamento de infecÇÕes virais e proliferaÇço celular anormal - Google Patents
anÁlogos de nucleosÍdeo de ciclobutil substituÍdos em 2' e 3' para tratamento de infecÇÕes virais e proliferaÇço celular anormalInfo
- Publication number
- BRPI0518984A2 BRPI0518984A2 BRPI0518984-5A BRPI0518984A BRPI0518984A2 BR PI0518984 A2 BRPI0518984 A2 BR PI0518984A2 BR PI0518984 A BRPI0518984 A BR PI0518984A BR PI0518984 A2 BRPI0518984 A2 BR PI0518984A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- cell proliferation
- abnormal cell
- viral infections
- nucleoside analogs
- Prior art date
Links
- 230000002159 abnormal effect Effects 0.000 title abstract 3
- 230000004663 cell proliferation Effects 0.000 title abstract 3
- 239000002777 nucleoside Substances 0.000 title abstract 3
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- -1 cyclobutyl nucleoside Chemical class 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 abstract 1
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 241000700739 Hepadnaviridae Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 241000712907 Retroviridae Species 0.000 abstract 1
- PPBOKXIGFIBOGK-BDTUAEFFSA-N bvdv Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)C1=CN=CN1 PPBOKXIGFIBOGK-BDTUAEFFSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63487504P | 2004-12-10 | 2004-12-10 | |
| PCT/US2005/044709 WO2006063281A2 (en) | 2004-12-10 | 2005-12-08 | 2' and 3' - substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518984A2 true BRPI0518984A2 (pt) | 2008-12-16 |
Family
ID=36578634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518984-5A BRPI0518984A2 (pt) | 2004-12-10 | 2005-12-08 | anÁlogos de nucleosÍdeo de ciclobutil substituÍdos em 2' e 3' para tratamento de infecÇÕes virais e proliferaÇço celular anormal |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7495006B2 (enExample) |
| EP (1) | EP1828145A4 (enExample) |
| JP (1) | JP2008523098A (enExample) |
| CN (1) | CN101115725A (enExample) |
| AU (1) | AU2005313912A1 (enExample) |
| BR (1) | BRPI0518984A2 (enExample) |
| CA (1) | CA2590115A1 (enExample) |
| MX (1) | MX2007006961A (enExample) |
| WO (1) | WO2006063281A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8791237B2 (en) * | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| US8114414B2 (en) * | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US7820180B2 (en) * | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US9012141B2 (en) * | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| JP2004500405A (ja) * | 2000-03-29 | 2004-01-08 | ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルヴァニア | 抗原の免疫原性を増強するための組成物および方法 |
| US7700344B2 (en) * | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| JP2008523098A (ja) | 2004-12-10 | 2008-07-03 | エモリー・ユニバーシテイ | ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 |
| US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| CA2899583A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| KR101593288B1 (ko) | 2011-03-07 | 2016-02-11 | 화이자 인코포레이티드 | 항균제로서 유용한 플루오로-피리디논 유도체 |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| CN103492368A (zh) | 2011-04-08 | 2014-01-01 | 辉瑞大药厂 | 用作抗菌剂的咪唑、吡唑和噻唑衍生物 |
| AU2012238374B2 (en) | 2011-04-08 | 2015-04-02 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
| PT2794628T (pt) | 2011-12-20 | 2017-07-05 | Riboscience Llc | Derivados nucleosídicos 4¿-azido-3¿-fluoro substituídos como inibidores de replicação de arn de vhc |
| PL2794629T3 (pl) | 2011-12-20 | 2018-02-28 | Riboscience Llc | 2',4'-difluoro-2'-metylo-podstawione pochodne nukleozydowe jako inhibitory replikacji rna hcv |
| US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
| JP2016519146A (ja) | 2013-05-16 | 2016-06-30 | リボサイエンス・エルエルシー | ４’−アジド，３’−デオキシ−３’−フルオロ置換ヌクレオシド誘導体 |
| NZ714927A (en) | 2013-05-16 | 2020-09-25 | Riboscience Llc | 4’-fluoro-2’-methyl substituted nucleoside derivatives |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| UA118722C2 (uk) | 2014-11-19 | 2019-02-25 | Ідорсія Фармасьютікалз Лтд | Антибактеріальні бензотіазольні похідні |
