UY29868A1 - Nucleocidos 4 modificados como agentes antivirales - Google Patents
Nucleocidos 4 modificados como agentes antiviralesInfo
- Publication number
- UY29868A1 UY29868A1 UY29868A UY29868A UY29868A1 UY 29868 A1 UY29868 A1 UY 29868A1 UY 29868 A UY29868 A UY 29868A UY 29868 A UY29868 A UY 29868A UY 29868 A1 UY29868 A1 UY 29868A1
- Authority
- UY
- Uruguay
- Prior art keywords
- nucleocidos
- modified
- antiviral agents
- beta
- virus
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proveen compuestos, métodos y composiciones para el tratamiento de un portador infectado con el virus de inmunodeficiencia humana y el virus de hepatitis B que comprende administrar una cantidad efectiva de un nucleósido 4´-C-sustituido B(Beta)-D- y B(Beta)-L-nucleósido descritos o una sal farmacéuticamente aceptable o profármaco del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72038805P | 2005-09-26 | 2005-09-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY29868A1 true UY29868A1 (es) | 2007-04-30 |
Family
ID=37900393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY29868A UY29868A1 (es) | 2005-09-26 | 2006-10-17 | Nucleocidos 4 modificados como agentes antivirales |
Country Status (17)
Country | Link |
---|---|
US (1) | US8569478B2 (es) |
EP (2) | EP1937825B1 (es) |
JP (1) | JP2009510075A (es) |
KR (1) | KR20080065272A (es) |
CN (2) | CN101310021A (es) |
AR (1) | AR056202A1 (es) |
AU (1) | AU2006294807B2 (es) |
BR (1) | BRPI0616738A2 (es) |
CA (2) | CA2623522C (es) |
EA (1) | EA200800932A1 (es) |
ES (1) | ES2617582T3 (es) |
IL (1) | IL190390A0 (es) |
NZ (3) | NZ567272A (es) |
PT (1) | PT1937825T (es) |
UY (1) | UY29868A1 (es) |
WO (1) | WO2007038507A2 (es) |
ZA (1) | ZA200802723B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
WO2004046331A2 (en) | 2002-11-15 | 2004-06-03 | Idenix (Cayman) Limited | 2’-branched nucleosides and flaviviridae mutation |
WO2005003147A2 (en) | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
CN100532388C (zh) * | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
WO2009052050A1 (en) * | 2007-10-15 | 2009-04-23 | Pharmasset, Inc. | Dioxolane thymine phosphoramidates as anti-hiv agents |
US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
US8716263B2 (en) | 2008-12-23 | 2014-05-06 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
EP3222628A1 (en) | 2008-12-23 | 2017-09-27 | Gilead Pharmasset LLC | Nucleoside phosphoramidates |
CN102666562A (zh) * | 2009-12-17 | 2012-09-12 | 诺威戴克斯医药公司 | 新颖的3’-脱氧-3‘-亚甲基-β-L-核苷 |
PT3290428T (pt) | 2010-03-31 | 2021-12-27 | Gilead Pharmasset Llc | Comprimido compreendendo 2-(((s)-(((2r,3r,4r,5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2h)-il)¿4¿fluoro¿3¿hidroxi¿4¿metiltetrahidrofuran¿2¿il)metoxi) (fenoxi)fosforil)amino)propanoato de (s)- isopropil cristalino |
EP2691409B1 (en) | 2011-03-31 | 2018-02-21 | Idenix Pharmaceuticals LLC. | Compounds and pharmaceutical compositions for the treatment of viral infections |
TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
ME03009B (me) | 2011-09-16 | 2018-10-20 | Gilead Pharmasset Llc | Metode za lecenje hcv-a |
TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的3’,5’-環磷酸酯及用於治療病毒感染之醫藥組成物 |
WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
EP2852603B1 (en) | 2012-05-22 | 2021-05-12 | Idenix Pharmaceuticals LLC | D-amino acid compounds for liver disease |
CN104379571A (zh) | 2012-05-23 | 2015-02-25 | 百时美施贵宝公司 | 用于制备festinavir的硫亚胺和亚砜方法 |
HUE029038T2 (en) | 2012-05-25 | 2017-01-30 | Janssen Sciences Ireland Uc | Uracil spirooxetan nucleosides |
EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
CN111848711A (zh) | 2012-10-08 | 2020-10-30 | 埃迪尼克斯医药有限责任公司 | 用于hcv感染的2′-氯核苷类似物 |
WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
JP2015508418A (ja) | 2013-01-31 | 2015-03-19 | ギリアド ファーマセット エルエルシー | 2種の抗ウイルス化合物のコンビナトリアル製剤 |
US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
US20140271547A1 (en) | 2013-03-13 | 2014-09-18 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
EP2986602A1 (en) | 2013-04-16 | 2016-02-24 | Bristol-Myers Squibb Company | Method for producing festinavir using 5-methyluridine as starting material |
WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
EP3008060A1 (en) | 2013-06-13 | 2016-04-20 | Bristol-Myers Squibb Company | Tert-butyl-sulphoxide method for producing festinavir |
WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
AU2014331863C1 (en) | 2013-10-11 | 2019-05-16 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
KR101718242B1 (ko) * | 2015-11-25 | 2017-03-21 | 주식회사 타미온 | Hiv 억제 활성을 가지는 신규한 화합물 및 이의 용도 |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
WO2021188959A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
CN111995649A (zh) * | 2020-04-09 | 2020-11-27 | 瀚海新拓(杭州)生物医药有限公司 | 一种蝶啶酮核苷酸类似物及其药物组合物、制备方法和医药用途 |
CN113501853B (zh) * | 2021-09-13 | 2021-12-07 | 南京颐媛生物医学研究院有限公司 | 4-硫代尿嘧啶脱氧核苷磷酸酯及其抗病毒药物用途 |
WO2023085242A1 (ja) * | 2021-11-12 | 2023-05-19 | 国立大学法人北海道大学 | 抗ウイルス剤 |
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US5223263A (en) | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
ZA867013B (en) * | 1985-09-17 | 1988-04-27 | Wellcome Found | Therapeutic nucleosides |
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NZ228645A (en) | 1988-04-11 | 1991-09-25 | Iaf Biochem Int | 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections |
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US5256641A (en) | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
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US5414078A (en) * | 1991-04-05 | 1995-05-09 | Emory University | Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors |
EP0594677A4 (en) | 1991-07-12 | 1997-09-17 | Vical Inc | Antiviral liponucleosides: treatment of hepatitis b |
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EP0746319A4 (en) | 1993-05-12 | 1997-11-05 | Karl Y Hostetler | ACYCLOVIR DERIVATIVES FOR TOPICAL USE |
US5696277A (en) | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
DE19632823C1 (de) * | 1996-08-14 | 1997-11-20 | Symbio Herborn Group Gmbh & Co | Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation |
FI107059B (fi) * | 1998-07-01 | 2001-05-31 | Metso Paper Inc | Paperikoneen formeri-puristinosa ja menetelmä rainan siirtämiseksi formerilta puristinosalle |
ATE250622T1 (de) * | 1999-05-12 | 2003-10-15 | Yamasa Corp | 4'-c-ethynyl-pyrimidine nukleoside |
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BRPI0407374A (pt) * | 2003-02-19 | 2006-01-10 | Univ Yale | Análogos de nucleosìdeo antiviral e métodos para tratar infecções virais, especialmente infecções de hiv |
WO2005003147A2 (en) * | 2003-05-30 | 2005-01-13 | Pharmasset, Inc. | Modified fluorinated nucleoside analogues |
US20090318380A1 (en) * | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
-
2006
- 2006-09-26 EA EA200800932A patent/EA200800932A1/ru unknown
- 2006-09-26 NZ NZ567272A patent/NZ567272A/en not_active IP Right Cessation
- 2006-09-26 NZ NZ609146A patent/NZ609146A/en not_active IP Right Cessation
- 2006-09-26 WO PCT/US2006/037470 patent/WO2007038507A2/en active Application Filing
- 2006-09-26 JP JP2008533517A patent/JP2009510075A/ja active Pending
- 2006-09-26 CN CNA2006800423211A patent/CN101310021A/zh active Pending
- 2006-09-26 ES ES06825120.6T patent/ES2617582T3/es active Active
- 2006-09-26 CA CA2623522A patent/CA2623522C/en not_active Expired - Fee Related
- 2006-09-26 CA CA2904692A patent/CA2904692A1/en not_active Abandoned
- 2006-09-26 PT PT68251206T patent/PT1937825T/pt unknown
- 2006-09-26 BR BRPI0616738-1A patent/BRPI0616738A2/pt not_active Application Discontinuation
- 2006-09-26 KR KR1020087009645A patent/KR20080065272A/ko active Search and Examination
- 2006-09-26 CN CN2012103530710A patent/CN102924549A/zh active Pending
- 2006-09-26 AU AU2006294807A patent/AU2006294807B2/en not_active Ceased
- 2006-09-26 EP EP06825120.6A patent/EP1937825B1/en active Active
- 2006-09-26 EP EP16201801.4A patent/EP3159351A3/en not_active Withdrawn
- 2006-09-26 NZ NZ597544A patent/NZ597544A/xx not_active IP Right Cessation
- 2006-09-26 US US12/067,995 patent/US8569478B2/en active Active
- 2006-09-27 AR ARP060104218A patent/AR056202A1/es unknown
- 2006-10-17 UY UY29868A patent/UY29868A1/es not_active Application Discontinuation
-
2008
- 2008-03-24 IL IL190390A patent/IL190390A0/en unknown
- 2008-03-27 ZA ZA200802723A patent/ZA200802723B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES2617582T3 (es) | 2017-06-19 |
CA2904692A1 (en) | 2007-04-05 |
NZ567272A (en) | 2012-02-24 |
EP1937825A4 (en) | 2010-06-23 |
IL190390A0 (en) | 2008-11-03 |
US8569478B2 (en) | 2013-10-29 |
ZA200802723B (en) | 2009-03-25 |
NZ597544A (en) | 2013-04-26 |
WO2007038507A2 (en) | 2007-04-05 |
EP3159351A2 (en) | 2017-04-26 |
AR056202A1 (es) | 2007-09-26 |
AU2006294807B2 (en) | 2013-01-17 |
EP1937825B1 (en) | 2016-12-21 |
WO2007038507A3 (en) | 2007-09-13 |
US20110021454A1 (en) | 2011-01-27 |
EP3159351A3 (en) | 2017-05-17 |
KR20080065272A (ko) | 2008-07-11 |
PT1937825T (pt) | 2017-03-08 |
AU2006294807A1 (en) | 2007-04-05 |
EA200800932A1 (ru) | 2008-10-30 |
CA2623522A1 (en) | 2007-04-05 |
CA2623522C (en) | 2015-12-08 |
JP2009510075A (ja) | 2009-03-12 |
NZ609146A (en) | 2014-08-29 |
EP1937825A2 (en) | 2008-07-02 |
CN101310021A (zh) | 2008-11-19 |
BRPI0616738A2 (pt) | 2011-06-28 |
CN102924549A (zh) | 2013-02-13 |
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