| CN107427530B (zh) | 2015-03-06 | 2020-09-08 | 阿堤亚制药公司 | 用于HCV治疗的β-D-2’-脱氧-2’α-氟-2’-β-C-取代的-2-改性的-N6-取代的嘌呤核苷酸 |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| AU2017324939B2 (en) | 2016-09-07 | 2021-10-14 | Atea Pharmaceuticals, Inc. | 2'-substituted-N6-substituted purine nucleotides for RNA virus treatment |
| US11058704B2 (en) | 2016-10-03 | 2021-07-13 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5′-nucleotidase |
| US10519186B2 (en) | 2017-02-01 | 2019-12-31 | Atea Pharmaceuticals, Inc. | Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus |
| TWI860279B (zh) | 2017-09-21 | 2024-11-01 | 美商里伯賽恩斯有限責任公司 | 作為hcv rna複製抑制劑之經4'-氟-2'-甲基取代之核苷衍生物 |
| KR20200140865A (ko) | 2018-04-10 | 2020-12-16 | 아테아 파마슈티컬즈, 인크. | 간경변증을 갖는 hcv 감염 환자의 치료 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN117500494A (zh) | 2021-06-17 | 2024-02-02 | 阿堤亚制药公司 | 有利的抗hcv联合疗法 |
| CN119431343A (zh) * | 2024-11-04 | 2025-02-14 | 河南大学 | 一种m6A去甲基化酶ALKBH1小分子抑制剂、合成方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855466A (en) * | 1987-12-28 | 1989-08-08 | E. R. Squibb & Sons, Inc. | Purinyl cyclobutanes |
| EP0330992A3 (en) * | 1988-02-29 | 1991-11-06 | Nippon Kayaku Kabushiki Kaisha | Novel cyclobutane derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| US5130462A (en) * | 1988-03-30 | 1992-07-14 | E. R. Squibb & Sons, Inc. | Cyclobutane derivatives |
| US5185459A (en) * | 1988-03-30 | 1993-02-09 | E. R. Squibb & Sons Inc. | Bis protected (hydroxymethyl)cyclobutanols |
| US5126345A (en) * | 1988-03-30 | 1992-06-30 | E. R. Squibb & Sons, Inc. | Bis (hydroxymethyl) cyclobutyl triazolopyrimidines |
| IL92096A0 (en) * | 1988-10-25 | 1990-07-12 | Abbott Lab | Carboxylic nucleoside analogs |
| US4918075A (en) * | 1988-12-20 | 1990-04-17 | E. R. Squibb & Sons, Inc. | Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents |
| AU635642B2 (en) * | 1990-05-24 | 1993-03-25 | E.R. Squibb & Sons, Inc. | Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines |
| US5324730A (en) * | 1990-05-24 | 1994-06-28 | Nippon Kayaku Kabushiki Kaisha | Phenoxyphosphoryloxymethyl cyclobutyl purines |
| US5166397A (en) * | 1990-09-20 | 1992-11-24 | Nippon Kayaku Kabushiki Kaisha | Process for producing optically active cyclobutylamines |
| US20040229839A1 (en) * | 2003-05-14 | 2004-11-18 | Biocryst Pharmaceuticals, Inc. | Substituted nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| JP2008523098A (ja) | 2004-12-10 | 2008-07-03 | エモリー・ユニバーシテイ | ウィルス感染および異常細胞増殖の治療用の２′および３′−置換シクロブチルヌクレオシド類縁体 |
-
2005
- 2005-12-08 JP JP2007545685A patent/JP2008523098A/ja not_active Withdrawn
- 2005-12-08 EP EP05853591A patent/EP1828145A4/en not_active Withdrawn
- 2005-12-08 CN CNA2005800477715A patent/CN101115725A/zh active Pending
- 2005-12-08 AU AU2005313912A patent/AU2005313912A1/en not_active Abandoned
- 2005-12-08 WO PCT/US2005/044709 patent/WO2006063281A2/en not_active Ceased
- 2005-12-08 BR BRPI0518984-5A patent/BRPI0518984A2/pt not_active IP Right Cessation
- 2005-12-08 US US11/301,326 patent/US7495006B2/en active Active
- 2005-12-08 MX MX2007006961A patent/MX2007006961A/es active IP Right Grant
- 2005-12-08 CA CA002590115A patent/CA2590115A1/en not_active Abandoned
-
2009
- 2009-02-10 US US12/368,876 patent/US8114994B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006063281A3 (en) | 2006-10-12 |
| EP1828145A4 (en) | 2009-08-19 |
| US7495006B2 (en) | 2009-02-24 |
| EP1828145A2 (en) | 2007-09-05 |
| CN101115725A (zh) | 2008-01-30 |
| US8114994B2 (en) | 2012-02-14 |
| CA2590115A1 (en) | 2006-06-15 |
| AU2005313912A1 (en) | 2006-06-15 |
| JP2008523098A (ja) | 2008-07-03 |
| US20060223835A1 (en) | 2006-10-05 |
| US20090149416A1 (en) | 2009-06-11 |
| MX2007006961A (es) | 2007-10-04 |
| WO2006063281A2 (en) | 2006-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 8A, 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |